Compound Summary


  Compound Information

药名:

rhein

别名:

4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-dihydroxy-7-methyl-9,10-dioxo-anthracene-2-carboxylic acid; SBB001152; C10401; AIDS001379; CCRIS 5129; Rhein; MLS000069639; 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (8CI); 4,5-DiOH-anthraquinone-2-COOH; 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; ACon1_000217; 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-7-methyl-9,10-dioxo-; 4,5-dihydroxy-anthraquinone-2-carboxylic acid; SMR000058210; 4,5-Dihydroxy-2-anthraquinonecarboxylic acid; 1,8-DIHYDROXY-3-CARBOXYL ANTHRAQUINONE; 4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; MEGxp0_001866; LMPK02000044; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid; AC1MHQNE; Rhubarb yellow; 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; 1,8-Dihydroxyanthraquinone-3-carboxylic acid; 275611_ALDRICH; NSC38629; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; 4-10-00-04088 (Beilstein Handbook Reference); EINECS 207-521-4; Chrysazin-3-carboxylic acid; NSC 38629; Rhein (1,8-dihydroxy-3-carboxyl anthraquinone); 478-43-3; Monorhein; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; Cassic acid; 4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylic acid; Rheic acid; AIDS-001379; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; SCHEMBL18601968; R7269_SIGMA; NCGC00023342-03; 4,5-dihydroxy-7-methyl-9,10-dioxoanthracene-2-carboxylic acid; BRN 2222155; 4,5-dihydroxy-9,10-diketo-anthracene-2-carboxylic acid

分子式:

C15H10O6

Smiles:

c1([H])c(O[H])c(C(=O)[C@]([H])(C(O[H])=C([H])C(C(O[H])=O)=C2[H])[C@@]2([H])C3=O)c3c([H])c1[H]

成分:

HBIN042199

OB_score:

47.06521

CAS_id:

478-43-3

SymMap_id:

SMIT00146

TCMID_id:

18744

TCMSP_id:

MOL002268

PubChem_id:

