Compound Summary


  Compound Information

药名:

trigonelline

别名:

Prestwick_70; N-Methylnicotinic acid betaine hydrochloride; 1-methyl-3-pyridin-1-iumcarboxylate hydrochloride; MFCD00077250; SCHEMBL468365; A833196; trigonelline ; trigonelline HCl; 1-methylpyridin-1-ium-3-carboxylate hydrochloride; AC1O4WFS; 1-Methylpyridinium-3-carboxylate hydrochloride; T-6500; CHEMBL489961; trigonellin; gynesine; trigonelline

分子式:

C7H7NO2

Smiles:

C[N+]1=CC=CC(=C1)C(=O)[O-]

成分:

HBIN047060;HBIN047059;HBIN028587

OB_score:

60.067561

CAS_id:

6138-40-5;112-80-1

SymMap_id:

SMIT01652;SMIT02615;SMIT05879

TCMID_id:

21646

TCMSP_id:

MOL003870

PubChem_id:

5570


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000157 Herba Lysimachiae 过路黄 For promoting diuresis and reducing yellowness
TCMBANKHE000563 秦蒿
TCMBANKHE001046 胡芦巴 Hyperlipemia, kidney vacuity cold, cold pain in lesser-abdomen, mounting qi , beriberi.
TCMBANKHE002107 Cortex Phellodendri 黄蘗 For clearing heat and eliminating dampness
TCMBANKHE002642 冬瓜子 Phlegm-heat cough, pulmonary welling abscess, intestinal welling abscess, white turbidity, vaginal discharge, beriberi, edema, strangury syndrome.
TCMBANKHE003234 Fructus Malvae 冬葵果 To remove heat and induce diuresis, to relieve edema./Treatment of urinary infection with oliguria, edema and thirst.
TCMBANKHE003895 大腹皮 Its decoction exerts an effect of enhancing the intestinal tensity and decreasing the extent of intestinal contraction in rabbits in vitro, which can be counteracted by atropine.
TCMBANKHE003919 Medicago sativa 苜蓿 To clear heat and cool blood, disinhibit damp and abate jaundice./Febrile diseases with vexation and fullness, jaundice, enteritis, dysentery, edema, urethral stone, hematochezia from hemorrhoids.
TCMBANKHE003952 Folium Rhododendri Daurici 满山红 Acute bronchitis, chronic bronchitis.
TCMBANKHE004121 Radix Stemoe 百部 1. To moisten the lungs and stop cough; 2. To kill lice and parasites/Wind-cold cough, pertussis, tuberculosis, senile cough and asthma, ascariasis, oxyuria disease, scab and lichen, eczema, cootie.
TCMBANKHE004267 Achillea millefolium 洋蓍草 To dispel wind, quicken blood, relieve pain, resolve toxin./Wind-damp impediment pain, knocks and falls, amenorrhea due to blood stasis, swelling toxin of welling abscess and sore, bleeding from hemorrhoids.
TCMBANKHE004523 Flos Gossampini 木棉花 Diarrhea, dysentery, hemoptysis, blood ejection, flooding, incised wound and bleeding, sore toxin, eczema.
TCMBANKHE006313 Radix et Rhizoma Rhei 大黄 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE006505 Semen Lablab Album 白扁豆 To invigorate the spleen and remove damp, paticularly the summer damp.Semen Lablab Album (stir-fried) To invigorate the spleen and remove damp./Treatment of weakness of the spleen and stomach with loss of appetite and loose bowels, excessive leukorrhea, vomiting, diarrhea, distress in the chest and distension in the abdomen caused by summer-damp.Semen Lablab Album (stir-fried) Diarrhea and excess
TCMBANKHE006660 Ramulus Cinmomi 桂枝 To induce perspiration, to warm the channels and stimulate menstrual discharge, to reinforce yang, to relieve palpitation, and to promote the descending of qi./Wind-cold exterior syndrome, cold-damp impediment pain, reversal cold of limbs, amenorrhea and dysmenorrhea, concretion and conglomeration, chest impediment, palpitation, phlegm-rheum, inhibited urination.
TCMBANKHE004838 Radix Sophorae Tonkinensis 山豆根 To remove toxic heat, promote the subsidence of swelling, and soothe the sore throat./Septicemia, ulcer of uterine cervix, chronic cervicitis, bacillary dysentery, enteritis, hydatid moles, chorioblastoma, asthma, chronic bronchitis, acute tonsillitis, laryngitis, accumulated fire toxin, swelling pain in throat, gingiva painful swelling.
TCMBANKHE005090 Caulis Sargentodoxae 大血藤 To remove toxic heat, to promote blood circulation, and to relieve rheumatic conditions./Intestinal welling abscess and abdominal pain, amenorrhea, dysmenorrhea, wind-damp impediment pain, painful swelling from knocks and falls.
TCMBANKHE005272 Astragalus sinicus 紫云英 To clear heat and resolve toxin, dispel wind and brighten eyes, cool blood and stanch bleeding./Pain in throat, wind-phlegm cough, red eyes with gall, clove sore, zoster, scab and lichen, hemorrhoids, gum hemorrhage, bleeding due to external injury, menstrual disorder, vaginal discharge, thrombocytopenic purpura.
TCMBANKHE005368 Pinellia pedatisecta 掌叶半夏 See Arisaema consanguineum./See Arisaema consanguineum.
