Compound Summary

  Compound Information

TCMBANKIN058739

药名:	crocetin
别名:	2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (all-E)- (8CI); C08588; (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate; AIDS-073359; 2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-;.alpha.-Crocetin; 8,8'-diapo-8,8'-carotenedioate; 8,8'-diapo-psi,psi-carotenedioate; AIDS073359; 2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-,(all-E)-; Crocetin; 27876-94-4; crocetin(2-); 8,8'-Diapocarotenedioic acid; NCI60_003871; 2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid; LMPR01070223; CHEBI:62767; (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid; 8,8'-Diapo-psi,psi-carotenedioic acid; EINECS 248-708-0; CCRIS 7484; Natural yellow 6; NSC 407300; CI 75100; 8,8'-diapocarotene-8,8'-dioate; 8,8'-diapocarotenedioate; crocetin dianion; α-crocetin
分子式:	C20H24O4
Smiles:	CC(=CC=CC=C(C)C=CC=C(C)C(=O)O)C=CC=C(C)C(=O)O
成分:	HBIN021703; HBIN015466
OB_score:	35.296366
CAS_id:	27876-94-4
SymMap_id:	SMIT00101; SMIT14798
TCMID_id:	23021; 4244
TCMSP_id:	MOL001406
PubChem_id:	5281232

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000372	Siegesbeckia orientalis	希莶			To dispel wind-damp, free channels and network vessels, clear heat and resolve toxin./Wind-damp impediment pain, lassitude in lumbus and knees, hemiplegia, hypertension, malaria, jaundice, swelling toxin of welling abscess and sore, wind papules, damp sore, animal and insect bites.
TCMBANKHE000799		水栀根
TCMBANKHE001408		栀子花
TCMBANKHE001458		重瓣栀子
TCMBANKHE002173	Stigma Croci	西红花			To activate blood circulation and eliminate blood stasis, to remove heat from blood and counteract toxicity, and to calm the nerves./Treatment of amenrrhea with abdominal mass formation, blood stasis after childbirth, eruptions in infectious diseases, emotional dejection, mania.
TCMBANKHE002659	Concretio Silicea Bambusae	天竺黄			For desolving phlegm
TCMBANKHE004376	Pericarpium Grati	石榴皮			To check diarrhea, arrest bleeding and repel worms./Chronic diarrhea, chronic dysentery, hematochezia, prolapse of rectum, flooding and spotting, leukorrhea, abdominal pain due to worm accumulation.
TCMBANKHE004561	Crocus sativus	臧红花			To quicken blood and transform stasis, dissipate depression and open binds./Anxiety and depression, glomus and oppression in chest and diaphragm, blood ejection, cold damage mania, fright palpitation, amenorrhea, postpartum blood stasis abdominal pain, painful swelling from knocks and falls.
TCMBANKHE009190	Fructus Mori	桑椹			To nourish n and blood and promote the production of body fluid./Its contains sugar, organic acid , vitamins B1, B2 and C and carotene. Its oleum contains oleic acid and linoleic acid.
TCMBANKHE007462		青风藤			Wind-damp impediment pain, pain from arthritis, swelling in joints, paralytic and pruritus.
TCMBANKHE007098	Fructus Gardeniae	栀子;生山栀			1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness;4.Treatment of febrile diseases with restlessness, jaundice with dark urine, hematuria with difficult painful urination, hemoptysis and epistaxis caused by heat in the blood, inflammation of the eye, boils and sores, external use for sprains and bruises.Fructus Gardeniae (charred): Hemoptysis, epistaxis, hematuria and abnormal uterine bleeding caused by heat in the blood./Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria.1. The active components such as crocin, crocetin, genipin, or alcoholic extract protect the liver from carbon tetrachloride and increasing biliary secretion. Oral use of its decoction induce gallbladder contraction.2. Oral or intraperitoneal use of its decoction and alcoholic extract exerts a sustained hypotensive effect in anaesthetized and un-anaesthetized animals.3. Hemostatic.
TCMBANKHE006205/YEM-166	Crotalaria albida|Crotalaria albida Heyne ex Roth	黄花地丁|响铃豆	响铃豆	云南民族药物志：第一卷	To drain lung and disperse phlegm, clear heat and disinhibit damp, resolve toxin and disperse swelling./Cough and asthma with abundant phlegm, damp-heat diarrhea dysentery, jaundice, dribbling pain of urination, insomnia and vexation, mammary welling abscess, swelling toxin of welling abscess and sore.	阿昌族/白族/傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/傈僳族/佤族/彝族
TCMBANKHE002101/YEM-745/XU-411	Gardenia jasminoides(L.)Ellis|Gardenia jasminoides	栀子花根|栀子	栀子	云南民族药物志：第四卷|广东省廉江市石岭镇		阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE005522/YEM-745/XU-411	Fructus Gardeniae|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides	栀子	栀子	云南民族药物志：第四卷|广东省廉江市石岭镇	1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness/Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria.	阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE008669/YEM-745/XU-411	Gardenia jasminoides [Syn. Gardenia florida ]|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides	栀子叶|栀子	栀子	云南民族药物志：第四卷|广东省廉江市石岭镇	To disperse swelling and resolve toxin, dispel wind and relieve pain./Knocks and falls, toxin of clove sore, hemorrhoids, chancre.	阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE006865/YEM-745/XU-411	Gardenia jasminoides var. grandiflora|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides	水蛭|栀子	栀子	云南民族药物志：第四卷|广东省廉江市石岭镇	To clear heat and resolve toxin, disperse swelling and relieve pain./Heat toxin, jaundice, nosebleed(epistaxis), nephritis with edema, sprain and contusion.	阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE004701/YEM-745/XU-411	Gardenia jasminoides var. grandiflora|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides	水栀叶|栀子	栀子	云南民族药物志：第四卷|广东省廉江市石岭镇	To disperse swelling./Knocks and falls.	阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI010126

Myopia

disease

Eye Diseases

31394821

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000476	NCOA2	GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75	nuclear receptor coactivator 2
TCMBANKGE000479	TIMP1	CLGI; EPA; EPO; HCI; TIMP; TIMP-1	TIMP metallopeptidase inhibitor 1
TCMBANKGE000712	COL1A1	CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4	collagen type I alpha 1 chain
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000787	VCAM1	CD106; INCAM-100	vascular cell adhesion molecule 1
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001085	MAPK8	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c	mitogen-activated protein kinase 8
TCMBANKGE001177	TP53	BCC7; BMFS5; LFS1; P53; TRP53	tumor protein p53
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE003157	CHRM2	HM2	cholinergic receptor muscarinic 2
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE011544	IGHG1	-	immunoglobulin heavy constant gamma 1 (G1m marker)
TCMBANKGE014050	GABRA1	ECA4; EIEE19; EJM; EJM5	gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014423	ADRA1A	ADRA1C; ADRA1L1; ALPHA1AAR	adrenoceptor alpha 1A