Compound Summary

  Compound Information

TCMBANKIN036796

药名:	puerarin
别名:	8-(beta-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one; NPI-31G; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; SCHEMBL14329031; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]-4-chromenone; 82435_FLUKA; daidzein 8-C-glucoside; Puerarin; P5555_SIGMA; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one; 3681-99-0; ANGC-3681-99-0; 8-(beta-D-Glucopyranosyl)-4',7-dihydroxyisoflavone; C10524; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]chromone
分子式:	C21H20O9
Smiles:	[C@]1([H])(O[H])[C@@]([H])(C([H])([H])O[H])O[C@@]([H])(c(c(O[H])c2[H])c(OC([H])=C(c3c([H])c([H])c(O[H])c([H])c3[H])C4=O)c4c2[H])[C@]([H])(O[H])[C@@]1([H])O[H]
成分:	HBIN041253
OB_score:	24.030898
CAS_id:	3681-99-0
SymMap_id:	SMIT00321
TCMID_id:	18166
TCMSP_id:	MOL012297
PubChem_id:	53384442
DrugBank_id:	DB12290

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004340		萱草根			Edema, jaundice, strangury-turbidity, vaginal discharge, spontaneous external bleeding, hematochezia, flooding and spotting, scrofula, mammary welling abscess, galactostasis.
TCMBANKHE000956	flos puerariae lobatae	葛花			To relieve fever, to promote the production of body fluid,to facilitate eruption, and to arrest diarrhea./Treatment of fever, headache and stiffness of th nape in exogenous affections, thirst, diabetes, measles with inadequate eruption, acute dysentery or diarrhea, stiff and painful nape in hypertension.
TCMBANKHE001091	Seseli ericephalum
TCMBANKHE001210		松子仁
TCMBANKHE001963	Angelica ursina
TCMBANKHE003749	Radix Puerariae	葛根			To relieve fever, to promote the production of body fluid,to facilitate eruption, and to arrest diarrhea./Angina pectoris, hypertension, headache due to externally contracted wind-heat, rigidity of neck, thirst, diabetes mellitus, non-eruption of measles, heat dysentery, diarrhea, deafness in early stage, optic nerve atrophy, retinitis.
TCMBANKHE005515	Pueraria calycina	黄毛茛
TCMBANKHE004172	Radix Bupleuri	柴胡			To relieve fever, to soothe the liver, and to cure drooping and ptosis./Common cold, influenza, malaria, acute pancreatitis, pleuritis, neuritis, gastritis, acute cholecystitis, hepatitis, fever due to external contraction, keratitis, cold-heat in turn, liver depression and rib-side pain, mammary distention, dizziness and headache, menstrual disorder, prolapse of rectum due to qi vacuity fall, prolapse of uterus, gastroptosis.
TCMBANKHE004195	Pueraria thomsonii	甘葛藤根			See Pueraria lobata ./See Pueraria lobata.
TCMBANKHE004447	Pueraria phaseoloides	三裂叶葛			See Pueraria lobata./See Pueraria lobata .
TCMBANKHE004598	Zizia aptera	芨芨芹
TCMBANKHE006055	Herba Potentillae Chinensis	委陵菜			To remove toxic heat and reduce heat in blood, and to relieve dysentery./Red dysentery and abdominal pain, enduring dysentery, bleeding hemorrhoids, swelling toxin of sore and welling abscess.
TCMBANKHE007707	Pueraria omeiensis	峨嵋葛			See Pueraria lobata./See Pueraria lobata.
TCMBANKHE008462	Peucedanum govanianum var. bicolo	丽江前胡;漓江前胡
TCMBANKHE007623	Libanotis condensata	密花岩风			To dispel wind and free network vessels, relieve pain./Pain in joints due to rheumatalgia, chest pain.
TCMBANKHE009074	Pueraria peduncularis	云南葛藤			To kill worms (stem), upbear yang and resolve exterior (root)./Impotence, common cold (root).
TCMBANKHE008092	Radix Cyathulae	川牛膝			To eliminate blood stasis and stimulate menstrual discharge, to allay arthralgia and ease the joint, and to relieve urinary disturbance./Amenorrhea with concretion and conglomeration, retention of placenta, impediment pain in joints, hematuria, blood strangury, knocks and falls.
TCMBANKHE007335/YEM-814	Pueraria lobata var. thomsonii|Pueraria lobata(Willd.)Ohwi	粉葛|葛	葛根	云南民族药物志：第四卷		阿昌族/布依族/傣族/德昂族/基诺族/景颇族/傈僳族/水族/佤族/瑶族/彝族
TCMBANKHE006012/YNS-310/YEM-919	Pueraria edulis|Pueraria edulis Pamp.	食用葛	云葛根|食用葛	云南药材标准：第七册|云南民族药物志：第五卷	解肌退热，生津，透疹，升阳止泻。用于外感发热，头痛，消渴，痢疾，泄泻，眩晕，胸痹，麻疹不透，酒毒伤中。|See Pueraria lobata./See Pueraria lobata.	哈尼族/苗族/瑶族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI005044	Ventricular Remodeling	phenotype	Pathological Conditions, Signs and Symptoms	31629735
TCMBANKDI029030	Myocardial fibrosis	phenotype	Pathological Conditions, Signs and Symptoms	31629735

