Compound Summary
Compound Information
药名: | ginsenoside Rh2 |
别名: | ginsenoside-rh2; 78214-33-2; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethylhex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-tri; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-methylol-tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methyl-hept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-tr; beta-D-Glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl; ginsenoside rh 2; Ginsenoside Rg3 metabolite; ginsenoside rh-2 |
分子式: | C36H62O8 |
Smiles: | C1([H])([H])C([H])([H])[C@](C([H])([H])[H])([C@@]([H])(C([H])([H])[C@@]([H])(O[H])[C@]([H])([C@@]([H])([C@](O[H])(C([H])([H])[H])C([H])([H])C([H])([H])\C([H])=C(/C([H])([H])[H])\C([H])([H])[H])C([H])( [H])C2([H])[H])[C@@]23C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C4([H])[H])[C@@]4([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]1([H])O[C@@]5([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])( O[H])[C@@]5([H])O[H] |
成分: | HBIN027764 |
OB_score: | 36.319512 |
CAS_id: | 78214-33-2 |
SymMap_id: | SMIT00601 |
TCMID_id: | 23085 |
TCMSP_id: | MOL005344 |
PubChem_id: | 14081290 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE004260 | Radix Ginseng | 人参 | To reinforce the vital energy, to remedy collapse and restore the normal pulse, to benefit the spleen and lung, to promote the production of body fluid, and to calm the nerves./Qi vacuity and verging on desertion, cold limbs and faint pulse, reduced food intake due to spleen vacuity, cough and asthma due to lung vacuity, fluid damage and thirst, diabetes mellitus due to internal heat, enduring illness qi vacuity, fright palpitation and insomnia, impotence, uterus cold, cardiac failure. | |||
| TCMBANKHE001345 | Radix Ginseng Rubra | 红参 | Replenish vital essence, promote blood circualtion and relieve collapse. To reinforce qi and to stanch bleeding./Treatment of collpase tendency due to asthenia, cool limbs and weak pulse. Qi cannot control blood, uterine bleeding, cardiac failure and cardiogenic shock. | |||
| TCMBANKHE001490 | 中国红参 | |||||
| TCMBANKHE002528 | 集安红参 | |||||
| TCMBANKHE003630 | 人参须 | |||||
| TCMBANKHE004248 | Radix Pacis quinquefolii | 西洋参 | 1. To replenish qi and promote body fluids; 2. To nourish yin and clear heat/Qi vacuity, yin depletion and effulgent fire, cough and asthma with phlegm-blood, vacuity heat and vexation fatigue, diabetes mellitus due to internal heat, thirst with dry throat. | |||
| TCMBANKHE004697 | Radix Kansui | 甘遂 | To cause drastic purgation and expel the retained water./Edema, ascites, flowing rheum in chest, concretion conglomeration accumulation and gathering, epilepsy, cough and asthma, urinar y and fecal stoppage. | |||
| TCMBANKHE005431 | Flos Rosae Rugosae | 玫瑰花 | To relieve stagnation of qi, regulate blood circulation, and to arrest pain./Liver stomach qi pain, reduced food intake with nausea and vomiting, menstrual disorder, painful wound from knocks and falls. | |||
| TCMBANKHE009030 | Resi myrrhae;Myrrha | 没药 | 1. To invigorate blood and stop pain; 2. To reduce swelling and promote healing/Stasis pain in chest and abdomen, amenorrhea, dysmenorrhea, concretion and conglomeration, knocks and falls, swollen welling abscess and sores, intestinal welling abscess, red eyes with gall. | |||
| TCMBANKHE007443 | Folium Ginseng | 人参叶 | To nourish qi and lung, expel summer-heat, to promote fluid secretion./Summerheat-heat and thirst, febrile diseases fluid damage, stomach yin insufficiency, diabetes mellitus, dry cough due to lung dryness, vacuity-fire toothache. | |||
