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Compound Summary

Compound Information

TCMBANKIN036847

药名:	hyperforin
别名:	(1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; C07608; Hyperforin; PDSP2_001346; 11079-53-1; (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-1-(2-methyl-1-oxopropyl)-8-(4-methylpent-3-enyl)bicyclo[3.3.1]non-3-ene-2,9-dione; Spectrum5_002025; NCGC00163120-01; hyperforin ; (1R,5R,7S,8R)-4-hydroxy-1-isobutyryl-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)bicyclo[3.3.1]non-3-ene-2,9-quinone
分子式:	C36H54O4
Smiles:	C1(O[H])=C(C([H])([H])\C([H])=C(/C([H])([H])[H])\C([H])([H])[H])C(=O)[C@@]([C@@](C([H])([H])C([H])([H])\C([H])=C(/C([H])([H])[H])\C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])\C([H])=C(/C([H]) ([H])[H])\C([H])([H])[H])C([H])([H])C2([H])[H])(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)[C@@]12C([H])([H])\C([H])=C(/C([H])([H])[H])\C([H])([H])[H]
成分:	HBIN029826
OB_score:	44.033175
CAS_id:	11079-53-1
SymMap_id:	SMIT00534
TCMID_id:	10882
TCMSP_id:	MOL003347
PubChem_id:	441298

