Compound Summary

  Compound Information

TCMBANKIN036851

药名:	chenodeoxycholic acid
别名:	(3alpha,5beta,7alpha,8xi)-3,7-dihydroxycholan-24-oic acid; 3-alpha,7-alpha-Dihydroxycholanic acid; Anthropodesoxycholic acid; SMP1_000064; 7-alpha-Hydroxylithocholic acid; BSPBio_000190; Spectrum5_002009; JN3; CDCA; Acide chenodeoxycholique [INN-French]; Acidum chenodeoxycholicum [INN-Latin]; (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 3-alpha,7-alpha-Dihydroxycholansaeure [German]; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- (9CI); (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid; Chenodesoxycholsaeure [German]; 5.BETA.-CHOLANIC ACID-3.ALPHA., SODIUM SALT; AIDS-045143; CCRIS 2195; Gallodesoxycholic acid; AIDS045143; Chenodiol (USAN); Chenix (TN); Chenix; 7alpha-hydroxylithocholic acid; SODIUM URSO; Prestwick1_000285; Chenic acid; 5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy-; HSCI1_000210; D00163; chenodeoxycholicacid; Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha., 5-.beta., 7-.alpha.)-; Chenodiol [USAN]; Anthropododesoxycholic acid; SPBio_002409; Prestwick0_000285; Anthropodeoxycholic acid; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7alpha)-; Chenodeoxycholic acid (JP15/INN); Chenodiol; NSC681066; CHEBI:16755; 474-25-9; Chenodeoxycholic acid; NSC-681066; 3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid; SBB002935; BPBio1_000210; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid; Prestwick2_000285; Acido chenodeoxicholico [INN-Spanish]; LMST04010032; Chendol; C02528; EINECS 207-481-8; Prestwick3_000285; NSC 657949
分子式:	C24H40O4
Smiles:	CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
成分:	HBIN020280
OB_score:	27.16752
CAS_id:	474-25-9
SymMap_id:	SMIT00745;SMIT14635
TCMID_id:	23282;3511
TCMSP_id:	MOL008842
PubChem_id:	10133

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE003755	Radix Ampelopsis	白蔹			To remove toxic heat, to cure carbuncles, and to reduce nodules./Swelling toxin of sore and welling abscess, burns and scalds, scrofula, damp sore, warm malaria, frightepilepsy, blood dysentery, intestinal wind, hemorrhoids and fistulas, leukorrhea, knocks and falls, bleeding due to external injury.
TCMBANKHE004762	Selenarctos thibetanus, Ursus arctos	熊胆			To clear heat and resolve toxin, calm liver and brighten eyes, stanch bleeding and kill worms./Fright wind, epilepsy, convulsion due to liver heat and liver wind, swollen pain in red eyes due to liver heat, aversion to light, eye screen, swelling pain of welling abscess and sore, swelling pain from hemorrhoids.
TCMBANKHE004901	Dicentra spectabilis	荷包牡丹根			To dispel wind, quicken blood, settle pain./Incised wound, sore toxin, stomachache.
TCMBANKHE007204	Gallus gallus domesticus	鸡脑			To extinguish wind and check tetany./Difficult delivery, child fright epilepsy, infant night crying.
TCMBANKHE007245	Hylomecon japonica	荷青花			To dispel wind and free network vessels, dissipate stasis and disperse swelling./Wind-damp impediment pain, knocks and falls.
TCMBANKHE007523	Folium Polygoni Tinctorii	蓼大青叶			To remove toxic heat, and to cause subsidence of eruptions by reducing heat in blood./Treatment of fever and eruptions in epidemic diseases, cough and asthma due to heat in the lung, inflammation of the throat, mnmps, erysipelas, carbuncle.
TCMBANKHE006371		白屈菜			Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE006641	Calculus Bovis	牛黄			To restore consciousness by reducing fire and eliminating phlegm , to relieve convulsions, and to counteract toxicity./Ardent fever, coma, fright epilepsy, convulsion, febrile diseases clouded spirit, wind stroke with orifice block, acute infant fright wind, swelling pain in throat, mouth and tongue sores, welling abscess and flat abscess with clove sore.
TCMBANKHE007961	Anser cygnoides domestica	白鹅膏			To moisten skin, disperse swollen welling abscess./Cracking, deafness, otitis media, dysphagia-occlusion and stomach reflux, drug poisoning, swollen welling abscess, scab and lichen.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI018318	Diarrhea	phenotype	Pathological Conditions, Signs and Symptoms	31268738
TCMBANKDI026055	Colitis, Collagenous	disease	Digestive System Diseases	21366635

