Compound Summary
Compound Information
药名: | fraxetin |
别名: | ZINC00113309; NCGC00096046-01; AIDS224554; SCHEMBL43472; ST24045548; KBio3_002724; BSPBio_003224; SMR000112323; V1540; Coumarin, 7,8-dihydroxy-6-methoxy; AJ-11417; UNII-CD3GD44O3K; CD3GD44O3K; C09265; 7,8-Dihydroxy-6-methoxy-2H-chromen-2-one; Spectrum_001507; STOCK1N-06249; 7,8-dihydroxy-6-methoxy-2-chromenone; CTK8E5461; MCULE-2693568829; AC1NRV6E; InChI=1/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H; 7,8-Dihydroxy-6-methoxy-chromen-2-one; MFCD00006873; AKOS000277991; Spectrum4_001686; CHEBI:5169; 7,8-Dihydroxy-6-methoxy-2-benzopyrone; 574-84-5; N1765; KSC-11-207-12; 7,8-dihydroxy-6-methoxychromen-2-one; Fraxetin; 7,8-Dihydroxy-6-methoxycoumarin, 98%; CC-23048; SR-05000002449-1; NCGC00169075-01; BG01517128; 254916_ALDRICH; 7,8-Dihydroxy-6-methoxy-2H-chromen-2-one #; ZINC113309; I14-19210; SR-05000002449; ZB003792; ACon0_001071; AX8110148; Q-100662; EINECS 209-376-2; Spectrum3_001842; MLS002207123; AK114503; KBio2_007123; NCGC00096046-02; KBio2_004555; SpecPlus_000477; 7,8-dihydroxy-6-methoxy-chromen-2-one; ST024715; KBio2_001987; KBio1_001517; CCG-38759; NCGC00017270-03; Spectrum2_001639; 2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy-; ACon1_000442; SC-65962; AN-46013; BG00604311; Spectrum5_000332; Oprea1_735469; KBioSS_001987; MolPort-001-683-945; KBioGR_001952; 574F845; 7,8-dihydroxy-6-methoxy-coumarin; NCGC00169075-02; KUC106681N; SPECTRUM1504069; SPBio_001737; DB-050316; TR-020064; AC1Q4F2E; DTXSID00205992; NCGC00017270-05; CHEMBL54909; BDBM50206215; C-30832; DivK1c_006573; AIDS-224554; Fraxetin, analytical standard; FT-0632418; 4CN-1003; NCGC00017270-02; BRD-K76587808-001-03-8; MEGxp0_000506; NCGC00017270-01; TNP00177; HAVWRBANWNTOJX-UHFFFAOYSA-N; 7,8-Dihydroxy-6-methoxycoumarin; NCGC00017270-04; Coumarin, 7,8-dihydroxy-6-methoxy-; KB-249406 |
分子式: | C10H8O5 |
Smiles: | c1(OC([H])([H])[H])c([H])c(C([H])=C([H])C(=O)O2)c2c(O[H])c1O[H] |
成分: | HBIN026733 |
OB_score: | 23.04093 |
CAS_id: | 574-84-5 |
SymMap_id: | SMIT00211 |
TCMID_id: | 7941 |
TCMSP_id: | MOL004667 |
PubChem_id: | 5273569 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE004385 | Fructus Aristolochiae | 马兜铃 | To remove heat from the lung and relieve cough and asthma, and to remove heat from the large intestine./Lung heat cough asthma, phlegm congestion and hasty qi , lung vacuity enduring cough, intestinal heat bleeding from hemorrhoids, swelling pain from hemorrhoids, edema. | |||
| TCMBANKHE001170 | 猕猴桃根 | |||||
| TCMBANKHE002337 | 龙脷叶 | |||||
| TCMBANKHE003734 | radix tripterygii wilfordii | 雷公藤 | To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage./Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen. | |||
| TCMBANKHE003882 | Semen Aesculi | 娑罗子 | To regulate the flow of qi, normalize the stomach function and relieve pain./Distending pain in chest and rib-side, distending pain in breast, dysmenorrhea, pain in stomach duct, pain in chest and abdomen. | |||
| TCMBANKHE005720 | Rhamnus cathartica | 药鼠李 | To moisten intestines and free stool./Intestinal dry and constipation, habitual constipation. | |||
| TCMBANKHE004113 | Fraxinus ornus | 花白蜡树 | ||||
| TCMBANKHE004172 | Radix Bupleuri | 柴胡 | To relieve fever, to soothe the liver, and to cure drooping and ptosis./Common cold, influenza, malaria, acute pancreatitis, pleuritis, neuritis, gastritis, acute cholecystitis, hepatitis, fever due to external contraction, keratitis, cold-heat in turn, liver depression and rib-side pain, mammary distention, dizziness and headache, menstrual disorder, prolapse of rectum due to qi vacuity fall, prolapse of uterus, gastroptosis. | |||
| TCMBANKHE004994 | Fraxinus floribunda | 西玛白蜡树 | ||||
| TCMBANKHE005660 | Aesculus hippocastanum | 欧洲七叶树 | See Aesculus wilsonii./See Aesculus wilsonii. | |||
