Compound Summary

  Compound Information

TCMBANKIN020949

药名:	papaverine
别名:	Cepaverin; AOB5339; 58-74-2; MFCD00012745; ZINC00056555; NCI60_003183; Drapavel; DSSTox_RID_77939; NCI-C56359; Myobid; BB_NC-0726; H754; Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride; Papaverine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material; Dynovas; Artegodan; Papavarine chlorhydrate; DTXSID9025825; NCGC00094258-03; Isoquinoline,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride; 1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline; Alapav; Papacon; AIDS000185; NSC35443 (HCL); SMR000058283; KBioGR_000914; Spasmo-Nit; Papavarine hydrochloride; HMS1569F08; 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-isoquinoline; DSSTox_CID_5825; Papaverine hydrochloride (JP17/USP); Pameion; NCGC00094258-06; BSPBio_002153; Chlorhydrate de papaverine [French]; Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride (1:1); SBB080541; AIDS-000185; Oprea1_387689; 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline; I01-13837; Optenyl; CTK8G2272; Papaverine Hcl; WLN: T66 CNJ B1R CO1 DO1& HO1 IO1; Dispamil; Lopac0_000957; Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-; Isoquinoline,7-dimethoxy-1-veratryl-, hydrochloride; MLS000028497; KBio2_005607; Lapav; Ro-Papav; Papanerin-HCl [German]; Cardiospan; Tox21_110226_1; TNP00305; Pavnell; HMS1920F06; LP00957; Pavagrant; SR-01000003098-2; SDCCGMLS-0003037.P003; AC1L1LRO; 6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride; 6,7-Dimethoxy-1-veratrylisoquinoline; Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl); TR-031684; Pavacot; Papaverine hydrochloride, United States Pharmacopeia (USP) Reference Standard; Paveron; Spectrum4_000467; Spectrum_000071; LS-267; SR-01000003098-11; Forpavin; Durapav; Cardoverina; Prestwick2_000583; Papaverine hydrochloride, powder; CCRIS 3804; 5-21-06-00182 (Beilstein Handbook Reference); Paverolan; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride; 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline; FT-0631269; ACon1_002094; NCGC00094258-04; EINECS 200-397-2; Papaverine; AC1Q3DLI; CHEMBL98123; Pavadel; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline hydrochloride; 58-74-2 (Parent); InChI=1/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H; REGID_for_CID_6084; BBC/116; Dipav; NCGC00094258-01; P0016; SPBio_002645; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline; 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride; NCGC00261642-01; PubChem6305; Cerebid; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline; Oprea1_810508; Vasal; Papanerin; P 3510; 23473EC6BQ; Pharmakon1600-01500459; C06533; Lopac-P-3510; Vaso-Pav; SCHEMBL121268; DivK1c_000321; Papaverina [Italian]; NSC136630; NSC 136630; KBio2_000471; Spectrum3_000537; MLS002222208; component of Copavin; 58-74-2 (FREE BASE ); Therapav; BG00717685; Prestwick1_000583; Pavacen; Copavin; AK-67336; Dilaves; PAP H; 4-[(6,7-dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene, chloride; UNII-23473EC6BQ; NCGC00015810-01; Papaversan; Tox21_500957; DSSTox_GSID_25825; Papaverine chlorohydrate; Papaverine hydrochloride [USAN:JAN]; EINECS 200-502-1; EU-0100957; Robaxapap; NCGC00094258-02; Papaverine hydrochloride [USP:JAN]; Papaverine, hydrochloride; Papaverine (hydrochloride); PAPAVERINE HYDROCHLORIDE; Prestwick0_000583; MEGxp0_001880; Delapav; D02218; Pavacap; BPBio1_000470; Ceraspan; AS-13262; NCGC00015810-03; Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, hydrochloride; Papanerin-hcl; NCGC00015810-12; KB-146860; RS 47; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride; CAS-61-25-6; UOTMYNBWXDUBNX-UHFFFAOYSA-N; Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (1:1); Papaverin; ACon1_000238; KBio2_003039; Prestwick3_000583; Pavabid (TN); Papaverine monohydrochloride; WLN: T66 CNJ B1R CO1 DO1& HO1 IO1 &GH; NSC757256; Pavatest; Papaverinium chloride; SR-01000003098; ST077145; ST023301; Pavakey; NSC-35443; BRN 0312930; Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI); SR-01000003098-9; 61-25-6 (HCL); SPBio_001015; NSC35443; MLS001148655; BSPBio_000426; IDI1_000321; Spectrum2_000978; Pavased; SPECTRUM1500459; Papanerine; NSC-757256; NCGC00094258-05; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-isoquinoline hydrochloride; KBioSS_000471; HY-18077A; Papaverine hydrochloride, European Pharmacopoeia (EP) Reference Standard; BG01663857; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinolinehydrochloride; S-M-R; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline; NINDS_000321; Papalease; Papaverine hydrochlorid; KBio3_001653; Pap-Kaps-150; MolPort-000-847-203; NCGC00015810-02; Isoquinoline, 6,7-dimethoxy-1-veratryl-; API0003748; CCG-40065; CS-5015; BAS 00674058; ARONIS23834; AKOS005111070; 61-25-6; NSC 35443; 4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene; C20H22ClNO4; 1-(3,7-dimethoxyisoquinoline hydrochloride; Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride (8CI); Tox21_110226; 6,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline; 1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline; Spectrum5_001188; Opera_ID_1617; Prestwick_376; SR-01000003098-4; Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-; KBio1_000321
分子式:	C20H21NO4
Smiles:	COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC
成分:	HBIN038790
OB_score:	64.042754
CAS_id:	58-74-2
SymMap_id:	SMIT00257
TCMID_id:	16611
TCMSP_id:	MOL006980
PubChem_id:	4680

