Compound Summary


  Compound Information

药名:

germacrone

分子式:

C15H22O

Smiles:

CC1=CCC(=C(C)C)C(=O)CC(=CCC1)C

成分:

HBIN027574; HBIN027572

OB_score:

20.308601; 32.496007

CAS_id:

6902-91-6

SymMap_id:

SMIT00095; SMIT03409

TCMID_id:

33450; 33451;23833

TCMSP_id:

MOL001163; MOL010729; MOL000910

PubChem_id:

6436348


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000105 墓头回
TCMBANKHE000214 Rhizoma Curcumae 莪术 To promote the flow of qi and eliminate blood stasis with strong effect, and to relieve pain by removing the stagnation of undigested food./1. Its volatile oil and its components curcumenol, curdione and B-elemene destroy directly the Ehrlich-Ascites tumor and leukemia615 in mice. 2. Promoting phagocytosis of monocytes. 3. Dilating peripheral blood vessels, inhibiting aggregation of thrombocytes and thrombosis, and improving microcirculation.
TCMBANKHE000404 Herba Gueldenstaedtiae Multiflorae 甜地丁
TCMBANKHE003724 Rhizoma Curcumae longae 姜黄 To eliminate blood stasis, promote the flow of qi, stimulate menstrual discharge and relieve pain./Gallstones, jaundice, leukaemia in early stage and carcinoma of uterine cervix in early stage, chronic ulcer, chronic scab, blood stasis and qi stagnation, pain in chest and abdomen and rib-side, dysmenorrhea, amenorrhea, postpartum stasis stagnation abdominal pain, wind-heat impediment pain, knocks and falls, swollen welling abscess.
TCMBANKHE003725 Rhizoma Zingiberis Recens 生姜 To induce perspiration and dispel cold, to warm the stomach and arret vomiting, and to resolve phlegm and relieve cough./Wind-cold common cold, fever and aversion to wind, headache and nasal congestion, vomiting, phlegm-rheum cough asthma, distention fullness, diarrhea.
TCMBANKHE003952 Folium Rhododendri Daurici 满山红 Acute bronchitis, chronic bronchitis.
TCMBANKHE004319 Herba ErodiiHerba Geranii 老鹳草 To remove obstruction of channels and collaterals, relieve rheumatic conditions, and arrest diarrhea./Wind-damp impediment pain, hypertonicity and numbness, aching sinews and bones, diarrhea and dysentery.
TCMBANKHE007098 Fructus Gardeniae 栀子;生山栀 1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness;4.Treatment of febrile diseases with restlessness, jaundice with dark urine, hematuria with difficult painful urination, hemoptysis and epistaxis caused by heat in the blood, inflammation of the eye, boils and sores, external use for sprains and bruises.Fructus Gardeniae (charred): Hemoptysis, epistaxis, hematuria and abnormal uterine bleeding caused by heat in the blood./Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria.1. The active components such as crocin, crocetin, genipin, or alcoholic extract protect the liver from carbon tetrachloride and increasing biliary secretion. Oral use of its decoction induce gallbladder contraction.2. Oral or intraperitoneal use of its decoction and alcoholic extract exerts a sustained hypotensive effect in anaesthetized and un-anaesthetized animals.3. Hemostatic.
TCMBANKHE004623 Rhododendron mucronulatum 迎山红 To resolve exterior, relieve cough and transform phlegm./Common cold, cough and asthma, abundant phlegm.
TCMBANKHE005005 Rhizoma Curcumae 广西莪术 Treatment of mass in the abdomen, amenorrhea due to blood stasis, distension and pain due to stagnation of undigested food, carcinoma of cervix at early stage./Treatment of mass in the abdomen, amenorrhea due to blood stasis, distension and pain due to stagnation of undigested food, carcinoma of cervix at early stage.
TCMBANKHE005139 Radix Angelicae Dahuricae 白芷 To dispel wind, to remove damp, to clear the stuffed nose, to relieve pain, and to promote the subsidence ofswelling and drainage of pus./Wind-cold common cold, nasal congestion, headache (especially in forehead and superciliary region), toothache, infections, acute mastitis, sores, excessive leukorrhea, stomachache.
TCMBANKHE005431 Flos Rosae Rugosae 玫瑰花 To relieve stagnation of qi, regulate blood circulation, and to arrest pain./Liver stomach qi pain, reduced food intake with nausea and vomiting, menstrual disorder, painful wound from knocks and falls.
TCMBANKHE005480 Rhododendron mucronulatum 映山红 To resolve exterior, relieve cough and transform phlegm./Common cold, cough and asthma, abundant phlegm.
TCMBANKHE006133 紫苏 Phlegm congestion and qi counterflow, cough and asthma, intestinal dry and constipation.
TCMBANKHE007520 Fructus Amomi 砂仁 To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy.
