Compound Summary

  Compound Information

TCMBANKIN058511

药名:	proanthocyanidin b2
别名:	29106-49-8; AC1L3V5O; EC-(4b,8)-EC; SC-83395; Procyanidol B2; (+)-Procyanidin B2; CS-5982; (2R,2'R,3R,3'R,4R)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol; AK554017; (2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol; Procyanidin dimer B2; (-)-Epicatechin-(4.beta.-8)-(-)-epicatechin; X1213; XFZJEEAOWLFHDH-NFJBMHMQSA-N; N2517; L88HKE854X; LMPK12030002; 4,8 inverted exclamation marka-Bi-[(+)-epicatechin]; NSC 623097; Procyanidin B2; cis,cis inverted exclamation marka-4,8 inverted exclamation marka-Bi(3,3 inverted exclamation marka,4 inverted exclamation marka,5,7-pentahydroxyflavane); Procyanidin B-2; Ambap29106-49-8; [4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol,2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-; C17639; J-017393; Proanthocyanidin B2; ZINC26490614; Procyanidin B2, analytical standard; cis,cis""-4,8""-Bi(3,3',4',5,7-pentahydroxyflavane); (4,8'-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R-(2alpha,3alpha,4beta(2'R*,3'R*)))-; CHEMBL38714; Epicathechin-(4beta->8)-epicathechin; (2R-(2alpha,3alpha,4beta(2'R*,3'R*)))-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-(4,8'-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol; FT-0686683; SCHEMBL288579; 2,3-cis-proanthocyanidin; C30H26O12; AC1Q7ABR; MFCD01861513; UNII-L88HKE854X; AKOS008901339; MolPort-003-932-480; CHEBI:75632; HY-N0796; (2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-8-yl]chromane-3,5,7-triol; [4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-; X1212; EBD2184995; Procyanidin-B2; (2r,2'r,3r,3'r,4r)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2h,2'h-4,8'-bichromen-3,3',5,5',7,7'-hexol; Epicatechin(4b->8)catechin; SCHEMBL676745; (4,8-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-; (2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-chromanyl]chroman-3,5,7-triol; Q-100247; Procyanidin dimer B1; 20315-25-7; (2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-[4,8'-bichroman]-3,3',5,5',7,7'-hexaol; AKOS030530133; Epicatechin-(4beta->8)-ent-epicatechin; procyanidin b1; LMPK12030001; Proanthocyanidin B1; (2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-8-yl]chroman-3,5,7-triol; ZINC26490620; EC-(4b,8)-C; HY-N0795; BG01789588; (2R,3R,4R)-2-(3,4-DIHYDROXYPHENYL)-4-[(2R,3S)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-3,4-DIHYDRO-2H-1-BENZOPYRAN-8-YL]-3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL; cis,trans′′-4,8′′-Bi-(3,3′,4′,5,7-Pentahydroxyflavane); Endotelon; CHEBI:75633; (2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-8-yl]chromane-3,5,7-triol; 19542_FLUKA; AK554016; Procyanidol oligomer; CS-5955; UNII-0566J48E7X; Procyanidin-B1; 4,8-Bi-(3,3',4',5,7-Pentahydroxyflavane); Ambap20315-25-7; Epicatechin(4beta->8)catechin; cis,trans''-4,8''-Bi-(3,3',4',5,7-Pentahydroxyflavane); (2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-8-yl]chroman-3,5,7-triol; 0566J48E7X; 2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-(4,8-Bi-2H-1-benzopyran)-3,3',5,5',7,7'-hexol; CHEMBL504937; (2R,2'R,3R,3'S,4R)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol; XFZJEEAOWLFHDH-UKWJTHFESA-N; Procyanidin B1, analytical standard; MFCD01861512; C30H26O12; V0244; MolPort-003-927-506; cis,trans inverted exclamation marka inverted exclamation marka-4,8 inverted exclamation marka inverted exclamation marka-Bi-(3,3 inverted exclamation marka,4 inverted exclamation marka,5,7-Pentahydroxyflavane); FT-0686682; Procyanidin B; Procyanidin B1; proanthocyanidin b1
分子式:	C30H26O12
Smiles:	C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
成分:	HBIN040747;HBIN040759;HBIN040746
OB_score:	67.873462
CAS_id:	20315-25-7
SymMap_id:	SMIT17307;SMIT02697;SMIT17308
TCMID_id:	17855;17862
TCMSP_id:	MOL000004
PubChem_id:	11250133