10168


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000695 对叶豆
TCMBANKHE004340 萱草根 Edema, jaundice, strangury-turbidity, vaginal discharge, spontaneous external bleeding, hematochezia, flooding and spotting, scrofula, mammary welling abscess, galactostasis.
TCMBANKHE001849 倒扣草
TCMBANKHE004699 fructus hippophae 沙棘
TCMBANKHE003269 Radix Polygoni Multiflori Preparata 制首乌 Treatment of anemia, dizziness and tinnitus, premature greying of the hair and beard, soreness and weakness of the loins and the knees, abnormal uterine bleeding and excessive leukorrhea, general debility in chronic malaria, hyperlipemia./Treatment of anemia, dizziness and tinnitus, premature greying of the hair and beard, soreness and weakness of the loins and the knees, abnormal uterine bleeding and excessive leukorrhea, general debility in chronic malaria, hyperlipemia.
TCMBANKHE003373 Exocarpium Citri grandis 化橘红 To dispel cold, eliminate damp and phlegm, and arrest emesis or nausea./Treatment of cough, itching of the throat and profuse expectoration in colds, nausea, vomiting and epigastric distension caused by improper diet or excessive drinking.
TCMBANKHE003426 Fructus Leonuri 茺蔚子 To activate blood circulation and regulate menstruation, to subdue hyperactivity of the liver, and to clear the eye of opacity./Treatment of menstrual disorders, amenorrhea, hysmenorrhea, inflammation of the eye with formation of corneal opacity, dizziness and headache.
TCMBANKHE003752 Radix Salviae liguliobae 丹参 To remove blood stasis and relieve pain, to promote the flow of blood and stimulate menstrual discharge, and to ease the mind./Angina pectoris, cerebral atherosclerosis, diffusive intravascular clotting, thrombophlebitis, hepatitis, acute surgical infection, mastitis, erysipelas, otitis media, tonsillitis, bone marrow infection, menstrual disorder, dysmenorrhea, amenorrhea, postpartum stasis stagnation abdominal pain, pain in heart and abdomen, concretion conglomeration accumulation and gathering, heat impediment swelling and pain, knocks and falls, heat entering construction-blood, vexation and agitation, insomnia and vexation, swelling toxin of welling abscess and sore, zoster, neurodermatitis, psoriasis.
TCMBANKHE003814 Semen Pharbitidis 牵牛子 To cause drastic purgation for clearing away retained fluid, and to kill worms./Edema distention fullness, inhibited urine and stool, phlegm-rheum and accumulation-gathering, qi counterflow with cough and asthma, abdominal pain due to worm accumulation, ascariasis, taeniasis.
TCMBANKHE003826 Rhizoma Cimicifugae 升麻 To induce perspiration and promote eruption, to remove toxic heat, and to cure drooping and ptosis./Prevention of ptosis, women’s hormone dysfunction diseases, seasonal epidemic fire toxin, mouth sore, sore pharynx, macula, cold-heat headache, swelling toxin of welling abscess and sore, center qi fall, spleen vacuity diarrhea, chronic dysentery, vaginal discharge, flooding.
TCMBANKHE003911 Folium Sene 番泻叶 To purge feces downward/Heat bind and accumulation, constipation w ith abdominal pain, edema distention fullness.
TCMBANKHE004026 Polygonum multiflorum;Caulis Polygoni Multiflori 夜交藤;首乌藤 To nourish heart and quiet spirit, dispel wind and free network vessels.;Treatment of insomnia, dream-disturbed sleep, general aching in blood deficiency, rheumatic arthralgia, external use for itching./Insomnia, frequent dreaming, anemia and generalized pain, muscle numbness, wind-damp impediment pain, wind papule itching.;1. Decreasing the level of blood lipids and inhibiting the formation of atherosclerosis.2. Oral admintration of its decoction increases the level of blood sugar in rabbits.
TCMBANKHE004144 Polygonum suffultum 红三七 To stanch bleeding and relieve pain, quicken blood and regulate menstruation, clear heat and eliminate damp./Painful wound from knocks and falls, bleeding due to external injury, blood ejection, hematochezia, flooding and spotting, red and white vaginal discharge, damp-heat dysentery, welling abscess.
TCMBANKHE004160 Semen Cassiae;Semen Sene 决明子 To remove heat from the liver, to improve eyesight, and to relax bowels./See Cassia obtusifolia.
TCMBANKHE004347 Rheum emodi [Syn. Rheum australe] 藏边大黄 To clear heat and resolve toxin, stanch bleeding and engender flesh./Lung heat cough, swelling pain in throat, swelling toxin of welling abscess and sore, bleeding due to external injury, hematochezia.
TCMBANKHE004404 Lignum Aquilariae Resitum 沉香 To promote the flow of qi and relieve pain, to arrest vomiting by warming the stomach, and to relieve asthma./Cold pain in stomach duct and abdomen, qi counterflow with asthma, stomach cold with retching counterflow, vacuity cold in lumbus and knees, vacuity constipation, qi strangury.
TCMBANKHE006313 Radix et Rhizoma Rhei 大黄 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE004697 Radix Kansui 甘遂 To cause drastic purgation and expel the retained water./Edema, ascites, flowing rheum in chest, concretion conglomeration accumulation and gathering, epilepsy, cough and asthma, urinar y and fecal stoppage.
TCMBANKHE005748 Rheum tanguticum 唐古特大黄 See Rheum officinale./See Rheum officinale.
TCMBANKHE008047 Ruta graveolens 臭草 To dispel wind, abate fever, disinhibit urine, quicken blood, resolve toxin, disperse swelling./Common cold with fever, wind-damp bone pain, infant fright wind, inhibited urination, diarrhea, mounting qi, amenorrhea, knocks and falls, heat toxin sores, eczema.
TCMBANKHE008555 Polygonum multiflorum 何首乌 To lower cholesterol, enrich yin and nourish blood, moisten intestines and free stool, interrupt malaria, dispel wind, resolve toxin./Backache, neurasthenia, hyperlipemia, neurosis, insomnia, dizziness due to anemia, palpitation, limp aching lumbus and knees due to liver kidney yin vacuity, premature graying in beard and hair, tinnitus, emission, intestinal dry and constipation, enduring malaria, wind papule itching, sore and welling abscess, scrofula, hemorrhoids.
TCMBANKHE008910 Semen Pharbitidis 牵牛子 To cause drastic purgation for clearing away retained fluid, and to kill worms./Edema distention fullness, inhibited urine and stool, phlegm-rheum and accumulation-gathering, qi counterflow with cough and asthma, abdominal pain due to worm accumulation, ascariasis, taeniasis.
TCMBANKHE008745 Cassia acutifolia 尖叶番泻叶 See Cassia angustifolia ./See Cassia angustifolia .
TCMBANKHE009105 Cassia mimosoides 山扁豆子 To clear heat and resolve toxin, fortify spleen and disinhibit damp, free stool./Jaundice, summerheat-heat and vomiting diarrhea, child gan accumulation, edema, inhibited urination, habitual constipation, poisonous snake bite.
TCMBANKHE005418/YNS-102 Rhizoma Polygoni cuspidati|Polygonum cuspidatum Sieb.et Zucc. 虎杖 虎杖叶 云南药材标准:第一册 平肝潜阳,祛痰息风。用于肝阳上亢,血压偏高,头晕头昏|To dispel wind and damp, to eliminate blood stasis and alleviate pain, to relieve cough, and to resolve phlegm./Hyperlipemia, impediment pain in joints, damp-heat jaundice, toxic jaundice, child jaundice, amenorrhea, hepatitis, appendicitis, candida vaginitis, concretion and conglomeration, cough with profuse phlegm, burns and scalds, knocks and falls, swelling toxin of welling abscess and sore.
TCMBANKHE006959/YNS-135/YEM-14 Semen Cassiae;Semen Sene|Cassia tora Linn.|Cassia tora L. 决明子;草决明|决明 决明根|草决明 云南药材标准:第三册|云南民族药物志:第一卷 安神补脑,清肝明目,理气止痛。主治失眠多梦,入睡易惊,腹内痉挛剧痛,腹部包块,黄疸,疟疾。|To remove heat from the liver, to improve eyesight, and to relax bowels.Treatment of inflammation in the eye with pain, photophobia and lacrimination, headache, dizziness, blurred vision and constipation./See Cassia obtusifolia.1. Oral adminstration of the hearbal powder can inhibit the rising of serum cholesterol and formation of atherosclerosis in rabbits.2. Its tincture and infusion can inhibit the myocardium of toad in vitro, and contract th eblood vessels of lower limbs.3. Its infusion can lower the blood pressure in dogs, cats and rabbits.4. Chrysophanol, one of the active components, is a laxative.5. Bacteriostatic. 傣族/基诺族/拉祜族/傈僳族/苗族/佤族/彝族/藏族
TCMBANKHE002025/YEM-235 Magnoliae Officinalis Praeparata|Magnolia officinalis Rehd.et Wils. 炙厚朴|厚朴 厚朴 云南民族药物志:第二卷 Treatment of accumulation of damp in the spleen and the stomach marked by epigastric strffiness, vomiting and diarrhea, abdominal distension and constipation due to retention of undigested food, cough and dyspnea caused by retanied damp./1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate. 彝族
TCMBANKHE004455/YEM-744/XU-850 Rheum palmatum|Rheum palmatum L. 掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 See Rheum officinale./See Rheum officinale. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE001627/YEM-744/XU-850 Radix et Rhizoma Rhei Praeparata|Rheum palmatum L.|Rheum palmatum 制大黄|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE007363/YEM-744/XU-850 Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum 大黄; 生锦纹; 生军|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE003708/YEM-744/XU-850 Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum 酒大黄|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000018 Pancreatic Neoplasm disease Digestive System Diseases; Neoplasms; Endocrine System Diseases 30674340
TCMBANKDI000052 Osteoporosis disease Nutritional and Metabolic Diseases; Musculoskeletal Diseases 27692562
TCMBANKDI000085 Inflammation phenotype Pathological Conditions, Signs and Symptoms 24721152

