Compound Summary
Compound Information
药名: | α-ecdysone |
别名: | ecdysone;Hydroxyecdysone; UNII-779A7KPL0Y; CHEMBL224128; 779A7KPL0Y; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; MolPort-002-507-287; A,22,25-Hexahydroxy-7-cholesten-6-one; LMST01010209; .beta-Ecdysterone; henanthren-6-one; MCULE-9660893096; 20-OH ecdysone; MLS001164644; 20E; BG00831842; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(1R,2R)-1,2,5-trihydroxy-1,5-dimethyl-hexyl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; CTK8E9736; AC1NUSFS; beta-ECDYSTERONE; AB3000033; 20-HYDROXYECDYSONE; Isoinokosterone; AKOS004120029; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-((2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]p; A,20; (2beta,3beta,5beta,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; DTXSID5040388; Crustecdysone; Crustecdyson; Ecdysterone; N1350; MFCD00036740; Insect moulting hormone; SCHEMBL22086; V0682; (2S,3R,5R,9R,10R,13R,14S,17S)-10,13-dimethyl-17-[(2R,3R)-6-methyl-2,3,6-tris(oxidanyl)heptan-2-yl]-2,3,14-tris(oxidanyl)-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one; 20-Hydroxyecdysone, >=93% (HPLC), powder; NKDFYOWSKOHCCO-YPVLXUMRSA-N; 20-E; (22R)-2beta,3beta,14alpha,20,22,25-hexahydroxy-5beta-cholest-7-en-6-one; 5289-74-7; CH0034; 137704-EP2374792A1; A829299; beta-Ecdysone; 20-Hydroxyecdyson; BB_NC-1013; BG01762865; Q-201054; A,3; Viticosterone; MLS002207226; Ecdysteron; A,22,25-Hexahydroxy-7-cholesten-6-one;Ecdysterone;Insect moulting hormone;Polypodine A; Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2b,3b,5b,22R)-; A,14; (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-((2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one; AC-19603; C27H44O7; 2beta,3beta,14alpha,20beta,22,25-Hexahydroxy-7-cholesten-6-one; 20-Hydroxy-a-ecdysone; TR-018728; THE-7; Polypodine A; b-Ecdysone; BDBM50326777; (2Beta,3beta,5beta)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; 2beta,3beta,14alpha,20,22R,25-hexahydroxy-5beta-cholest-7-en-6-one; ZINC238809241; 20-Hydroxyecdysone;2; HMS2230L09; Commisterone; 2,3,14-Trihydroxy-10,13-dimethyl-17-(1,2,5-trihydroxy-1,5-dimethyl-hexyl)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-6-one; s2417; SMR000539832; 289E747; CHEBI:16587 |
分子式: | C27H44O6 |
Smiles: | CC(C1CCC2(C1(CCC3C2=CC(=O)C4C3(CC(C(C4)O)O)C)C)O)C(CCC(C)(C)O)O |
成分: | HBIN015501;HBIN024784 |
SymMap_id: | SMIT01390 |
TCMID_id: | 39994;6677 |
PubChem_id: | 19212 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE003647 | Polypodium vulgare | To clear heat, resolve toxin and disinhibit damp./Damp-heat strangury pain, wind-damp-heat impediment, swollen welling abscess, sore and boil, wind papule itching, knocks and falls. | ||||
| TCMBANKHE003757 | Matteuccia struthiopteris | 小叶贯众 | To clear heat and resolve toxin, kill worms, stanch bleeding./Febrile diseases macular eruption, parotitis, damp-heat sore toxin, abdominal pain due to ascariasis, oxyuria disease, red dysentery and bloody stool, hematuria, blood ejection, spontaneous external bleeding, flooding and spotting [=metrorrhagia and metrostaxis]. | |||
| TCMBANKHE003911 | Folium Sene | 番泻叶 | To purge feces downward/Heat bind and accumulation, constipation w ith abdominal pain, edema distention fullness. | |||
| TCMBANKHE004952 | Lemmaphyllum microphyllum | 螺厣草 | To clear lung and relieve cough, cool blood and stanch bleeding, clear heat and resolve toxin./Lung heat cough, pulmonary welling abscess, hemoptysis, blood ejection, spontaneous external bleeding, hematuria, hematochezia, flooding and spotting, swelling pain in throat, parotitis, dysentery, scrofula, swelling toxin of welling abscess and sore, damp itchy skin, wind-fire toothache, wind-damp bone pain. | |||
| TCMBANKHE005177 | Pteridium aquilinum | 欧洲蕨 | ||||
| TCMBANKHE007439 | Bombyx mori | 白僵蚕 | To dispel wind and resolve tetany, transform phlegm and dissipate binds, resolve toxin and disinhibit throat./Epilepsy, fright wind and convulsion, swelling pain in throat, acute infection of upper respiratory tract, epidemic parotitis, diabetes mellitus, temporomandibular lymphrnoditis, facial paralysis, itchy skin. | |||
