Compound Summary

  Compound Information

TCMBANKIN000086

药名:	cucurbitacin e
别名:	NSC521775; acetic acid [(5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-3,11-diketo-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-4-keto-1,1-dimethyl-hex-2-enyl] ester; .alpha.-Elaterine; [(5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate; LMST01010107; .alpha.-Elaterin; NCI60_000150; 19-Nor-9.beta.,10.alpha.-lanosta-1,5,23-triene-3,11,22-trione, 2,16.alpha.,20,25-tetrahydroxy-9-methyl-, 25-acetate; [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxo-hept-3-en-2-yl] ethanoate; ELATERIN, ALPHA; [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; acetic acid [(E,5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-3,11-diketo-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-4-keto-1,1-dimethyl-hex-2-enyl] ester; [(E,5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate; Cucurbitacine E; 19-Norlanosta-1,5,23-triene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (9.beta.,10.alpha.,16.alpha.,23E)-; Cucurbitacin E; [(6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; acetic acid [(5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxohex-2-enyl] ester; [(6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxo-hept-3-en-2-yl] ethanoate; 18444-66-1; C08797; acetic acid [(E,5R)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxohex-2-enyl] ester
分子式:	C32H44O8
Smiles:	CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3C=C(C(=O)C4(C)C)O)C)C)C)O)O
成分:	HBIN021850
SymMap_id:	SMIT01356;SMIT04678
TCMID_id:	4319
TCMSP_id:	MOL002444
PubChem_id:	5353547

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004526	Rhizoma Bolbostemmae	土贝母			To dissolve lumps, cause subsidence of swelling, and counteract toxicity./Treatment of mastitis, chronic lymphadenitis, tuberculosis of cervical lymph nodes, hypertrophic rhinitis.
TCMBANKHE004709	Begonia nantoensis	南投秋海棠
TCMBANKHE004718	Bryonia alba	白泻根
TCMBANKHE007551	Catechu	儿茶			To reduce toxic and to remove dampness./To arrest exudation, promote the growth of new tissue, and cure wounds.
TCMBANKHE006621	Gratiola officinalis	药水八角
TCMBANKHE006184	Radix Angelicae Pubescentis	独活			To relieve rheumatic conditions, and to remove obstruction from the channels and relieve pain./Wind-cold-damp impediment (especially in lower part of body), pain in lumbus and knees, headache, toothache.
TCMBANKHE006580	Calycis Melo	瓜蒂			Vomiting promotion/Wind stroke, epilepsy, throat impediment, indigestion of overnight food, distending pain in stomach duct, damp-heat jaundice, chronic hepatitis, cirrhosis.
TCMBANKHE008403	Crinodendron hookerianum	红百合木
TCMBANKHE008763	Ecballium elaterium	喷瓜
TCMBANKHE008507	Iberis umbellata	伞形屈曲花
TCMBANKHE006668/YEM-19	Aquilaria sinensis|Aquilaria sinensis (Lour.) Spreng.	白木香	沉香	云南民族药物志：第一卷	See Aquilaria agallocha./See Aquilaria agallocha .	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族/藏族
TCMBANKHE004426/YEM-669	Cucumis sativus|Cucumis sativus L.	黄瓜	黄瓜	云南民族药物志：第四卷	To clear heat, disinhibit water, resolve toxin./Febrile diseases thirst, short voidings of reddish urine, burns and scalds, scant urine with edema, sweat macule, prickly heat.	傣族/哈尼族/佤族/彝族
TCMBANKHE008148/YEM-669	Cucumis sativus|Cucumis sativus L.	黄瓜	黄瓜	云南民族药物志：第四卷	To clear heat, disinhibit water, resolve toxin./Febrile diseases thirst, short voidings of reddish urine, burns and scalds, scant urine with edema, sweat macule, prickly heat.	傣族/哈尼族/佤族/彝族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000008	Brain Neoplasms	group	Neoplasms; Nervous System Diseases	24577085
TCMBANKDI006869	Necrosis	phenotype	Pathological Conditions, Signs and Symptoms	24763055
TCMBANKDI015740	Colorectal Neoplasms	group	Digestive System Diseases; Neoplasms	24763055
TCMBANKDI024649	Neuroblastoma	disease	Neoplasms	24577085

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000919	GADD45B	GADD45BETA; MYD118	growth arrest and DNA damage inducible beta
TCMBANKGE000920	GADD45A	DDIT1; GADD45	growth arrest and DNA damage inducible alpha
TCMBANKGE000921	CCNB1	CCNB	cyclin B1
TCMBANKGE000922	GADD45G	CR6; DDIT2; GADD45gamma; GRP17	growth arrest and DNA damage inducible gamma
TCMBANKGE000923	CDK1	CDC2; CDC28A; P34CDC2	cyclin dependent kinase 1
TCMBANKGE001177	TP53	BCC7; BMFS5; LFS1; P53; TRP53	tumor protein p53