Compound Summary

  Compound Information

TCMBANKIN061326

药名:	(R)-N-Methylcoclaurine
别名:	7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-, (1R)-; 1betaH-Coclaurine, 2-methyl-; 5096-70-8; AIDS-226940; (1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol; 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-6-methoxy-2-methyl-, (R)-; (1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol; (R)-1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol; C05243; (-)-1(R)-N-Methylcoclaurine; AIDS226940; d-n-methyl coclaurine
分子式:	C18H21NO3
Smiles:	CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)O)OC
成分:	HBIN042346;HBIN024344
OB_score:	3.348081
CAS_id:	5096-70-8
SymMap_id:	SMIT04780;SMIT16566
TCMID_id:	14240
TCMSP_id:	MOL002562
PubChem_id:	440595

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004791	Herba Spirodelae	浮萍			To dispel wind-heat, to promote eruption, and to cause diuresis./Wind-heat exterior syndrome, non-eruption of measles, dormant papules with pruritus, edema, dribbling urinary block, sore and lichen, erysipelas, scalds.
TCMBANKHE007071	Tricholoma matsutake [Syn. Armillaria matsutake]	松蕈			To soothe channels and quicken network vessels, rectify qi and transform phlegm, disinhibit damp and transform turbidity./Pain in lumbus and legs, incessant urinary turbidity, numbness in limbs, hypertonicity of sinews and vessels, abundant phlegm and shortness of breath.
TCMBANKHE006907		高良姜			Cold pain in stomach duct and abdomen, vomiting, diarrhea.
TCMBANKHE006961	Alpinia speciosa	大草寇			To dissipate cold and dry damp, dispel phlegm and interrupt malaria, fortify spleen and warm stomach./Cold pain in heart and abdomen, distention fullness in chest and abdomen, cold-damp accumulation and obstruction, indigestion, vomiting and diarrhea.
TCMBANKHE005815/YEM-921/YEM-1011/XU-36/XU-396	Ocimum basilicum|Ocimum basilicum L.	罗勒	芳香草	云南民族药物志：第五卷|云南省德宏州芒市风平镇	To course wind and resolve exterior, transform damp and harmonize center, move qi and quicken blood, resolve toxin and disperse swelling./Common cold with headache, fever and cough, summerheat stroke, non-digestion of food accumulation, no thought of food and drink, distention fullness and pain in stomach duct and abdomen, vomiting and diarrhea, wind-damp impediment pain, emission, menstrual disorder, toothache, bad breath, damp-sore of skin, dormant papules with pruritus, knocks and falls, snake or insect bites.	傣族
TCMBANKHE005257/YEM-104	Folium Nelumbinis|Nelumbo nucifera Gaertn.	荷叶|莲	莲	云南民族药物志：第一卷	To relieve summer-heat, to invigorate the spleen function of the spleen and arrest bleeding by reducing heat in blood./Summerheat-heat vexation and thirst, summerheat-damp diarrhea, spleen vacuity diarrhea, blood heat, blood ejection, spontaneous external bleeding, hematochezia, flooding and spotting.	阿昌族/傣族/德昂族/景颇族/傈僳族/彝族/藏族
TCMBANKHE004674/YEM-476	Cocculus laurifolius|Cocculus laurifolius DC.	衡州乌药|樟叶木防已	樟叶木防已	云南民族药物志：第三卷	To normalize qi and loosen chest, dispel wind and relieve pain./Hypertension, headache, mounting qi, abdominal pain, rheumatic pain in legs.	傣族
TCMBANKHE005543/YEM-754	Alpinia galanga|Alpinia galanga(L.)Willd.	大良姜|大高良姜	红豆蔻	云南民族药物志：第四卷	To warm stomach, dissipate cold, relieve pain./Qi pain in heart and stomach, stomach cold, food damage vomiting and diarrhea.	阿昌族/傣族/德昂族/哈尼族/基诺族/景颇族/傈僳族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000309	SCN5A	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1	sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000425	DRD1	DADR; DRD1A	dopamine receptor D1
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000633	ADRB2	ADRB2R; ADRBR; B2AR; BAR; BETA2AR	adrenoceptor beta 2
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000784	CALM3	CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3	calmodulin 3
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001194	ADRA2A	ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32	adrenoceptor alpha 2A
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001506	ADRA1B	ADRA1; ALPHA1BAR	adrenoceptor alpha 1B
TCMBANKGE001943	ADRA1D	ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2	adrenoceptor alpha 1D
TCMBANKGE003157	CHRM2	HM2	cholinergic receptor muscarinic 2
TCMBANKGE003625	SLC6A4	5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT	solute carrier family 6 member 4
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE005535	CHRM1	HM1; M1; M1R	cholinergic receptor muscarinic 1
TCMBANKGE006943	CHRM3	EGBRS; HM3; PBS	cholinergic receptor muscarinic 3
TCMBANKGE008056	ADRA2C	ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR	adrenoceptor alpha 2C
TCMBANKGE008124	ADRA2B	ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; FAME2; alpha-2BAR	adrenoceptor alpha 2B
TCMBANKGE008702	OPRM1	LMOR; M-OR-1; MOP; MOR; MOR1; OPRM	opioid receptor mu 1
TCMBANKGE008921	RXRA	NR2B1	retinoid X receptor alpha
TCMBANKGE009256	SLC6A2	NAT1; NET; NET1; SLC6A5	solute carrier family 6 member 2
TCMBANKGE009455	CHRM5	HM5	cholinergic receptor muscarinic 5
TCMBANKGE009758	PDE3A	CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB	phosphodiesterase 3A
TCMBANKGE011079	PRSS1	TRP1; TRY1; TRY4; TRYP1	serine protease 1
TCMBANKGE011923	CHRM4	HM4; M4R	cholinergic receptor muscarinic 4
TCMBANKGE012155	SLC6A3	DAT; DAT1; PKDYS; PKDYS1	solute carrier family 6 member 3
TCMBANKGE013826	DRD5	DBDR; DRD1B; DRD1L2	dopamine receptor D5
TCMBANKGE014423	ADRA1A	ADRA1C; ADRA1L1; ALPHA1AAR	adrenoceptor alpha 1A
TCMBANKGE014625	OPRD1	DOP; DOR; DOR1; OPRD	opioid receptor delta 1
TCMBANKGE014790	ADRB1	ADRB1R; B1AR; BETA1AR; FNSS2; RHR	adrenoceptor beta 1