TCMBANKHE007795 Herba Selaginellae 卷柏 To promote blood circulation and to stimulate menstrual discharge.Herba Selaginellae (carbonized) To remove blood stasis and to arrest bleeding./Amenorrhea, concretion and conglomeration, knocks and falls, abdominal pain, asthma (raw), blood ejection, hematuria, hematochezia, prolapse of rectum (scorch-fry).
TCMBANKHE000590/XU-724 Curcuma zedoaria [Syn. Curcuma aeruginosa]|Curcuma zedoaria 莪术 广西省贵港市平南县 To break blood and dispel stasis, move qi and relieve pain, anticancer./Amenorrhea and dysmenorrhea, concretion conglomeration accumulation and gathering, food accumulation, distending pain in stomach duct and abdomen, indigestion, carcinoma of ovary, carcinoma of skin, genital carcinoma, malignant lymphoma, primary hepatoma, carcinoma of thyroid, carcinoma of stomach, carcinoma of lung.
TCMBANKHE007889 杜仲叶 Lumbar and back pain, limp aching inability of legs and knees, hypertension.
TCMBANKHE008098 Radix Curcumae 郁金 1. To invigorate blood and stop pain; 2. To promote qi circulation and release stagnation; 3. To cool blood and clear heat in the heart; 4. To relieve jaundice and facilitate gall bladder function/See Curcuma longa.
TCMBANKHE009030 Resi myrrhae;Myrrha 没药 1. To invigorate blood and stop pain; 2. To reduce swelling and promote healing/Stasis pain in chest and abdomen, amenorrhea, dysmenorrhea, concretion and conglomeration, knocks and falls, swollen welling abscess and sores, intestinal welling abscess, red eyes with gall.
TCMBANKHE005495/XU-730 Radix Euphorbiae Pekinensis|Euphorbia pekinensis 京大戟|大戟 陕西省安康市旬阳县 To cause drastic purgation./Treatment of anasarca, hydrothorax and ascites with dyspnea, constipation and oliguria.
TCMBANKHE005522/YEM-745/XU-411 Fructus Gardeniae|Gardenia jasminoides(L.)Ellis|Gardenia jasminoides 栀子 栀子 云南民族药物志:第四卷|广东省廉江市石岭镇 1. To clear heat and reduce fire; 2. To cool blood and release toxins; 3. To eliminate dampness/Acute icterohepatitis, febrile diseases, vexation, melancholia, restlessness, stagnation of damp-heat in liver and gall, fever, jaundice, short voidings of reddish urine, blood ejection, spontaneous external bleeding, dysentery with hematochezia and hematuria. 阿昌族/布依族/傣族/德昂族/景颇族/傈僳族/苗族/水族/瑶族/彝族/壮族
TCMBANKHE004691/YEM-353/YEM-961 Fructus Amomi|Amomum villosum Lour. 缩砂仁; 砂仁|阳春砂 阳春砂仁 云南民族药物志:第五卷 Treatment of accumulation of damp in the spleen and the stomach marked by epigastric stuffieness and anorexia, vomiting and diarrhea in deficiency cold syndrome of the spleen and the stomach, pernicious vomiting of pregnancy, threatened abortion.; To eliminate damp and improve appetite, to warm the spleen and check diarrhea, and to prevent abortion./1. Its decoction lower thab 1% concentration stimulates and that higher than 1% or the saturated solution of its volatile oil inhibits the intestines of guinea-pigs in vitro.2. Its volatile oil acts as stomachic tonic and exaggerates the diacharge of flatus.; Abdominal pain glomus distention, food stagnation in torpid stomach, dysphagia-occlusion, vomiting, cold dysentery, stirring fetus in pregnancy. 阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/瑶族/彝族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000168 NR3C1 GCCR; GCR; GCRST; GR; GRL nuclear receptor subfamily 3 group C member 1
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000221 GRIA2 GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B glutamate ionotropic receptor AMPA type subunit 2
TCMBANKGE000458 CYP2B6 CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450 cytochrome P450 family 2 subfamily B member 6
TCMBANKGE000513 CYP2C19 CPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19 cytochrome P450 family 2 subfamily C member 19
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE001007 NR1I2 BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR nuclear receptor subfamily 1 group I member 2
TCMBANKGE001008 CYP3A4 CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1 cytochrome P450 family 3 subfamily A member 4
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE005535 CHRM1 HM1; M1; M1R cholinergic receptor muscarinic 1
TCMBANKGE009256 SLC6A2 NAT1; NET; NET1; SLC6A5 solute carrier family 6 member 2
TCMBANKGE010277 CYP2D6 CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 cytochrome P450 family 2 subfamily D member 6
TCMBANKGE011031 CYP2C9 CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9 cytochrome P450 family 2 subfamily C member 9
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1
TCMBANKGE014050 GABRA1 ECA4; EIEE19; EJM; EJM5 gamma-aminobutyric acid type A receptor subunit alpha1
TCMBANKGE014941 DPEP1 MBD1; MDP; RDP dipeptidase 1
TCMBANKGE015090 CYP1A2 CP12; CYPIA2; P3-450; P450(PA) cytochrome P450 family 1 subfamily A member 2