Compound Summary

  Compound Information

TCMBANKIN036887

药名:	poricoic acid A
别名:	AIDS113410; NSC715080; AIDS-113410; poricoicacid a; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-1,2,3,4,7,8-hexahydrocyclopenta[h]naphthalen-3-yl]-5-isopropyl-hex-5-enoic acid; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-1,2,3,4,7,8-hexahydrocyclopenta[h]naphthalen-3-yl]-6-methyl-5-methylene-heptanoic acid; (R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-Carboxy-ethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-2,3,3a,4,6,7,8,9b-octahydro-1H-benz[e]inden-3-yl]-6-methyl-5-methylene-heptanoic acid; poricoic acid a; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,7,8-hexahydrocyclopenta[h]naphthalen-3-yl]-6-methyl-5-methylidene-heptanoic acid; NCI60_039753; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,7,8-hexahydrocyclopenta[h]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid; 16.alpha.-Hydroxy-3,4-seco-24-methyllanosta-4(28),7,9(11),24(24(sup 1))-tetraene-3,21-dioic acid; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-1,2,3,4,7,8-hexahydrocyclopenta[h]naphthalen-3-yl]-6-methyl-5-methyleneheptanoic acid
分子式:	C31H46O5
Smiles:	C(=C([H])[H])(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])=C2C(=C([H])C([H])([H])[C@](C([H])([H])[H])([C@@]([H])([C@]([H])(C(O[H])=O)C([H])([H])C([H])([H])C(=C([H])[H])C([H])(C([H])([H])[H])C([H])([H])[ H])[C@]([H])(O[H])C3([H])[H])[C@]23C([H])([H])[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(O[H])=O
成分:	HBIN040570
OB_score:	30.606946
CAS_id:	137551-38-3
SymMap_id:	SMIT02921;SMIT17290
TCMID_id:	31829;17708
TCMSP_id:	MOL000290
PubChem_id:	5471851

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000735	Exodermis Poria	茯苓皮			Treatment of edema with oliguria, dizziness and palpitation caused by retained fluid, diminished function of the spleen marked by anorexia, loose stools or diarrhea, restlessness and insomnia./1. An active component pachyman promotes macrophage phagocytosis in mice, and enhances lymphocyte-blastogensis rate in vitro.2. Preventing the formation of gastric ulcer under stress in rats3. Diuretic and liver-protective.
TCMBANKHE004571	Poria	茯神			For promoting diuresis and desolving inflammation
TCMBANKHE008458	Isodon japonica [Syn. Rabdosia japonica ]	毛叶香茶菜			To clear heat and resolve toxin, quicken blood and disperse swelling./Hepatitis, gastritis, mastitis, amenorrhea, knocks and falls, pain in joints, snake or insect bites.
TCMBANKHE004711	Rabdosia rubescens	冬淩草			To clear heat and resolve toxin, quicken blood and relieve pain, anticancer./Swelling pain in throat, common cold with headache, trachitis, chronic hepatitis, pain in joints due to rheumatalgia, snake or insect bites, carcinoma of mammary glands, carcinoma of esophagus.
TCMBANKHE006277	Rabdosia nervosa	显脉香茶菜			To disinhibit damp and harmonize stomach, resolve toxin and close sores./Acute hepatitis, indigestion, pemphigus, eczema, itchy skin, burns and scalds, poisonous snake bites.
TCMBANKHE006944	Caulis Erycibes	丁公藤			To dispel wind and deprive dampness, reduce swelling, relieve pain./Wind-damp impediment pain, hemiplegia, painful swelling from knocks and falls.
TCMBANKHE007344/YEM-665	Poria; Sclerotium Poriae Cocos; Sclerotium Poriae Cocos|Poria cocos(Schw.)Wolf	茯苓; 云苓|茯苓	茯苓	云南民族药物志：第四卷	To cause diuresis, to invigorate the spleen function, and to calm the mind.; Treatment of edema with oliguria, dizziness and palpitation caused by retained fluid, diminished function of the spleen marked by anorexia, loose stools or diarrhea, restlessness and insomnia./Neurasthenia, disquieted heart spirit, fright palpitation and insomnia, insomnia, pelvic inflammation, edema, scant urine with edema, phlegm-rheum dizziness, reduced food intake due to spleen vacuity, sloppy stool and diarrhea, chronic diarrhea.; 1. An active component pachyman promotes macrophage phagocytosis in mice, and enhances lymphocyte-blastogensis rate in vitro.2. Preventing the formation of gastric ulcer under stress in rats3. Diuretic and liver-protective.	阿昌族/傣族/德昂族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE004574/YEM-665	Poria|Poria cocos(Schw.)Wolf	茯苓	茯苓	云南民族药物志：第四卷	To cause diuresis, to invigorate the spleen function, and to calm the mind./Neurasthenia, disquieted heart spirit, fright palpitation and insomnia, insomnia, pelvic inflammation, edema, scant urine with edema, phlegm-rheum dizziness, reduced food intake due to spleen vacuity, sloppy stool and diarrhea, chronic diarrhea.	阿昌族/傣族/德昂族/景颇族/傈僳族/苗族/彝族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000090	Acute kidney injury	disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	30716432
TCMBANKDI001795	Reperfusion Injury	disease	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases	30716432

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000168	NR3C1	GCCR; GCR; GCRST; GR; GRL	nuclear receptor subfamily 3 group C member 1
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor