Compound Summary

  Compound Information

TCMBANKIN027842

药名:	vincristine
别名:	AC-20336; 57-22-7; AKOS015965501
分子式:	C46H56N4O10
Smiles:	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
成分:	HBIN047954
SymMap_id:	SMIT18173
TCMID_id:	22481
PubChem_id:	138114288
DrugBank_id:	DB00541

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004610	Ramulus Uncariae cum Uncis	钩藤			To remove heat, subdue hyperactivity of the liver, and arrest convulsions./Infant fright wind and night crying, exuberant heat stirring wind, epilepsy of pregnancy, liver yang dizziness, liver fire headache.
TCMBANKHE007889		杜仲叶			Lumbar and back pain, limp aching inability of legs and knees, hypertension.
TCMBANKHE004162/YEM-17	Catharanthus roseus|Catharanthus roseus (L.) G.Don	长春花	长春花	云南民族药物志：第一卷	To resolve toxin, clear heat and calm liver, anticancer./Hypertension, swelling toxin of welling abscess and sore, scalds.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000052	TNF	DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F	tumor necrosis factor
TCMBANKGE000294	CDKN1A	CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1	cyclin dependent kinase inhibitor 1A
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000323	BRCA1	BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53	BRCA1 DNA repair associated
TCMBANKGE000695	MAPK13	MAPK 13; MAPK-13; PRKM13; SAPK4; p38delta	mitogen-activated protein kinase 13
TCMBANKGE000866	PRKCB	PKC-beta; PKCB; PKCI(2); PKCbeta; PRKCB1; PRKCB2	protein kinase C beta
TCMBANKGE000918	MAPK9	JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; SAPK; SAPK1a; p54a; p54aSAPK	mitogen-activated protein kinase 9
TCMBANKGE001051	MAP2K7	JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4	mitogen-activated protein kinase kinase 7
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001076	SOD2	GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD	superoxide dismutase 2
TCMBANKGE001085	MAPK8	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c	mitogen-activated protein kinase 8
TCMBANKGE001097	HIF1A	HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78	hypoxia inducible factor 1 subunit alpha
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001169	BCL2L1	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52	BCL2 like 1
TCMBANKGE002334	TEP1	TLP1; TP1; TROVE1; VAULT2; p240	telomerase associated protein 1
TCMBANKGE002747	MAP4K4	FLH21957; HEL-S-31; HGK; MEKKK4; NIK	mitogen-activated protein kinase kinase kinase kinase 4
TCMBANKGE005120	TRAP1	HSP 75; HSP75; HSP90L; TRAP-1	TNF receptor associated protein 1
TCMBANKGE009264	RPSA	37LRP; 67LR; ICAS; LAMBR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; SA; lamR; p40	ribosomal protein SA
TCMBANKGE012852	XRCC6	CTC75; CTCBF; G22P1; KU70; ML8; TLAA	X-ray repair cross complementing 6