Compound Summary


  Compound Information

药名:

corilagin

别名:

Corilagin; C10219; .beta.-D-Glucopyranose, cyclic 3,6-[(1R)-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); 23094-69-1; AIDS-025842; beta-D-Glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy(1,1'-biphenyl)-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), (R)-; AIDS025842; corilagin

分子式:

C27H24O17

Smiles:

c1(O[H])c(c(c(C([H])=O)c([H])c(O[H])c2O[H])c2O[H])c([H])c(C(OC([H])([H])[C@@]3([H])O[C@@]([H])(OC(c4c([H])c(O[H])c(O[H])c(O[H])c4[H])=O)[C@]([H])(O[H])C([H])([H])[C@]3([H])O[H])=O)c(O[H])c1O[H]

成分:

HBIN021473

OB_score:

3.013721

CAS_id:

23094-69-1

SymMap_id:

SMIT00224

TCMID_id:

4055

TCMSP_id:

MOL005079

PubChem_id:

134692185


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE001911 Herba Acalyphae 铁苋菜 1. Treatment of diarrhea and dysentery of darnpness-heat type. Recently, also for amebic dysentery and typhoid fever. 2. Treatment of hemoptysis, hematemesis, hemafecia, metrorrhagia, etc. 3. Treatment of dyspneic cough of lung-heat type./1. Bacteriostatic. 2. Astringent and protective on intestinal mucosa. 3. Antiasthmatic.
TCMBANKHE002901 松花粉 Treatment of eczema, impetigo, erosion of the skin with exudation, traumatic bleeding, diaper dermatitis.
TCMBANKHE003524 Fructus Phyllanthi 余甘子 To remove heat from blood, to promote digestion and the production of body fluid, and to relieve cough./Treatment of heat in the blood and blood stasis, liver and gall bladder diseases, dyspepsia, abdominal pain, cough, sore throat, dryness of the mouth.
TCMBANKHE004018 Pseudobulbus Cremastrae seu Pleiones;Asarum sagittarioides 山慈菇 To remove toxic heat, and to dissolve lumps./Common cold, stomachache, toothache, knocks and falls, snake bite.
TCMBANKHE004047 Semen Ricini 蓖麻子 To induce subsidence of swelling and remove toxic substances, to cause purgation./Swelling toxin of welling abscess and flat abscess, throat impediment, scrofula, dry stool.
TCMBANKHE004319 Herba ErodiiHerba Geranii 老鹳草 To remove obstruction of channels and collaterals, relieve rheumatic conditions, and arrest diarrhea./Wind-damp impediment pain, hypertonicity and numbness, aching sinews and bones, diarrhea and dysentery.
TCMBANKHE004376 Pericarpium Grati 石榴皮 To check diarrhea, arrest bleeding and repel worms./Chronic diarrhea, chronic dysentery, hematochezia, prolapse of rectum, flooding and spotting, leukorrhea, abdominal pain due to worm accumulation.
TCMBANKHE007080 大风子 Numbing wind, scab and lichen, red bayberry sore.
TCMBANKHE005380 Herba Euphorbiae humifusae 地锦草 To remove toxic heat and to arrest bleeding by reducing heat in blood./Dysentery, enteritis, hemoptysis, hematuria, hematochezia, flooding and spotting, swollen welling abscess, sore and boil.
TCMBANKHE005497 Rhizoma Belamcandae 射干 To remove toxic heat, eliminate phlegm, and soothe the sore throat./Heat toxin and phlegm-fire stasis, swelling pain in throat, cough and asthma.
TCMBANKHE008965 Coriaria japonica 日本马桑
TCMBANKHE005998 Acer nikoense 毛果槭
TCMBANKHE008074 Aleurites cordata [Syn. Aleurites fordii] 桐油 To promote vomiting and expel phlegm drool, clear heat and resolve toxin, contract damp and kill worms./Scab and lichen, shank sore, burns and scalds, cracking from frostbite.
TCMBANKHE008294 泽漆 Edema and qi fullness, phlegm-rheum cough asthma, malaria, bacillary dysentery, scrofula, tuberculous fistula, medullitis.
TCMBANKHE006645/XU-532 Sapium japonicum 白木乌桕 广西省田林县 To dissipate stasis blood, strengthen lumbus and knees./Taxation damage, aching in lumbus and knees.
TCMBANKHE006523/XU-115 Flos Genkwa|Daphne genkwa Sieb. et Zucc 芫花 湖北神农架 1. To transform water and stop cough; 2. To resolve phlegm and stop cough; 3. To kill worms/Edema, ascites, hydrothorax, cough with profuse phlegm, chronic bronchitis, malaria, scalp infection, infection of skin, tinea capitis, neurodermatitis, induce abortion, toothache.
TCMBANKHE007748/YEM-22/XU-390 Herba andrographitis|Andrographis paniculata (Burm. f,)Nees|Andrographis paniculata 穿心莲 穿心莲 云南民族药物志:第一卷|云南省普洱市镇沅县 1. To clear heat and release toxins; 2. To dry dampness/Infection of upper respiratory tract, fever, wind-heat common cold, bacillary dysentery, diarrhea, tonsillitis, pneumonia, tuberculosis, lung heat cough, pulmonary welling abscess, postlithotripsy urinary tract infection, warm disease fever, pertussis, swelling pain in throat, damp-heat jaundice, strangury syndrome, erysipelas, sore and welling abscess, eczema, poisonous snake bite. 阿昌族/傣族/德昂族/景颇族/傈僳族
