Compound Summary

  Compound Information

TCMBANKIN000054

药名:	sinomenine
别名:	Cucoline; Spectrum3_001134; EINECS 204-094-6; 9-alpha,13-alpha,14-alpha-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-; UPCMLD-DP085:001; NCGC00161641-01; Spectrum2_001242; SPECTRUM1505253; C09643; Sabianine A; (9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one; BSPBio_002627; KBio3_002127; BRN 0095280; STOCK1N-06056; 365602_ALDRICH; SPBio_001144; 5-21-13-00516 (Beilstein Handbook Reference); KBioGR_002508; BCBcMAP01_000195; Coculine; 7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-morphinan-6-one; CCRIS 1550; Spectrum4_001981; Spectrum5_001621; Kukoline; Sinomenine; SMP1_000273
分子式:	C19H23NO4
Smiles:	CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
成分:	HBIN044111
CAS_id:	115-53-7
SymMap_id:	SMIT01618;SMIT03180
TCMID_id:	19939
TCMSP_id:	MOL000625;MOL012920
PubChem_id:	5459308

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE003465	Corydalis pallida var. tenuis
TCMBANKHE005790	Menispermum dauricum	蝙蝠葛根			To clear heat and resolve toxin, disperse swelling and relieve pain, disinhibit damp./Swelling pain in throat, lung heat cough, epidemic parotitis, diarrhea, jaundice, wind-damp impediment pain, swelling pain from hemorrhoids, snake or insect bites.
TCMBANKHE004121	Radix Stemoe	百部			1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie.
TCMBANKHE007156	Herba Patriniae	败酱草			1. To eliminate heat and toxic material, relieve abscess and promote pus drainage. 2. To remove blood stasis and alleviate pain/1. Two active components, patrinene and isopatrinene, possess sedative effect. 2. To promote regeneration of hepatic cells and portal circulation, protect hepatic cells from degernation and improve hepatic function.
TCMBANKHE008052	Corydalis incisa	紫花鱼灯草			To resolve toxin and kill worms, relieve pain./Toxin swelling of sores, scab and lai, intractable lichen, eczema, poisonous snake bite.
TCMBANKHE007598	Stephania dielsiana	血散薯			To clear heat and resolve toxin, dissipate stasis and relieve pain./Infection of upper respiratory tract, pharyngitis, sore and welling abscess, stomachache, gastroenteritis, toothache, neuralgia, knocks and falls.
TCMBANKHE007813	Corydalis pallida	菊花黄连			To clear heat and resolve toxin, disperse swelling and relieve pain./Welling abscess and boil, innominate toxin swelling.
TCMBANKHE006056	Rhizoma Menispermi	北豆根			To remove toxic heat and relieve rheumatic pains./Treatment of sore throat, colitis, dysentery, rheumatic arthralgia.
TCMBANKHE006744	Menispermum dauricum	蝙蝠葛			To clear heat and resolve toxin, disperse swelling and relieve pain./Lumbago, scrofula, swelling pain in throat, diarrhea and dysentery, swelling pain from hemorrhoids.
TCMBANKHE007462		青风藤			Wind-damp impediment pain, pain from arthritis, swelling in joints, paralytic and pruritus.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000003	Encephalitis	disease	Nervous System Diseases	27724964
TCMBANKDI000083	Infarction, Middle Cerebral Artery	disease	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases	27724964
TCMBANKDI000085	Inflammation	phenotype	Pathological Conditions, Signs and Symptoms	26795599
TCMBANKDI000090	Acute kidney injury	disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	26795599
TCMBANKDI004007	Cerebral Infarction	disease	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases	27724964
TCMBANKDI015773	Brain Edema	phenotype	Nervous System Diseases	27724964
TCMBANKDI018658	Osteolysis	phenotype	Musculoskeletal Diseases	30797069
TCMBANKDI023464	Epilepsy	disease	Nervous System Diseases	29776417
TCMBANKDI023555	Hypoxia	phenotype	Pathological Conditions, Signs and Symptoms	27724964
TCMBANKDI025576	Pain, Postoperative	phenotype	Pathological Conditions, Signs and Symptoms	26915970
TCMBANKDI027585	Mammary Neoplasms, Experimental	phenotype	Neoplasms	30797069
TCMBANKDI031985	Brain Ischemia	disease	Nervous System Diseases; Cardiovascular Diseases	21585344

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000051	IL1B	IL-1; IL1-BETA; IL1F2; IL1beta	interleukin 1 beta
TCMBANKGE000052	TNF	DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F	tumor necrosis factor
TCMBANKGE000053	NFKB1	CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB	nuclear factor kappa B subunit 1
TCMBANKGE000204	CXCL8	GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8	C-X-C motif chemokine ligand 8
TCMBANKGE000223	KEAP1	INrf2; KLHL19	kelch like ECH associated protein 1
TCMBANKGE000541	CRYAB	CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2	crystallin alpha B
TCMBANKGE000542	NLRP1	AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NALP1; PP1044; SLEV1; VAMAS1	NLR family pyrin domain containing 1
TCMBANKGE000543	OSCAR	PIGR3; PIgR-3	osteoclast associated Ig-like receptor
TCMBANKGE000544	CXCR1	C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA	C-X-C motif chemokine receptor 1
TCMBANKGE000562	IL18	IGIF; IL-18; IL-1g; IL1F4	interleukin 18
TCMBANKGE000868	NFATC1	NF-ATC; NF-ATc1.2; NFAT2; NFATc	nuclear factor of activated T cells 1
TCMBANKGE000869	DRD2	D2DR; D2R	dopamine receptor D2
TCMBANKGE001114	IL6	BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6	interleukin 6
TCMBANKGE001126	NFE2L2	HEBP1; IMDDHH; NRF2; Nrf-2	nuclear factor, erythroid 2 like 2
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001197	FOS	AP-1; C-FOS; p55	Fos proto-oncogene, AP-1 transcription factor subunit