Compound Summary


  Compound Information

药名:

(-)-anonaine

别名:

C09339; 3,5-DIOXA-11-AZAPENTACYCLO[10.7.1.0(2),?.0?,(2)?.0(1)?,(1)?]ICOSA-1(20),2(6),7,14,16,18-HEXAENE; 1862-41-5; SCHEMBL15800852; 3,5-dioxa-11-azapentacyclo[10.7.1.0;{2,6}.0;{8,20}.0;{14,19}]icosa-1(20),2(6),7,14(19),15,17-hexaene; 1,2-Methylenedioxynoraporphine; Anonaine; J3.604.525F; Anonain; ACon1_001472; NCGC00180471-01; AC1MR46Q; (-)-Annonaine; 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,7-tetrahydro-, (R)-; (+)-Anonaine;anonaine

分子式:

C17H15NO2

Smiles:

C1CNC2CC3=CC=CC=C3C4=C2C1=CC5=C4OCO5

成分:

HBIN016257;HBIN016256

OB_score:

25.140853

CAS_id:

1862-41-5

SymMap_id:

SMIT00753

TCMID_id:

35593;1348

TCMSP_id:

MOL009166

PubChem_id:

160597


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000350 Receptaculum Nelumbinis 莲房 To remove blood stasis and arrest bleeding./Treatment of abnormal uterine bleeding, hematurial hemorrhoidal bleeding, postpartum blood stasis, lochiorrhea.
TCMBANKHE002237 Stamen Nelumbinis 莲须 To astringe the kindey and arrest spontaneous emission./Treatment of seminal emission, spermatorrhea, excessive leukorrhea, frequent urination.
TCMBANKHE002277 荷花
TCMBANKHE002301 莲衣
TCMBANKHE003066 Artabotrys uncinatus
TCMBANKHE003720 herba centellae 积雪草 To remove heat and damp, to counteract toxicity, and to cause subsidence of swelling./Sand qi abdominal pain, summerheat-heat diarrhea, dysentery, damp-heat jaundice, sand strangury, blood strangury, blood ejection, spontaneous external bleeding, red eyes, swollen throat, wind papules, scab and lichen, swelling toxin of clove welling abscess, knocks and falls, hypertension.
TCMBANKHE003730 Gentiana scabra var. buesgeri 龙胆 Acute icterohepatitis, urinary tract infection, acute conjunctivitis, dribbling pain of urination, damp-heat jaundice, genital swelling and itch, damp-heat vaginal discharge, distended head and headache due to liver-gallbladder repletion fire, red eyes with gall, deafness, swelling in ear, pain in rib-side, bitter taste, fright wind and convulsion.
TCMBANKHE004086 Plumula Nelumbinis 莲子心 To remove heat from the heart and calm the nerves, to restore the coordination between the heart and the kidney, to check emission, and to arrest bleeding./Heat entering pericardium, clouded spirit with delirious speech, non-interaction of heart and kidney, insomnia and emission, blood ejection due to blood heat, hypertension.
TCMBANKHE004755 Semen Impatientis 急性子 To remove stagnation of qi, eliminate blood stasis, and soften hard masses./Concretion and conglomeration, lump glomus, amenorrhea, dysphagia-occlusion.
TCMBANKHE004791 Herba Spirodelae 浮萍 To dispel wind-heat, to promote eruption, and to cause diuresis./Wind-heat exterior syndrome, non-eruption of measles, dormant papules with pruritus, edema, dribbling urinary block, sore and lichen, erysipelas, scalds.
TCMBANKHE005020 Annona reticulata 牛心番荔枝 To clear heat and check dysentery, expel worms./Heat toxin dysentery, intestinal parasitic disease.
TCMBANKHE007483 Annona squamosa 番荔枝 To supplement stomach and spleen, clear heat and resolve toxin, kill worms./Malign sore and swelling toxin, intestinal parasitic disease.
TCMBANKHE006761 nodus nelumbinis rhizomatis 藕节 To arrest bleeding and remove blood stasis./Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding.
TCMBANKHE007734 Fructus Tribuli 蒺藜 To subdue hyperactivity of the liver, to promote blood circulation, to dispel wind, to clear the eye of opacity, and to arrest itching./1. Antitussive, expectorant and antiasthmatic. 2. Its alcoholic infusion exerts hypotensive effect in anesthetized animals.
TCMBANKHE008259/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 荷梗|莲 云南民族药物志:第一卷 To dispel summerheat, rectify qi and transform damp./Summerheat-damp and oppression in chest, diarrhea, dysentery, strangury, Vaginal discharge. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE006652/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 莲子|莲 云南民族药物志:第一卷 To supplement spleen and check diarrhea, boost kidney and secure essence, nourish heart and quiet spirit./Chronic diarrhea, inappetence, emission, restlessness, fright palpitation, insomnia, flooding and spotting, excessive leukorrhea. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005257/YEM-104 Folium Nelumbinis|Nelumbo nucifera Gaertn. 荷叶|莲 云南民族药物志:第一卷 To relieve summer-heat, to invigorate the spleen function of the spleen and arrest bleeding by reducing heat in blood./Summerheat-heat vexation and thirst, summerheat-damp diarrhea, spleen vacuity diarrhea, blood heat, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005111/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 荷叶蒂|莲 云南民族药物志:第一卷 To clear summerheat and eliminate damp, dispel stasis and stanch bleeding, quiet fetus./Summerheat-damp diarrhea, blood dysentery, flooding and spotting, stirring fetus in pregnancy. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE007683/YEM-104 Nelumbo nucifera|Nelumbo nucifera Gaertn. 藕|莲 云南民族药物志:第一卷 To clear heat and engender liquid, cool blood, stanch bleeding and dissipate stasis./Febrile diseases with vexation and thirst, blood ejection, spontaneous external bleeding, precipitate blood. 阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE005228/YEM-235 Cortex Magnoliae officilis;Magnolia officinalis|Magnolia officinalis Rehd.et Wils. 厚朴 厚朴 云南民族药物志:第二卷 To eliminate damp and relieve distension;To dry damp and disperse phlegm, precipitate qi and eliminate fullness, lower blood pressure./1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate.5.Amebic dysentery, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distention and constipation, phlegm-rheum cough asthma. 彝族
TCMBANKHE003733/YEM-396 Melia azedarach 莲花|棟 苦棟皮 云南民族药物志:第二卷 To clear heat and dispel damp, kill worms and relieve itch./Prickly heat. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/普米族/佤族/瑶族/彝族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE000965 CHRNA7 CHRNA7-2; NACHRA7 cholinergic receptor nicotinic alpha 7 subunit
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001139 SLC6A12 BGT-1; BGT1; GAT2 solute carrier family 6 member 12
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001293 SLC6A19 B0AT1; HND solute carrier family 6 member 19
TCMBANKGE001506 ADRA1B ADRA1; ALPHA1BAR adrenoceptor alpha 1B
TCMBANKGE001943 ADRA1D ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 adrenoceptor alpha 1D
TCMBANKGE002677 SLC6A8 CCDS1; CRT; CRTR; CT1; CTR5 solute carrier family 6 member 8
TCMBANKGE002699 TH DYT14; DYT5b; TYH tyrosine hydroxylase
TCMBANKGE003625 SLC6A4 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT solute carrier family 6 member 4
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE005535 CHRM1 HM1; M1; M1R cholinergic receptor muscarinic 1
TCMBANKGE006364 SLC6A1 GABATHG; GABATR; GAT1; MAE solute carrier family 6 member 1
TCMBANKGE006943 CHRM3 EGBRS; HM3; PBS cholinergic receptor muscarinic 3
TCMBANKGE007362 SLC6A11 GAT-3; GAT3; GAT4 solute carrier family 6 member 11
TCMBANKGE007648 SLC6A5 GLYT-2; GLYT2; HKPX3; NET1 solute carrier family 6 member 5
TCMBANKGE007935 SLC6A13 GAT-2; GAT2; GAT3 solute carrier family 6 member 13
TCMBANKGE008487 SLC6A7 PROT solute carrier family 6 member 7
TCMBANKGE008702 OPRM1 LMOR; M-OR-1; MOP; MOR; MOR1; OPRM opioid receptor mu 1
TCMBANKGE008921 RXRA NR2B1 retinoid X receptor alpha
TCMBANKGE009056 SLC6A15 NTT73; SBAT1; V7-3; hv7-3 solute carrier family 6 member 15
TCMBANKGE009256 SLC6A2 NAT1; NET; NET1; SLC6A5 solute carrier family 6 member 2
TCMBANKGE009294 HTR3A 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3 5-hydroxytryptamine receptor 3A
TCMBANKGE009455 CHRM5 HM5 cholinergic receptor muscarinic 5
TCMBANKGE011363 DDC AADC dopa decarboxylase
TCMBANKGE011487 SLC6A16 NT5; NTT5 solute carrier family 6 member 16
TCMBANKGE011852 SLC6A17 MRT48; NTT4 solute carrier family 6 member 17
TCMBANKGE012155 SLC6A3 DAT; DAT1; PKDYS; PKDYS1 solute carrier family 6 member 3
TCMBANKGE013548 SLC6A18 Xtrp2 solute carrier family 6 member 18
TCMBANKGE014515 SLC6A9 GCENSG; GLYT1 solute carrier family 6 member 9
TCMBANKGE014625 OPRD1 DOP; DOR; DOR1; OPRD opioid receptor delta 1
TCMBANKGE014810 SLC6A20 SIT1; XT3; Xtrp3 solute carrier family 6 member 20