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000047	AKT1	AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA	AKT serine/threonine kinase 1
TCMBANKGE000052	TNF	DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F	tumor necrosis factor
TCMBANKGE000093	IFNB1	IFB; IFF; IFN-beta; IFNB	interferon beta 1
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000196	FAS	ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6	Fas cell surface death receptor
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000229	ACE2	ACEH	angiotensin I converting enzyme 2
TCMBANKGE000241	CASP8	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5	caspase 8
TCMBANKGE000256	PRKCA	AAG6; PKC-alpha; PKCA; PKCI+/-; PKCalpha; PRKACA	protein kinase C alpha
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000298	SOD1	ALS; ALS1; HEL-S-44; IPOA; SOD; STAHP; hSod1; homodimer	superoxide dismutase 1
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000326	SELP	CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL	selectin P
TCMBANKGE000414	CYP19A1	ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM	cytochrome P450 family 19 subfamily A member 1
TCMBANKGE000522	AGTR1	AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R	angiotensin II receptor type 1
TCMBANKGE000784	CALM3	CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3	calmodulin 3
TCMBANKGE000787	VCAM1	CD106; INCAM-100	vascular cell adhesion molecule 1
TCMBANKGE000825	CDKN1B	CDKN4; KIP1; MEN1B; MEN4; P27KIP1	cyclin dependent kinase inhibitor 1B
TCMBANKGE000881	PLAT	T-PA; TPA	plasminogen activator, tissue type
TCMBANKGE000918	MAPK9	JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; SAPK; SAPK1a; p54a; p54aSAPK	mitogen-activated protein kinase 9
TCMBANKGE000994	AKR1B1	ADR; ALDR1; ALR2; AR	aldo-keto reductase family 1 member B
TCMBANKGE001013	BIRC5	API4; EPR-1	baculoviral IAP repeat containing 5
TCMBANKGE001037	MMP2	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1	matrix metallopeptidase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001097	HIF1A	HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78	hypoxia inducible factor 1 subunit alpha
TCMBANKGE001098	NFKBIA	EDAID2; IKBA; MAD-3; NFKBI	NFKB inhibitor alpha
TCMBANKGE001107	NOS3	ECNOS; eNOS	nitric oxide synthase 3
TCMBANKGE001118	MMP9	CLG4B; GELB; MANDP2; MMP-9	matrix metallopeptidase 9
TCMBANKGE001130	BAD	BBC2; BCL2L8	BCL2 associated agonist of cell death
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001132	BAX	BCL2L4	BCL2 associated X, apoptosis regulator
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001171	SRC	ASV; SRC1; THC6; c-SRC; p60-Src	SRC proto-oncogene, non-receptor tyrosine kinase
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001184	RELA	CMCU; NFKB3; p65	RELA proto-oncogene, NF-kB subunit
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001197	FOS	AP-1; C-FOS; p55	Fos proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE002980	CHEK2	CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1	checkpoint kinase 2
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE007151	TIMP2	CSC-21K; DDC8	TIMP metallopeptidase inhibitor 2
TCMBANKGE007368	GSTP1	DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI	glutathione S-transferase pi 1
TCMBANKGE008830	JAK3	JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK	Janus kinase 3
TCMBANKGE009361	GPT	AAT1; ALT1; GPT1	glutamic--pyruvic transaminase
TCMBANKGE010401	PLIN2	ADFP; ADRP	perilipin 2
TCMBANKGE011107	PGP	AUM; G3PP; PGPase	phosphoglycolate phosphatase
TCMBANKGE011117	CDKN2AIP	CARF	CDKN2A interacting protein
TCMBANKGE011407	PDGFA	PDGF-A; PDGF1	platelet derived growth factor subunit A
TCMBANKGE012222	IFNA13	-	interferon alpha 13
TCMBANKGE013473	F2R	CF2R; HTR; PAR-1; PAR1; TR	coagulation factor II thrombin receptor
TCMBANKGE014653	ITGB5	-	integrin subunit beta 5
TCMBANKGE014837	LEPR	CD295; LEP-R; LEPRD; OB-R; OBR	leptin receptor