Compound Summary

  Compound Information

TCMBANKIN028288

药名:	morphine
别名:	(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol; 7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol; RMS; Hard stuff; Morpho; Cube juice; 47106-99-0; EINECS 200-320-2; 64-31-3 (SULFATE); (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol; (-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol; Morphin; Nepenthe; Roxanol; (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL; CCRIS 5762; AIDS-001987; Moscontin; Statex SR; Unkie; Morphia; Morphina [Italian]; M-Eslon; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)-; Morphinum; Ms Emma; 4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol; (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol; Dolcontin; 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4a,5,7a,8-tetrahydro-12-methyl-; Morphinism; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5..alpha.,6.alpha.)-; MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE; 57-27-2 (FREE BASE ); (-)-Morphine; Dulcontin; 8053-16-5; Meconium; (-)Morphine sulfate; Ospalivina; NSC11441(SULFATE); Morphium; Morphin [German]; l-Morphine; 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4alpha,5,7alpha,8-tetrahydro-12-methyl-; Dreamer; HSDB 2134; Hocus; 85201-37-2; AIDS001987; 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol; DEA No. 9300; Duromorph; Morfina [Italian]; Morphina; Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-; MOI; CHEBI:17303
分子式:	C17H19NO3
Smiles:	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
成分:	HBIN035767
OB_score:	24.693918
CAS_id:	57-27-2
SymMap_id:	SMIT00256
TCMID_id:	14973
TCMSP_id:	MOL006979
PubChem_id:	5288826

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE001563		罂粟嫩苗
TCMBANKHE002713		白罂粟
TCMBANKHE003096		丽春花果实
TCMBANKHE005508	Bufo bufo gargarizans, Bufo melanostictus	蟾酥			To resolve toxin, relieve pain, open orifices and arouse spirit./Welling abscess and flat abscess with clove sores, swelling pain in throat, summerheat stroke with vomiting and diarrhea, abdominal pain and clouded spirit, local anesthesia.
TCMBANKHE003990	Folium Llicis Chinensis	四季青			To clearheat and toxic materials./Angina pectoris, coronary heart disease, thrombophlebitis, thromboangiitis obliterans (Buerger’s disease), lung heat cough, swelling pain in throat, dysentery, diarrhea, infection of biliary tract , urinary tract infection, burns and scalds, heat toxin swollen welling abscess, ulcer of lower limb, eczema, frostbite, cracking, wound, bleeding due to external injury.
TCMBANKHE005699	Rhizoma Corydalis	廷胡索;廷胡;玄胡;元胡;元胡索;玄胡素			For stagnation of vital energy or blood stasis resulting in headache, chest pain, hypochondriac pain, epigastric pain, abdominal pain, backache, arthralgia, dysmenorrhea or trauma. Recently, alos used for angina pectoris, peptic ulcer and neuralgia./1. Its components d-corydaline and d1-tetrahydropalmatine are analgesics.2. Decreasing the secretion of gastric juice and the amount of pepsin.
TCMBANKHE004577	pericarpium papaveris	罂粟壳			1. Astringe the intestine, relieve diarrhea and alleviate pain. 2. Astringe the lung and relieve cough./Enduring cough, chronic diarrhea, prolapse of rectum, pain in stomach duct and abdomen.
TCMBANKHE007520	Fructus Amomi	砂仁			To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy.
TCMBANKHE006371		白屈菜			Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE006958	Papaver commutatum [Syn. Papaver rhoeas ]	丽春花			To suppress cough, settle pain, check diarrhea./Cough, migraine, abdominal pain, dysentery.
TCMBANKHE007330	Adina pilulifera [Syn. Cephalanthus pilulifera ]	水团花			To clear heat and disinhibit damp, disperse stasis and settle pain, engender flesh and stanch bleeding./Dysentery, enteritis, edema, swelling toxin of welling abscess and sore, eczema, foot rot, enduring sores, bleeding due to external injury.
TCMBANKHE007928		白药子			Septicemia, acute hepatitis, bacillary dysentery, parotitis, neurodermatitis, swelling pain in throat, heat toxin swollen welling abscess, wind-damp impediment pain, abdominal pain and diarrhea, blood ejection, bleeding, spontaneous external bleeding, bleeding due to external injury.
