Compound Summary

  Compound Information

TCMBANKIN058521

药名:	(-)-epicatechin-3-gallate
别名:	epicatechin-3-gallate; L-Epicatechin gallate; (-)-epicatechin gallate; (+)- Catechin gallate table; catechin gallate; 7-o-galloyl- (+) -catechin; (-)-epicatechin-3-o-gallate; (?)-epicatechin-3-o-gallate; (-)-Catechin gallate; Epicatechin gallate; (-)-Epicatechin-3-gallate; KBioSS_000794; 1257-08-5; DivK1c_006371; Spectrum2_000165; NSC 636594; KBioGR_001980; Epicatechol, 3-gallate, (-)- (8CI); [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate; (−)-Epicatechin gallate; SPECTRUM210238; KBio2_003362; [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl] 3,4,5-trihydroxybenzoate; MEGxp0_000810; KBio1_001315; (-)-Epicatechin gallate; SpecPlus_000275; BSPBio_001632; KBio2_000794; SPBio_000029; (−)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; Spectrum5_000080; SDCCGMLS-0066549.P001; Spectrum3_000246; E3893_SIAL; Spectrum_000314; Epicatechol, gallate (6CI); 3,4,5-trihydroxybenzoic acid [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] ester; KBio3_001132; Spectrum4_001540; Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2R-cis)-; Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7- dihydroxy-2H-1-benzopyran-3-yl ester, (-)-cis-; AIDS000675; 3,4,5-trihydroxybenzoic acid [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-chromanyl] ester; KBio2_005930; Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester; (−)-cis-3,3′,4′,5,7-Pentahydroxyflavane 3-gallate; AIDS-000675; catechin gallate ; catechin-3 gallate; CG; 7-o-galloyl-(+)-catechin; (-)-Epicatechin-3-O-gallate,; (-)-Epicatechin-3-gallate,; (-)-epicatechin 3-o-gallate ; SpecPlus_000275; (-)-Epicatechin gallate; KBioSS_000794; [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl] 3,4,5-trihydroxybenzoate; Benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester; LMPK12020090; KBio2_003362; ECG; 92587OVD8Z; 1257-08-5; 3,4,5-Trihydroxybenzoic Acid (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl Ester; AS-15722; Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (2R-cis)-; UNII-92587OVD8Z; KBio3_001132; 3-Galloyl-(2R,3R)-(-)-Epicatechin; SR-05000002675; (-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; CCG-38376; (-) epicatechin gallate; NSC636594; 3,4,5-Trihydroxy-benzoic acid 2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester; 3-O-Galloylepicatechin; CHEMBL36327; BDBM50153015; (-)-epicatechingallate; Epicatechin gallate; (-)-cis-3,3',4',5,7-Pentahydroxyflavane 3-gallate; AM84365; Q-200002; Epicatechol, 3-gallate, (-)-; ZINC3978503; SCHEMBL39047; C-22380; KBio1_001315; (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate; epi-Catechin 3-O-gallate; MolPort-001-740-964; (-)-epi-Catechin 3-O-gallate; DivK1c_006371; Epicatechol, gallate (6CI); (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate; C22H18O10; Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7- dihydroxy-2H-1-benzopyran-3-yl ester, (-)-cis-; BRD-K50660797-001-01-0; NSC 636594; epicatechin-3-O-gallate; Epicatechin 3-gallate; (-)-Epicatechin-3-gallate; (-)-Epicatechin gallate,; (-)epicatechingallate; HY-N0002; epicatechin gallate, (2R-cis)-isomer; L-Epicatechin gallate; NCGC00179135-01; (-)-Epicatechin-3-O-gallate; KBio2_000794; SDCCGMLS-0066549.P001; CTK8E0233; epicatechin monogallate; CS-3761; BSPBio_001632; 3,4,5-Trihydroxy-benzoic acid (2R,3R)-2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-chroman-3-yl ester; 2.57E+87; AC-6037; AN-48941; Teatannin; Spectrum_000314; Spectrum5_000080; MEGxp0_000810; [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate; Epicatechin gallate, primary pharmaceutical reference standard; Spectrum2_000165; (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate; Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester; Epicatechol, gallate; NP-002326; AC1L32YN; 3-Galloyl-(-)-epicatechin; (-)-Epicatechin 3-O-gallate; SPECTRUM210238; SPBio_000029; ST24033389; AC1Q5X10; Epicatechol, 3-gallate, (-)- (8CI); KBio2_005930; AJ-47571; MCULE-8110076741; Spectrum4_001540; epicatechin gallate (ECG); E0890; [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate; (-)-Epicatechin gallate, >=98% (HPLC), from green tea; AKOS015965216; SR-05000002675-1; 3-Gallate(-)-Epicatechol; CHEBI:70255; KB-277863; LS-38401; LSHVYAFMTMFKBA-TZIWHRDSSA-N; (-)-cis-3,3 inverted exclamation marka,4 inverted exclamation marka,5,7-Pentahydroxyflavane 3-gallate; MFCD00075936; AX8001457; AB0017581; KBioGR_001980; Spectrum3_000246; CE0014; Q429; AIDS-231457; [(2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl] 3,4,5-trihydroxybenzoate; 3,4,5-trihydroxybenzoic acid [(2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] ester; [(2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate; Benzoic acid, 3,4,5-trihydroxy-, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester; 3,4,5-trihydroxybenzoic acid [(2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-chromanyl] ester; AIDS231457; 3,4,5-trihydroxybenzoic acid [(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] ester; (-)-epicatechin gallate; epicatechin-3 gallate; 3,4,5-trihydroxybenzoic acid [(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-chromanyl] ester; epicatechin gallate ; [(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl] 3,4,5-trihydroxybenzoate; Epicatechin-3-gallate; [(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate; epicatechin gallate; Benzoic acid, 3,4,5-trihydroxy-, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, cis-; Epicatechin-3-galloyl ester; 863-03-6
分子式:	C22H18O10
Smiles:	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
成分:	HBIN025297; HBIN025298; HBIN032936; HBIN025314; HBIN019941; HBIN019939; HBIN013393; HBIN025300; HBIN025301; HBIN019940; HBIN025313
OB_score:	3.009837; 53.56733; 17.885867
CAS_id:	1257-08-5; 1257-08-5; 863-03-6
SymMap_id:	SMIT08382; SMIT18569; SMIT18968; SMIT15252; SMIT08110; SMIT07219
TCMID_id:	35984; 33478; 39025; 24267; 25803; 6863
TCMSP_id:	MOL006820; MOL006504; MOL005467
PubChem_id:	107905; 65056; 6419835; 367141

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE001722	Scurrura atropurpurea	黑子梨果寄生			Anticarcinoma.
TCMBANKHE001911	Herba Acalyphae	铁苋菜			1. Treatment of diarrhea and dysentery of darnpness-heat type. Recently, also for amebic dysentery and typhoid fever. 2. Treatment of hemoptysis, hematemesis, hemafecia, metrorrhagia, etc. 3. Treatment of dyspneic cough of lung-heat type./1. Bacteriostatic. 2. Astringent and protective on intestinal mucosa. 3. Antiasthmatic.
TCMBANKHE003426	Fructus Leonuri	茺蔚子			To activate blood circulation and regulate menstruation, to subdue hyperactivity of the liver, and to clear the eye of opacity./Treatment of menstrual disorders, amenorrhea, hysmenorrhea, inflammation of the eye with formation of corneal opacity, dizziness and headache.
TCMBANKHE003524	Fructus Phyllanthi	余甘子			To remove heat from blood, to promote digestion and the production of body fluid, and to relieve cough./Treatment of heat in the blood and blood stasis, liver and gall bladder diseases, dyspepsia, abdominal pain, cough, sore throat, dryness of the mouth.
TCMBANKHE003726	Cortex Cinmomi	肉桂			To supplement body fire, reinforce yang, and lead the fire back to the kidney, to dispel cold and relieve pain, and to activate blood circulation and stimulate menstrual discharge./Impotence, uterus cold, cold pain in lumbus and knees, kidney vacuity asthma, yang vacuity dizziness, red eyes and sore pharynx, cold pain in heart and abdomen, vacuity cold vomiting and diarrhea, cold mounting, running piglet, amenorrhea, dysmenorrhea.
TCMBANKHE003755	Radix Ampelopsis	白蔹			To remove toxic heat, to cure carbuncles, and to reduce nodules./Swelling toxin of sore and welling abscess, burns and scalds, scrofula, damp sore, warm malaria, frightepilepsy, blood dysentery, intestinal wind, hemorrhoids and fistulas, leukorrhea, knocks and falls, bleeding due to external injury.
TCMBANKHE003782	Fructus Corni	山茱萸			To replenish the liver and kidney, restrain seminal discharge and relieve collapse./Dizziness and tinnitus, aching in lumbus and knees, impotence and emission, enuresis and frequent urination, flooding and spotting with vaginal discharge, vacuity and profuse sweating, vacuity desertion due to great sweating, diabetes mellitus due to internal heat, dysmenorrhea.
TCMBANKHE003895		大腹皮			Its decoction exerts an effect of enhancing the intestinal tensity and decreasing the extent of intestinal contraction in rabbits in vitro, which can be counteracted by atropine.
TCMBANKHE003986		苦丁茶			Common cold, summerheat stroke with fever, jaundice, acute gastroenteritis, bacillary dysentery, sore and boil.
TCMBANKHE006313	Radix et Rhizoma Rhei	大黄			To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE006554	Radix Sanguisorbae	地榆			To arrest bleeding by dispelling heat for blood, and to counteract toxicity and cure sores./Blood ejection, hemoptysis, duodenal ulcer, spontaneous external bleeding, hematuria, hematochezia, bleeding from hemorrhoids, blood dysentery, flooding and spotting, red and white vaginal discharge, swelling pain of welling abscess and sore, eczema, pudendal itch, burns and scalds, snake or insect bites.
TCMBANKHE006592	Ancistrocladus korupensis	钩枝藤
TCMBANKHE005748	Rheum tanguticum	唐古特大黄			See Rheum officinale./See Rheum officinale.