TCMBANKHE005444 白鲜皮 To clear heat and dry damp, dispel wind and relieve itch, resolve toxin./1. Inhibiting the growth of pathogenic fungi. 2. Its infusion lowers vaccine-induced fever in rabbits. 3. Dictamnine, one of its active components, increase the myocardial tone of frogs. Dermatitis, psoriasis, icterohepatitis, damp-heat sore and papules, profuse pus, yellow-water sore, damp ulceration on skin, itchy skin, damp-heat jaundice, damp-heat impediment.
TCMBANKHE006099 桑白皮 Lung heat cough asthma, water-rheum collecting lung, distention fullness and rapid asthma, edema, beriberi, inhibited urination.
TCMBANKHE005841 Rhizoma Arisaematis 天南星 To remove damp-phlegm, to dispel wind and arrest convulsions, and to promote the subsidence of induration and swelling./Wind stroke with congesting phlegm, deviated eyes and mouth, hemiplegia, deadlimb, wind-phlegm dizziness, epilepsy, fright wind, tetanus, spasm, neuralgia, cough with profuse phlegm, swollen welling abscess, scrofula, poisonous snake bite, knocks and falls, carcinoma of uterine cervix.
TCMBANKHE005881 Campanula rotundifolia 圆叶风铃草
TCMBANKHE006031 Bulbus Fritillariae Ussuriensis 平贝母 To remove heat from the lung, relieve cough and resolve phlegm./Dry cough due to lung dryness, dry cough, yin vacuity taxation cough, cough with phlegm and blood.
TCMBANKHE006298 Lycopersicon esculentum ;西红柿 To engender liquid and allay thirst, fortify stomach and disperse food./Thirst, inappetence.
TCMBANKHE006352 Abrus Precatorius L. 相思子 Vomiting, welling abscess, parotitis, scab and lichen, wind-damp bone pain.
TCMBANKHE007295 Radix Aucklandiae 木香 To relieve pain by promoting the flow of qi, and to improve digestion by reinforcing the spleen function. /Distending pain in chest and stomach duct, diarrhea and tenesmus, non-digestion of food accumu lation, no thought of food and drink.
TCMBANKHE006696 Pisum sativum 豌豆 To harmonize center and precipitate qi, free milk and disinhibit water, resolve toxin./Cholera cramp, beriberi with edema, diabetes mellitus, vomiting of sour matter, abdominal distention and diarrhea, scant breast milk, swollen welling abscess.
TCMBANKHE007230 Rhizoma Pinelliae 半夏 To remove damp and phlegm, to relieve nausea and vomiting, and to eliminate stuffiness in the chest and the epigastrium./Cough and asthma with abundant phlegm, vomiting nausea, glomus in chest, dizziness, headache, vexation and agitation in night, goiters with phlegm node, swelling toxin of welling abscess and flat abscess.
TCMBANKHE009190 Fructus Mori 桑椹 To nourish n and blood and promote the production of body fluid./Its contains sugar, organic acid , vitamins B1, B2 and C and carotene. Its oleum contains oleic acid and linoleic acid.
TCMBANKHE007721 Exocarpium Benincasae 冬瓜皮 1. To promote diuresis to relieve edema. 2. To clear summer-heat./Edema, inhibited urination [=dysuria], diarrhea, swelling of sores.
TCMBANKHE007141 Triglochin maritimum 海韭菜 To clear heat and engender liquid, resolve toxin and disinhibit damp./Exuberant heat fluid damage, stomach heat vexation thirst, dribbling pain of urination.
TCMBANKHE008697 Caulis Aristolochiae seu Clematis 木通 1. To promote water metabolism and relieve abnormal urination; 2. To clear heat and promote lactation/Acute urethritis, short voidings of reddish urine, strangury-turbidity, edema, nephritis with edema, galactostasis, heat vexation in chest, throat pain, mouth sore, tongue sores, wind-damp impediment pain, galactostasis, amenorrhea, dysmenorrhea.
TCMBANKHE007269 Fructus Viticis 蔓荆子 To dispel wind-heat from the head and eyes./Externally contracted wind-heat, dizziness and headache, migraine, gum swelling and pain, red eyes with gall, delacrimation, wind-damp impediment pain, hypertonicity of limbs.
TCMBANKHE007625 Radix Solani melongee 茄根
TCMBANKHE008359 Semen Oroxyli 木蝴蝶 To remove heat from the lung and relieve sore throat, and to regulate the flow of qi of the liver and the stomach./Lung heat cough, throat impediment, aphonia, liver stomach qi pain.
TCMBANKHE006421/YEM-1037/XU-804 Trichosanthes kirilowii Maxim.|Trichosanthes kirilowii 瓜蒌|栝楼 天花粉 云南民族药物志:第五卷|云南省昭通市盐津县 Angina pectoris, lung heat cough, chest impediment, diabetes mellitus, acute mastitis, constipation, swelling toxin of welling abscess and sore. 苗族/彝族
TCMBANKHE007607/YNS-333/YEM-207/XU-39/XU-129 Mirabilis jalapa|Mirabilis jalapa Linn.|Mirabilis jalapa L. 紫茉莉叶|紫茉莉 紫茉莉根|紫茉莉 云南药材标准:第四册|云南民族药物志:第一卷|云南省昆明市盘龙区黑龙潭 淸热利湿,活血消肿。用于乳痈,赤白带下,月经不调;热淋;痈疮肿毒|To clear heat and resolve toxin, dispel wind and percolate damp, quicken blood./Welling abscess, boil, scab sore, lichen, wound. 阿昌族/白族/傣族/德昂族/哈尼族/基诺族/景颇族/傈僳族/佤族/彝族
TCMBANKHE004393/YEM-220 Quisqualis indica|Quisqualis indica L. 使君子叶|使君子 使君子 云南民族药物志:第二卷 To rectify qi and fortify spleen, resolve toxin and kill worms./Child gan accumulation, distention fullness in stomach duct and abdomen, worm accumulation, ulcerating sore and boil. 阿昌族/傣族/德昂族/景颇族/傈僳族/普米族/佤族/瑶族
TCMBANKHE004087/YEM-220 Fructus Quisqualis|Quisqualis indica L. 使君子 使君子 云南民族药物志:第二卷 To kill worms./Ascariasis, oxyuria disease, child gan accumulation. 阿昌族/傣族/德昂族/景颇族/傈僳族/普米族/佤族/瑶族
TCMBANKHE003627/YNS-137/YEM-227 Semen Benincasae|Benincasa hispida (Thunb.) Cogn.|Benincasa hispida (Thunb.)Cogn. 冬瓜仁|冬瓜 苦冬瓜|冬瓜 云南药材标准:第三册|云南民族药物志:第二卷 祛湿利水,用于治疗感冒发热,喉炎,咳嗽咳血,胸腹胀痛,虚劳心悸,月经不调,产后流血。|For promoting diuresis and desolving inflammation 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/佤族
TCMBANKHE005716/YEM-243 Semen Canbis;Fructus Canbis;Fructus cannabis|Cannabis sativa L. 火麻仁;麻子仁|大麻 大麻 云南民族药物志:第二卷 To cause Taxation.;Purging by moisterizing/Blood and liquid depletion, intestinal dry and constipation. 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE006164/YEM-243 Cannabis sativa|Cannabis sativa L. 麻花|大麻 大麻 云南民族药物志:第二卷 To dispel wind, quicken blood, engender hairs./Numbness in limbs, itchy body, shedding of eyebrow and hair, amenorrhea. 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/彝族/藏族
TCMBANKHE005619/YEM-411 Solanum melongena|Solanum melongena L. 茄子|茄 茄子 云南民族药物志:第二卷 To clear heat and quicken blood, disperse swelling and relieve pain./Intestinal wind bleeding, heat toxin swollen welling abscess. 傣族/德昂族/基诺族/佤族
TCMBANKHE004273/YEM-411 Solanum melongena|Solanum melongena L. 茄叶|茄 茄子 云南民族药物志:第二卷 To dissipate blood and disperse swelling./Blood strangury, blood dysentery, intestinal wind bleeding, swollen welling abscess, frostbite. 傣族/德昂族/基诺族/佤族
TCMBANKHE005494/YEM-445 Fructus Hordei Germitus|Hordeum vulgare L. 麦芽|大麦 大麦 云南民族药物志:第三卷 To invigo rate the function of the spleen, to regulate the function of the stomach, and to promote the flow of milk./Food accumulation, abdominal distention and diarrhea, nausea and vomiting, inappetence, galactostasis, distending pain in breast. 佤族/彝族
TCMBANKHE004643/YEM-590/XU-716 Folium Mori|Morus alba L.|Morus alba 桑叶|桑 桑叶 云南民族药物志:第三卷|云南省昭通市盐津县 To dispel wind-heat and to remove heat from the lung, to subdue hyperactivity of the liver and improve eyesight./Wind-heat common cold, lung heat dry cough, dizziness and headache, red eyes and clouded vision. 阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族
TCMBANKHE007773/YEM-590/XU-716 Ramulus Mori|Morus alba L.|Morus alba 桑枝|桑 桑叶 云南民族药物志:第三卷|云南省昭通市盐津县 To relieve rheumatic arthralgia./Hypertension, aching pain in joints, numbness in joints. 阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族
TCMBANKHE002152/YEM-590/XU-716 Cortex Mori radicis Praeparata|Morus alba L.|Morus alba 炙桑柏皮|桑 桑叶 云南民族药物志:第三卷|云南省昭通市盐津县 Treatment of cough and asthma caused by heat in the lung, anasarca with oliguria./Its extract is hypotensive, cardio-inhibitory and vasoconstrictive, and excites the intestines and uterus in experimental animals. 阿昌族/布依族/傣族/德昂族/哈尼族/景颇族/傈僳族/苗族/水族/佤族/彝族/藏族
TCMBANKHE004071/YEM-649 Bulbus Allii|Allium sativum L. 大蒜 大蒜 云南民族药物志:第四卷 Toxication reduction, anthelmintic, dampness removal, and itching control/Cold pain in stomach duct and abdomen, diarrhea, dysentery, bacillary dysentery, amebic dysentery, tuberculosis, epidemic encephalitis, cholera, trichomoniasis, laryngeal carcinoma, pertussis, throat impediment, dry cough, common cold, malaria, edema, swelling toxin of welling abscess and boil, intestinal welling abscess, lichen sore, snake or insect bites, ancylostomiasis, oxyuria disease, taenia infection, vaginal discharge and pudendal itch, clavus. 阿昌族/布依族/傣族/德昂族/回族/哈尼族/基诺族/景颇族/傈僳族/水族/佤族/彝族/藏族
TCMBANKHE006699/YEM-696 Cucurbita moschata|Cucurbita moschata(Duch.ex Lam.)Duch.ex Poiret 南瓜 南瓜 云南民族药物志:第四卷 To resolve toxin and disperse swelling./Pulmonary welling abscess, asthma, swollen welling abscess, scalds, poisonous bee stings. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/佤族/彝族
TCMBANKHE007363/YEM-744/XU-850 Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum 大黄; 生锦纹; 生军|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000018 Pancreatic Neoplasm disease Digestive System Diseases; Neoplasms; Endocrine System Diseases 23108405
TCMBANKDI000067 Head and Neck Neoplasms group Neoplasms 30339884