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE001247		苏土虫
TCMBANKHE003990	Folium Llicis Chinensis	四季青			To clearheat and toxic materials./Angina pectoris, coronary heart disease, thrombophlebitis, thromboangiitis obliterans (Buerger’s disease), lung heat cough, swelling pain in throat, dysentery, diarrhea, infection of biliary tract , urinary tract infection, burns and scalds, heat toxin swollen welling abscess, ulcer of lower limb, eczema, frostbite, cracking, wound, bleeding due to external injury.
TCMBANKHE004003	Rauwolfia serpentina	印度萝芙木			To lower blood pressure./Hypertension.
TCMBANKHE004248	Radix Pacis quinquefolii	西洋参			1. To replenish qi and promote body fluids; 2. To nourish yin and clear heat/Qi vacuity, yin depletion and effulgent fire, cough and asthma with phlegm-blood, vacuity heat and vexation fatigue, diabetes mellitus due to internal heat, thirst with dry throat.
TCMBANKHE004577	pericarpium papaveris	罂粟壳			1. Astringe the intestine, relieve diarrhea and alleviate pain. 2. Astringe the lung and relieve cough./Enduring cough, chronic diarrhea, prolapse of rectum, pain in stomach duct and abdomen.
TCMBANKHE007520	Fructus Amomi	砂仁			To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy.
TCMBANKHE005699	Rhizoma Corydalis	廷胡索;廷胡;玄胡;元胡;元胡索;玄胡素			For stagnation of vital energy or blood stasis resulting in headache, chest pain, hypochondriac pain, epigastric pain, abdominal pain, backache, arthralgia, dysmenorrhea or trauma. Recently, alos used for angina pectoris, peptic ulcer and neuralgia./1. Its components d-corydaline and d1-tetrahydropalmatine are analgesics.2. Decreasing the secretion of gastric juice and the amount of pepsin.
TCMBANKHE006122	Papaver album	白花罂粟
TCMBANKHE006371		白屈菜			Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE007928		白药子			Septicemia, acute hepatitis, bacillary dysentery, parotitis, neurodermatitis, swelling pain in throat, heat toxin swollen welling abscess, wind-damp impediment pain, abdominal pain and diarrhea, blood ejection, bleeding, spontaneous external bleeding, bleeding due to external injury.
TCMBANKHE006476/YEM-509	Papaver somniferum|Papaver somniferum L.	鸦片|罂粟	罂粟	云南民族药物志：第三卷	To relieve pain, astringe intestines, suppress cough./Pain in heart and abdomen, chronic diarrhea, chronic dysentery, dry cough without phlegm.	傣族/基诺族/佤族/彝族
TCMBANKHE006850/YEM-509	Papaver somniferum|Papaver somniferum L.	罂粟	罂粟	云南民族药物志：第三卷	To fortify spleen and promote digestion, clear heat and disinhibit urine./Stomach reflux, abdominal pain, diarrhea, prolapse of rectum.	傣族/基诺族/佤族/彝族
TCMBANKHE004576/YEM-509	pericarpium papaveris|Papaver somniferum L.	粟壳|罂粟	罂粟	云南民族药物志：第三卷	For chronic diarrhea and dysentery, or those accompanied with ab dominal pain. For chronic cough with little expectoration/1. Slowing the rate of breathing and depressing the cough reflex, and exerting an antitussive effect. 2. Relaxing the smo9th muscles of gastrointestinal tract and trachea. 3. Being an analgesic acting on the central nervous system	傣族/基诺族/佤族/彝族
TCMBANKHE004643/YEM-590/XU-716	Folium Mori|Morus alba L.|Morus alba	桑叶|桑	桑叶	云南民族药物志：第三卷|云南省昭通市盐津县	To dispel wind-heat and to remove heat from the lung, to subdue hyperactivity of the liver and improve eyesight./Wind-heat common cold, lung heat dry cough, dizziness and headache, red eyes and clouded vision.	阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族
TCMBANKHE004691/YEM-353/YEM-961	Fructus Amomi|Amomum villosum Lour.	缩砂仁; 砂仁|阳春砂	阳春砂仁	云南民族药物志：第五卷	Treatment of accumulation of damp in the spleen and the stomach marked by epigastric stuffieness and anorexia, vomiting and diarrhea in deficiency cold syndrome of the spleen and the stomach, pernicious vomiting of pregnancy, threatened abortion.; To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./1. Its decoction lower thab 1% concentration stimulates and that higher than 1% or the saturated solution of its volatile oil inhibits the intestines of guinea-pigs in vitro.2. Its volatile oil acts as stomachic tonic and exaggerates the diacharge of flatus.; Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/瑶族/彝族/壮族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000121	KCNH2	ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1	potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000476	NCOA2	GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75	nuclear receptor coactivator 2
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000784	CALM3	CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3	calmodulin 3
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001515	ADM	AM; PAMP	adrenomedullin
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE003984	TDP1	-	tyrosyl-DNA phosphodiesterase 1
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE008172	MAOA	BRNRS; MAO-A	monoamine oxidase A
TCMBANKGE008723	PDE10A	ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A19	phosphodiesterase 10A
TCMBANKGE008857	LPL	HDLCQ11; LIPD	lipoprotein lipase
TCMBANKGE008921	RXRA	NR2B1	retinoid X receptor alpha
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE013926	RXRB	DAUDI6; H-2RIIBP; NR2B2; RCoR-1	retinoid X receptor beta