化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000919	Hypericum wightianum	遍地锦			To clear heat and resolve toxin, arrest diarrhea./White mouth sore in children, infant pneumonia, stomatitis, mammary welling abscess, yellow-water sore, poisonous snake bites, diarrhea, enduring dysentery.
TCMBANKHE003696	Hypericum subsessile
TCMBANKHE003799	Fructus Forsythiae	连翘			To remove toxic heat, to cause subsidence of sweeling,and to eliminate modulation./Influenza in early stage, common cold in early stage, wind-heat common cold, encephalitis, hepatitis, tuberculosis, warm disease, heat strangury with inhibited pain, welling abscess, welling abscess and flat abscess, toxin swelling, scrofula, goiter and tuberculosis, throat impediment.
TCMBANKHE004222	Hypericum curvisepalum	贯叶金丝桃
TCMBANKHE005890	Hypericum lancasteri	展萼金丝桃
TCMBANKHE006060	Herba Hyperici Japonici	地耳草			1.To deprive dampness and relieve jaundice. 2. To clear away heat and toxic material. 3. To promote blood circulation and relieve edema./Damp-heat jaundice, diarrhea, dysentery, intestinal welling abscess, pulmonary welling abscess, swelling toxin of welling abscess and boil, nipple moth, mouth sore, red eyes with gall, poisonous snake bite, knocks and falls.
TCMBANKHE006886	Hypericum perforatum	贯叶连翘			To promote astriction and stanch bleeding, regulate menstruation and free milk, clear heat and resolve toxin, disinhibit damp./Hemoptysis, blood ejection, intestinal wind bleeding, flooding and spotting, bleeding due to external injury, menstrual disorder, galactostasis, jaundice, throat pain, red eyes with gall, urinary tract infection, mouth sore, nose sores, swelling toxin of welling abscess and boil, burns and scalds.
TCMBANKHE008503	Radix Sophorae flavescentis	苦参			To remove heat and damp, to kill parasites, and to cause diuresis./Arrhythmia, otitis media, acute conjunctivitis, chronic conjunctivitis, trichomoniasis, septicemia, edema, damp-heat diarrhea, intestinal wind bleeding, acute jaundice, inhibited urination, vaginal discharge, pudendal itch, scab and lichen, leprosy, itchy skin, eczema, damp toxin sore, suppurative nest sore.
TCMBANKHE006447	Hypericum erectum	小连翘			To regulate menstruation and stanch bleeding, dissipate stasis and relieve pain, resolve toxin and disperse swelling./Blood ejection, hemoptysis, spontaneous external bleeding, hematochezia, flooding and spotting, bleeding due to external injury, menstrual disorder, postpartum galactostasis, knocks and falls, pain in joints due to rheumatalgia, swelling toxin of sore and boil, poisonous snake bite.
TCMBANKHE006682	Hypericum ascyron	黄海棠			To cool blood and stanch bleeding, quicken blood and regulate menstruation, clear heat and resolve toxin./Blood ejection due to blood heat, hemoptysis, hematuria, hematochezia, flooding and spotting, knocks and falls, bleeding due to external injury, menstrual disorder, dysmenorrhea, galactostasis, wind-heat common cold, malaria, hepatitis, dysentery, diarrhea, poisonous snake bite, scalds, eczema, yellow-water sore.
TCMBANKHE006755	Herba Hyperici japonici	田基黄;地耳草			1.To deprive dampness and relieve jaundice. 2. To clear away heat and toxic material. 3. To promote blood circulation and relieve edema./Damp-heat jaundice, diarrhea, dysentery, intestinal welling abscess, pulmonary welling abscess, swelling toxin of welling abscess and boil, nipple moth, mouth sore, red eyes with gall, poisonous snake bite, knocks and falls.
TCMBANKHE007164	Hypericum elodeoides	挺茎遍地金			See Hypericum wightianum./See Hypericum wightianum.
TCMBANKHE006980	Hypericum faberi	扬子小连翘
TCMBANKHE007572	Hypericum sampsonii	元宝草			To cool blood and stanch bleeding, clear heat and resolve toxin, quicken blood and regulate menstruation, dispel wind and free network vessels./Blood ejection, hemoptysis, spontaneous external bleeding, blood strangury, bleeding from wounds, enteritis, dysentery, mammary welling abscess, swollen welling abscess and toxin of clove sore, scalds, snake bite, menstrual disorder, menstrual pain, leukorrhea, knocks and falls, wind-damp impediment pain, pain in lumbus and leg, tinea capitis, mouth sore, eye screen.
TCMBANKHE007878	Hypericum patulum	金丝梅			To clear heat and rectify damp, resolve toxin, course liver and free network vessels, dispel stasis and relieve pain./Damp-heat strangury, hepatitis, common cold, tonsillitis, mounting qi with unilateral sagging of one testicle, pain in sinews and bones, knocks and falls.
TCMBANKHE007748/YEM-22/XU-390	Herba andrographitis\|Andrographis paniculata (Burm. f,)Nees\|Andrographis paniculata	穿心莲	穿心莲	云南民族药物志：第一卷\|云南省普洱市镇沅县	1. To clear heat and release toxins; 2. To dry dampness/Infection of upper respiratory tract, fever, wind-heat common cold, bacillary dysentery, diarrhea, tonsillitis, pneumonia, tuberculosis, lung heat cough, pulmonary welling abscess, postlithotripsy urinary tract infection, warm disease fever, pertussis, swelling pain in throat, damp-heat jaundice, strangury syndrome, erysipelas, sore and welling abscess, eczema, poisonous snake bite.	阿昌族/傣族/德昂族/景颇族/傈僳族

植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000008	Brain Neoplasms	group	Neoplasms; Nervous System Diseases	20883786
TCMBANKDI016118	Cerebellar Neoplasms	group	Neoplasms; Nervous System Diseases	20883786
TCMBANKDI026275	Glioblastoma	disease	Neoplasms	20883786
TCMBANKDI028593	Medulloblastoma	disease	Neoplasms	20883786

化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000405	LONP1	CODASS; LON; LONP; LonHS; PIM1; PRSS15; hLON	lon peptidase 1, mitochondrial
TCMBANKGE000473	TRPC6	FSGS2; TRP6	transient receptor potential cation channel subfamily C member 6
TCMBANKGE001118	MMP9	CLG4B; GELB; MANDP2; MMP-9	matrix metallopeptidase 9
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A