Compound Summary

  Compound Information

TCMBANKIN060429

药名:	Cyclopamine
分子式:	C27H41NO2
Smiles:	CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
成分:	HBIN022330;HBIN000389
OB_score:	55.42172
CAS_id:	4449-51-8
SymMap_id:	SMIT10216;SMIT14866
TCMID_id:	4521;30863
TCMSP_id:	MOL009027
PubChem_id:	442972

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE006087	Buibus Fritillariae Pallidiflorae	伊贝母			To remove heat from the lung, to resolve phlegm, and to reduce nodules./Lung heat cough, sticky phlegm and oppression in chest, consumption cough and hemoptysis, scrofula, swollen welling abscess.
TCMBANKHE004399	Veratrum nigrum	藜芦			To promote vomiting, dispel wind and transform phlegm, lower blood pressure, kill worms./Wind stroke with congesting phlegm, epilepsy, malaria, scab and lichen, malign sore.
TCMBANKHE004802	Veratrum album	白藜芦醇; 白藜芦
TCMBANKHE005359	Bulbus Fritillariae Cirrhosae	川贝母			To remove heat, moisten the lung, resolve phlegm and relieve cough./Lung heat cough, dry cough, chronic bronchitis, infection of upper respiratory tract, tuberculosis, gastric ulcer, duodenal ulcer, yin vacuity taxation cough, cough with phlegm and blood.
TCMBANKHE005572	Veratrum californicum	加州藜芦
TCMBANKHE005874		玳玳花			Oppression in chest due to glomus, distending pain in stomach duct and abdomen, vomiting, reduced food intake.
TCMBANKHE007281	Taxus yunnanensis	云南红豆杉
TCMBANKHE008310	Cortex Eucommiae	杜仲			To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy.
TCMBANKHE008167/YEM-39/XU-672	Cortex Eucommiae|Eucommia ulmoides Oliv.|Eucommia ulmoides	杜仲	杜仲	云南民族药物志：第一卷|贵州省岑巩县平庄镇师兆村	To tonify the liver and the kidney, to strengthen the tendons and bones, and to prevent miscarrige./Hypertension, kidney vacuity lumbago, weakness in sinews and bones, stirring fetus in pregnancy.	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000017	Liver Cirrhosis	disease	Pathological Conditions, Signs and Symptoms; Digestive System Diseases	28052321
TCMBANKDI000018	Pancreatic Neoplasm	disease	Digestive System Diseases; Neoplasms; Endocrine System Diseases	23786654
TCMBANKDI000032	Hepatitis C, Chronic	disease	Digestive System Diseases; Infections	21793033
TCMBANKDI000048	Neoplasms	group	Neoplasms	23146903
TCMBANKDI000052	Osteoporosis	disease	Nutritional and Metabolic Diseases; Musculoskeletal Diseases	30352124
TCMBANKDI000083	Infarction, Middle Cerebral Artery	disease	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases	23696546
TCMBANKDI000089	Asthma	disease	Respiratory Tract Diseases; Immune System Diseases	29867080
TCMBANKDI000090	Acute kidney injury	disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	31461626
TCMBANKDI000160	Hypersensitivity	group	Immune System Diseases	29867080
TCMBANKDI001795	Reperfusion Injury	disease	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases	31461626
TCMBANKDI003324	Cholangiocarcinoma	disease	Neoplasms	23703673
TCMBANKDI006869	Necrosis	phenotype	Pathological Conditions, Signs and Symptoms	23172661
TCMBANKDI006871	Hyperplasia	phenotype	Pathological Conditions, Signs and Symptoms	23766265
TCMBANKDI007361	Multiple Myeloma	disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases	23847194
TCMBANKDI007930	Bile Duct Neoplasms	group	Digestive System Diseases; Neoplasms	23703673
TCMBANKDI008386	oligodendroglioma	disease	Neoplasms	23474492
TCMBANKDI011242	Metaplasia	phenotype	Pathological Conditions, Signs and Symptoms	29867080
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	23786654
TCMBANKDI013888	Fibrosis	phenotype	Pathological Conditions, Signs and Symptoms	22302193
TCMBANKDI015452	Thyroid Neoplasm	disease	Neoplasms; Endocrine System Diseases	25078145
TCMBANKDI015496	Liver neoplasms	group	Digestive System Diseases; Neoplasms	21793033
TCMBANKDI020561	Renal fibrosis	disease	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	22302193
TCMBANKDI020745	Neointima	disease	Pathological Conditions, Signs and Symptoms	23766265
TCMBANKDI023109	Neointimal hyperplasia	disease	-	23766265
TCMBANKDI024649	Neuroblastoma	disease	Neoplasms	21803487
TCMBANKDI026694	Adrenocortical carcinoma	disease	Neoplasms; Endocrine System Diseases	24712566