| TCMBANKHE004506/YEM-137 | Radix Notoginseng|Panax notoginseng (Burk.) F, H. Chen ex C.Chow et al. | 三七 | 三七 | 云南民族药物志：第一卷 | To eliminate blood stasis, arrest bleeding, cause subsidence of swelling and alleviate pain./Hemoptysis, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting, bleeding due to external injury, angina pectoris, stabbing pain in chest and abdomen, painful swelling from knocks and falls. | 彝族 |
| TCMBANKHE004505/YEM-137 | Radix Notoginseng|Panax notoginseng (Burk.) F, H. Chen ex C.Chow et al. | 汉三七|三七 | 三七 | 云南民族药物志：第一卷 | Treatment of hemoptysis, hematemesis, epistaxis, hematochezia, abnormal uterine bleeding, traumatic bleeding, pricking pain in the chest and abdomen, traumatic swelling and pain./1. Flavonoid glycoside, one of its components, increases coronary flow, reduces myocardial oxygen consumption and lowers arterial pressure.2.Cardiotonic on frogs' hearts in vitro; low concentration of its extract exerts a vasoconstrictive effect on the vessels of frogs' leg and high concentration, vasodilative3. Its liquid extract shortens clotting time and exerts hemostatic effect in rabbit. | 彝族 |
| TCMBANKHE004643/YEM-590/XU-716 | Folium Mori|Morus alba L.|Morus alba | 桑叶|桑 | 桑叶 | 云南民族药物志：第三卷|云南省昭通市盐津县 | To dispel wind-heat and to remove heat from the lung, to subdue hyperactivity of the liver and improve eyesight./Wind-heat common cold, lung heat dry cough, dizziness and headache, red eyes and clouded vision. | 阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族 |
| TCMBANKHE008893/YEM-702 | Panax ginseng [Syn. Panax schinseng ]|Panax ginseng C.A.Mey. | 人参芦|人参 | 人参 | 云南民族药物志：第四卷 | To upbear yang and raise fall./Spleen vacuity qi fall, enduring diarrhea, prolapse of rectum. | 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族 |
| TCMBANKHE000387/YEM-702 | Panax ginseng C.A.Mey. | 人参子|人参 | 人参 | 云南民族药物志：第四卷 | 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族 | |
| TCMBANKHE001243/YEM-702 | Panax ginseng C.A.Mey. | 人参花|人参 | 人参 | 云南民族药物志：第四卷 | 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI000022 | Prostatic Neoplasms | group | Neoplasms; Male Urogenital Diseases | 29457293 |
| TCMBANKDI015740 | Colorectal Neoplasms | group | Digestive System Diseases; Neoplasms | 21194832 |
| TCMBANKDI027599 | Corneal Neovascularization | disease | Pathological Conditions, Signs and Symptoms; Eye Diseases | 29465315 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000051 | IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | interleukin 1 beta |
| TCMBANKGE000052 | TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | tumor necrosis factor |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000247 | SLC2A4 | GLUT4 | solute carrier family 2 member 4 |
| TCMBANKGE000729 | CASP1 | ICE; IL1BC; P45 | caspase 1 |
| TCMBANKGE000957 | MAP2K4 | JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1 | mitogen-activated protein kinase kinase 4 |
| TCMBANKGE001073 | PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | prostaglandin-endoperoxide synthase 2 |
| TCMBANKGE001098 | NFKBIA | EDAID2; IKBA; MAD-3; NFKBI | NFKB inhibitor alpha |
| TCMBANKGE001132 | BAX | BCL2L4 | BCL2 associated X, apoptosis regulator |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001162 | IFNG | IFG; IFI | interferon gamma |
| TCMBANKGE003371 | ADCYAP1 | PACAP | adenylate cyclase activating polypeptide 1 |
| TCMBANKGE007697 | PSMG1 | C21LRP; DSCR2; LRPC21; PAC-1; PAC1 | proteasome assembly chaperone 1 |
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