Compound Summary


  Compound Information

药名:

coptisine

别名:

Y0053; BDBM50030257; C19H14NO4; UNII-0GCL71VN14; AK198733; HSDB 8323; CHEMBL362071; Coptisine sulfate; 6020-18-4 (chloride); DTXSID10188404; XYHOBCMEDLZUMP-UHFFFAOYSA-N; AC1Q701I; Coptisine; alkaloid; C16938; HY-N0430; N1737; Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-; 1198398-71-8; 0GCL71VN14; MEGxp0_001731; N2494; Q-100421; LS-44700; AC1L2HUS; KPT; CHEBI:67862; bis[methylenedioxy]protoberberine; I14-18844; NCI60_000465; 6,7-Dihydro[1,3]dioxolo[4,5-G][1,3]dioxolo[7,8]isoquino[3,2-A]isoquinolin-5-Ium; FT-0689356; FT-0645075; ZINC1709414; 3486-66-6; 7,8,13,13a-Tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium; AKOS015903291; Bis(1,3)benzodioxolo(5,6-a:4',5'-g)quinolizinium, 6,7-dihydro-; Coptisin; SCHEMBL156866; Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium, 6,7-dihydro-; 348C666; MolPort-020-005-796

分子式:

C19H14NO4

Smiles:

c12c(OC([H])([H])O1)c([H])c3c(C([H])([H])C([H])([H])N(C([H])=C(C([H])=C(OC([H])([H])O4)C4=C5[H])C5=C6[H])=C36)c2[H]

成分:

HBIN021430

OB_score:

30.671852

CAS_id:

3486-66-6

SymMap_id:

SMIT00107

TCMID_id:

4032

TCMSP_id:

MOL001458

PubChem_id:

72322


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000785 Coptis gulinensis
TCMBANKHE000810 Radix Zanthoxyli 两面针 To promote the flow of qi, relieve pain, to eliminate blood stasis, to promote blood circulation and dispel wind./Treatment of traumatic injury, rheumatic arthralgia, stomach-ache, teethache, bitten by venomous snake, applied for burn caused by hot liquid or fire.
TCMBANKHE006167 Herba Corydalis bungeae 苦地丁 Influenza, infection of upper respiratory tract, tonsillitis, infective hepatitis, enteritis, dysentery, nephritis, parotitis, conjunctivitis, acute appendicitis, clove sore and swollen welling abscess, scrofula.
TCMBANKHE001149 Caulis Mahoniae 功劳木 To remove dimp-heat, quench fire, and counteract toxicity./Berberine is the main active component with an action similar to Rhizoma Coptidis. Another active component, isotetrandrine, is an anticarcinogenic agent.
TCMBANKHE001205 Corydalis longicalcarata 长距延胡索
TCMBANKHE001683 三七花
TCMBANKHE002371 Radix Rumicis japonici 羊蹄根 For cooling blood and stopping bleeding
TCMBANKHE002544 Hypecoum japonicum 地棠草
TCMBANKHE002730 橘络
TCMBANKHE002762 Radix et Rhizoma Thalictri 马尾莲 Influenza, fever in children, common cold with fever, measles papules, malaria, damp-heat diarrhea dysentery, jaundice, red eyes with gall.
TCMBANKHE003021 关黄柏
TCMBANKHE003746 Radix Scutellariae 黄芩 To remove damp-heat, to quench fire and counteract toxicity, to arrest bleeding, and to prevent abortion./Chest oppression with retching, diarrhea, jaundice, lung heat cough, infection of upper respiratory tract, acute tonsillitis, acute pharyngolaryngitis, ardent fever with vexation and thirst, blood heat, blood ejection, spontaneous external bleeding, swelling toxin of welling abscess and sore, stirring fetus in pregnancy.
TCMBANKHE003748 Rhizoma Coptidis 黄连 To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds.
TCMBANKHE003755 Radix Ampelopsis 白蔹 To remove toxic heat, to cure carbuncles, and to reduce nodules./Swelling toxin of sore and welling abscess, burns and scalds, scrofula, damp sore, warm malaria, frightepilepsy, blood dysentery, intestinal wind, hemorrhoids and fistulas, leukorrhea, knocks and falls, bleeding due to external injury.
TCMBANKHE005792 Thalictrum petaloideum 瓣蕊唐松草 To clear heat, dry damp, resolve toxin./Damp-heat diarrhea dysentery, jaundice, lung heat cough, red eyes with gall, swelling welling abscess and sore and boil, exudative dermatitis
TCMBANKHE004088 Rhizoma Corydalis Decumbentis 夏天无 To promote the flow of qi and blood, to remove obstruction from the collaterals and to relieve pain./Pain in deep tissues, neuralgia, swelling pain from fracture, hypertension, hemiplegia, sequel of poliomyelitis, sciatica, rheumatic arthritis, knocks and falls.
TCMBANKHE004287 Radix Achyranthis bidentatae 牛膝 To replenish the liver and the kidney, to strengthen the tendons and bones, to eliminate blood stasis and stimulate menstrual discharge, and to lead the blood to flow downward./Aching in lumbus and knees, amenorrhea due to blood stasis, dysmenorrhea, postpartum blood stasis abdominal pain, concretion and conglomeration, retention of placenta , heat strangury, blood strangury, knocks and falls, swollen welling abscess and malign sore, swelling pain in throat.
TCMBANKHE004312 Mahonia japonica 华南功劳木 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE004376 Pericarpium Grati 石榴皮 To check diarrhea, arrest bleeding and repel worms./Chronic diarrhea, chronic dysentery, hematochezia, prolapse of rectum, flooding and spotting, leukorrhea, abdominal pain due to worm accumulation.
TCMBANKHE004459 Fructus Lycii 枸杞子 To benefit the liver and the kidney, to replenish vital essence and to improve eyesight./Lassitude in lumbus and knees, emission, dizziness and dim vision, lung disease with cough, diabetes mellitus.
TCMBANKHE004522 Rhizoma Corydalis 延胡索 1. To invigorate blood and promote qi circulation; 2. To stop pain/Chest and rib-side pain, pain in stomach duct and abdomen, neuralgia, gastrointestinal spasm, amenorrhea and dysmenorrhea, postpartum stasis stagnation abdominal pain, painful swelling from knocks and falls.
TCMBANKHE006458 Coptis teetoides [Syn. Coptis teeta] 云南黄连 See Coptis chinensis./See Coptis chinensis.
TCMBANKHE004901 Dicentra spectabilis 荷包牡丹根 To dispel wind, quicken blood, settle pain./Incised wound, sore toxin, stomachache.
TCMBANKHE005112 Corydalis remota [Syn. Corydalis bulbosa var. typica ] 齿瓣延胡索 To quicken blood and dissipate stasis, move qi and relieve pain./Pain in lumbus and knees, pain in heart and abdomen, dysmenorrhea, postpartum stasis stagnation abdominal pain, painful swelling from knocks and falls.
TCMBANKHE007201 Mahonia japonica 华南功劳叶 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE007757 Corydalis adunca 灰绿延胡索 To clear lung and relieve cough, clear liver and disinhibit gallbladder, relieve pain./Lung heat cough, fever and chest pain, liver-gallbladder damp-heat, pain in rib-side, fever, anorexy for greasy food, jaundice, damp-heat diarrhea.
