Compound Summary

  Compound Information

TCMBANKIN000027

药名:	taxol
别名:	Paclitaxel
分子式:	C47H51NO14
Smiles:	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
成分:	HBIN045705
CAS_id:	33069-62-4
TCMID_id:	20795
PubChem_id:	36314

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE006791		落羽杉
TCMBANKHE005103	Taxus wallichiana	喜马拉雅红豆杉
TCMBANKHE005116	Taxus cuspidata	紫杉			To disinhibit urine and free channels, anticancer./Kidney disease, diabetes mellitus, carcinoma of ovary, carcinoma of mammary glands.
TCMBANKHE005329	Taxus chinensis	红豆杉
TCMBANKHE005439	Taxus baccata	浆果紫杉
TCMBANKHE007481	Cephalotaxus hainanensis [Syn. Cephalotaxus mannii ]	海南粗榧			Anticancer./Carcinoma.
TCMBANKHE007832	Taxus brevifolia	短叶红豆杉
TCMBANKHE008274	Ta x u s m e d i a	介质红豆杉
TCMBANKHE006189	Taxus sumatrana	苏门答腊红豆杉;苏门达腊红豆杉
TCMBANKHE007281	Taxus yunnanensis	云南红豆杉
TCMBANKHE008411	Ta xus ma i rei	美丽红豆杉			To disperse accumulation, expel roundworm./Food accumulation, ascariasis.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000001	Stomach Neoplasms	group	Digestive System Diseases; Neoplasms	24129235
TCMBANKDI000002	Hyperalgesia	phenotype	Pathological Conditions, Signs and Symptoms; Nervous System Diseases	21145656
TCMBANKDI000007	melanoma	disease	Neoplasms	24080340
TCMBANKDI000019	Parkinson Disease	disease	Nervous System Diseases	25332110
TCMBANKDI000047	Neoplasm Metastasis	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	31779616
TCMBANKDI000048	Neoplasms	group	Neoplasms	30322956
TCMBANKDI000084	Platelet aggregation	phenotype	-	22936655
TCMBANKDI000088	Lung Neoplasms	group	Neoplasms; Respiratory Tract Diseases	31779616
TCMBANKDI002163	Neoplasms, Experimental	phenotype	Neoplasms	20890306
TCMBANKDI002740	Uterine Cervical Neoplasm	disease	Neoplasms; Female Urogenital Diseases and Pregnancy Complications	24853425
TCMBANKDI002987	Respiratory Function Tests	phenotype	-	21621341
TCMBANKDI003353	Carcinogenesis	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	28589243
TCMBANKDI006869	Necrosis	phenotype	Pathological Conditions, Signs and Symptoms	28162276
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	24853425
TCMBANKDI013453	Proteinuria	phenotype	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	21984124
TCMBANKDI013888	Fibrosis	phenotype	Pathological Conditions, Signs and Symptoms	21984124
TCMBANKDI014770	Polyploidy	phenotype	Pathological Conditions, Signs and Symptoms	21368834
TCMBANKDI015242	Peripheral Nervous System Diseases	group	Nervous System Diseases	23726937
TCMBANKDI015496	Liver neoplasms	group	Digestive System Diseases; Neoplasms	29748662
TCMBANKDI015697	Carcinoma, Transitional Cell	disease	Neoplasms	20682548
TCMBANKDI015964	Lymphatic Metastasis	disease	Pathological Conditions, Signs and Symptoms; Neoplasms	25827073
TCMBANKDI022179	Longevity	phenotype	-	26913604
TCMBANKDI022691	Triple Negative Breast Neoplasms	disease	Neoplasms; Skin and Connective Tissue Diseases	24667715
TCMBANKDI025125	Smoking	phenotype	Behavior and Behavior Mechanisms	21621341
TCMBANKDI026887	ovarian neoplasm	disease	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases	31623606
TCMBANKDI029899	Lymphoma	group	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases	21621341
TCMBANKDI031190	Thrombosis	phenotype	Cardiovascular Diseases	22936655

