Compound Summary


  Compound Information

药名:

Fumarine

别名:

C05189; TNP00339; 7-methyl-2,3:9,10-bis[methylenebis(oxy)]-7,13a-secoberbin-13a-one; ST036759; Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-; Bis(1,3)benzodioxolo(4,5-c:5',6'-g)azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-; HSCI1_000268; EINECS 204-999-6; AIDS-040935; Corydinine; 4,6,7,14-Tetrahydro-5-methyl-bis(1,3)benzodioxolo(4,5-c-5',6'-g)azecin-13(5H)-one; Oprea1_722246; NCGC00142402-01; Biflorine; Macleyine; 130-86-9; NCGC00017389-01; 7-methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-15(7H)-one; 7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-; Alk-3; 6164-47-2 (HCL); Oprea1_718853; AIDS040935; 7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one; HSDB 3527; CHEBI:16415; AI3-62909; ACon1_001550; DTXSID00178935; Bis(1,3)benzodioxolo(5,6-c:5',6'-g)azecin-14(6H)-one, 5,7,8,15-tetrahydro-6-methyl-; Bis[1,3]benzodioxolo[5,6-c:5',6'-g]azecin-14(6H)-one,5,7,8,15-tetrahydro-6-methyl-; AC1L4H3I; CHEMBL486179; 14-METHYL-7,9,20,22-TETRAOXA-14-AZAPENTACYCLO[15.7.0.0?,(1)(2).0?,(1)?.0(1)?,(2)(3)]TETRACOSA-1(24),4,6(10),11,17,19(23)-HEXAEN-2-ONE; CTK4F3162; MCULE-2865552640; BDBM50377937; 24240-05-9; AC1Q6P91; NCGC00385257-01_C20H19NO5_1,3-Benzodioxolo[5,6-c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one, 5,7,8,15-tetrahydro-6-methyl-; C20H19NO5; protopine ; Pseudoprotopine; MolPort-028-610-216; 6-methyl-5,7,8,15-tetrahydrobis[1,3]benzodioxolo[5,6-c:5',6'-g]azecin-14(6h)-one; 7,13a-Secoberbin-13a-one, 7-methyl-2,3:10,11-bis(methylenedioxy)-; ZINC31502517; protopine

分子式:

C20H19NO5

Smiles:

CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3

成分:

HBIN026829;HBIN040936

OB_score:

59.262505

CAS_id:

130-86-9

SymMap_id:

SMIT03311;SMIT01582

TCMID_id:

17969

TCMSP_id:

MOL000787

PubChem_id:

4970


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE004260 Radix Ginseng 人参 To reinforce the vital energy, to remedy collapse and restore the normal pulse, to benefit the spleen and lung, to promote the production of body fluid, and to calm the nerves./Qi vacuity and verging on desertion, cold limbs and faint pulse, reduced food intake due to spleen vacuity, cough and asthma due to lung vacuity, fluid damage and thirst, diabetes mellitus due to internal heat, enduring illness qi vacuity, fright palpitation and insomnia, impotence, uterus cold, cardiac failure.
TCMBANKHE006167 Herba Corydalis bungeae 苦地丁 Influenza, infection of upper respiratory tract, tonsillitis, infective hepatitis, enteritis, dysentery, nephritis, parotitis, conjunctivitis, acute appendicitis, clove sore and swollen welling abscess, scrofula.
TCMBANKHE001205 Corydalis longicalcarata 长距延胡索
TCMBANKHE001683 三七花
TCMBANKHE002371 Radix Rumicis japonici 羊蹄根 For cooling blood and stopping bleeding
TCMBANKHE002730 橘络
TCMBANKHE002762 Radix et Rhizoma Thalictri 马尾莲 Influenza, fever in children, common cold with fever, measles papules, malaria, damp-heat diarrhea dysentery, jaundice, red eyes with gall.
TCMBANKHE003755 Radix Ampelopsis 白蔹 To remove toxic heat, to cure carbuncles, and to reduce nodules./Swelling toxin of sore and welling abscess, burns and scalds, scrofula, damp sore, warm malaria, frightepilepsy, blood dysentery, intestinal wind, hemorrhoids and fistulas, leukorrhea, knocks and falls, bleeding due to external injury.
TCMBANKHE003901 Argemone mexicana 蓟罂粟 To effuse sweat and disinhibit water, clear heat and resolve toxin, relieve pain and itch./Common cold without sweating, jaundice, strangury, edema, eyelid laceration, mounting qi , scab and lai, syphilis.
TCMBANKHE005699 Rhizoma Corydalis 廷胡索;廷胡;玄胡;元胡;元胡索;玄胡素 For stagnation of vital energy or blood stasis resulting in headache, chest pain, hypochondriac pain, epigastric pain, abdominal pain, backache, arthralgia, dysmenorrhea or trauma. Recently, alos used for angina pectoris, peptic ulcer and neuralgia./1. Its components d-corydaline and d1-tetrahydropalmatine are analgesics.2. Decreasing the secretion of gastric juice and the amount of pepsin.
TCMBANKHE005792 Thalictrum petaloideum 瓣蕊唐松草 To clear heat, dry damp, resolve toxin./Damp-heat diarrhea dysentery, jaundice, lung heat cough, red eyes with gall, swelling welling abscess and sore and boil, exudative dermatitis
TCMBANKHE004088 Rhizoma Corydalis Decumbentis 夏天无 To promote the flow of qi and blood, to remove obstruction from the collaterals and to relieve pain./Pain in deep tissues, neuralgia, swelling pain from fracture, hypertension, hemiplegia, sequel of poliomyelitis, sciatica, rheumatic arthritis, knocks and falls.
TCMBANKHE004376 Pericarpium Grati 石榴皮 To check diarrhea, arrest bleeding and repel worms./Chronic diarrhea, chronic dysentery, hematochezia, prolapse of rectum, flooding and spotting, leukorrhea, abdominal pain due to worm accumulation.
TCMBANKHE004522 Rhizoma Corydalis 延胡索 1. To invigorate blood and promote qi circulation; 2. To stop pain/Chest and rib-side pain, pain in stomach duct and abdomen, neuralgia, gastrointestinal spasm, amenorrhea and dysmenorrhea, postpartum stasis stagnation abdominal pain, painful swelling from knocks and falls.
TCMBANKHE004577 pericarpium papaveris 罂粟壳 1. Astringe the intestine, relieve diarrhea and alleviate pain. 2. Astringe the lung and relieve cough./Enduring cough, chronic diarrhea, prolapse of rectum, pain in stomach duct and abdomen.
TCMBANKHE004636 Fructus Zizyphi Jujubae 大枣 To tonify the spleen and replenish qi, to nourish blood, and to ease the mind./Reduced food intake due to spleen vacuity, lack of strength and sloppy stool, visceral agitation.
TCMBANKHE005112 Corydalis remota [Syn. Corydalis bulbosa var. typica ] 齿瓣延胡索 To quicken blood and dissipate stasis, move qi and relieve pain./Pain in lumbus and knees, pain in heart and abdomen, dysmenorrhea, postpartum stasis stagnation abdominal pain, painful swelling from knocks and falls.
TCMBANKHE007977 Thalictrum thunbergii 烟锅草 To clear heat and resolve toxin, dry damp./Pertussis, toothache, swelling toxin of welling abscess and sore, acute dermitis, eczema.
TCMBANKHE007757 Corydalis adunca 灰绿延胡索 To clear lung and relieve cough, clear liver and disinhibit gallbladder, relieve pain./Lung heat cough, fever and chest pain, liver-gallbladder damp-heat, pain in rib-side, fever, anorexy for greasy food, jaundice, damp-heat diarrhea.
TCMBANKHE007730 Fructus Meliae Toosendan 川楝子 To relieve pain by smoothing the flow of the liver qi and to repel worms./Chest and rib-side pain, distending pain in stomach duct, mounting qi , abdominal pain due to worm accumulation.
TCMBANKHE006371 白屈菜 Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE006154 Thalictrum faberi 大叶唐松草 To clear heat, drain fire, resolve toxin./Dysentery, diarrhea, red eyes with gall, damp-heat jaundice.