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000202	RUNX2	AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA	RUNX family transcription factor 2
TCMBANKGE000233	DES	CDCD3; CSM1; CSM2; LGMD1D; LGMD1E; LGMD2R	desmin
TCMBANKGE000280	VIM	-	vimentin
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000877	ABCG2	ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1	ATP binding cassette subfamily G member 2 (Junior blood group)
TCMBANKGE000878	MIR7-3HG	C19orf30; Huh7; LINC00306; NCRNA00306; PGSF1; uc002mbe.2	MIR7-3 host gene
TCMBANKGE000879	SERPINE2	GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI	serpin family E member 2
TCMBANKGE000880	Psl1	Tpa	promotion susceptibility QTL 1
TCMBANKGE000881	PLAT	T-PA; TPA	plasminogen activator, tissue type
TCMBANKGE000882	SERPINE1	PAI; PAI-1; PAI1; PLANH1	serpin family E member 1
TCMBANKGE000883	MIR25	MIRN25; hsa-mir-25; miR-25	microRNA 25
TCMBANKGE000884	FN1	CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; SMDCF	fibronectin 1
TCMBANKGE000885	SPP1	BNSP; BSPI; ETA-1; OPN	secreted phosphoprotein 1
TCMBANKGE000886	SOX9	CMD1; CMPD1; SRA1; SRXX2; SRXY10	SRY-box transcription factor 9
TCMBANKGE000887	PPM1D	IDDGIP; JDVS; PP2C-DELTA; WIP1	protein phosphatase, Mg2+/Mn2+ dependent 1D
TCMBANKGE000888	PLK2	SNK; hPlk2; hSNK	polo like kinase 2
TCMBANKGE000889	HFE	HFE1; HH; HLA-H; MVCD7; TFQTL2	homeostatic iron regulator
TCMBANKGE000890	FUT1	H; HH; HSC	fucosyltransferase 1 (H blood group)
TCMBANKGE000891	ABCC3	ABC31; EST90757; MLP2; MOAT-D; MRP3; cMOAT2	ATP binding cassette subfamily C member 3
TCMBANKGE000892	SP7	OI11; OI12; OSX; osterix	Sp7 transcription factor
TCMBANKGE000893	IBSP	BNSP; BSP; BSP-II; SP-II	integrin binding sialoprotein
TCMBANKGE000894	Bglap2	BGP2; Bglap1; Bgp; Og2; mOC-B	bone gamma-carboxyglutamate protein 2
TCMBANKGE000895	SUFU	JBTS32; PRO1280; SUFUH; SUFUXL	SUFU negative regulator of hedgehog signaling
TCMBANKGE000896	SFRP1	FRP; FRP-1; FRP1; FrzA; SARP2	secreted frizzled related protein 1
TCMBANKGE000897	GLI3	ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV	GLI family zinc finger 3
TCMBANKGE000898	MYC	MRTL; MYCC; bHLHe39; c-Myc	MYC proto-oncogene, bHLH transcription factor
TCMBANKGE000899	GLI2	CJS; HPE9; PHS2; THP1; THP2	GLI family zinc finger 2
TCMBANKGE000900	GALNT1	GALNAC-T1	polypeptide N-acetylgalactosaminyltransferase 1
TCMBANKGE000901	ANGPT1	AGP1; AGPT; ANG1	angiopoietin 1
TCMBANKGE000902	HAS2	-	hyaluronan synthase 2
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000904	PTCH1	BCNS; NBCCS; PTC; PTC1; PTCH	patched 1
TCMBANKGE000905	GATA6	-	GATA binding protein 6
TCMBANKGE000906	FOXA2	HNF-3-beta; HNF3B; TCF3B	forkhead box A2
TCMBANKGE000907	SPDEF	PDEF; bA375E1.3	SAM pointed domain containing ETS transcription factor
TCMBANKGE000908	MUC5AC	MUC5; TBM; leB; mucin	mucin 5AC, oligomeric mucus/gel-forming
TCMBANKGE000909	GLI1	GLI; PAPA8; PPD1	GLI family zinc finger 1
TCMBANKGE000910	SLC22A3	EMT; EMTH; OCT3	solute carrier family 22 member 3
TCMBANKGE000911	ITK	EMT; LPFS1; LYK; PSCTK2	IL2 inducible T cell kinase
TCMBANKGE000912	SHH	HHG1; HLP3; HPE3; MCOPCB5; SMMCI; ShhNC; TPT; TPTPS	sonic hedgehog signaling molecule
TCMBANKGE000913	IHH	BDA1; HHG2	Indian hedgehog signaling molecule
TCMBANKGE000914	SMOX	C20orf16; PAO; PAO-1; PAO1; PAOH; PAOH1; SMO	spermine oxidase
TCMBANKGE000915	BMPR2	BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK	bone morphogenetic protein receptor type 2
TCMBANKGE000916	SMO	CRJS; FZD11; Gx; SMOH	smoothened, frizzled class receptor
TCMBANKGE001010	TNFRSF10A	APO2; CD261; DR4; TRAILR-1; TRAILR1	TNF receptor superfamily member 10a
TCMBANKGE001011	TNFSF10	APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL	TNF superfamily member 10
TCMBANKGE001097	HIF1A	HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8; bHLHe78	hypoxia inducible factor 1 subunit alpha
TCMBANKGE001109	ALPP	ALP; ALPI; IAP; PALP; PLAP; PLAP-1	alkaline phosphatase, placental
TCMBANKGE001113	ACTA2	ACTSA	actin alpha 2, smooth muscle
TCMBANKGE001123	CTNNB1	CTNNB; EVR7; MRD19; NEDSDV; armadillo	catenin beta 1
TCMBANKGE001146	SNAI1	SLUGH2; SNA; SNAH; SNAIL; SNAIL1; dJ710H13.1	snail family transcriptional repressor 1
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001172	HSP90AA1	EL52; HEL-S-65p; HSP86; HSP89A; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp103; Hsp89; Hsp90; LAP-2; LAP2	heat shock protein 90 alpha family class A member 1
TCMBANKGE001173	MCL1	BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT	MCL1 apoptosis regulator, BCL2 family member
TCMBANKGE001181	TGFB1	CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta	transforming growth factor beta 1