Compound Summary

  Compound Information

TCMBANKIN036827

药名:	xanthohumol
别名:	CHEBI:134289; xanthohumol(1-); 2',4,4'-trihydroxy-6'-methoxy-3-prenylchalcone; 3-hydroxy-6-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-5-methoxy-2-(3-methylbut-2-en-1-yl)phenolate
分子式:	C21H22O5
Smiles:	CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=CC=C(C=C2)O)O)C
成分:	HBIN048442
OB_score:	1.017584
CAS_id:	569-83-5
SymMap_id:	SMIT00652
TCMID_id:	22745
TCMSP_id:	MOL006653
PubChem_id:	639665
DrugBank_id:	DB15359

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE007958	Libanotis buchtormensis	岩凤			To effuse exterior and dissipate cold, dispel wind and eliminate damp, disperse swelling and relieve pain./Wind-cold common cold, headache, toothache, wind-damp impediment pain, sinew and bone numbness, wound swelling from knocks and falls.
TCMBANKHE004471	Humulus lupulus	啤酒花			To fortify stomach and disperse food, disinhibit urine and quiet spirit, eliminate inflammation./Indigestion, abdominal distention, edema, cystitis, tuberculosis, cough, insomnia, leprosy.
TCMBANKHE004613	flos Sophorae	槐花			To arrest bleeding by reducing heat in blood, and to quench excess fire in the liver./1. Its component rutin decreases capillay permeability. 2. Lowering blood pressure transiently in anesthetized dog. 3. Inhibiting the growth of various dermatomyces.
TCMBANKHE008503	Radix Sophorae flavescentis	苦参			To remove heat and damp, to kill parasites, and to cause diuresis./Arrhythmia, otitis media, acute conjunctivitis, chronic conjunctivitis, trichomoniasis, septicemia, edema, damp-heat diarrhea, intestinal wind bleeding, acute jaundice, inhibited urination, vaginal discharge, pudendal itch, scab and lichen, leprosy, itchy skin, eczema, damp toxin sore, suppurative nest sore.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000026	Obesity	disease	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases	30999670
TCMBANKDI000033	Non-alcoholic Fatty Liver Disease	disease	Digestive System Diseases	30999670
TCMBANKDI007450	Hemorrhage	phenotype	Pathological Conditions, Signs and Symptoms	28188927
TCMBANKDI008034	Diabetes Mellitus	group	Nutritional and Metabolic Diseases; Endocrine System Diseases	30999670
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	23503627
TCMBANKDI014083	Peritoneal Diseases	group	Digestive System Diseases	22447626
TCMBANKDI016139	Endometriosis	disease	Female Urogenital Diseases and Pregnancy Complications	22447626
TCMBANKDI029884	Acute Lung Injury	disease	Respiratory Tract Diseases	28285192
TCMBANKDI031190	Thrombosis	phenotype	Cardiovascular Diseases	28188927

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000053	NFKB1	CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB	nuclear factor kappa B subunit 1
TCMBANKGE000199	ICAM1	BB2; CD54; P3.58	intercellular adhesion molecule 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000223	KEAP1	INrf2; KLHL19	kelch like ECH associated protein 1
TCMBANKGE000274	CCL2	GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF	C-C motif chemokine ligand 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000318	HMGB1	HMG-1; HMG1; HMG3; SBP-1	high mobility group box 1
TCMBANKGE000584	TXNIP	ARRDC6; EST01027; HHCPA78; THIF; VDUP1	thioredoxin interacting protein
TCMBANKGE000788	SELE	CD62E; ELAM; ELAM1; ESEL; LECAM2	selectin E
TCMBANKGE001052	NLRP3	AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1	NLR family pyrin domain containing 3
TCMBANKGE001068	CXCL1	FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1	C-X-C motif chemokine ligand 1
TCMBANKGE001126	NFE2L2	HEBP1; IMDDHH; NRF2; Nrf-2	nuclear factor, erythroid 2 like 2
TCMBANKGE001127	PRKAA1	AMPK; AMPKa1	protein kinase AMP-activated catalytic subunit alpha 1
TCMBANKGE001128	PRKAA2	AMPK; AMPK2; AMPKa2; PRKAA	protein kinase AMP-activated catalytic subunit alpha 2
TCMBANKGE001182	SIRT1	SIR2; SIR2L1; SIR2alpha	sirtuin 1