TCMBANKHE006212 Semen Astragali Complanati;Semen Astragali Complati 潼蒺藜;沙苑子 Treatment of back pain, nocturnal emission and premature ejaculation in deficiency syndromes of the kidney, turbid discharge with urination, excessive leukorrhea, dribbling of urine after urination, dizziness and blurred vision,to benefit the liver./Treatment of back pain, nocturnal emission and premature ejaculation in deficiency syndromes of the kidney, turbid discharge with urination, excessive leukorrhea, dribbling of urine after urination, dizziness and blurred vision.
TCMBANKHE008498 fructus Sophorae 槐角 For cooling blood and stopping bleeding
TCMBANKHE007291 Corydalis suaveolens [Syn. Corydalis sheareri] 尖距紫堇 To quicken blood and relieve pain, clear heat and resolve toxin./Stomachache, abdominal pain and diarrhea, knocks and falls, swelling toxin of welling abscess and sore, red eyes with gall.
TCMBANKHE006524 Nandina domestica 南天竹子 To constrain lung and relieve cough, calm asthma./Enduring cough, asthma, pertussis.
TCMBANKHE007173 Thalictrum atriplex 狭序唐松草 To clear heat and resolve toxin, cool liver, check dysentery./Swelling and toxin of sore and welling abscess, damp-heat jaundice, dysentery, conjunctivitis.
TCMBANKHE008855 Corydalis ledebouriana 对叶元胡
TCMBANKHE008004 Corydalis ambigua var. amurensis [Syn. Corydalis ambigua] 东北延胡索 To quicken blood and dissipate stasis, rectify qi and relieve pain./Pain in lumbus and knees, pain in heart and abdomen, dysmenorrhea, menstrual disorder, postpartum stasis stagnation abdominal pain, flooding and spotting, concretion and conglomeration, knocks and falls.
TCMBANKHE009030 Resi myrrhae;Myrrha 没药 1. To invigorate blood and stop pain; 2. To reduce swelling and promote healing/Stasis pain in chest and abdomen, amenorrhea, dysmenorrhea, concretion and conglomeration, knocks and falls, swollen welling abscess and sores, intestinal welling abscess, red eyes with gall.
TCMBANKHE008341 Fructus Zizyphi Jujubae 大枣 To tonify the spleen and replenish qi, to nourish blood, and to ease the mind./Reduced food intake due to spleen vacuity, lack of strength and sloppy stool, visceral agitation.
TCMBANKHE008122 Thalictrum microgynum 小果唐松草 To clear heat and resolve toxin, disinhibit damp./Yellow swelling in whole body, yellow eyes, knocks and falls.
TCMBANKHE008320 Corydalis repens 全叶延胡索 See Corydalis ambigua var. amurensis./See Corydalis ambigua var. amurensis .
TCMBANKHE008723/XU-511 Thalictrum glandulosissimum 金丝马尾连 湖北省远安县荷花镇 See Thalictrum foliolosum./See Thalictrum foliolosum.
TCMBANKHE004238/YEM-1014 Phellodendron amurense;Cortex Phellodendri|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄柏|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 1. To clear heat and dry dampness; 2. To reduce fire and release toxins/Damp-heat dysentery, tuberculosis, epidemic meningitis, acute conjunctivitis, trachoma, fever, abdominal pain, diarrhea, suppurative hematochezia, tenesmus, jaundice, yellow thick foul leukorrhagia, swelling pain in knees and feet, urinary tract infection, boil, sore, ulcer, eczema, mouth sore, hemorrhoids, burns, scalds, exuberance of fire with tidal fever, tidal fever with night sweat, emission. 瑶族/壮族
TCMBANKHE000631/YEM-135 herba meconpsis integrifoliae|Meconopsis integrifolia(Maxim.) Franch. 绿绒蒿|全缘叶绿绒蒿 全缘叶绿绒蒿 云南民族药物志:第一卷 傈僳族/藏族
TCMBANKHE006850/YEM-509 Papaver somniferum|Papaver somniferum L. 罂粟 罂粟 云南民族药物志:第三卷 To fortify spleen and promote digestion, clear heat and disinhibit urine./Stomach reflux, abdominal pain, diarrhea, prolapse of rectum. 傣族/基诺族/佤族/彝族
TCMBANKHE005663/YNS-73/YEM-663 Toddalia asiatica|Toddalia asiatica (L.) Lam.|Toddalia asiatica(L.)Lam. 飞龙掌血 飞龙掌血茎|飞龙掌血 云南药材标准:第四册|云南民族药物志:第四卷 活血止痛,祛风散寒。用于胃脘疼痛;腰痛,寒湿痹痛,跌倒损伤;皮肤瘙痒|To dispel wind and relieve pain, stanch bleeding and dissipate stasis./Wind-damp Pain, stomachache, knocks and falls, blood ejection, spontaneous external bleeding, knife wound, amenorrhea, dysmenorrhea. 阿昌族/布依族/傣族/德昂族/哈尼族/基诺族/景颇族/拉祜族/傈僳族/苗族/佤族/瑶族/彝族/壮族
TCMBANKHE007603/YEM-702 Panax ginseng [Syn. Panax schinseng ]|Panax ginseng C.A.Mey. 人参花蕾|人参 人参 云南民族药物志:第四卷 To supplement original qi greatly, supplement spleen and boost lung, engender liquid and allay thirst, quiet spirit and boost wits./Qi vacuity and verging on desertion, spleen vacuity and fatigued body, inappetence, vomiting, diarrhea, lung vacuity and shortness of breath, cough, hasty asthma, vacuity and profuse sweating, fluid damage and thirst, diabetes mellitus, insomnia and frequent dreaming, fright palpitation and amnesia, anemia with yellow complexion, kidney vacuity impotence, frequent urination, qi -blood fluids vacuity depletion. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000022 Prostatic Neoplasms group Neoplasms; Male Urogenital Diseases 22033245
TCMBANKDI017015 Neoplasms, Hormone-Dependent phenotype Neoplasms 22033245