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000257	Flos Dolichoris	扁豆花			To strengthen the spleen and transform dampness/To clear summer-heat and eliminate dampness from the upper-jiao, invigorate the spleen and strengthen the stomach: For summer heat-dampness syndrome with feeling of oppression in the chest, dysuria and diarrhea, vomiting, diarrhea and dysentery of dampnes
TCMBANKHE002044	Semen Phaseoli	赤小豆			To cause diuresis, to counteract toxicity, and to promote the drainage of pus./Decoction inhibits the growth of Staphylococcus aureus, Shigella flexneri and Bacillus typhoid in vitro.
TCMBANKHE002206		罗布麻叶
TCMBANKHE002533	Betula pubescens
TCMBANKHE003028		粉萆薢			Treatment of chyluria, turbid urine mixed with whitish substance or whitish discharge from urethra, excessive leukorrhea, rheumatic arthralgia with limitation of motion and pain in the loins and knees.
TCMBANKHE003726	Cortex Cinmomi	肉桂			To supplement body fire, reinforce yang, and lead the fire back to the kidney, to dispel cold and relieve pain, and to activate blood circulation and stimulate menstrual discharge./Impotence, uterus cold, cold pain in lumbus and knees, kidney vacuity asthma, yang vacuity dizziness, red eyes and sore pharynx, cold pain in heart and abdomen, vacuity cold vomiting and diarrhea, cold mounting, running piglet, amenorrhea, dysmenorrhea.
TCMBANKHE003856	Fagopyrum cymosum [Syn. Polygonum cymosum ]	天荞麦根			To clear heat and resolve toxin, quicken blood and disperse welling abscess, dispel wind and eliminate damp./Swelling pain in throat, sores, scrofula, hepatitis, pulmonary welling abscess, aching sinews and bones, head wind, stomachache, bacillary dysentery, Vaginal discharge.
TCMBANKHE003895		大腹皮			Its decoction exerts an effect of enhancing the intestinal tensity and decreasing the extent of intestinal contraction in rabbits in vitro, which can be counteracted by atropine.
TCMBANKHE007658	Cola acuminata	苏丹可乐果			To raise spirit.
TCMBANKHE004055	Fragaria vesca	野草莓
TCMBANKHE004250	Theobroma cacao	可可			To warm yang, disinhibit urine, raise spirit.
TCMBANKHE006165	Rhizoma Dioscoreae bulbiferae	黄药子			To remove phlegm, disperse the lumps, detoxify and relieve swelling. /Goiter and tuberculosis, throat impediment, swelling toxin of welling abscess and sore, poisonous snake bite, carcinoma, blood ejection, spontaneous external bleeding, hemoptysis, pertussis, lung heat cough.
TCMBANKHE006166	Vaccinium vitis-idaea	越橘叶			To disinhibit urine, resolve toxin./Strangury syndrome, pain wind.
TCMBANKHE007924	semen arecae	槟榔			1. To kill parasites; 2. To promote qi circulation; 3. To promote water metabolism/Wormccumulation, food stagnation, distending pain in stomach duct and abdomen, diarrhea and tenesmus, beriberi, edema, malaria.
TCMBANKHE005579	Davallia mariesii	海州骨碎补			To move blood and quicken network vessels, dispel wind and relieve pain, supplement kidney and strengthen bones./Wind-damp impediment pain, knocks and falls, kindey vacuity toothache, lumbago, chronic diarrhea.
TCMBANKHE005660	Aesculus hippocastanum	欧洲七叶树			See Aesculus wilsonii./See Aesculus wilsonii.
TCMBANKHE006293	Crataegus monogyna	单子山楂
TCMBANKHE008616	Herba Bidentis	鬼针草			1. To clear the superficial heat. 2. To clear heat and toxic materials. 3. To clear dampness and heat from the gastrointestines./Swelling pain in throat, dysentery, diarrhea, jaundice, intestinal welling abscess, swelling toxin of clove sore, snake or insect bites, wind-damp impediment pain, knocks and falls.
TCMBANKHE006558	Larix gmelini	落叶松
TCMBANKHE006660	Ramulus Cinmomi	桂枝			To induce perspiration, to warm the channels and stimulate menstrual discharge, to reinforce yang, to relieve palpitation, and to promote the descending of qi./Wind-cold exterior syndrome, cold-damp impediment pain, reversal cold of limbs, amenorrhea and dysmenorrhea, concretion and conglomeration, chest impediment, palpitation, phlegm-rheum, inhibited urination.
TCMBANKHE006730	Pyrola incarnata	红花鹿蹄草			See Pyrola calliantha./See Pyrola calliantha.
TCMBANKHE006757	Garcinia mangostana	倒捻子
TCMBANKHE009026	Dioscorea alata	毛薯			To fortify spleen and check diarrhea, nourish lung and enrich kidney, resolve toxin and close sores./Spleen vacuity diarrhea, kidney vacuity and emission, vaginal discharge, frequent urination, vacuity taxation cough, diabetes mellitus, ulcerating sores, burns and scalds.
TCMBANKHE008280	Thujopsis dolobrata	罗汉柏
TCMBANKHE007978	Uncaria sinensis	华钩藤			See Uncaria rhynchophylla./See Uncaria rhynchophylla.
TCMBANKHE009077	Antenoron neofiliforme	短毛金线草根
TCMBANKHE007867/XU-103	Flos Buddlejae|Buddleja officinalis	密蒙花		云南省昆明市盘龙区	To remove heat, replenish the liver and clear the eye of corneal opacity./Red eyes with gall, delacrimation and photophobia, liver vacuity dim vision, dim vision, malaria.
TCMBANKHE007983/YNS-220/XU-214	Dioscorea cirrhosa [Syn. Dioscorea pogonoides]|Dioscorea cirrhosa Lour.|Dioscorea cirrhosa	薯莨|薯茛	薯莨	云南药材标准：第七册|广西省桂林市荔浦县新坪镇	主咳血，咯血。呕血，尿血，便血，崩漏，月经不调，痛经，闭经，产后腹痛，脘腹胀痛，痧胀腹痛，热度血痢，水泻，关节痛，跌打肿痛，带状孢疹，外伤出血。(百度)|To quicken blood and stanch bleeding, rectify qi and relieve pain, clear heat and resolve toxin./Coughing of blood, hemoptysis, blood ejection, spontaneous external bleeding, hematuria, hematochezia, flooding and spotting [= metrorrhagia and metrostaxis], menstrual disorder [= menoxenia], dysmenorrhea, menstrual block, postpartum abdominal pain, distending pain in stomach duct and abdomen, sand distention and abdominal pain, heat toxin blood dysentery, water diarrhea, pain in joints, painful swelling from knocks and falls, sore and boil, zoster, bleeding due to external injury.
TCMBANKHE006996/YNS-139/YEM-101/XU-673	Cassia fistula|Cassia fistula L.|Cassia fistula L.	婆罗门皂荚|腊肠树	腊肠树/腊肠树叶|腊肠豆	云南药材标准：第三册/云南药材标准：第五册|云南民族药物志：第一卷|广西省桂林市全州县	治疗耳鼻炎起硬结，小儿便秘；皮治黄疸性肝炎。软冷：用于食物中毒，便秘，腹胀，发热，小儿惊风，鼻衄，黄疸性肝炎，胃痛，腹痛/清火解毒，除风止痛，用于风湿痹痛，中风偏瘫，风火头痛，头目晕眩，口舌生疮，小便热痈，无名肿毒。|To clear heat and free stool, transform stagnation and relieve pain./Heat wind in heart and diaphragm, steaming bone fever and chills, three worms.	阿昌族/傣族/德昂族/景颇族/拉祜族/傈僳族/佤族/藏族
TCMBANKHE005980/YEM-13	herba Menthae;Mentha haplocalyx Briq|Mentha haplocalyx Briq.	薄荷	薄荷	云南民族药物志：第一卷	To dispel wind-heat from the head and eyes, and to promote eruption./Chronic urticaria, infection of upper respiratory tract, sarcoma, wind-heat exterior syndrome, headache and red eyes, swelling pain in throat, non-eruption of measles, dormant papules with pruritus, liver depression and rib-side pain, abdominal distention.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族
TCMBANKHE006138/YNS-38/YEM-27/XU-51	Campylotropis hirtella|Campylotropis hirtella (Franch.) Schindl|Campylotropis hirtella (Franch.) Schindl.|Campylotropis hirtella Franch. Schindl.	毛杭子梢|大红袍	大红袍	云南药材标准：第六册|云南民族药物志：第一卷|云南省丽江市玉龙纳西族自治县白沙乡玉水寨丽江高山植物园	活血止血，调经止血。用于月经不调，痛经，崩漏，带下，胃脘痛，外伤出血，烧烫伤，皮肤瘙痒。|To quicken blood and regulate menstruation, rectify qi and relieve pain, clear heat and disinhibit damp./Menstrual disorder, amenorrhea, dysmenorrhea, vaginal discharge, dysentery, pain in stomach duct, bleeding due to external injury, yellow-water sore, burns and scalds.	傈僳族/纳西族/彝族
TCMBANKHE008622/YNS-103/YEM-312/XU-348	Arachis hypogaea|Arachis hypogaea Linn.|Arachis hypogaea L.	落花生	花生壳|落花生	云南药材标准：第七册|云南民族药物志：第二卷|云南省文山州广南县	健脾化痰、敛肺止咳。用于痰浊咳嗽。|To fortify spleen and nourish stomach, moisten lung and transform phlegm./Stomach reflux, scant breast milk, beriberi, lung heat dry cough, dry stool.	傣族/哈尼族/佤族
TCMBANKHE004012/YEM-314	Vitis vinifera|Vitis vinifera L.	欧洲葡萄|葡萄	葡萄	云南民族药物志：第二卷	To supplement qi and blood, strengthen sinews and bones, disinhibit urine./Vacuity of qi and blood, lung vacuity cough, palpitation and night sweating, wind-damp impediment pain, strangury, edema.	傣族/藏族
TCMBANKHE008566/YEM-346	Euphoria longan [Syn. Dimocarpus longan]|Dimocarpus longan Lour.	龙眼叶|龙眼	龙眼	云南民族药物志：第二卷	To effuse exterior and clear heat, resolve toxin, dry damp./Common cold, malaria, swelling of clove, hemorrhoids, eczema.	傈僳族/瑶族/壮族
TCMBANKHE008852/YEM-661	Cinnamomum bejolghota|Cinnamomum bejolghota(Buch.-Ham.)Sweet	蹲野桂皮|钝叶桂	钝叶桂	云南民族药物志：第四卷	To dispel wind and dissipate cold, warm menstruation and quicken blood, relieve pain./Bleeding due to external injury (external use), wind-cold impediment pain, lumbago, menstrual block, dysmenorrhea, painful swelling from knocks and falls, cold pain in stomach duct, abdominal pain, vacuity cold diarrhea, snake bite.	傣族/基诺族/拉祜族/佤族
TCMBANKHE006444/YEM-848	Vigna angularis|Vigna angularis(Will.)ohwi et Ohashi	赤豆	赤豆	云南民族药物志：第五卷	To disinhibit water, disperse edema and abate jaundice, clear heat, resolve toxin and disperse welling abscess./Edema, leg qi , jaundice, strangury, hematochezia, swelling toxin sores, lichen papules.	傣族/傈僳族/水族/彝族
TCMBANKHE007939/YEM-89	Rhizoma Fagopyri Cymosi|Fagopyrum dibotrys (D.Don)Hara	金荞麦	金荞麦	云南民族药物志：第一卷	1. Its extractum and component flavanol promotes macrophage phagocytosis in the peritoneum of mouse.2. Flavanol is also an anti-inflammatory component. It promotes blood circulation and inhibits the agglutination of blood platelet./1. To clear heat and toxic material. For lung abscess, cough due to lung-heat, also for sorethroat and skin infection. 2. To promote blood circulation to eliminate blood stasis. For menorrhalgia due to blood stasis, postpartum abdominal pain due to blood	傣族/哈尼族/基诺族/彝族/藏族
TCMBANKHE003769/YEM-948	Cinnamomum camphora|Cinnamomum camphora(L.)Persl	樟树皮|樟	樟	云南民族药物志：第五卷	To dispel wind and eliminate damp, warm stomach and harmonize center, kill worms and cure sores./Wind-damp impediment pain, pain in stomach duct, vomiting and diarrhea, leg qi swelling and pain, knocks and falls, scab and lichen with sore toxin, poisonous insect stings.	阿昌族/布依族/傣族/德昂族/回族/哈尼族/景颇族/傈僳族/苗族/水族/瑶族/彝族/藏族/壮族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI015496

Liver neoplasms

group

Digestive System Diseases; Neoplasms

31101057

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000476	NCOA2	GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75	nuclear receptor coactivator 2
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000851	PKM	CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1; p58	pyruvate kinase M1/2
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001097	HIF1A	HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78	hypoxia inducible factor 1 subunit alpha
TCMBANKGE001172	HSP90AA1	EL52; HEL-S-65p; HSP86; HSP89A; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp103; Hsp89; Hsp90; LAP-2; LAP2	heat shock protein 90 alpha family class A member 1
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE007924	PKIA	PRKACN1	cAMP-dependent protein kinase inhibitor alpha
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE014050	GABRA1	ECA4; EIEE19; EJM; EJM5	gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014941	DPEP1	MBD1; MDP; RDP	dipeptidase 1