Compound Summary
Compound Information
药名: | piperine |
别名: | KBio2_003371; AIDS024972; SPBio_002547; ZINC01529772; Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-; 1-[5-(3,4-Methylenedioxyphenyl)-1-oxo-2,4-pentadienyl]piperidine; DivK1c_000954; NSC242267; CCRIS 5572; 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-; P49007_ALDRICH; BSPBio_000608; 7780-20-3; Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-; 1-[5-(3,4-pentadienyl]piperidine; Piperin; Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-; Piperine (aliphatic); piperine ; SCHEMBL14171509; Spectrum2_000049; KBioSS_000803; 1-PIPEROYL-(E,E)-PIPERIDINE; ZINC5945454; IDI1_000954; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one; Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (Z,E)-; NCGC00094872-03; Prestwick1_000474; 1-Piperoyl-piperidine; InChI=1/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3; NCGC00094872-01; Piperidine, 1-piperoyl-, (E,E)-; Piperidine, 1-[5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl]-; SR-01000638580-1; Piperidine,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl]-; UNII-Z3C7H03C5M; KBio1_000954; BPBio1_000670; N-[(E,E)-piperoyl]-piperidine; 1-Piperoylpiperidine; Piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-; 5-(1,3-benzodioxol-5-yl)-1-piperidino-penta-2,4-dien-1-one; NCGC00094872-02; Z3C7H03C5M; (2Z,4E)-5-(2H-1,3-BENZODIOXOL-5-YL)-1-(PIPERIDIN-1-YL)PENTA-2,4-DIEN-1-ONE; piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-; NSC21727; 1-(5-(3,4-Methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)piperidine; Spectrum_000323; (2Z,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one; 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine; (E,E) 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)penta-2,4-dien-1-one; Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)- (9CI); Spectrum4_000708; 1-Piperoylpiperidine, (E,E)-; KBio3_002015; Prestwick3_000474; AIDS-024972; Spectrum3_000868; KBio2_005939; Prestwick_398; Prestwick0_000474; Prestwick2_000474; Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-; (E,E)-1-piperoylpiperidine; FEMA No. 2909; SPBio_000177; C03882; 147030-08-8; N-[(E,E)-Piperoyl]piperidine; 80810_FLUKA; Piperoylpiperidine; 5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)penta-2,4-dien-1-one; Spectrum5_001507; 94-62-2; 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine; W290904_ALDRICH; NINDS_000954; BSPBio_002515; 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one; 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine; 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine; Piperine; 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-yl-penta-2,4-dien-1-one; Piperidine,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-; KBioGR_001235; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidino-penta-2,4-dien-1-one; NSC 242267; AC1LU7IP; SDCCGMLS-0066693.P001; AI3-01439; NSC 21727; Isopiperine; KBio2_000803; Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-yl-penta-2,4-dien-1-one; CHEBI:28821; ST5307921; 30511-76-3; NSC-242267; SPECTRUM1500873; EINECS 202-348-0 |
分子式: | C17H19NO3 |
Smiles: | c12c(OC([H])([H])O1)c([H])c([H])c(\C([H])=C([H])\C([H])=C([H])\C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])c2[H] |
成分: | HBIN040071 |
OB_score: | 42.516744 |
CAS_id: | 94-62-2 |
SymMap_id: | SMIT00114 |
TCMID_id: | 17437 |
TCMSP_id: | MOL001592 |
PubChem_id: | 638024 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE000956 | flos puerariae lobatae | 葛花 | To relieve fever, to promote the production of body fluid,to facilitate eruption, and to arrest diarrhea./Treatment of fever, headache and stiffness of th nape in exogenous affections, thirst, diabetes, measles with inadequate eruption, acute dysentery or diarrhea, stiff and painful nape in hypertension. | |||
| TCMBANKHE007765 | 覆盆子 | Impotence with premature ejaculation, emission, infertility due to uterus cold, frequent urination and enuresis, dizziness and dim vision, premature graying in beard and hair. | ||||
| TCMBANKHE005150 | 荜茇根 | |||||
| TCMBANKHE008361 | 荜茇 | Cold pain in stomach duct and abdomen, vomiting, diarrhea, headache, toothache, deep-source nasal congestion, coronary heart disease, angina pectoris. | ||||
| TCMBANKHE007140 | Piper guineense | 几内亚胡椒 | ||||
| TCMBANKHE006164/YEM-243 | Cannabis sativa|Cannabis sativa L. | 麻花|大麻 | 大麻 | 云南民族药物志：第二卷 | To dispel wind, quicken blood, engender hairs./Numbness in limbs, itchy body, shedding of eyebrow and hair, amenorrhea. | 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族 |