TCMBANKHE004576/YEM-509	pericarpium papaveris|Papaver somniferum L.	粟壳|罂粟	罂粟	云南民族药物志：第三卷	For chronic diarrhea and dysentery, or those accompanied with ab dominal pain. For chronic cough with little expectoration/1. Slowing the rate of breathing and depressing the cough reflex, and exerting an antitussive effect. 2. Relaxing the smo9th muscles of gastrointestinal tract and trachea. 3. Being an analgesic acting on the central nervous system	傣族/基诺族/佤族/彝族
TCMBANKHE006476/YEM-509	Papaver somniferum|Papaver somniferum L.	鸦片|罂粟	罂粟	云南民族药物志：第三卷	To relieve pain, astringe intestines, suppress cough./Pain in heart and abdomen, chronic diarrhea, chronic dysentery, dry cough without phlegm.	傣族/基诺族/佤族/彝族
TCMBANKHE006850/YEM-509	Papaver somniferum|Papaver somniferum L.	罂粟	罂粟	云南民族药物志：第三卷	To fortify spleen and promote digestion, clear heat and disinhibit urine./Stomach reflux, abdominal pain, diarrhea, prolapse of rectum.	傣族/基诺族/佤族/彝族
TCMBANKHE004691/YEM-353/YEM-961	Fructus Amomi|Amomum villosum Lour.	缩砂仁; 砂仁|阳春砂	阳春砂仁	云南民族药物志：第五卷	Treatment of accumulation of damp in the spleen and the stomach marked by epigastric stuffieness and anorexia, vomiting and diarrhea in deficiency cold syndrome of the spleen and the stomach, pernicious vomiting of pregnancy, threatened abortion.; To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./1. Its decoction lower thab 1% concentration stimulates and that higher than 1% or the saturated solution of its volatile oil inhibits the intestines of guinea-pigs in vitro.2. Its volatile oil acts as stomachic tonic and exaggerates the diacharge of flatus.; Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/瑶族/彝族/壮族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000135	CXCR4	CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS	C-X-C motif chemokine receptor 4
TCMBANKGE000196	FAS	ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6	Fas cell surface death receptor
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000212	GRIN1	GluN1; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; NMDAR1; NR1	glutamate ionotropic receptor NMDA type subunit 1
TCMBANKGE000219	CCR5	CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22	C-C motif chemokine receptor 5
TCMBANKGE000241	CASP8	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5	caspase 8
TCMBANKGE000264	ABCB1	ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1	ATP binding cassette subfamily B member 1
TCMBANKGE000274	CCL2	GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF	C-C motif chemokine ligand 2
TCMBANKGE000315	IL4	BCGF-1; BCGF1; BSF-1; BSF1; IL-4	interleukin 4
TCMBANKGE000316	IL5	EDF; IL-5; TRF	interleukin 5
TCMBANKGE000403	ATF2	CRE-BP1; CREB-2; CREB2; HB16; TREB7	activating transcription factor 2
TCMBANKGE000408	CCR3	C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3; CMKBR3	C-C motif chemokine receptor 3
TCMBANKGE000425	DRD1	DADR; DRD1A	dopamine receptor D1
TCMBANKGE000449	CCK	-	cholecystokinin
TCMBANKGE000521	PLCG1	NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1	phospholipase C gamma 1
TCMBANKGE000556	MAPK10	JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK	mitogen-activated protein kinase 10
TCMBANKGE000598	MDK	ARAP; MK; NEGF2	midkine
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000792	FASLG	ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; FASL; TNFSF6; TNLG1A	Fas ligand
TCMBANKGE000845	CCL4	ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4	C-C motif chemokine ligand 4
TCMBANKGE000857	AHSA1	AHA1; C14orf3; hAha1; p38	activator of HSP90 ATPase activity 1
TCMBANKGE000866	PRKCB	PKC-beta; PKCB; PKCI(2); PKCbeta; PRKCB1; PRKCB2	protein kinase C beta
TCMBANKGE000869	DRD2	D2DR; D2R	dopamine receptor D2
TCMBANKGE000881	PLAT	T-PA; TPA	plasminogen activator, tissue type
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000970	FASN	FAS; OA-519; SDR27X1	fatty acid synthase
TCMBANKGE000979	KDR	CD309; FLK1; VEGFR; VEGFR2	kinase insert domain receptor
TCMBANKGE001011	TNFSF10	APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL	TNF superfamily member 10
TCMBANKGE001037	MMP2	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1	matrix metallopeptidase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001076	SOD2	GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD	superoxide dismutase 2
