Compound Summary


  Compound Information

药名:

sophocarpine

别名:

Sophocarpine; ZINC5282946; AIDS-122681; AIDS122681; 145572-44-7 (MONOHYDRATE); (-)-(7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-Decahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; Matridin-15-one, 13,14-didehydro-; Matridin-15-one, 13,14-didehydro- (9CI); (-)-Sophocarpine; 1H,5H,10H-Dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-; BB_NC-1020; 13,14-Didehydromatridin-15-one; (-)-sophocarpine

分子式:

C15H22N2O

Smiles:

C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4

成分:

HBIN044342;HBIN044343

OB_score:

64.264332

CAS_id:

6483-15-4

SymMap_id:

SMIT00185

TCMID_id:

20061

TCMSP_id:

MOL003627

PubChem_id:

115269;115269


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000946 Flos Mume 梅花 To ease the mind, the regulate the stomach function, to resolve phlegm, and counteract toxicity./Treament of depression with fidgetness, epigastric pain due to stagnation of qi of the liver and stomach, globus hystericus, scrofula, ulcers.
TCMBANKHE001046 胡芦巴 Hyperlipemia, kidney vacuity cold, cold pain in lesser-abdomen, mounting qi , beriberi.
TCMBANKHE006167 Herba Corydalis bungeae 苦地丁 Influenza, infection of upper respiratory tract, tonsillitis, infective hepatitis, enteritis, dysentery, nephritis, parotitis, conjunctivitis, acute appendicitis, clove sore and swollen welling abscess, scrofula.
TCMBANKHE001092 苦豆草
TCMBANKHE001194 Herba Sophorae Alopecuroidis 苦甘草 1. To clear heat and toxic material, deprive dampness and kill parasites. For sorethroat, dysentery, trichomonas enteritis, toothache, stomachache and leucorrhagia, external use for tinea and eczema. 2. To relieve dyspnea and cough. 3. Anticarcinogenic. For malignant hydatidiform mole, chorionic epithelioma and leukemia./1. To clear heat and toxic material, deprive dampness and kill parasites. For sorethroat, dysentery, trichomonas enteritis, toothache, stomachache and leucorrhagia, external use for tinea and eczema. 2. To relieve dyspnea and cough. 3. Anticarcinogenic. F
TCMBANKHE003410 柔枝槐
TCMBANKHE003666 沙参槐
TCMBANKHE005727 南鹤虱
TCMBANKHE005787 Sophora viciifolia 白刺花 To clear heat and disinhibit throat, cool blood and disperse swelling./Swelling pain in throat, cough, hepatitis, dysentery, strangury syndrome, edema, hematuria, nosebleed(epistaxis), hematochezia.
TCMBANKHE004142 Aconitum soongaricum 准格尔乌头
TCMBANKHE004344 南鹤虱 Ascariasis, oxyuria disease, taeniasis, ancylostomiasis, abdominal pain due to worm accumulation, child gan accumulation, pudendal itch.
TCMBANKHE004530 Aconitum nagarum var. lasiandrum 宣威乌头 See Aconitum brachypodum./See Aconitum brachypodum.
TCMBANKHE004613 flos Sophorae 槐花 To arrest bleeding by reducing heat in blood, and to quench excess fire in the liver./1. Its component rutin decreases capillay permeability. 2. Lowering blood pressure transiently in anesthetized dog. 3. Inhibiting the growth of various dermatomyces.
TCMBANKHE004838 Radix Sophorae Tonkinensis 山豆根 To remove toxic heat, promote the subsidence of swelling, and soothe the sore throat./Septicemia, ulcer of uterine cervix, chronic cervicitis, bacillary dysentery, enteritis, hydatid moles, chorioblastoma, asthma, chronic bronchitis, acute tonsillitis, laryngitis, accumulated fire toxin, swelling pain in throat, gingiva painful swelling.
TCMBANKHE005298 Sophora pachycarpa 甘肃槐树
TCMBANKHE007042 白刺花叶
TCMBANKHE008036 Aconitum karakolicum 多根乌头 See Aconitum carmichaeli./See Aconitum carmichaeli.
TCMBANKHE008700 Aconitum monticola 山地乌头
TCMBANKHE007521 Sophora alopecuroides 苦豆子 To clear heat and dry damp, kill worms and relieve pain./Dysentery, stomachache, excessive leukorrhea, eczema, sore and boil, intractable lichen.
TCMBANKHE008498 fructus Sophorae 槐角 For cooling blood and stopping bleeding
TCMBANKHE008503 Radix Sophorae flavescentis 苦参 To remove heat and damp, to kill parasites, and to cause diuresis./Arrhythmia, otitis media, acute conjunctivitis, chronic conjunctivitis, trichomoniasis, septicemia, edema, damp-heat diarrhea, intestinal wind bleeding, acute jaundice, inhibited urination, vaginal discharge, pudendal itch, scab and lichen, leprosy, itchy skin, eczema, damp toxin sore, suppurative nest sore.
TCMBANKHE003980/YEM-928 Aconitum carmichaeli|Aconitum carmichaeli Debx. 乌头 乌头 云南民族药物志:第五卷 To dispel wind and eliminate damp, warm channels, dissipate cold and relieve pain./Wind-cold-damp impediment, pain in joints, numbness in limbs, hemiplegia, head wind headache, cold pain in heart and abdomen, cold mounting with pain, stasis pain from knocks and falls, swelling toxin of flat abscess. 阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE008328/YEM-99 Sophora flavescens [Syn. Sophora angustfolia]|Sophora flavescens Ait. 苦参实|苦参 苦参 云南民族药物志:第一卷 To clear heat and resolve toxin, free stool, kill worms./Acute bacillary dysentery, constipation, ascariasis. 阿昌族/白族/傣族/德昂族/景颇族/傈僳族/彝族
TCMBANKHE006936/YEM-99 Sophora flavescens [Syn. Sophora angustfolia]|Sophora flavescens Ait. 苦参实|苦参 苦参 云南民族药物志:第一卷 To clear heat and resolve toxin, free stool, kill worms./Acute bacillary dysentery, constipation, ascariasis. 阿昌族/白族/傣族/德昂族/景颇族/傈僳族/彝族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000067 Head and Neck Neoplasms group Neoplasms 28571917
TCMBANKDI015496 Liver neoplasms group Digestive System Diseases; Neoplasms 26945965

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000053 NFKB1 CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB nuclear factor kappa B subunit 1
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000911 ITK EMT; LPFS1; LYK; PSCTK2 IL2 inducible T cell kinase
TCMBANKGE001102 MIR21 MIRN21; hsa-mir-21; miR-21; miRNA21 microRNA 21
TCMBANKGE001117 PTEN 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; TEP1 phosphatase and tensin homolog
TCMBANKGE001123 CTNNB1 CTNNB; EVR7; MRD19; NEDSDV; armadillo catenin beta 1
TCMBANKGE001181 TGFB1 CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta transforming growth factor beta 1
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14