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000121 KCNH2 ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000425 DRD1 DADR; DRD1A dopamine receptor D1
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000784 CALM3 CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3 calmodulin 3
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000923 CDK1 CDC2; CDC28A; P34CDC2 cyclin dependent kinase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE000979 KDR CD309; FLK1; VEGFR; VEGFR2 kinase insert domain receptor
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001166 BCL2 Bcl-2; PPP1R50 BCL2 apoptosis regulator
TCMBANKGE001173 MCL1 BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT MCL1 apoptosis regulator, BCL2 family member
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001506 ADRA1B ADRA1; ALPHA1BAR adrenoceptor alpha 1B
TCMBANKGE001943 ADRA1D ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 adrenoceptor alpha 1D
TCMBANKGE003625 SLC6A4 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT solute carrier family 6 member 4
TCMBANKGE003643 F7 SPCA coagulation factor VII
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE005535 CHRM1 HM1; M1; M1R cholinergic receptor muscarinic 1
TCMBANKGE006943 CHRM3 EGBRS; HM3; PBS cholinergic receptor muscarinic 3
TCMBANKGE008702 OPRM1 LMOR; M-OR-1; MOP; MOR; MOR1; OPRM opioid receptor mu 1
TCMBANKGE009294 HTR3A 5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; HTR3 5-hydroxytryptamine receptor 3A
TCMBANKGE009455 CHRM5 HM5 cholinergic receptor muscarinic 5
TCMBANKGE009758 PDE3A CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB phosphodiesterase 3A
TCMBANKGE009951 CACNA1S CACNL1A3; CCHL1A3; Cav1.1; HOKPP; HOKPP1; MHS5; TTPP1; hypoPP calcium voltage-gated channel subunit alpha1 S
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1
TCMBANKGE011923 CHRM4 HM4; M4R cholinergic receptor muscarinic 4
TCMBANKGE012155 SLC6A3 DAT; DAT1; PKDYS; PKDYS1 solute carrier family 6 member 3
TCMBANKGE014625 OPRD1 DOP; DOR; DOR1; OPRD opioid receptor delta 1