TCMBANKHE008293/YNS-297/YEM-236 Phyllanthus urinaria|Phyllanthus urinaria L. 叶下珠 叶下珠 |叶下珠 云南药材标准:第一册|云南民族药物志:第二卷 清热化湿,利水消肿。用于湿热黄疸,胁痛胀满、小便不利、湿热泻利|To clear heat and calm liver, disinhibit water and resolve toxin./Cough, enteritis, dysentery, infective hepatitis, nephritis with edema, urinary tract infection, child gan accumulation, acute conjunctivitis nephelium, mouth sore, head sore, innominate toxin swelling. 傣族/基诺族/傈僳族/佤族/瑶族
TCMBANKHE006284/YNS-302/YEM-404/XU-755 Phyllanthus emblica|Phyllanthus emblica L. 油柑根|余甘子 余甘子树皮|滇橄榄 云南药材标准:第三册|云南民族药物志:第二卷|广东省廉江市石岭镇 解毒消肿,收敛止血,杀菌去腐,用于痈肿,疳疔疮毒,阴囊湿疹,外伤出血,跌打损伤,蛇虫叮咬。|To clear heat and disinhibit damp, resolve toxin and dissipate binds./Diarrhea, dysentery, jaundice, scrofula, eczema of skin, centipede bite. 阿昌族/白族/布朗族/傣族/哈尼族/基诺族/拉祜族/傈僳族/纳西族/普米族/佤族/瑶族/彝族/藏族/壮族
TCMBANKHE005888/YNS-302/YEM-404/XU-755 Phyllanthus emblica|Phyllanthus emblica L. 油柑叶|余甘子 余甘子树皮|滇橄榄 云南药材标准:第三册|云南民族药物志:第二卷|广东省廉江市石岭镇 解毒消肿,收敛止血,杀菌去腐,用于痈肿,疳疔疮毒,阴囊湿疹,外伤出血,跌打损伤,蛇虫叮咬。|To clear heat and resolve toxin, disinhibit damp and disperse swelling./Mouth sore, clove sore, eczema, dermatitis, edema, hypertension, poisonous snake bite, knocks and falls. 阿昌族/白族/布朗族/傣族/哈尼族/基诺族/拉祜族/傈僳族/纳西族/普米族/佤族/瑶族/彝族/藏族/壮族
TCMBANKHE006825/YNS-302/YEM-404/XU-755 Phyllanthus emblica|Phyllanthus emblica L. 油柑木皮|余甘子 余甘子树皮|滇橄榄 云南药材标准:第三册|云南民族药物志:第二卷|广东省廉江市石岭镇 解毒消肿,收敛止血,杀菌去腐,用于痈肿,疳疔疮毒,阴囊湿疹,外伤出血,跌打损伤,蛇虫叮咬。|To clear heat and disinhibit damp, cool blood and resolve toxin./Mouth sore, clove sore, hemorrhoids, scrotal eczema, bleeding due to external injury. 阿昌族/白族/布朗族/傣族/哈尼族/基诺族/拉祜族/傈僳族/纳西族/普米族/佤族/瑶族/彝族/藏族/壮族
TCMBANKHE004261/YNS-302/YEM-404/XU-755 Phyllanthus emblica|Phyllanthus emblica L. 庵摩勒|余甘子 余甘子树皮|滇橄榄 云南药材标准:第三册|云南民族药物志:第二卷|广东省廉江市石岭镇 解毒消肿,收敛止血,杀菌去腐,用于痈肿,疳疔疮毒,阴囊湿疹,外伤出血,跌打损伤,蛇虫叮咬。|To relieve cough and transform phlegm, engender liquid and allay thirst, resolve toxin./Common cold with fever, cough, throat pain, diphtheria, enteritis, diarrhea, eczema, heat vexation and thirst. 阿昌族/白族/布朗族/傣族/哈尼族/基诺族/拉祜族/傈僳族/纳西族/普米族/佤族/瑶族/彝族/藏族/壮族
TCMBANKHE004190/YEM-422/XU-781 Sapium sebiferum|Sapium sebiferum(L.)Roxb. 乌桕木根皮|乌桕 乌桕 云南民族药物志:第三卷|云南省文山州富宁县 To drain precipitation and expel water, dissipate binds and disperse swelling, resolve snake toxin, lower blood pressure./Edema, ascites, urinary and fecal st oppage, hypertension, concretion conglomeration accumulation and gathering, painful swelling from clove sore, eczema, scab and lichen, poisonous snake bite. 傣族/傈僳族/苗族/瑶族/壮族
TCMBANKHE006576/YEM-61/XU-569 Fructus Chebulae|Terminalia chebula Retz.|Terminalia chebula var. tomentella 诃子|微毛诃子 诃子 云南民族药物志:第一卷|云南省临沧市永德县 To check diarrhea and chronic cough, and to soothe the sore throat./Chronic diarrhea and dysentery, hematochezia, prolapse of rectum, cough and asthma due to lung vacuity, incessant cough, aphonia due to throat pain. 阿昌族/傣族/德昂族/景颇族/傈僳族/藏族
TCMBANKHE004574/YEM-665 Poria|Poria cocos(Schw.)Wolf 茯苓 茯苓 云南民族药物志:第四卷 To cause diuresis, to invigorate the spleen function, and to calm the mind./Neurasthenia, disquieted heart spirit, fright palpitation and insomnia, insomnia, pelvic inflammation, edema, scant urine with edema, phlegm-rheum dizziness, reduced food intake due to spleen vacuity, sloppy stool and diarrhea, chronic diarrhea. 阿昌族/傣族/德昂族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE007344/YEM-665 Poria; Sclerotium Poriae Cocos; Sclerotium Poriae Cocos|Poria cocos(Schw.)Wolf 茯苓; 云苓|茯苓 茯苓 云南民族药物志:第四卷 To cause diuresis, to invigorate the spleen function, and to calm the mind.; Treatment of edema with oliguria, dizziness and palpitation caused by retained fluid, diminished function of the spleen marked by anorexia, loose stools or diarrhea, restlessness and insomnia./Neurasthenia, disquieted heart spirit, fright palpitation and insomnia, insomnia, pelvic inflammation, edema, scant urine with edema, phlegm-rheum dizziness, reduced food intake due to spleen vacuity, sloppy stool and diarrhea, chronic diarrhea.; 1. An active component pachyman promotes macrophage phagocytosis in mice, and enhances lymphocyte-blastogensis rate in vitro.2. Preventing the formation of gastric ulcer under stress in rats3. Diuretic and liver-protective. 阿昌族/傣族/德昂族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE007056/YEM-9 Herba Lobeliae Chinensis|Lobelia chinensis Lour. 半边莲 半边莲 云南民族药物志:第一卷 To cause diuresis, and to remove toxic heat./Edema, edema and enlarged abdomen, edema in face and foot, swollen welling abscess and clove sores, snake or insect bites. 阿昌族/傣族/德昂族/景颇族/傈僳族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI002231 Cholestasis disease Digestive System Diseases 29235094
TCMBANKDI018635 Liver Failure, Acute disease Digestive System Diseases 30630510

