Compound Summary
Compound Information
药名: | longatin |
别名: | (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one; NSC121869; SMR000059119; (S,R)-Noscapine; C09592; STK054401; BSPBio_000346; 128-62-1; AIDS011873; (3S)-3-[(5R)-6-methyl-4-(methyloxy)-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-bis(methyloxy)-2-benzofuran-1(3H)-one; Lopac0_000840; Tocris-1697; Noscapine (TN); alpha-Narcotine; .beta.-Narcotine; alpha-narcotine; EINECS 204-899-2; Noscapine [BAN:INN:JAN]; Coscopin (VAN); L-alpha-Narcotine; 4-27-00-06838 (Beilstein Handbook Reference); 1368-39-4; Lopac-N-9007; 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)-isoquinolin-5-yl),(S-(R*,S*))-; L-alpha-Noscapine; CAS-128-62-1; BRN 0099933; BSPBio_002113; SDCCGMLS-0066644.P001; 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-,(S-(R*,S*))-; HSDB 3372; KBio2_004117; TNP00110; SPBio_001053; (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one; NCGC00017174-02; 567-86-2; KBio2_006685; Spectrum5_001276; (-)-alpha-Norcotine; NCGC00017174-01; KBioGR_000872; Spectrum2_000987; (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one; Noscapinum [INN-Latin]; NCGC00015757-01; Spectrum_001069; KBio3_001613; ST055757; (-)-Narcotine; Spectrum3_000527; 8-Methoxyhydrastin; 5-(6,7-Dimethoxyphthalidyl)-5,6,7,8-tetrahydro-4-methoxy-8-methyl-1,3-dioxolo(4,5-g)isoquinoline; L-alpha-2-Methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1,2,3,4-tetrahydroisoquinaline; TNP00034; KBio2_001549; Spectrum4_000456; Longactin; 8057-19-0; Noscapina [INN-Spanish]; KBioSS_001549; (-)-3-(2-Methyl-6,7-methylendioxy-8-methoxy-1-isochinolyl)-6,7-dimethoxyphthalid; NCGC00016388-01; Narcotine (8CI); 8055-18-3; NCGC00023230-02; AIDS-011873; D01036; CBMicro_048259; SPBio_002565; BIM-0048054.P001; NCI60_004322; Prestwick1_000563; Prestwick3_000563; (-)-.alpha.-Narcotine; Prestwick_959; (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one; MLS000069475; 363960_ALDRICH; BPBio1_000382; Coscopin; Methoxyhydrastine; Prestwick0_000563; Prestwick2_000563; Noscapine (JP15/USP/INN); AC1NSW29; 5-[(1S)-4,5-dimethoxy-3-methylidene-1H-2-benzofuran-1-yl]-4-methoxy-6,9-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline; narcotine; Noscapine; gnoscopine; Noskapin; α-narcotine |
分子式: | C22H23NO7 |
Smiles: | CN1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3 |
成分: | HBIN033490;HBIN036350;HBIN037412;HBIN028264;HBIN037413;HBIN015621 |
OB_score: | 53.286844; 40.662118 |
CAS_id: | 128-62-1; 1368-39-4 |
SymMap_id: | SMIT10475; SMIT15662; SMIT10472; SMIT16805 |
TCMID_id: | 8901; 25441; 15258 |
TCMSP_id: | MOL009330; MOL009327 |
PubChem_id: | 275196 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE002732 | 蚕沙 | 1. Treatment of damp-heat obstruction syndrome. Silkworm excrement (Cansha) is used with Tetrandra root (Fangji), Coix seed (Yiyiren) and Talc (Huashi) in the formula Xuanbi Tang .2. Eczema. The decoction of the herb is used for external washing. 3. Treat | ||||
| TCMBANKHE003990 | Folium Llicis Chinensis | 四季青 | To clearheat and toxic materials./Angina pectoris, coronary heart disease, thrombophlebitis, thromboangiitis obliterans (Buerger’s disease), lung heat cough, swelling pain in throat, dysentery, diarrhea, infection of biliary tract , urinary tract infection, burns and scalds, heat toxin swollen welling abscess, ulcer of lower limb, eczema, frostbite, cracking, wound, bleeding due to external injury. | |||