TCMBANKGE001097	HIF1A	HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78	hypoxia inducible factor 1 subunit alpha
TCMBANKGE001114	IL6	BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6	interleukin 6
TCMBANKGE001132	BAX	BCL2L4	BCL2 associated X, apoptosis regulator
TCMBANKGE001144	CD14	-	CD14 molecule
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001154	CREB1	CREB; CREB-1	cAMP responsive element binding protein 1
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001161	IL2	IL-2; TCGF; lymphokine	interleukin 2
TCMBANKGE001162	IFNG	IFG; IFI	interferon gamma
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001176	CAT	-	catalase
TCMBANKGE001191	GRIA1	GLUH1; GLUR1; GLURA; GluA1; HBGR1	glutamate ionotropic receptor AMPA type subunit 1
TCMBANKGE001197	FOS	AP-1; C-FOS; p55	Fos proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE001201	MAPK3	ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK	mitogen-activated protein kinase 3
TCMBANKGE001203	MAPK1	ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK	mitogen-activated protein kinase 1
TCMBANKGE001326	SRD5A2	-	steroid 5 alpha-reductase 2
TCMBANKGE001536	DLD	DLDD; DLDH; E3; GCSL; LAD; OGDC-E3; PHE3	dihydrolipoamide dehydrogenase
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE002342	GNAI3	87U6; ARCND1	G protein subunit alpha i3
TCMBANKGE002699	TH	DYT14; DYT5b; TYH	tyrosine hydroxylase
TCMBANKGE003157	CHRM2	HM2	cholinergic receptor muscarinic 2
TCMBANKGE003415	GATA3	HDR; HDRS	GATA binding protein 3
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE003775	ARRB1	ARB1; ARR1	arrestin beta 1
TCMBANKGE004002	CAMKK2	CAMKK; CAMKKB	calcium/calmodulin dependent protein kinase kinase 2
TCMBANKGE005288	PDYN	ADCA; PENKB; SCA23	prodynorphin
TCMBANKGE005296	ARL6IP5	DERP11; GTRAP3-18; HSPC127; JWA; PRAF3; Yip6b; addicsin; hp22; jmx	ADP ribosylation factor like GTPase 6 interacting protein 5
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE005653	GRIN2A	EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A	glutamate ionotropic receptor NMDA type subunit 2A
TCMBANKGE005865	CAMK4	CaMK IV; CaMK-GR; CaMKIV; caMK	calcium/calmodulin dependent protein kinase IV
TCMBANKGE006438	PCSK1	BMIQ12; NEC1; PC1; PC3; SPC3	proprotein convertase subtilisin/kexin type 1
TCMBANKGE006869	PTGER3	EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R; lnc003875	prostaglandin E receptor 3
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE007368	GSTP1	DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI	glutathione S-transferase pi 1
TCMBANKGE007855	FCAMR	CD351; FCA/MR; FKSG87	Fc fragment of IgA and IgM receptor
TCMBANKGE008012	MAP2	MAP-2; MAP2A; MAP2B; MAP2C	microtubule associated protein 2
TCMBANKGE008163	GRIN3A	GluN3A; NMDAR-L; NMDAR3A; NR3A	glutamate ionotropic receptor NMDA type subunit 3A
TCMBANKGE008702	OPRM1	LMOR; M-OR-1; MOP; MOR; MOR1; OPRM	opioid receptor mu 1
TCMBANKGE008743	OPRK1	K-OR-1; KOP; KOR; KOR-1; KOR1; OPRK	opioid receptor kappa 1
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE009527	GADL1	ADC; CSADC; HuADC; HuCSADC	glutamate decarboxylase like 1
TCMBANKGE009924	ADCY8	AC8; ADCY3; HBAC1	adenylate cyclase 8
TCMBANKGE009956	LITAF	PIG7; SIMPLE; TP53I7	lipopolysaccharide induced TNF factor
TCMBANKGE010467	MC4R	BMIQ20	melanocortin 4 receptor
TCMBANKGE010770	PCSK2	NEC 2; NEC-2; NEC2; PC2; SPC2	proprotein convertase subtilisin/kexin type 2
TCMBANKGE010995	GUSB	BG; MPS7	glucuronidase beta
TCMBANKGE011468	DLG4	MRD62; PSD95; SAP-90; SAP90	discs large MAGUK scaffold protein 4
TCMBANKGE011923	CHRM4	HM4; M4R	cholinergic receptor muscarinic 4
TCMBANKGE012410	ARC	Arg3.1; hArc	activity regulated cytoskeleton associated protein
TCMBANKGE013286	DLAT	DLTA; E2; PBC; PDC-E2; PDCE2	dihydrolipoamide S-acetyltransferase
TCMBANKGE013309	SLC17A7	BNPI; VGLUT1	solute carrier family 17 member 7
TCMBANKGE013550	NDUFS1	CI-75Kd; CI-75k; MC1DN5; PRO1304	NADH:ubiquinone oxidoreductase core subunit S1
TCMBANKGE013929	GNA12	NNX3; RMP; gep	G protein subunit alpha 12
TCMBANKGE014322	IL23A	IL-23; IL-23A; IL23P19; P19; SGRF	interleukin 23 subunit alpha
TCMBANKGE014423	ADRA1A	ADRA1C; ADRA1L1; ALPHA1AAR	adrenoceptor alpha 1A
TCMBANKGE014473	CRH	CRF; CRH1	corticotropin releasing hormone
TCMBANKGE014625	OPRD1	DOP; DOR; DOR1; OPRD	opioid receptor delta 1
TCMBANKGE014904	DBI	ACBD1; ACBP; CCK-RP; EP	diazepam binding inhibitor, acyl-CoA binding protein