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000053	NFKB1	CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB	nuclear factor kappa B subunit 1
TCMBANKGE000149	MAP3K12	DLK; MEKK12; MUK; ZPK; ZPKP1	mitogen-activated protein kinase kinase kinase 12
TCMBANKGE000150	MIR192	MIRN192; miR-192; miRNA192	microRNA 192
TCMBANKGE000151	UBE2C	UBCH10; dJ447F3.2	ubiquitin conjugating enzyme E2 C
TCMBANKGE000152	RANBP10	-	RAN binding protein 10
TCMBANKGE000153	USP7	HAUSP; TEF1	ubiquitin specific peptidase 7
TCMBANKGE000154	CCR2	CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R	C-C motif chemokine receptor 2
TCMBANKGE000155	SPAG5	DEEPEST; MAP126; hMAP126	sperm associated antigen 5
TCMBANKGE000156	Atat1	0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT	alpha tubulin acetyltransferase 1
TCMBANKGE000157	PRC1	ASE1	protein regulator of cytokinesis 1
TCMBANKGE000158	RHOA	ARH12; ARHA; EDFAOB; RHO12; RHOH12	ras homolog family member A
TCMBANKGE000159	RHOH	ARHH; TTF	ras homolog family member H
TCMBANKGE000175	FBXW7	AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; SEL-10; SEL10; hAgo; hCdc4	F-box and WD repeat domain containing 7
TCMBANKGE000238	IL10	CSIF; GVHDS; IL-10; IL10A; TGIF	interleukin 10
TCMBANKGE000274	CCL2	GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF	C-C motif chemokine ligand 2
TCMBANKGE000280	VIM	-	vimentin
TCMBANKGE000289	EIF2AK3	PEK; PERK; WRS	eukaryotic translation initiation factor 2 alpha kinase 3
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000590	ILK	HEL-S-28; ILK-1; ILK-2; P59; p59ILK	integrin linked kinase
TCMBANKGE000635	AURKA	AIK; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7	aurora kinase A
TCMBANKGE000990	EGFR	ERBB; ERBB1; HER1; NISBD2; PIG61; mENA	epidermal growth factor receptor
TCMBANKGE001051	MAP2K7	JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4	mitogen-activated protein kinase kinase 7
TCMBANKGE001061	CDK5	LIS7; PSSALRE	cyclin dependent kinase 5
TCMBANKGE001062	PLK1	PLK; STPK13	polo like kinase 1
TCMBANKGE001083	MAP3K5	ASK1; MAPKKK5; MEKK5	mitogen-activated protein kinase kinase kinase 5
TCMBANKGE001085	MAPK8	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c	mitogen-activated protein kinase 8
TCMBANKGE001096	TLR4	ARMD10; CD284; TLR-4; TOLL	toll like receptor 4
TCMBANKGE001102	MIR21	MIRN21; hsa-mir-21; miR-21; miRNA21	microRNA 21
TCMBANKGE001106	MTOR	FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS	mechanistic target of rapamycin kinase
TCMBANKGE001123	CTNNB1	CTNNB; EVR7; MRD19; NEDSDV; armadillo	catenin beta 1
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001132	BAX	BCL2L4	BCL2 associated X, apoptosis regulator
TCMBANKGE001133	PTK2	FADK; FAK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK	protein tyrosine kinase 2
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001169	BCL2L1	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52	BCL2 like 1
TCMBANKGE001173	MCL1	BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT	MCL1 apoptosis regulator, BCL2 family member
TCMBANKGE001177	TP53	BCC7; BMFS5; LFS1; P53; TRP53	tumor protein p53
TCMBANKGE001179	SMAD2	JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2	SMAD family member 2
TCMBANKGE001180	SMAD3	HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3	SMAD family member 3
TCMBANKGE001181	TGFB1	CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta	transforming growth factor beta 1
TCMBANKGE001200	STMN1	C1orf215; LAP18; Lag; OP18; PP17; PP19; PR22; SMN	stathmin 1
TCMBANKGE001203	MAPK1	ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK	mitogen-activated protein kinase 1