Compound Summary

  Compound Information

TCMBANKIN060725

药名:	vincaleukoblastine;vinblastine;leurosidine;vincovalinine
分子式:	C46H58N4O9
Smiles:	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
成分:	HBIN047940;HBIN047936;HBIN033029;HBIN047953
CAS_id:	865-21-4
TCMID_id:	32899;22471;12727;34378
PubChem_id:	3823887;133126830;442110
DrugBank_id:	DB00570

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE008165	Vinca erecta	直立长春花
TCMBANKHE004162/YEM-17	Catharanthus roseus|Catharanthus roseus (L.) G.Don	长春花	长春花	云南民族药物志：第一卷	To resolve toxin, clear heat and calm liver, anticancer./Hypertension, swelling toxin of welling abscess and sore, scalds.

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000008	Brain Neoplasms	group	Neoplasms; Nervous System Diseases	27573663
TCMBANKDI000009	Glioma	disease	Neoplasms	22393086
TCMBANKDI000087	Neoplasm Recurrence, Local	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	22393086
TCMBANKDI000088	Lung Neoplasms	group	Neoplasms; Respiratory Tract Diseases	27270426
TCMBANKDI001279	Subarachnoid Hemorrhage	disease	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases	21854561
TCMBANKDI002310	Kidney Neoplasm	disease	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	31702432
TCMBANKDI004662	Neurofibromatosis 1	disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases	27573663
TCMBANKDI005542	Ureteral Neoplasms	group	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases	31702432
TCMBANKDI009080	Alopecia	disease	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases	22371887
TCMBANKDI009582	Neutropenia	disease	Hemic and Lymphatic Diseases	23182987
TCMBANKDI009947	Fibromatosis	disease	Neoplasms	24212959
TCMBANKDI010160	Lung diseases	group	Respiratory Tract Diseases	22371887
TCMBANKDI012424	Neoplasm Invasiveness	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	21502557
TCMBANKDI015496	Liver neoplasms	group	Digestive System Diseases; Neoplasms	23664889
TCMBANKDI015697	Carcinoma, Transitional Cell	disease	Neoplasms	31702432
TCMBANKDI015740	Colorectal Neoplasms	group	Digestive System Diseases; Neoplasms	23664889
TCMBANKDI020657	Gastrointestinal Diseases	group	Digestive System Diseases	22371887
TCMBANKDI023958	Vision Disorders	group	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases	27573663
TCMBANKDI026275	Glioblastoma	disease	Neoplasms	30082792
TCMBANKDI026277	Hemangiosarcoma	disease	Neoplasms	27211551
TCMBANKDI026644	Fatigue	phenotype	Pathological Conditions, Signs and Symptoms	22371887
TCMBANKDI027339	Hodgkin Disease	disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases	30658935
TCMBANKDI028208	Astrocytoma	disease	Neoplasms	27573663

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000264	ABCB1	ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1	ATP binding cassette subfamily B member 1
TCMBANKGE000294	CDKN1A	CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1	cyclin dependent kinase inhibitor 1A
TCMBANKGE000313	JUN	AP-1; AP1; c-Jun; cJUN; p39	Jun proto-oncogene, AP-1 transcription factor subunit
TCMBANKGE000396	TOP1	TOPI	DNA topoisomerase I
TCMBANKGE000898	MYC	MRTL; MYCC; bHLHe39; c-Myc	MYC proto-oncogene, bHLH transcription factor
TCMBANKGE000979	KDR	CD309; FLK1; VEGFR; VEGFR2	kinase insert domain receptor
TCMBANKGE001013	BIRC5	API4; EPR-1	baculoviral IAP repeat containing 5
TCMBANKGE001076	SOD2	GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD	superoxide dismutase 2
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001171	SRC	ASV; SRC1; THC6; c-SRC; p60-Src	SRC proto-oncogene, non-receptor tyrosine kinase
TCMBANKGE003455	ABCA3	ABC-C; ABC3; EST111653; LBM180; SMDP3	ATP binding cassette subfamily A member 3
TCMBANKGE011107	PGP	AUM; G3PP; PGPase	phosphoglycolate phosphatase
TCMBANKGE011670	ATP2C1	ATP2C1A; BCPM; HHD; PMR1; SPCA1; hSPCA1	ATPase secretory pathway Ca2+ transporting 1
TCMBANKGE011697	ABCA2	ABC2; IDPOGSA	ATP binding cassette subfamily A member 2
TCMBANKGE011698	ITGA5	CD49e; FNRA; VLA-5; VLA5A	integrin subunit alpha 5
TCMBANKGE014849	ITGA2	BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2	integrin subunit alpha 2