Compound Summary


  Compound Information

药名:

sinapic acid

别名:

A829376; (E)-3-(4-hydroxy-3,5-dimethoxy-phenyl)prop-2-enoic acid; 3-(3,5-Dimethoxy-4-hydroxyphenyl)acrylate; ST5308240; (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid; InChI=1/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13; 85429_FLUKA; 2-propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-, (2E)-; 3,5-Dimethoxy-4-hydroxycinnamic acid; (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate; (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid; ZB005508; 2-propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-; C00482; sinapicacid; 49508_FLUKA; MLS001066354; Sinapic acid; SXX; 3-(4-hydroxy-3,5-dimethoxyphenyl)acrylic acid; 3,5-dimethoxy-4-hydroxycinnamic acid; 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid; trans-sinapate; AIDS024970; (E)-3-(3,5-dimethoxy-4-oxidanyl-phenyl)prop-2-enoate; AC1NUT1R; NSC59261; (E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid; CHEBI:30023; 4-Hydroxy-3,5-dimethoxy-cinnamic acid; 2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-, (E)-; Synapoic acid; SINAPINATE; (E)-3-(4-hydroxy-3,5-dimethoxy-phenyl)acrylic acid; 530-59-6; AIDS-024970; D7927_SIGMA; SMR000471879; (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoate; (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)acrylic acid; CHEBI:15714; CINNAMIC ACID,3,5-DIMETHOXY,4-HYDROXY; (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate; Cinnamic acid, 4-hydroxy-3,5-dimethoxy-, (E)-; (E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid; InChI=1/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3; 7362-37-0; 3-(4-hydroxy-3,5-dimethoxy-phenyl)acrylic acid; 3-(4-hydroxy-3,5-dimethoxy-phenyl)prop-2-enoic acid; 3,5-dimethoxy-4-hydroxycinnamate; 4-hydroxy-3,5-dimethoxycinnamate

分子式:

C11H12O5

Smiles:

COC1=CC(=CC(=C1O)OC)C=CC(=O)O

成分:

HBIN044062

OB_score:

64.146062

CAS_id:

530-59-6

SymMap_id:

SMIT00488;SMIT17717

TCMID_id:

23139;19896

TCMSP_id:

MOL002152

PubChem_id:

637775


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000541 甘草头
TCMBANKHE001384 Radix Glycyrrhizae uralensis 甘草稍
TCMBANKHE003349 甘草节
TCMBANKHE003520 Semen Glycine Max 黑豆
TCMBANKHE003728 Radix Glycyrrhizae 甘草 To reinforce the function of the spleen and replenish qi, to remove heat and counteract toxicity, to dispel phlegm and relieve cough, to alleviate spasmodic pain, and to moderate drug actions./1. Its decoction can inhibit intestinal smooth muscles of rabbins in vitro, but glycyrrhizin and glycyrrhetinic acid have no this effect.2. Possessing an adrenocorticomimetic effect.3. Its extract and glycyrrhizin exerts a detoxifying effect.4. Antitussive and antiasthmatic. 5. Glycyrrhizin has anti-inflammatory effect similar to hydrocortisone.
TCMBANKHE003826 Rhizoma Cimicifugae 升麻 To induce perspiration and promote eruption, to remove toxic heat, and to cure drooping and ptosis./Prevention of ptosis, women’s hormone dysfunction diseases, seasonal epidemic fire toxin, mouth sore, sore pharynx, macula, cold-heat headache, swelling toxin of welling abscess and sore, center qi fall, spleen vacuity diarrhea, chronic dysentery, vaginal discharge, flooding.
TCMBANKHE003843 Citrus limon 柠檬 To engender liquid and allay thirst, dispel summerheat, quiet fetus./Stomach heat fluid damage, summerheat stroke with vexation and thirst, inappetence, glomus distention in stomach duct and abdomen, lung heat dry cough, vomiting in pregnancy.
TCMBANKHE004095 Semen Sipis 芥子 To relieve dyspnea and cough by eliminating cold-phlegm, to reduce modulation, and to relieve pain by removing the obstruction of collateral./Vomiting with stomach cold, pain in heart and abdomen, lung cold cough, impediment pain, throat impediment, flowing phlegm, knocks and falls.
TCMBANKHE004097 Citrus limonia 黎檬叶 See Citrus limon./See Citrus limon.
TCMBANKHE008337 Acer saccharinum 银白槭
TCMBANKHE006069 Erica australis 南方欧石楠
TCMBANKHE006218 Juglans nigra 黑胡桃
TCMBANKHE006287 Herba Portulacae 马齿苋 To remove toxic heat, and to arrest bleeding./Heat toxin blood dysentery, acute bacillary dysentery, pertussis, enteritis, appendicitis, swollen welling abscess and clove sores, eczema, erysipelas, bleeding, postpartum bleeding, hematochezia, bleeding from hemorrhoids, flooding and spotting, ascariasis, ancylostomiasis, snake or insect bites.
TCMBANKHE005015 Pterocarpus santalinus 似紫檀
TCMBANKHE005226 Rhizoma Dryriae 骨碎补 To replenish the kidney, to strengthen the bones, to promote the healing of fracture, and to relieve pain./Kidney vacuity lumbago, tinnitus and deafness, tooth mobilizing, wrenching and contusion from knocks and falls, sinew and bone wound, alopecia areata, white patch wind.
TCMBANKHE005274 Cynanchum thesioides 地梢瓜 To clear vacuity fire, boost qi, engender liquid, promote lactation./Upflaming vacuity fire, throat pain, qi and yin vacuity, fatigued spirit and amnesia, vacuity vexation and thirst, dizziness and insomnia, postpartum vacuity weakness, scant breast milk.
TCMBANKHE007721 Exocarpium Benincasae 冬瓜皮 1. To promote diuresis to relieve edema. 2. To clear summer-heat./Edema, inhibited urination [=dysuria], diarrhea, swelling of sores.
TCMBANKHE006054 Radix chuanxiong;Rhizoma Chuanxiong 川芎 1. To invigorate blood and promote qi circulation; 2. To expel wind and stop pain/Cerebral ischemia, postpartum pain, acute icterohepatitis, menstrual disorder, amenorrhea and dysmenorrhea, concretion and conglomeration, chest and rib-side stabbing pain, painful swelling from knocks and falls, headache, wind-damp impediment pain.
TCMBANKHE006073 Allium cepa 洋葱 To fortify stomach and rectify qi, resolve toxin and kill worms, lower blood-fat./Reduced food intake with abdominal distention, wound, ulcer, trichomoniasis, hyperlipemia.
TCMBANKHE008128 Capparis spinosa 老鼠瓜 To dispel wind, dissipate cold, eliminate damp./Acute rheumatic arthritis, chronic rheumatic arthritis.
TCMBANKHE006792 Lepidium sativum 家独行菜 To relieve cough and dispel phlegm, warm center, disinhibit urine, hasten delivery./Cough, asthma, abundant phlegm, hiccough, diarrhea, dysentery, abdominal distention, edema, inhibited urination, scab and lichen.
TCMBANKHE006927 Asarum europaeum 欧细辛
TCMBANKHE006985 Citrus limonia 黎檬根 See Citrus limon./See Citrus limon.
TCMBANKHE008104 Radix chuanxiong;Rhizoma Chuanxiong 川芎 1. To invigorate blood and promote qi circulation; 2. To expel wind and stop pain/Cerebral ischemia, postpartum pain, acute icterohepatitis, menstrual disorder, amenorrhea and dysmenorrhea, concretion and conglomeration, chest and rib-side stabbing pain, painful swelling from knocks and falls, headache, wind-damp impediment pain.
TCMBANKHE008006 Urtica dioica 异株荨麻 See Urtica cannabina./See Urtica cannabina.
TCMBANKHE008203 Citrus limon 柠檬皮 To soothe stagnation and move qi, fortify stomach and relieve pain./Blood stasis and abdominal pain, menstrual disorder, no thought of food and drink.
TCMBANKHE005228/YEM-235 Cortex Magnoliae officilis;Magnolia officinalis|Magnolia officinalis Rehd.et Wils. 厚朴 厚朴 云南民族药物志:第二卷 To eliminate damp and relieve distension;To dry damp and disperse phlegm, precipitate qi and eliminate fullness, lower blood pressure./1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate.5.Amebic dysentery, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distention and constipation, phlegm-rheum cough asthma. 彝族
TCMBANKHE008188/YEM-310 Brassica oleracea var. capitata|Brassica oleracea L. var. capitata L. 甘蓝|莲花白 莲花白 云南民族药物志:第二卷 To clear heat and disinhibit damp, dissipate binds and relieve pain, boost kidney and supplement vacuity./Damp-heat jaundice, pain from ulcer in digestive tract, stiffness in joints, vacuity detriment. 傣族
TCMBANKHE008762/YEM-310 Brassica oleracea|Brassica oleracea L. var. capitata L. 野芥|莲花白 莲花白 云南民族药物志:第二卷 傣族
TCMBANKHE003727/YEM-310 Brassica oleracea var. capitata|Brassica oleracea L. var. capitata L. 甘蓝|莲花白 莲花白 云南民族药物志:第二卷 To clear heat and disinhibit damp, dissipate binds and relieve pain, boost kidney and supplement vacuity./Damp-heat jaundice, pain from ulcer in digestive tract, stiffness in joints, vacuity detriment. 傣族
TCMBANKHE004012/YEM-314 Vitis vinifera|Vitis vinifera L. 欧洲葡萄|葡萄 葡萄 云南民族药物志:第二卷 To supplement qi and blood, strengthen sinews and bones, disinhibit urine./Vacuity of qi and blood, lung vacuity cough, palpitation and night sweating, wind-damp impediment pain, strangury, edema. 傣族/藏族
TCMBANKHE004332/YEM-378/XU-663 Foeniculum vulgare|Foeniculum vulgare Mill. 茴香茎叶|茴香 小茴香 云南民族药物志:第二卷|云南省玉溪市澄江县 To expel wind, normalize qi, relieve pain./Sand qi, mounting qi, swollen welling abscess. 白族/布依族/傣族/傈僳族/纳西族/彝族/藏族/壮族
TCMBANKHE005494/YEM-445 Fructus Hordei Germitus|Hordeum vulgare L. 麦芽|大麦 大麦 云南民族药物志:第三卷 To invigo rate the function of the spleen, to regulate the function of the stomach, and to promote the flow of milk./Food accumulation, abdominal distention and diarrhea, nausea and vomiting, inappetence, galactostasis, distending pain in breast. 佤族/彝族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000221 GRIA2 GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B glutamate ionotropic receptor AMPA type subunit 2
TCMBANKGE000576 CHAT CHOACTASE; CMS1A; CMS1A2; CMS6 choline O-acetyltransferase
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001142 CHDH - choline dehydrogenase
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE001755 MAOB - monoamine oxidase B
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE014050 GABRA1 ECA4; EIEE19; EJM; EJM5 gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014941 DPEP1 MBD1; MDP; RDP dipeptidase 1