| TCMBANKHE004404 | Lignum Aquilariae Resitum | 沉香 | To promote the flow of qi and relieve pain, to arrest vomiting by warming the stomach, and to relieve asthma./Cold pain in stomach duct and abdomen, qi counterflow with asthma, stomach cold with retching counterflow, vacuity cold in lumbus and knees, vacuity constipation, qi strangury. | |||
| TCMBANKHE004577 | pericarpium papaveris | 罂粟壳 | 1. Astringe the intestine, relieve diarrhea and alleviate pain. 2. Astringe the lung and relieve cough./Enduring cough, chronic diarrhea, prolapse of rectum, pain in stomach duct and abdomen. | |||
| TCMBANKHE006958 | Papaver commutatum [Syn. Papaver rhoeas ] | 丽春花 | To suppress cough, settle pain, check diarrhea./Cough, migraine, abdominal pain, dysentery. | |||
| TCMBANKHE006476/YEM-509 | Papaver somniferum|Papaver somniferum L. | 鸦片|罂粟 | 罂粟 | 云南民族药物志：第三卷 | To relieve pain, astringe intestines, suppress cough./Pain in heart and abdomen, chronic diarrhea, chronic dysentery, dry cough without phlegm. | 傣族/基诺族/佤族/彝族 |
| TCMBANKHE006850/YEM-509 | Papaver somniferum|Papaver somniferum L. | 罂粟 | 罂粟 | 云南民族药物志：第三卷 | To fortify spleen and promote digestion, clear heat and disinhibit urine./Stomach reflux, abdominal pain, diarrhea, prolapse of rectum. | 傣族/基诺族/佤族/彝族 |
| TCMBANKHE004276/YEM-974 | Citrus sinensis|Citrus sinensis(L.)Osbeck | 甜橙 | 黄果树 | 云南民族药物志：第五卷 | To move qi, precipitate qi, relieve pain, disperse distention, free milk./Galactostasis. | 布依族/水族/佤族/彝族/壮族 |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000121 | KCNH2 | ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 | potassium voltage-gated channel subfamily H member 2 |
| TCMBANKGE000181 | PIM1 | PIM | Pim-1 proto-oncogene, serine/threonine kinase |
| TCMBANKGE000201 | ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 |
| TCMBANKGE000205 | NOS2 | HEP-NOS; INOS; NOS; NOS2A | nitric oxide synthase 2 |
| TCMBANKGE000286 | GSK3B | - | glycogen synthase kinase 3 beta |
| TCMBANKGE000309 | SCN5A | CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 | sodium voltage-gated channel alpha subunit 5 |
| TCMBANKGE000701 | ESR2 | ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 | estrogen receptor 2 |
| TCMBANKGE000766 | ACHE | ACEE; ARACHE; N-ACHE; YT | acetylcholinesterase (Cartwright blood group) |
| TCMBANKGE000784 | CALM3 | CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3 | calmodulin 3 |
| TCMBANKGE000813 | DPP4 | ADABP; ADCP2; CD26; DPPIV; TP103 | dipeptidyl peptidase 4 |
| TCMBANKGE000903 | PTGS1 | COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS | prostaglandin-endoperoxide synthase 1 |
| TCMBANKGE000979 | KDR | CD309; FLK1; VEGFR; VEGFR2 | kinase insert domain receptor |
| TCMBANKGE001073 | PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | prostaglandin-endoperoxide synthase 2 |
| TCMBANKGE001185 | PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | peroxisome proliferator activated receptor gamma |
| TCMBANKGE004266 | AR | AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM | androgen receptor |
| TCMBANKGE009455 | CHRM5 | HM5 | cholinergic receptor muscarinic 5 |
| TCMBANKGE011079 | PRSS1 | TRP1; TRY1; TRY4; TRYP1 | serine protease 1 |
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