| TCMBANKHE005577 | Lychnis fulgens | 大花剪秋罗 | To clear heat and disinhibit urine, fortify spleen, quiet spirit./Inhibited urination, child gan accumulation, night sweating, headache, insomnia. | |||
| TCMBANKHE007643 | Vinca minor | 蔓长春花 | ||||
| TCMBANKHE005747 | Blechnum minus | 小乌毛蕨 | ||||
| TCMBANKHE008355 | Polypodium niponicum | 水龙骨 | To clear heat and disinhibit damp, quicken blood and free network vessels./Opacity of urine, diarrhea, strangury, wind-damp impediment pain, knocks and falls. | |||
| TCMBANKHE008310 | Cortex Eucommiae | 杜仲 | To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy. | |||
| TCMBANKHE007018 | Bombyx mori | 原蚕蛾 | To supplement kidney and invigorate yang , rough essence, stanch bleeding, resolve toxin and disperse swelling./Impotence and emission, white turbidity, blood strangury, incised wound and bleeding, swelling pain in throat, mouth and tongue sores, swelling toxin of welling abscess and sore, frostbite, snake bite. | |||
| TCMBANKHE000209/YEM-208 | Osmunda japonica|Osmunda japonica Thunb. | 紫箕 | 紫箕贯众 | 云南民族药物志：第一卷 | To clear heat and resolve toxin, dispel stasis and stanch bleeding, kill worms./Influenza, epidemic encephalitis, parotitis, swelling toxin of welling abscess and sore, measles papules, varicella, dysentery, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting, vaginal discharge, intestinal parasitic disease. | 傈僳族 |
| TCMBANKHE004110/YEM-208 | Rhizoma Dryopteris crassirhizomae|Osmunda japonica Thunb. | 贯众|紫箕 | 紫箕贯众 | 云南民族药物志：第一卷 | 1. To clear heat and toxic material. For preventing and treating pestilence and seasonal febrile diseases, such as influenza, epidemic cerebrospinal meningitis, mumps, measles, etc., also for viral pneumonia. 2. To cool the blood nad stop bleeding. For profuse uterine bleeding due to blood-heat, hematemesis, epistaxis, hemafacia, eruptive diseases, etc.3. To kill parasites/1.Antivirotic and bacteriostatic. 2. Parasiticidal effect on hookworm, roundworm and whipworm, etc. in human, and its component filmarone, on tapeworm. 3. Its decoction shortens the blood clotting time in rabbits. 4. Its extract exerts an abortive effect. | 傈僳族 |
| TCMBANKHE008167/YEM-39/XU-672 | Cortex Eucommiae|Eucommia ulmoides Oliv.|Eucommia ulmoides | 杜仲 | 杜仲 | 云南民族药物志：第一卷|贵州省岑巩县平庄镇师兆村 | To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy. | 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族 |
| TCMBANKHE005834/YEM-597/YEM-808 | Paris polyphylla var. yunnanensis|Paris polyphylla Smith var.chinensis(Franch.)Hara | 云南重楼|七叶一枝花 | 华重楼 | 云南民族药物志：第四卷 | See Paris polyphylla ./See Paris polyphylla . | 阿昌族/傣族/德昂族/景颇族/傈僳族/佤族/瑶族/彝族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI000048 | Neoplasms | group | Neoplasms | 30120247 |
| TCMBANKDI003353 | Carcinogenesis | phenotype | Pathological Conditions, Signs and Symptoms; Neoplasms | 30120247 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000246 | FOXO1 | FKH1; FKHR; FOXO1A | forkhead box O1 |
| TCMBANKGE000295 | FOXO3 | AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A | forkhead box O3 |
| TCMBANKGE000669 | LAS1L | Las1; Las1-like; WTS; dJ475B7.2 | LAS1 like ribosome biogenesis factor |
| TCMBANKGE000670 | HDAC8 | CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6; RPD3; WTS | histone deacetylase 8 |
| TCMBANKGE000671 | SLCO1A2 | OATP; OATP-A; OATP1A2; SLC21A3 | solute carrier organic anion transporter family member 1A2 |
| TCMBANKGE001059 | LATS1 | WARTS; wts | large tumor suppressor kinase 1 |
| TCMBANKGE001060 | YAP1 | COB1; YAP; YAP2; YAP65; YKI | Yes1 associated transcriptional regulator |
| TCMBANKGE001083 | MAP3K5 | ASK1; MAPKKK5; MEKK5 | mitogen-activated protein kinase kinase kinase 5 |
| TCMBANKGE001085 | MAPK8 | JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c | mitogen-activated protein kinase 8 |
| TCMBANKGE005603 | PTGFR | FP | prostaglandin F receptor |
滇ICP备16009434号-1 |
Dai SX Lab