TCMBANKHE007867/XU-103	Flos Buddlejae|Buddleja officinalis	密蒙花		云南省昆明市盘龙区	To remove heat, replenish the liver and clear the eye of corneal opacity./Red eyes with gall, delacrimation and photophobia, liver vacuity dim vision, dim vision, malaria.
TCMBANKHE006388/YEM-259/XU-440	Camellia sinensis [Syn. Thea sinensis]|Camellia sinensis (L.)O.Kuntze var.assamica(Masters)Kitam.|Camellia sinensis	茶叶|普洱茶|茶	普洱茶	云南民族药物志：第二卷|云南省昭通市盐津县	To clear head and eyes, eliminate vexation and allay thirst, disperse food, transform phlegm, disinhibit urine, resolve toxin./Headache, dim vision, red eyes, desire to sleep, common cold, vexation and thirst, food accumulation, bad breath, phlegm asthma, epilepsy, inhibited urination, diarrhea, throat swelling, swelling of sores and boils, burns and scalds.	傣族/哈尼族/彝族/藏族
TCMBANKHE006383/YEM-407	Prunus persica|Prunus persica(L.)Batsch	桃根|桃	桃仁	云南民族药物志：第二卷	To clear heat and disinhibit damp, quicken blood and relieve pain, disperse swollen welling abscess./Jaundice, sand qi abdominal pain, lumbago, taxation damage due to knocks and falls, wind-damp impediment pain, amenorrhea, blood ejection, spontaneous external bleeding, swollen welling abscess, hemorrhoids.	阿昌族/白族/傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/傈僳族/苗族/水族/佤族/瑶族/彝族/藏族/壮族
TCMBANKHE007363/YEM-744/XU-850	Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum	大黄; 生锦纹; 生军|掌叶大黄	掌叶大黄	云南民族药物志：第四卷|西藏昌都地区芒康县	To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect.	阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE004455/YEM-744/XU-850	Rheum palmatum|Rheum palmatum L.	掌叶大黄	掌叶大黄	云南民族药物志：第四卷|西藏昌都地区芒康县	See Rheum officinale./See Rheum officinale.	阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族
TCMBANKHE007939/YEM-89	Rhizoma Fagopyri Cymosi|Fagopyrum dibotrys (D.Don)Hara	金荞麦	金荞麦	云南民族药物志：第一卷	1. Its extractum and component flavanol promotes macrophage phagocytosis in the peritoneum of mouse.2. Flavanol is also an anti-inflammatory component. It promotes blood circulation and inhibits the agglutination of blood platelet./1. To clear heat and toxic material. For lung abscess, cough due to lung-heat, also for sorethroat and skin infection. 2. To promote blood circulation to eliminate blood stasis. For menorrhalgia due to blood stasis, postpartum abdominal pain due to blood	傣族/哈尼族/基诺族/彝族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000301	SLC2A1	CSE; DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; HTLVR; PED; SDCHCN	solute carrier family 2 member 1
TCMBANKGE000392	PGD	6PGD	phosphogluconate dehydrogenase
TCMBANKGE000533	SLCO1B1	HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6	solute carrier organic anion transporter family member 1B1
TCMBANKGE000568	MET	AUTS9; DFNB97; HGFR; RCCP2; c-Met	MET proto-oncogene, receptor tyrosine kinase
TCMBANKGE000836	BACE1	ASP2; BACE; HSPC104	beta-secretase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE003643	F7	SPCA	coagulation factor VII
TCMBANKGE003794	SLC5A2	SGLT2	solute carrier family 5 member 2
TCMBANKGE005752	SLC5A10	SGLT-5; SGLT5	solute carrier family 5 member 10
TCMBANKGE006375	SLCO1B3	HBLRR; LST-2; LST-3TM13; LST3; OATP-8; OATP1B3; OATP8; SLC21A8	solute carrier organic anion transporter family member 1B3
TCMBANKGE007026	CBR4	SDR45C1	carbonyl reductase 4
TCMBANKGE007615	SLC5A3	BCW2; SMIT; SMIT1; SMIT2	solute carrier family 5 member 3
TCMBANKGE007656	FSHR	FSHR1; FSHRO; LGR1; ODG1	follicle stimulating hormone receptor
TCMBANKGE009236	SLC5A1	D22S675; NAGT; SGLT1	solute carrier family 5 member 1
TCMBANKGE010521	SLC5A11	KST1; RKST1; SGLT6; SMIT2	solute carrier family 5 member 11
TCMBANKGE010960	SLC5A4	DJ90G24.4; SAAT1; SGLT3	solute carrier family 5 member 4
TCMBANKGE011164	GLUD1	GDH; GDH1; GLUD	glutamate dehydrogenase 1
TCMBANKGE013060	HSD17B8	D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1; dJ1033B10.9	hydroxysteroid 17-beta dehydrogenase 8
TCMBANKGE013566	GLUD2	GDH2; GLUDP1	glutamate dehydrogenase 2
TCMBANKGE014679	SLC5A9	SGLT4	solute carrier family 5 member 9