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000031 DNMT3A DNMT3A2; HESJAS; M.HsaIIIA; TBRS DNA methyltransferase 3 alpha
TCMBANKGE000051 IL1B IL-1; IL1-BETA; IL1F2; IL1beta interleukin 1 beta
TCMBANKGE000052 TNF DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F tumor necrosis factor
TCMBANKGE000171 DNMT1 ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI DNA methyltransferase 1
TCMBANKGE000729 CASP1 ICE; IL1BC; P45 caspase 1
TCMBANKGE000811 KL HFTC3 klotho
TCMBANKGE000933 IKBKB IKK-beta; IKK2; IKKB; IMD15; IMD15A; IMD15B; NFKBIKB inhibitor of nuclear factor kappa B kinase subunit beta
TCMBANKGE000990 EGFR ERBB; ERBB1; HER1; NISBD2; PIG61; mENA epidermal growth factor receptor
TCMBANKGE001089 PARP1 ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1 poly(ADP-ribose) polymerase 1
TCMBANKGE001114 IL6 BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 interleukin 6
TCMBANKGE001132 BAX BCL2L4 BCL2 associated X, apoptosis regulator
TCMBANKGE001156 CASP3 CPP32; CPP32B; SCA-1 caspase 3
TCMBANKGE001166 BCL2 Bcl-2; PPP1R50 BCL2 apoptosis regulator
TCMBANKGE001178 STAT3 ADMIO; ADMIO1; APRF; HIES signal transducer and activator of transcription 3