Compound Summary


  Compound Information

药名:

geniposide

别名:

AKOS015965362; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)-; 27745-20-6; Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S-(1alpha,4aalpha,7aalpha))-; ZINC03882101; 24512-63-8; Geniposide; (1S,4aS,7aS)-7-(hydroxymethyl)-1-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylate; AC-20245; C09781; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylate; (1S,4aS,7aS)-7-methylol-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[d]pyran-4-carboxylic acid methyl ester

分子式:

C17H24O10

Smiles:

[C@]1([H])(O[C@@]2([H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]([H])(C([H])([H])O[H])O2)OC([H])=C(C(OC([H])([H])[H])=O)[C@@]([H])(C([H])([H])C([H])=C3C([H])([H])O[H])[C@]13[H]

成分:

HBIN027450

OB_score:

3.777078

CAS_id:

24512-63-8

SymMap_id:

SMIT00539

TCMID_id:

8275

TCMSP_id:

MOL003701;MOL004557;MOL012516

PubChem_id:

137706142


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000799 水栀根
TCMBANKHE001408 栀子花
TCMBANKHE001458 重瓣栀子
TCMBANKHE002659 Concretio Silicea Bambusae 天竺黄 For desolving phlegm
TCMBANKHE003598 Cornus suecica
TCMBANKHE005622 鸡矢藤 Wind-damp pain, diarrhea, dysentery, pain in stomach duct and abdomen, qi vacuity edema, heavy head and low food intake, liver spleen enlargement, scrofula, intestinal welling abscess, innominate toxin swelling, knocks and falls.
TCMBANKHE004287 Radix Achyranthis bidentatae 牛膝 To replenish the liver and the kidney, to strengthen the tendons and bones, to eliminate blood stasis and stimulate menstrual discharge, and to lead the blood to flow downward./Aching in lumbus and knees, amenorrhea due to blood stasis, dysmenorrhea, postpartum blood stasis abdominal pain, concretion and conglomeration, retention of placenta , heat strangury, blood strangury, knocks and falls, swollen welling abscess and malign sore, swelling pain in throat.
TCMBANKHE004664 Radix Codonopsis pilosulae 党参 To reinforce qi and invigorate the function of the spleen and the lung./Spleen-stomach vacuity, reduced food intake and sloppy stool, lassitude in limbs, cough and asthma due to lung vacuity, shortness of breath and spontaneous sweating, qi-blood depletion.
TCMBANKHE004946 Herba Hedyotis Diffusae 白花蛇舌草 1. To eliminate heat and toxic material, promote blood circulation and remove blood stasis. 2. To clear dampness-heat./Lung heat cough asthma, swelling pain in throat, intestinal welling abscess, swelling of sores and boils, poisonous snake bite, heat strangury with inhibited pain, edema, dysentery, enteritis, damp-heat jaundice, carcinoma.
TCMBANKHE005363 Semen Plantaginis 车前子 To remove heat, to cause diuresis and eliminate damp, to relieve dysuria, to clear the eye, and to promote expectoration./1. Diuretic. 2. Expectorant and antitussive.
TCMBANKHE009133 Radix Codonopsis pilosulae 西党;党参 Treatment of weakness of the spleen and the lung manifested by shortness of breath, cough, palpitation, anorexia, loose stools, diabetes caused by internal heat;To reinforce qi and invigorate the function of the spleen and the lung./Treatment of weakness of the spleen and the lung manifested by shortness of breath, cough, palpitation, anorexia, loose stools, diabetes caused by internal heat;Spleen-stomach vacuity, reduced food intake and sloppy stool, lassitude in limbs, cough and asthma due to lung vacuity, shortness of breath and spontaneous sweating, qi-blood depletion.
TCMBANKHE005874 玳玳花 Oppression in chest due to glomus, distending pain in stomach duct and abdomen, vomiting, reduced food intake.
TCMBANKHE008657 Genipa americana 京尼平
TCMBANKHE008532 Radix Rehmanniae Preparata 熟地黄 To nourish n and replenish blood, reinforce the essence of life and marrow./Blood vacuity with yellow complexion, dizziness and palpitation, menstrual disorder [=menoxenia], incessant flooding and spotting, liver-kidney yin depletion, tidal fever with night sweat, impotence and emission, sterility and infertility, limp aching lumbus and knees, tinnitus and deafness, dizzy head and vision, premature graying in beard and hair, diabetes mellitus, constipation, kidney vacuity hasty asthma.
TCMBANKHE008565 Rehmannia glutinosa [Syn. Rehmannia glutinosa f. huechingensis] 干地黄 To enrich yin and clear heat, cool blood and supplement blood, lower blood sugar levels./Diabetes mellitus, dermatitis, rheumatism, diphtheria, acute tonsillitis, febrile diseases with vexation and thirst, steaming bone taxation fever, warm disease macular eruption, blood ejection due to blood heat, spontaneous external bleeding due to blood heat, flooding and spotting due to blood heat, hematuria due to blood heat, hematochezia due to blood heat, anemia with yellow complexion, palpitation and dizziness, blood depletion and amenorrhea.
TCMBANKHE007098 Fructus Gardeniae 栀子;生山栀 1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness;4.Treatment of febrile diseases with restlessness, jaundice with dark urine, hematuria with difficult painful urination, hemoptysis and epistaxis caused by heat in the blood, inflammation of the eye, boils and sores, external use for sprains and bruises.Fructus Gardeniae (charred): Hemoptysis, epistaxis, hematuria and abnormal uterine bleeding caused by heat in the blood./Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria.1. The active components such as crocin, crocetin, genipin, or alcoholic extract protect the liver from carbon tetrachloride and increasing biliary secretion. Oral use of its decoction induce gallbladder contraction.2. Oral or intraperitoneal use of its decoction and alcoholic extract exerts a sustained hypotensive effect in anaesthetized and un-anaesthetized animals.3. Hemostatic.