| TCMBANKHE005948 | Rhamnus frangula [Syn. Frangula alnus] | 欧鼠李 | To moisten intestines and free stool./Habitual constipation, abdominal pain. | |||
| TCMBANKHE005998 | Acer nikoense | 毛果槭 | ||||
| TCMBANKHE008463 | Rhamnus frangula [Syn. Frangula alnus] | 欧鼠李;偶数里 | To moisten intestines and free stool./Habitual constipation, abdominal pain. | |||
| TCMBANKHE008639 | Fraxinus bungeana | 小叶梣 | See Fraxinus rhynchophylla ./See Fraxinus rhynchophylla . | |||
| TCMBANKHE007751 | Cortex Fraxini | 秦皮 | To remove damp-heat, to arrest discharges, and to improve eyesight./1. Inhibiting the growth of dysentery bacillus and staphylococcus.2. Antitussive and expectorant.3. Aesculin, one of its active components, prolongs the hypnotic effect of hexobarbital in mice.4. Aescuktin, another active component, exerts an antihistaminic effect and relaxes smooth muscles of guinea-pig's trachea in vitro.5. Analgesic. The effect of aescuktin is stronger than that of aspirin but weaker than codeine. | |||
| TCMBANKHE007419 | Aesculus turbinata | 日本七叶树 | ||||
| TCMBANKHE008470 | Fraxinus chinensis | 白蜡树 | See Fraxinus rhynchophylla./See Fraxinus rhynchophylla . | |||
| TCMBANKHE006781/YEM-333 | Radix Saposhnikoviae divaricatae|Saposhnikovia divaricata (Turcz.)Schischk. | 防风 | 防风 | 云南民族药物志：第二卷 | To induce diaphoresis, to dispel wind, to alleviate rheumatic conditions, and to relieve spasm./Migraine, headache and generalized pain, common cold, rheumatoid arthritis, externally contracted wind-cold, wind-damp impediment pain, aching pain in joints, abdominal pain and diarrhea, intestinal wind bleeding, tetanus, wind papule itching, sores. | 阿昌族/傣族/德昂族/景颇族/傈僳族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000052 | TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | tumor necrosis factor |
| TCMBANKGE000181 | PIM1 | PIM | Pim-1 proto-oncogene, serine/threonine kinase |
| TCMBANKGE000201 | ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000221 | GRIA2 | GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B | glutamate ionotropic receptor AMPA type subunit 2 |
| TCMBANKGE000241 | CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | caspase 8 |
| TCMBANKGE000523 | BMP4 | BMP2B; BMP2B1; MCOPS6; OFC11; ZYME | bone morphogenetic protein 4 |
| TCMBANKGE000633 | ADRB2 | ADRB2R; ADRBR; B2AR; BAR; BETA2AR | adrenoceptor beta 2 |
| TCMBANKGE000813 | DPP4 | ADABP; ADCP2; CD26; DPPIV; TP103 | dipeptidyl peptidase 4 |
| TCMBANKGE000903 | PTGS1 | COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS | prostaglandin-endoperoxide synthase 1 |
| TCMBANKGE000938 | CDK2 | CDKN2; p33(CDK2) | cyclin dependent kinase 2 |
| TCMBANKGE000970 | FASN | FAS; OA-519; SDR27X1 | fatty acid synthase |
| TCMBANKGE001073 | PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | prostaglandin-endoperoxide synthase 2 |
| TCMBANKGE001108 | BMP2 | BDA2; BMP2A; SSFSC | bone morphogenetic protein 2 |
| TCMBANKGE001131 | CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | caspase 9 |
| TCMBANKGE001132 | BAX | BCL2L4 | BCL2 associated X, apoptosis regulator |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001185 | PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | peroxisome proliferator activated receptor gamma |
| TCMBANKGE001755 | MAOB | - | monoamine oxidase B |
| TCMBANKGE004450 | CA4 | CAIV; Car4; RP17 | carbonic anhydrase 4 |
| TCMBANKGE006339 | CA2 | CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 | carbonic anhydrase 2 |
| TCMBANKGE008474 | CA1 | CA-I; CAB; Car1; HEL-S-11 | carbonic anhydrase 1 |
| TCMBANKGE011079 | PRSS1 | TRP1; TRY1; TRY4; TRYP1 | serine protease 1 |
| TCMBANKGE012736 | CA9 | CAIX; MN | carbonic anhydrase 9 |
| TCMBANKGE014941 | DPEP1 | MBD1; MDP; RDP | dipeptidase 1 |
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