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000199	ICAM1	BB2; CD54; P3.58	intercellular adhesion molecule 1
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000247	SLC2A4	GLUT4	solute carrier family 2 member 4
TCMBANKGE000260	APOB	FCHL2; FLDB; LDLCQ4; apoB-100; apoB-48	apolipoprotein B
TCMBANKGE000299	HMGCR	LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000328	PTPN11	BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2	protein tyrosine phosphatase non-receptor type 11
TCMBANKGE000474	NCOA1	F-SRC-1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74	nuclear receptor coactivator 1
TCMBANKGE000476	NCOA2	GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75	nuclear receptor coactivator 2
TCMBANKGE000781	LDLR	FH; FHC; FHCL1; LDLCQ2	low density lipoprotein receptor
TCMBANKGE000787	VCAM1	CD106; INCAM-100	vascular cell adhesion molecule 1
TCMBANKGE000951	CYP7B1	CBAS3; CP7B; SPG5A	cytochrome P450 family 7 subfamily B member 1
TCMBANKGE000956	NR1H4	BAR; FXR; HRR-1; HRR1; PFIC5; RIP14	nuclear receptor subfamily 1 group H member 4
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001116	CYP7A1	CP7A; CYP7; CYPVII	cytochrome P450 family 7 subfamily A member 1
TCMBANKGE001135	SREBF1	SREBP1; bHLHd1	sterol regulatory element binding transcription factor 1
TCMBANKGE001141	PPARA	NR1C1; PPAR; PPARalpha; hPPAR	peroxisome proliferator activated receptor alpha
TCMBANKGE001146	SNAI1	SLUGH2; SNA; SNAH; SNAIL; SNAIL1; dJ710H13.1	snail family transcriptional repressor 1
TCMBANKGE001147	CDH1	Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO	cadherin 1
TCMBANKGE001585	ZFHX3	ATBF1; ATBT; C16orf47; ZFH-3; ZNF927	zinc finger homeobox 3
TCMBANKGE001897	SLC10A2	ASBT; IBAT; ISBT; NTCP2; PBAM	solute carrier family 10 member 2
TCMBANKGE002388	NR3C2	MCR; MLR; MR; NR3C2VIT	nuclear receptor subfamily 3 group C member 2
TCMBANKGE003602	CES2	CE-2; CES2A1; PCE-2; iCE	carboxylesterase 2
TCMBANKGE003768	POU2F1	OCT1; OTF1; oct-1B	POU class 2 homeobox 1
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE004666	OAS3	p100; p100OAS	2'-5'-oligoadenylate synthetase 3
TCMBANKGE004856	ALAS1	ALAS; ALAS-H; ALAS3; ALASH; MIG4	5'-aminolevulinate synthase 1
TCMBANKGE004972	CYP8B1	CP8B; CYP12	cytochrome P450 family 8 subfamily B member 1
TCMBANKGE006375	SLCO1B3	HBLRR; LST-2; LST-3TM13; LST3; OATP-8; OATP1B3; OATP8; SLC21A8	solute carrier organic anion transporter family member 1B3
TCMBANKGE007830	NR0B2	SHP; SHP1	nuclear receptor subfamily 0 group B member 2
TCMBANKGE010789	HNF1A	HNF-1A; HNF1; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1	HNF1 homeobox A
TCMBANKGE010809	ABCB4	ABC21; GBD1; ICP3; MDR2; MDR2/3; MDR3; PFIC-3; PGY3	ATP binding cassette subfamily B member 4
TCMBANKGE010837	FABP6	I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP	fatty acid binding protein 6
TCMBANKGE011588	HNF4A	FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14	hepatocyte nuclear factor 4 alpha
TCMBANKGE012726	MTTP	ABL; MTP	microsomal triglyceride transfer protein