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000223 KEAP1 INrf2; KLHL19 kelch like ECH associated protein 1
TCMBANKGE000265 SQSTM1 A170; DMRV; FTDALS3; NADGP; OSIL; PDB3; ZIP3; p60; p62; p62B sequestosome 1
TCMBANKGE000266 DCTN4 DYN4; P62 dynactin subunit 4
TCMBANKGE000267 GTF2H1 BTF2; P62; TFB1; TFIIH general transcription factor IIH subunit 1
TCMBANKGE000268 NUP62 IBSN; SNDI; p62 nucleoporin 62
TCMBANKGE000270 KHDRBS1 Sam68; p62; p68 KH RNA binding domain containing, signal transduction associated 1
TCMBANKGE000330 HMOX1 HMOX1D; HO-1; HSP32; bK286B10 heme oxygenase 1
TCMBANKGE000476 NCOA2 GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75 nuclear receptor coactivator 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000823 GABPA E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07 GA binding protein transcription factor subunit alpha
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE001011 TNFSF10 APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL TNF superfamily member 10
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001126 NFE2L2 HEBP1; IMDDHH; NRF2; Nrf-2 nuclear factor, erythroid 2 like 2
TCMBANKGE001151 GPX4 GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx glutathione peroxidase 4
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE008921 RXRA NR2B1 retinoid X receptor alpha
TCMBANKGE009389 LYZ LYZF1; LZM lysozyme
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1