Compound Summary

  Compound Information

TCMBANKIN060757

药名:	hirsutine
分子式:	C22H28N2O3
Smiles:	CCC1CN2CCC3=C(C2CC1C(=COC)C(=O)OC)NC4=CC=CC=C34
成分:	HBIN029414;HBIN024610
OB_score:	34.440544;32.750656
CAS_id:	7729-23-9
SymMap_id:	SMIT00283;SMIT09753
TCMID_id:	9552
TCMSP_id:	MOL008487;MOL008465
PubChem_id:	3037884

---

   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE000715	Uncaria guianensis	圭亚那钩藤
TCMBANKHE001591	Uncaria attenuata	夏钩藤
TCMBANKHE002833	Uncaria tomentosa	秘鲁钩藤
TCMBANKHE003608	Uncaria nervosa	多买钩藤
TCMBANKHE004610	Ramulus Uncariae cum Uncis	钩藤			To remove heat, subdue hyperactivity of the liver, and arrest convulsions./Infant fright wind and night crying, exuberant heat stirring wind, epilepsy of pregnancy, liver yang dizziness, liver fire headache.
TCMBANKHE007721	Exocarpium Benincasae	冬瓜皮			1. To promote diuresis to relieve edema. 2. To clear summer-heat./Edema, inhibited urination [=dysuria], diarrhea, swelling of sores.
TCMBANKHE006665	Cephalanthus occidentalis	风箱树叶			To clear heat and resolve toxin, contract damp and relieve itch./Itching sore of skin, heaven-borne sore, foot rot, knocks and falls, toothache, dysentery, enteritis.
TCMBANKHE007889		杜仲叶			Lumbar and back pain, limp aching inability of legs and knees, hypertension.
TCMBANKHE007978	Uncaria sinensis	华钩藤			See Uncaria rhynchophylla./See Uncaria rhynchophylla.
TCMBANKHE006899/YNS-5/YEM-284/XU-215	Uncaria sessilifructus [Syn. Nauclea sessilifructus ]|Uncaria sessilifructus Roxb.|Uncaria sessilifructus	白钩藤	白钩藤	云南药材标准：第三册|云南民族药物志：第二卷|广西省来宾市金秀县六段村永新村	清火解毒，消肿止痛，除风通血。用于风湿病肢体关节红肿热痛或酸痛重着；风火气血不和所致的头目胀痛。	彝族

---

   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000088

Lung Neoplasms

group

Neoplasms; Respiratory Tract Diseases

29789524

---

   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000046	PIK3R1	AGM7; GRB1; IMD36; p85; p85-ALPHA	phosphoinositide-3-kinase regulatory subunit 1
TCMBANKGE000047	AKT1	AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA	AKT serine/threonine kinase 1
TCMBANKGE000121	KCNH2	ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1	potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000305	PIK3CD	APDS; IMD14; P110DELTA; PI3K; p110D	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
TCMBANKGE000306	PIK3CG	PI3CG; PI3K; PI3Kgamma; PIK3; p110gamma; p120-PI3K	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
TCMBANKGE000307	PIK3CB	P110BETA; PI3K; PI3KBETA; PIK3C1	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
TCMBANKGE000308	PIK3CA	CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; PI3K; PI3K-alpha; p110-alpha	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000631	PTPRU	FMI; PCP-2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U; hPTP-J	protein tyrosine phosphatase receptor type U
TCMBANKGE000632	ROCK1	P160ROCK; ROCK-I	Rho associated coiled-coil containing protein kinase 1
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000784	CALM3	CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3	calmodulin 3
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001117	PTEN	10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; TEP1	phosphatase and tensin homolog
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE008056	ADRA2C	ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR	adrenoceptor alpha 2C
TCMBANKGE008124	ADRA2B	ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; FAME2; alpha-2BAR	adrenoceptor alpha 2B
TCMBANKGE008702	OPRM1	LMOR; M-OR-1; MOP; MOR; MOR1; OPRM	opioid receptor mu 1
TCMBANKGE008921	RXRA	NR2B1	retinoid X receptor alpha
TCMBANKGE009294	HTR3A	5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3	5-hydroxytryptamine receptor 3A
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE011923	CHRM4	HM4; M4R	cholinergic receptor muscarinic 4
TCMBANKGE013926	RXRB	DAUDI6; H-2RIIBP; NR2B2; RCoR-1	retinoid X receptor beta
TCMBANKGE014625	OPRD1	DOP; DOR; DOR1; OPRD	opioid receptor delta 1