Compound Summary

  Compound Information

TCMBANKIN059700

药名:	Withaferine
分子式:	C28H38O6
Smiles:	CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO
成分:	HBIN048301;HBIN048300
OB_score:	33.138283
CAS_id:	5119-48-2
SymMap_id:	SMIT05683;SMIT18226
TCMID_id:	22684
TCMSP_id:	MOL003644
PubChem_id:	265237

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE005727		南鹤虱
TCMBANKHE004344		南鹤虱			Ascariasis, oxyuria disease, taeniasis, ancylostomiasis, abdominal pain due to worm accumulation, child gan accumulation, pudendal itch.
TCMBANKHE004838	Radix Sophorae Tonkinensis	山豆根			To remove toxic heat, promote the subsidence of swelling, and soothe the sore throat./Septicemia, ulcer of uterine cervix, chronic cervicitis, bacillary dysentery, enteritis, hydatid moles, chorioblastoma, asthma, chronic bronchitis, acute tonsillitis, laryngitis, accumulated fire toxin, swelling pain in throat, gingiva painful swelling.
TCMBANKHE006426	Flos Daturae	洋金花			To relieve asthma and cough, to alleviate pain, and to arrest spasm./Cough and asthma without phlegm, cold pain in heart and Datura stramonium .
TCMBANKHE008395	Withania somnifera	催眠睡茄
TCMBANKHE004016/XU-43	Solanum torvum|Solanum torvum Swartz	水茄		云南省丽江市宁蒗彝族自治县阿海水电站附近	To quicken blood, dissipate stasis and relieve pain./painful wound from knocks and falls, taxation damage in lumbar muscle, sand, stomachache, clove sore, swollen welling abscess.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000018	Pancreatic Neoplasm	disease	Digestive System Diseases; Neoplasms; Endocrine System Diseases	25444914
TCMBANKDI000022	Prostatic Neoplasms	group	Neoplasms; Male Urogenital Diseases	26913603
TCMBANKDI000048	Neoplasms	group	Neoplasms	28425984
TCMBANKDI000052	Osteoporosis	disease	Nutritional and Metabolic Diseases; Musculoskeletal Diseases	23969857
TCMBANKDI000075	Diabetes	disease	Endocrine System Diseases	23969857
TCMBANKDI000085	Inflammation	phenotype	Pathological Conditions, Signs and Symptoms	27250656
TCMBANKDI000088	Lung Neoplasms	group	Neoplasms; Respiratory Tract Diseases	30696468
TCMBANKDI002628	Pancreatitis, Chronic	disease	Digestive System Diseases	27418337
TCMBANKDI011552	Kidney Diseases	group	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	27250656
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	30696468
TCMBANKDI013656	Glucose tolerance test	phenotype	-	23318585
TCMBANKDI015496	Liver neoplasms	group	Digestive System Diseases; Neoplasms	30696468
TCMBANKDI017288	Amyotrophic Lateral Sclerosis	disease	Nutritional and Metabolic Diseases; Nervous System Diseases	25404049
TCMBANKDI018581	Gliosis	phenotype	Pathological Conditions, Signs and Symptoms	27685630
TCMBANKDI022179	Longevity	phenotype	-	25404049
TCMBANKDI024232	Pancreatitis	disease	Digestive System Diseases	27418337
TCMBANKDI024649	Neuroblastoma	disease	Neoplasms	29939160
TCMBANKDI026275	Glioblastoma	disease	Neoplasms	31642559

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000241	CASP8	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5	caspase 8
TCMBANKGE000403	ATF2	CRE-BP1; CREB-2; CREB2; HB16; TREB7	activating transcription factor 2
TCMBANKGE000644	TNFRSF1A	CD120a; FPF; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; p55; p55-R; p60	TNF receptor superfamily member 1A
TCMBANKGE000715	BID	FP497	BH3 interacting domain death agonist
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000797	HSPB1	CMT2F; HEL-S-102; HMN2B; HS.76067; HSP27; HSP28; Hsp25; SRP27	heat shock protein family B (small) member 1
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001132	BAX	BCL2L4	BCL2 associated X, apoptosis regulator
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001184	RELA	CMCU; NFKB3; p65	RELA proto-oncogene, NF-kB subunit
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor