Compound Summary

  Compound Information

TCMBANKIN012636

药名:	tetrahydroalstonine
别名:	Tetrahydroalstonine; C11682; 6474-90-4; Alstonine, 3,4,5,6-tetrahydro- (8CI); 4-27-00-07926 (Beilstein Handbook Reference); NCGC00163632-01; Prestwick1_000593; PDSP2_001642; Prestwick2_000593; SPBio_002685; NSC 72115; Alstonine, 3,4,5,6-tetrahydro; 16,17-Didehydro-19-methyloxayohimban-16-carboxylic acid, methyl ester; 4CN-0678; SCHEMBL14095094; BRN 0097270; EINECS 229-331-0; METHYL (15S,16S,20S)-16-METHYL-17-OXA-3,13-DIAZAPENTACYCLO[11.8.0.0(2),(1)?.0?,?.0(1)?,(2)?]HENICOSA-2(10),4,6,8,18-PENTAENE-19-CARBOXYLATE; MFCD00083501; Methyl (19alpha,20alpha)-16,17-didehydro-19-methyloxayohimban-16-carboxylate; Alstonine, 3,4,5,6-tetrahydro-, (3alpha)-; AIDS-003047; Prestwick_462; CHEBI:95146; HMS1569H08; Prestwick0_000593; AKOS032948288; Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19-alpha,20-alpha)-; AIDS003047
分子式:	C21H25N2O3+
Smiles:	CC1C2C[NH+]3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45
成分:	HBIN046052
CAS_id:	6974-90-4
SymMap_id:	SMIT01642;SMIT09747
TCMID_id:	21039
TCMSP_id:	MOL008457
PubChem_id:	11871584

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000029	Alstonia restricta	攸县鸭脚树
TCMBANKHE003782	Fructus Corni	山茱萸			To replenish the liver and kidney, restrain seminal discharge and relieve collapse./Dizziness and tinnitus, aching in lumbus and knees, impotence and emission, enuresis and frequent urination, flooding and spotting with vaginal discharge, vacuity and profuse sweating, vacuity desertion due to great sweating, diabetes mellitus due to internal heat, dysmenorrhea.
TCMBANKHE007954	Flos Rhododendri Mollis	闹羊花			To relieve rheumatic conditions, and to eliminate blood stasis and alleviate pain./Tachycardia, palpitation, hypertension, wind-damp impediment pain, knocks and falls, intractable lichen.
TCMBANKHE004610	Ramulus Uncariae cum Uncis	钩藤			To remove heat, subdue hyperactivity of the liver, and arrest convulsions./Infant fright wind and night crying, exuberant heat stirring wind, epilepsy of pregnancy, liver yang dizziness, liver fire headache.
TCMBANKHE005206		赤芍药
TCMBANKHE006903	Alstonia mairei	羊角棉			To resolve toxin, stanch bleeding./Swelling toxin of welling abscess and sore, bleeding due to external injury.
TCMBANKHE007721	Exocarpium Benincasae	冬瓜皮			1. To promote diuresis to relieve edema. 2. To clear summer-heat./Edema, inhibited urination [=dysuria], diarrhea, swelling of sores.
TCMBANKHE007889		杜仲叶			Lumbar and back pain, limp aching inability of legs and knees, hypertension.
TCMBANKHE004162/YEM-17	Catharanthus roseus|Catharanthus roseus (L.) G.Don	长春花	长春花	云南民族药物志：第一卷	To resolve toxin, clear heat and calm liver, anticancer./Hypertension, swelling toxin of welling abscess and sore, scalds.
TCMBANKHE006235/YNS-53/YEM-31	Alstonia scholaris|Alstonia scholaris(Linn.)R.Br.|Alstonia scholaris(L.)R.Br.	象皮木|糖胶树	灯台树/灯台叶|灯台树	云南药材标准：第三册/云南药材标准：第七册|云南民族药物志：第一卷	除风通血，消肿止痛，解毒安胎，止咳化痰。用于风盛所致的头目昏痛；风湿病肢体关节肿胀疼痛；孕期体弱多病，妊娠呕吐，月子病(产后病)出现面色苍白、心悸、胸闷、气短、头昏、头晕，形瘦体弱，咳嗽喘息，失眠多梦等；感冒咳嗽痰多，咽喉肿痛；孕期保健。/止咳祛痰。用于咳嗽，百日咳。|To clear heat and resolve toxin, relieve cough and dispel phlegm, stanch bleeding and disperse swelling./Common cold with fever, lung heat cough asthma, pertussis, icterohepatitis, stomachache, vomiting and diarrhea, malaria, swollen welling abscess and sores, painful swelling from knocks and falls, bleeding due to external injury.	傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/傈僳族/佤族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000121	KCNH2	ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1	potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000425	DRD1	DADR; DRD1A	dopamine receptor D1
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE008056	ADRA2C	ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR	adrenoceptor alpha 2C
TCMBANKGE008702	OPRM1	LMOR; M-OR-1; MOP; MOR; MOR1; OPRM	opioid receptor mu 1
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE011923	CHRM4	HM4; M4R	cholinergic receptor muscarinic 4
TCMBANKGE014625	OPRD1	DOP; DOR; DOR1; OPRD	opioid receptor delta 1