TCMBANKHE007155 Radix Scrophulariae 玄参; 元参 To reduce heat from blood, to nourish yin, to quench fire, and to counteract toxicity. Treatment of febrile diseases with impairment of yin manifested by deep red tongue and dire thirst, or with eruptions, constipation due to impairment of body fluid, phthisis with cough, conjunctivitis, sore throat, scrofula, diphtheria, boils and sores./Heat entering construction-blood, generalized fever, vexation and thirst, crimson tongue, macular eruption, steaming bone taxation cough, vacuity vexation and insomnia, fluid damage and constipation, dry eyes with clouded flowery vision, swelling pain in throat, scrofula with phlegm node, sore toxin of welling abscess and flat abscess. 1. Its alcoholic extract and its component methoxycinnamic acid can lower the typhoid vaccine-induced fever in rabbits.2. Its water or alcoholic infusion and decoction exert a mild hypotensive effect on anesthetized animals3. Lowering the level of blood sugar.4. Its infusion inhibits the growth of some dermatomyces.
TCMBANKHE007889 杜仲叶 Lumbar and back pain, limp aching inability of legs and knees, hypertension.
TCMBANKHE008310 Cortex Eucommiae 杜仲 To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy.
TCMBANKHE008911/YEM-126 Radix Achyranthis bidentatae|Achyranthes bidentata Blume 牛膝;怀牛膝|牛膝 牛膝 云南民族药物志:第一卷 To replenish the liver and the kidney, to strengthen the tendons and bones, to eliminate blood stasis and stimulate menstrual discharge, and to lead the blood to flow downward.Treament of soreness of the lumbar and knee joints with weakness inthe legs, amenorrhea with mass formation in the abdomen, dizziness due to hyperactivity of the liver./Aching in lumbus and knees, amenorrhea due to blood stasis, dysmenorrhea, postpartum blood stasis abdominal pain, concretion and conglomeration, retention of placenta , heat strangury, blood strangury, knocks and falls, swollen welling abscess and malign sore, swelling pain in throat. 阿昌族/白族/傣族/德昂族/景颇族/傈僳族/彝族
TCMBANKHE008167/YEM-39/XU-672 Cortex Eucommiae|Eucommia ulmoides Oliv.|Eucommia ulmoides 杜仲 杜仲 云南民族药物志:第一卷|贵州省岑巩县平庄镇师兆村 To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy. 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族
TCMBANKHE009042/YEM-578 Lantana camara|Lantana camara L. 五色梅|马缨丹 倒钩草 云南民族药物志:第三卷 To resolve toxin and disperse swelling, dispel wind and relieve itch./Swollen welling abscess, damp toxin, scab and lai, sore toxin. 傣族/哈尼族/佤族/壮族
TCMBANKHE002101/YEM-745/XU-411 Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 栀子花根|栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE006865/YEM-745/XU-411 Gardenia jasminoides var. grandiflora|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 水蛭|栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 To clear heat and resolve toxin, disperse swelling and relieve pain./Heat toxin, jaundice, nosebleed(epistaxis), nephritis with edema, sprain and contusion. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE004701/YEM-745/XU-411 Gardenia jasminoides var. grandiflora|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 水栀叶|栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 To disperse swelling./Knocks and falls. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE005522/YEM-745/XU-411 Fructus Gardeniae|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness/Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE008669/YEM-745/XU-411 Gardenia jasminoides [Syn. Gardenia florida ]|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 栀子叶|栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 To disperse swelling and resolve toxin, dispel wind and relieve pain./Knocks and falls, toxin of clove sore, hemorrhoids, chancre. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000081 Diabetes Mellitus, Experimental disease Nutritional and Metabolic Diseases; Endocrine System Diseases 25950476
TCMBANKDI005796 Memory Disorders disease Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms 24329968
TCMBANKDI009722 Cardiac Hypertrophy phenotype Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases 26845648
TCMBANKDI020247 Cardiomegaly phenotype Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases 26845648
TCMBANKDI020794 Hypercholesterolemia disease Nutritional and Metabolic Diseases 31911244

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000330 HMOX1 HMOX1D; HO-1; HSP32; bK286B10 heme oxygenase 1
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000997 GCG GLP-1; GLP1; GLP2; GRPP glucagon
TCMBANKGE001166 BCL2 Bcl-2; PPP1R50 BCL2 apoptosis regulator
TCMBANKGE002615 PLB1 PLB; PLB/LIP phospholipase B1
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE007692 GSTM1 GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1 glutathione S-transferase mu 1
TCMBANKGE009771 GAP43 B-50; GAP-43; PP46 growth associated protein 43
TCMBANKGE013337 GSTM2 GST4; GSTM; GSTM2-2; GTHMUS glutathione S-transferase mu 2