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000223 KEAP1 INrf2; KLHL19 kelch like ECH associated protein 1
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000328 PTPN11 BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 protein tyrosine phosphatase non-receptor type 11
TCMBANKGE000949 UGT2B4 HLUG25; UDPGT2B4; UDPGTH1; UDPGTh-1; UGT2B11 UDP glucuronosyltransferase family 2 member B4
TCMBANKGE000950 SULT2A1 DHEA-ST; DHEAS; HST; ST2; ST2A1; ST2A3; STD; hSTa sulfotransferase family 2A member 1
TCMBANKGE000951 CYP7B1 CBAS3; CP7B; SPG5A cytochrome P450 family 7 subfamily B member 1
TCMBANKGE000952 SLC10A1 NTCP solute carrier family 10 member 1
TCMBANKGE000953 PTPN6 HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1 protein tyrosine phosphatase non-receptor type 6
TCMBANKGE000954 ABCB11 ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP ATP binding cassette subfamily B member 11
TCMBANKGE000955 ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP ATP binding cassette subfamily C member 2
TCMBANKGE000956 NR1H4 BAR; FXR; HRR-1; HRR1; PFIC5; RIP14 nuclear receptor subfamily 1 group H member 4
TCMBANKGE000989 ACACA ACAC; ACACAD; ACC; ACC1; ACCA acetyl-CoA carboxylase alpha
TCMBANKGE001027 STK11 LKB1; PJS; hLKB1 serine/threonine kinase 11
TCMBANKGE001112 PRKAB1 AMPK; HAMPKb protein kinase AMP-activated non-catalytic subunit beta 1
TCMBANKGE001116 CYP7A1 CP7A; CYP7; CYPVII cytochrome P450 family 7 subfamily A member 1
TCMBANKGE001126 NFE2L2 HEBP1; IMDDHH; NRF2; Nrf-2 nuclear factor, erythroid 2 like 2
TCMBANKGE001127 PRKAA1 AMPK; AMPKa1 protein kinase AMP-activated catalytic subunit alpha 1
TCMBANKGE001128 PRKAA2 AMPK; AMPK2; AMPKa2; PRKAA protein kinase AMP-activated catalytic subunit alpha 2