| TCMBANKHE006499/YEM-675 | Fructus Piperis|Piper nigrum L. | 胡椒 | 胡椒 | 云南民族药物志：第四卷 | To dispel cold from the stomach, and to eliminate phlegm./Vomiting with stomach cold, abdominal pain and diarrhea, inappetence, convulsion, epilepsy and profuse phlegm. | 傣族/回族/傈僳族/佤族/彝族/藏族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI012119 | Nerve Degeneration | phenotype | Pathological Conditions, Signs and Symptoms | 29378605 |
| TCMBANKDI013888 | Fibrosis | phenotype | Pathological Conditions, Signs and Symptoms | 28330809 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000007 | IL12B | CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2 | interleukin 12B |
| TCMBANKGE000051 | IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | interleukin 1 beta |
| TCMBANKGE000052 | TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | tumor necrosis factor |
| TCMBANKGE000199 | ICAM1 | BB2; CD54; P3.58 | intercellular adhesion molecule 1 |
| TCMBANKGE000201 | ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000264 | ABCB1 | ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 | ATP binding cassette subfamily B member 1 |
| TCMBANKGE000286 | GSK3B | - | glycogen synthase kinase 3 beta |
| TCMBANKGE000309 | SCN5A | CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 | sodium voltage-gated channel alpha subunit 5 |
| TCMBANKGE000338 | CHUK | IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16 | component of inhibitor of nuclear factor kappa B kinase complex |
| TCMBANKGE000360 | CCNA2 | CCN1; CCNA | cyclin A2 |
| TCMBANKGE000403 | ATF2 | CRE-BP1; CREB-2; CREB2; HB16; TREB7 | activating transcription factor 2 |
| TCMBANKGE000633 | ADRB2 | ADRB2R; ADRBR; B2AR; BAR; BETA2AR | adrenoceptor beta 2 |
| TCMBANKGE000764 | TRPV1 | VR1 | transient receptor potential cation channel subfamily V member 1 |
| TCMBANKGE000766 | ACHE | ACEE; ARACHE; N-ACHE; YT | acetylcholinesterase (Cartwright blood group) |
| TCMBANKGE000813 | DPP4 | ADABP; ADCP2; CD26; DPPIV; TP103 | dipeptidyl peptidase 4 |
| TCMBANKGE000938 | CDK2 | CDKN2; p33(CDK2) | cyclin dependent kinase 2 |
| TCMBANKGE001073 | PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | prostaglandin-endoperoxide synthase 2 |
| TCMBANKGE001114 | IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | interleukin 6 |
| TCMBANKGE001154 | CREB1 | CREB; CREB-1 | cAMP responsive element binding protein 1 |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001185 | PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | peroxisome proliferator activated receptor gamma |
| TCMBANKGE001197 | FOS | AP-1; C-FOS; p55 | Fos proto-oncogene, AP-1 transcription factor subunit |
| TCMBANKGE001467 | LTA4H | - | leukotriene A4 hydrolase |
| TCMBANKGE001506 | ADRA1B | ADRA1; ALPHA1BAR | adrenoceptor alpha 1B |
| TCMBANKGE001755 | MAOB | - | monoamine oxidase B |
| TCMBANKGE003317 | DPAGT1 | ALG7; CDG-Ij; CDG1J; CMS13; CMSTA2; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT | dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 |
| TCMBANKGE003438 | SOAT2 | ACACT2; ACAT2; ARGP2 | sterol O-acyltransferase 2 |
| TCMBANKGE004266 | AR | AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM | androgen receptor |
| TCMBANKGE004731 | ABCB5 | ABCB5alpha; ABCB5beta; EST422562 | ATP binding cassette subfamily B member 5 |
| TCMBANKGE005535 | CHRM1 | HM1; M1; M1R | cholinergic receptor muscarinic 1 |
| TCMBANKGE006339 | CA2 | CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 | carbonic anhydrase 2 |
| TCMBANKGE006645 | PIDD1 | LRDD; PIDD | p53-induced death domain protein 1 |
| TCMBANKGE006943 | CHRM3 | EGBRS; HM3; PBS | cholinergic receptor muscarinic 3 |
| TCMBANKGE008056 | ADRA2C | ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR | adrenoceptor alpha 2C |
| TCMBANKGE008172 | MAOA | BRNRS; MAO-A | monoamine oxidase A |
| TCMBANKGE009758 | PDE3A | CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB | phosphodiesterase 3A |
| TCMBANKGE011079 | PRSS1 | TRP1; TRY1; TRY4; TRYP1 | serine protease 1 |
| TCMBANKGE012155 | SLC6A3 | DAT; DAT1; PKDYS; PKDYS1 | solute carrier family 6 member 3 |
| TCMBANKGE013940 | SOAT1 | ACACT; ACAT; ACAT-1; ACAT1; SOAT; STAT | sterol O-acyltransferase 1 |
| TCMBANKGE015025 | CHKB | CHETK; CHKL; CK; CKB; CKEKB; EK; EKB; MDCMC | choline kinase beta |
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