Compound Summary


  Compound Information

药名:

breviscapine

别名:

5,6,4'-trihydroxyflavone-7-o-beta-d-galactonic acid;scutellarin;5,6,4'-trihydroxyflavone-7-o-β-d-galactonicacid;(2S,3S,4S,5R,6S)-6-[[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-7-chromenyl]oxy]-3,4,5-trihydroxy-2-tetrahydropyrancarboxylic acid; CHEBI:61284; 676536-34-8; 1329-06-2; 4H-1-Benzopyran-4-one, 7-(.beta.-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-; Flavone, 4',5,6,7-tetrahydroxy-, 7-beta-D-glucopyranuronoside; scutellarin(1-); scutellarein 7-O-beta-D-glucuronate; Scutellarein-7beta-D-glucuronide; AIDS-314104; AIDS314104; 32647-60-2; Scutellarein-7-O-beta-D-glucuronide; Scutellarein-7-glucuronide; Breviscapine; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; 116122-36-2; Breviscapin; MEGxp0_000554; beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl; Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, beta-D-; Scutellarin; Scutellarein-7beta-D-glucuronoside; 27740-01-8; 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranosiduronate; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-chromen-7-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-keto-chromen-7-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-chromen-7-yl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid

分子式:

C21H18O12

Smiles:

C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O

成分:

HBIN018837;HBIN011088;HBIN043533

OB_score:

2.643486

CAS_id:

116122-36-2

SymMap_id:

SMIT00173

TCMID_id:

2606;32121;21719;19572

TCMSP_id:

MOL002931

PubChem_id:

6426802;185617


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE003734 radix tripterygii wilfordii 雷公藤 To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage./Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen.
TCMBANKHE003746 Radix Scutellariae 黄芩 To remove damp-heat, to quench fire and counteract toxicity, to arrest bleeding, and to prevent abortion./Chest oppression with retching, diarrhea, jaundice, lung heat cough, infection of upper respiratory tract, acute tonsillitis, acute pharyngolaryngitis, ardent fever with vexation and thirst, blood heat, blood ejection, spontaneous external bleeding, swelling toxin of welling abscess and sore, stirring fetus in pregnancy.
TCMBANKHE003805 Sorbaria sorbifolia 珍珠梅 To quicken blood and dispel stasis, disperse swelling and relieve pain./Fracture, knocks and falls, wind-damp impediment pain.
TCMBANKHE004259 Plantago major 大车前 See Plantago asiatica./See Plantago asiatica.
TCMBANKHE004516 Sorbaria arborea 高丛珍珠梅 See Sorbaria sorbifolia ./See Sorbaria sorbifolia .
TCMBANKHE006246 Scutellaria altissima 高黄芩
TCMBANKHE006133 紫苏 Phlegm congestion and qi counterflow, cough and asthma, intestinal dry and constipation.
TCMBANKHE006914 Ramulus Euonymi 鬼箭羽 For activating blood and modulating period/Concretion and conglomeration, pain in heart and abdomen, amenorrhea, dysmenorrhea, postpartum stasis stagnation abdominal pain, retention of lochia, mounting qi , joint running impediment pain, swelling of sores, painful wound from knocks and falls, burns and scalds, poisonous snake bite.
TCMBANKHE007803 Herba Scutellariae barbatae 半枝莲 To remove toxic heat, and to cause diuresis./Heat toxin swollen welling abscess, throat pain, pulmonary welling abscess, intestinal welling abscess, scrofula, poisonous snake bite, knocks and falls, blood ejection, spontaneous external bleeding, blood strangury, edema, ascites, carcinoma.
TCMBANKHE007928 白药子 Septicemia, acute hepatitis, bacillary dysentery, parotitis, neurodermatitis, swelling pain in throat, heat toxin swollen welling abscess, wind-damp impediment pain, abdominal pain and diarrhea, blood ejection, bleeding, spontaneous external bleeding, bleeding due to external injury.
TCMBANKHE008042 Clerodendron fragrans 臭茉莉 To dispel wind and eliminate damp, quicken blood and disperse swelling./Wind-damp bone pain, beriberi, edema, hemorrhoids, prolapse of rectum, itchy papules, scab sore, chronic medullitis.
TCMBANKHE007163 Bulbus Lilii 百合 To nourish yin and moisten the lung, and to tranquilize the mind./Yin vacuity enduring cough, phlegm containing blood, fright palpitation and vacuity vexation, insomnia and frequent dreaming, trance.
TCMBANKHE008975 Bulbus Lilii 百合 To nourish yin and moisten the lung, and to tranquilize the mind./Yin vacuity enduring cough, phlegm containing blood, fright palpitation and vacuity vexation, insomnia and frequent dreaming, trance.
TCMBANKHE008359 Semen Oroxyli 木蝴蝶 To remove heat from the lung and relieve sore throat, and to regulate the flow of qi of the liver and the stomach./Lung heat cough, throat impediment, aphonia, liver stomach qi pain.
TCMBANKHE005979/YNS-177/YEM-122/XU-155 Oroxylum indicum|Oroxylum indicum (L.)Vent. 木瑚蝶树皮|木蝴蝶|千张纸 木蝴蝶树皮|木蝴蝶 云南药材标准:第三册|云南民族药物志:第一卷|云南省普洱市江城县国庆乡和平村弄扎河小组 清热利湿退黄;利咽消肿。主传染性黄疽肝炎;咽喉肿痛|To clear heat and disinhibit damp, abate jaundice, disinhibit throat and disperse swelling./Infective hepatitis, swelling pain in throat. 傣族/哈尼族/基诺族/拉祜族/傈僳族/佤族/彝族/藏族
TCMBANKHE005300/YEM-502/XU-414/XU-629/XU-653 Perilla frutescens var. acuta [Syn. Perilla frutescens var. purpurascens ]|Perilla frutescens(L.)Britt.|Perilla frutescens var. crispa 尖紫苏叶|紫苏|回回苏 紫苏 云南民族药物志:第三卷|湖北省宜昌市夷陵区 See Perilla frutescens var. arguta ./See Perilla frutescens var. arguta . 傣族/回族/哈尼族/傈僳族/苗族/水族/佤族/瑶族/彝族/壮族
TCMBANKHE003745/YEM-786/XU-131/XU-268/XU-643 Erigeron breviscapus|Erigeron breviscapus(Vant.)Hand.-Mazz.|Erigeron breviscapus (Vant.) Hand. -Mazz. 灯盏细辛|短葶飞蓬|短葶飞蓬(灯盏花) 灯盏花 云南民族药物志:第四卷|云南省迪庆州维西县 To dissipate cold and resolve exterior, dispel wind and eliminate damp, quicken network vessels and relieve pain, disperse accumulation./Common cold with headache and nasal congestion, wind-damp impediment pain, paralysis, acute gastritis, child gan accumulation, knocks and falls. 阿昌族/白族/傣族/德昂族/基诺族/傈僳族/苗族/彝族/藏族/壮族
TCMBANKHE005331/YNS-287/YEM-823/XU-183 Scoparia dulcis|Scoparia dulcis L. 野甘草 野甘草|冰糖草 云南药材标准:第三册|云南民族药物志:第四卷|广西省钦州市钦北区 用于治疗偏头痛,腰痛,尿频尿痛,肾炎,疮疖,外用治痱子,皮肤湿疹,主治小儿高热,咽喉肿痛,咳嗽,牙痛,肠炎。|To clear heat and resolve toxin, disinhibit urine and disperse edema./Lung heat cough, summerheat-heat diarrhea, beriberi with general edema, child measles, papules, eczema, prickly heat, laryngitis, erysipelas. 阿昌族/傣族/德昂族/基诺族/景颇族/傈僳族/佤族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000056 Heart failure disease Cardiovascular Diseases
TCMBANKDI000083 Infarction, Middle Cerebral Artery disease Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
TCMBANKDI005044 Ventricular Remodeling phenotype Pathological Conditions, Signs and Symptoms
TCMBANKDI013888 Fibrosis phenotype Pathological Conditions, Signs and Symptoms
TCMBANKDI019632 Myocardial Infarction disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
TCMBANKDI024568 Ventricular Dysfunction, Left phenotype Cardiovascular Diseases

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000052 TNF DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F tumor necrosis factor
TCMBANKGE000224 AGT ANHU; SERPINA8; hFLT1 angiotensinogen
TCMBANKGE000274 CCL2 GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF C-C motif chemokine ligand 2
TCMBANKGE000851 PKM CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1; p58 pyruvate kinase M1/2
TCMBANKGE000856 CRK CRKII; p38 CRK proto-oncogene, adaptor protein
TCMBANKGE000857 AHSA1 AHA1; C14orf3; hAha1; p38 activator of HSP90 ATPase activity 1
TCMBANKGE000858 RBPJ AOS3; CBF-1; CBF1; IGKJRB; IGKJRB1; KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH; csl recombination signal binding protein for immunoglobulin kappa J region
TCMBANKGE000884 FN1 CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; SMDCF fibronectin 1
TCMBANKGE000945 HES1 HES-1; HHL; HRY; bHLHb39 hes family bHLH transcription factor 1
TCMBANKGE001030 NOTCH1 AOS5; AOVD1; TAN1; hN1 notch receptor 1
TCMBANKGE001156 CASP3 CPP32; CPP32B; SCA-1 caspase 3
TCMBANKGE001181 TGFB1 CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta transforming growth factor beta 1
TCMBANKGE001201 MAPK3 ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK mitogen-activated protein kinase 3
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001203 MAPK1 ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK mitogen-activated protein kinase 1
TCMBANKGE014619 HES4 bHLHb42 hes family bHLH transcription factor 4