TCMBANKHE007813 Corydalis pallida 菊花黄连 To clear heat and resolve toxin, disperse swelling and relieve pain./Welling abscess and boil, innominate toxin swelling.
TCMBANKHE007866 Coptis deltoidea 三角叶黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE008052 Corydalis incisa 紫花鱼灯草 To resolve toxin and kill worms, relieve pain./Toxin swelling of sores, scab and lai, intractable lichen, eczema, poisonous snake bite.
TCMBANKHE008275 Coptis chinensis var. brevisepala 短萼黄连 See Coptis chinensis ./See Coptis chinensis .
TCMBANKHE008161 Coptis japonica 日本黄连
TCMBANKHE006768 Coptis linearisepala 线萼黄连
TCMBANKHE006154 Thalictrum faberi 大叶唐松草 To clear heat, drain fire, resolve toxin./Dysentery, diarrhea, red eyes with gall, damp-heat jaundice.
TCMBANKHE006212 Semen Astragali Complanati;Semen Astragali Complati 潼蒺藜;沙苑子 Treatment of back pain, nocturnal emission and premature ejaculation in deficiency syndromes of the kidney, turbid discharge with urination, excessive leukorrhea, dribbling of urine after urination, dizziness and blurred vision,to benefit the liver./Treatment of back pain, nocturnal emission and premature ejaculation in deficiency syndromes of the kidney, turbid discharge with urination, excessive leukorrhea, dribbling of urine after urination, dizziness and blurred vision.
TCMBANKHE006371 白屈菜 Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE007173 Thalictrum atriplex 狭序唐松草 To clear heat and resolve toxin, cool liver, check dysentery./Swelling and toxin of sore and welling abscess, damp-heat jaundice, dysentery, conjunctivitis.
TCMBANKHE008855 Corydalis ledebouriana 对叶元胡
TCMBANKHE006924 Coptis omeiensis 峨眉野黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE007303 广藿香 Summerheat-damp lassitude, oppression in chest, vomiting diarrhea with abdominal pain, deep-source nasal congestion and headache.
TCMBANKHE008004 Corydalis ambigua var. amurensis [Syn. Corydalis ambigua] 东北延胡索 To quicken blood and dissipate stasis, rectify qi and relieve pain./Pain in lumbus and knees, pain in heart and abdomen, dysmenorrhea, menstrual disorder, postpartum stasis stagnation abdominal pain, flooding and spotting, concretion and conglomeration, knocks and falls.
TCMBANKHE008122 Thalictrum microgynum 小果唐松草 To clear heat and resolve toxin, disinhibit damp./Yellow swelling in whole body, yellow eyes, knocks and falls.
TCMBANKHE007977 Thalictrum thunbergii 烟锅草 To clear heat and resolve toxin, dry damp./Pertussis, toothache, swelling toxin of welling abscess and sore, acute dermitis, eczema.
TCMBANKHE008320 Corydalis repens 全叶延胡索 See Corydalis ambigua var. amurensis./See Corydalis ambigua var. amurensis .
TCMBANKHE008360 Hypecoum leptocarpum 细果角茴香 To clear heat and resolve toxin, cool blood./Common cold with fever, headache, throat pain, red eyes with gall, pain in joints, pneumonia, hepatitis, cholecystitis, blood ejection, spontaneous external bleeding, hematochezia.
TCMBANKHE008723/XU-511 Thalictrum glandulosissimum 金丝马尾连 湖北省远安县荷花镇 See Thalictrum foliolosum./See Thalictrum foliolosum.
TCMBANKHE004238/YEM-1014 Phellodendron amurense;Cortex Phellodendri|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄柏|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 1. To clear heat and dry dampness; 2. To reduce fire and release toxins/Damp-heat dysentery, tuberculosis, epidemic meningitis, acute conjunctivitis, trachoma, fever, abdominal pain, diarrhea, suppurative hematochezia, tenesmus, jaundice, yellow thick foul leukorrhagia, swelling pain in knees and feet, urinary tract infection, boil, sore, ulcer, eczema, mouth sore, hemorrhoids, burns, scalds, exuberance of fire with tidal fever, tidal fever with night sweat, emission. 瑶族/壮族
TCMBANKHE008911/YEM-126 Radix Achyranthis bidentatae|Achyranthes bidentata Blume 牛膝;怀牛膝|牛膝 牛膝 云南民族药物志:第一卷 To replenish the liver and the kidney, to strengthen the tendons and bones, to eliminate blood stasis and stimulate menstrual discharge, and to lead the blood to flow downward.Treament of soreness of the lumbar and knee joints with weakness inthe legs, amenorrhea with mass formation in the abdomen, dizziness due to hyperactivity of the liver./Aching in lumbus and knees, amenorrhea due to blood stasis, dysmenorrhea, postpartum blood stasis abdominal pain, concretion and conglomeration, retention of placenta , heat strangury, blood strangury, knocks and falls, swollen welling abscess and malign sore, swelling pain in throat. 阿昌族/白族/傣族/德昂族/景颇族/傈僳族/彝族
TCMBANKHE000631/YEM-135 herba meconpsis integrifoliae|Meconopsis integrifolia(Maxim.) Franch. 绿绒蒿|全缘叶绿绒蒿 全缘叶绿绒蒿 云南民族药物志:第一卷 傈僳族/藏族
TCMBANKHE006417/YEM-931 Brassica chinensis|Brassica chinensis L. 陈冬菜卤汁|小白菜 小白菜 云南民族药物志:第五卷 To eliminate vexation and heat, engender liquid and allay thirst, clear lung and transform phlegm, free intestines and stomach./Phlegm fire cough, swelling pain in throat. 傣族/佤族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000121 KCNH2 ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE001045 CCND1 BCL1; D11S287E; PRAD1; U21B31 cyclin D1
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE008172 MAOA BRNRS; MAO-A monoamine oxidase A
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1