Compound Summary
Compound Information
药名: | Stephanine |
别名: | 517-63-5; stephanine; stephanine ; 1,2-methylenedioxy-8-methoxyaporphine; 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,8-tetrahydro-9-methoxy-7-methyl-, (R)- |
分子式: | C19H19NO3 |
Smiles: | CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC=C5OC)OCO3 |
成分: | HBIN044793 |
OB_score: | 27.453644 |
CAS_id: | 517-63-5 |
SymMap_id: | SMIT08509;SMIT17788 |
TCMID_id: | 20303 |
TCMSP_id: | MOL006985 |
PubChem_id: | 160501 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE001500 | Radix Stephaniae Dielsianae | 头花千金藤 | 1. Remove wind-dampness and relieve pain: For arthralgia of heat type with marked redness, swelling and pain ofjoints. 2. Promote blood circulation to remove blood stasis, clear away toxic material and relieve swelling: For carbuncle, snake bite and traum/1. Its total alkaloid and iodomethyl quatemary ammonium of sinoacutine inhibit the neuromuscular system and relax the striated muscles. 2. Its component stephanine inhibits the growth of sarcoma180 and Werck's carcinoma256 in rats. | |||
| TCMBANKHE003744 | Rhizoma Atractylodis macrocephalae | 白术 | To invigorate the function of the spleen and replenish qi, to eliminate damp by causing diuresis, to arrest excesssive perspiration, and to prevent miscarriage./Spleen qi vacuity, fatigue hypodynamia, reduced food intake with abdominal distention, sloppy stool, water-rheum collecting internally, inhibited urination, edema, phlegm-rheum dizziness, damp impediment, qi vacuity, spontaneous sweating, stirring fetus in pregnancy. | |||
| TCMBANKHE004121 | Radix Stemoe | 百部 | 1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie. | |||
| TCMBANKHE007157 | Magnolia coco | 夜合花 | To move qi and dissipate stasis, relieve cough, check discharge./Liver depression and qi pain, knocks and falls, concretion and conglomeration, Vaginal discharge. | |||
| TCMBANKHE007051 | Stephania japonica | 千金藤 | To clear heat and resolve toxin, dispel wind and relieve pain, disinhibit water and disperse edema./Swelling pain in throat, swollen welling abscess, sore and boil, poisonous snake bite, wind-damp impediment pain, stomachache, beriberi with edema, nephritis with edema, urinary tract infection, rheumatic arthritis, sciatica. | |||
| TCMBANKHE007928 | 白药子 | Septicemia, acute hepatitis, bacillary dysentery, parotitis, neurodermatitis, swelling pain in throat, heat toxin swollen welling abscess, wind-damp impediment pain, abdominal pain and diarrhea, blood ejection, bleeding, spontaneous external bleeding, bleeding due to external injury. | ||||
| TCMBANKHE005917/YNS-55/YEM-141/YEM-655 | Stephania delavayi [Syn. Stephania epigaea ]|Stephania epigaea H.S.Lo | 地不容|地不容(山乌龟) | 地不容 |地不容 | 云南药材标准：第一册|云南民族药物志：第四卷 | 祛风除湿，清热解毒，止痛。用于胃痛，风湿痹痛，咽喉不利，痈肿疮毒|To rectify qi and relieve pain, dispel wind-damp, disperse swelling toxin./Qi stagnation and food accumulation, pain in stomach duct and abdomen, wind-damp impediment pain, swelling toxin of welling abscess and sore, poisonous snake bite. | 傣族/基诺族/拉祜族/佤族/彝族/藏族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000121 | KCNH2 | ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 | potassium voltage-gated channel subfamily H member 2 |
| TCMBANKGE000181 | PIM1 | PIM | Pim-1 proto-oncogene, serine/threonine kinase |
| TCMBANKGE000201 | ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000286 | GSK3B | - | glycogen synthase kinase 3 beta |
| TCMBANKGE000309 | SCN5A | CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 | sodium voltage-gated channel alpha subunit 5 |
| TCMBANKGE000478 | CHEK1 | CHK1 | checkpoint kinase 1 |
| TCMBANKGE000633 | ADRB2 | ADRB2R; ADRBR; B2AR; BAR; BETA2AR | adrenoceptor beta 2 |
| TCMBANKGE000701 | ESR2 | ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 | estrogen receptor 2 |
| TCMBANKGE000766 | ACHE | ACEE; ARACHE; N-ACHE; YT | acetylcholinesterase (Cartwright blood group) |
| TCMBANKGE000813 | DPP4 | ADABP; ADCP2; CD26; DPPIV; TP103 | dipeptidyl peptidase 4 |
| TCMBANKGE000903 | PTGS1 | COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS | prostaglandin-endoperoxide synthase 1 |
| TCMBANKGE000938 | CDK2 | CDKN2; p33(CDK2) | cyclin dependent kinase 2 |
| TCMBANKGE000965 | CHRNA7 | CHRNA7-2; NACHRA7 | cholinergic receptor nicotinic alpha 7 subunit |
| TCMBANKGE001073 | PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | prostaglandin-endoperoxide synthase 2 |
| TCMBANKGE001202 | MAPK14 | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA | mitogen-activated protein kinase 14 |
| TCMBANKGE001506 | ADRA1B | ADRA1; ALPHA1BAR | adrenoceptor alpha 1B |
| TCMBANKGE001943 | ADRA1D | ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 | adrenoceptor alpha 1D |
| TCMBANKGE004266 | AR | AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM | androgen receptor |
| TCMBANKGE005535 | CHRM1 | HM1; M1; M1R | cholinergic receptor muscarinic 1 |
| TCMBANKGE006943 | CHRM3 | EGBRS; HM3; PBS | cholinergic receptor muscarinic 3 |
| TCMBANKGE008702 | OPRM1 | LMOR; M-OR-1; MOP; MOR; MOR1; OPRM | opioid receptor mu 1 |
| TCMBANKGE008921 | RXRA | NR2B1 | retinoid X receptor alpha |
| TCMBANKGE009294 | HTR3A | 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3 | 5-hydroxytryptamine receptor 3A |
| TCMBANKGE009455 | CHRM5 | HM5 | cholinergic receptor muscarinic 5 |
| TCMBANKGE011923 | CHRM4 | HM4; M4R | cholinergic receptor muscarinic 4 |
| TCMBANKGE014050 | GABRA1 | ECA4; EIEE19; EJM; EJM5 | gamma-aminobutyric acid type A receptor subunit alpha1 |
| TCMBANKGE014625 | OPRD1 | DOP; DOR; DOR1; OPRD | opioid receptor delta 1 |
滇ICP备16009434号-1 |
Dai SX Lab