Compound Summary

  Compound Information

TCMBANKIN061606

药名:	Silibinin
别名:	7C3MT; NSC 651520; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-7-yl]-4-chromanone; Silybin (7CI); AC-6081; MEGxp0_001301; Silybine; BC216320; Spectrum3_001132; AIDS-003063; SDCCGMLS-0066916.P001; 4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; SMP2_000323; KBio3_002123; 3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)- 2-(hydroxymethyl)-1,4-benzodioxan-6-yl)-4-chromanone; Silibinin [INN]; AIDS003063; silybin; ZINC21992919; 3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl)-4-chromanone; Spectrum2_001694; BB_NC-1044; NCGC00091057-01; Silibinina [INN-Spanish]; NSC651520; 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydroxy-, (2R-(2-alpha,3-beta,6(2R*,3R*)))-; EINECS 245-302-5; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxy-phenyl)-3-methylol-2,3-dihydro-1,4-benzodioxin-7-yl]chroman-4-one; Spectrum5_001893; Flavobin Spofa; SPECTRUM1505256; 4H-1-Benzopyran-4-one, 2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-(2alpha,3beta,6(2R*,3R*)))-; Silibininum [INN-Latin]; Silibinine [INN-French]; Silymarin I; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-7-yl]chroman-4-one; ZINC02033589; Silliver; Flavobin; Silymarine I; KBioGR_002481; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxy-phenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-7-yl]chroman-4-one; AKOS015965310; Spectrum4_001978; SPBio_001648; BSPBio_002623;SILYBIN
分子式:	C25H22O10
Smiles:	COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
成分:	HBIN044028;HBIN044034
OB_score:	0.92583
CAS_id:	22888-70-6
SymMap_id:	SMIT08887;SMIT17712
TCMID_id:	32977;19879
TCMSP_id:	MOL007450
PubChem_id:	31553

---

   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE006366	Radix Moghaniae Philippinensis	千斤拔
TCMBANKHE006357		水飞蓟			Acute hepatitis, chronic hepatitis, cirrhosis, fatty liver, gallstones, cholangitis.
TCMBANKHE001493/XU-632	Folium Pini|Pinus massoniana	松针|马尾松		吉林省白山市抚松县	1. To tranquilize the mind. For palpitation, insomnia, amnesia. Recently used for neurasthenia, chronic Keshan disease, hypertension, coronary heart diseases and cor pulmonale. 2. External use for depriving dampness, killing parasite and alleviate itching. For exudative dermatitis, scabies and tinea./1. To tranquilize the mind. For palpitation, insomnia, amnesia. Recently used for neurasthenia, chronic Keshan disease, hypertension, coronary heart diseases and cor pulmonale. 2. External use for depriving dampness, killing parasite and alleviate itching

---

   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

---

   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000137	PLAU	ATF; BDPLT5; QPD; UPA; URK; u-PA	plasminogen activator, urokinase
TCMBANKGE000139	POR	CPR; CYPOR; P450R	cytochrome p450 oxidoreductase
TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000241	CASP8	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5	caspase 8
TCMBANKGE000258	EGR1	AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225	early growth response 1
TCMBANKGE000264	ABCB1	ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1	ATP binding cassette subfamily B member 1
TCMBANKGE000276	NOS1	IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS	nitric oxide synthase 1
TCMBANKGE000315	IL4	BCGF-1; BCGF1; BSF-1; BSF1; IL-4	interleukin 4
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000624	ALPL	AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP	alkaline phosphatase, biomineralization associated
TCMBANKGE000713	CCN2	CTGF; HCS24; IGFBP8; NOV2	cellular communication network factor 2
TCMBANKGE000728	MGMT	-	O-6-methylguanine-DNA methyltransferase
TCMBANKGE000749	ALOX5	5-LO; 5-LOX; 5LPG; LOG5	arachidonate 5-lipoxygenase
TCMBANKGE000766	ACHE	ACEE; ARACHE; N-ACHE; YT	acetylcholinesterase (Cartwright blood group)
TCMBANKGE000877	ABCG2	ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1	ATP binding cassette subfamily G member 2 (Junior blood group)
TCMBANKGE000954	ABCB11	ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP	ATP binding cassette subfamily B member 11
TCMBANKGE001008	CYP3A4	CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1	cytochrome P450 family 3 subfamily A member 4
TCMBANKGE001014	TNFRSF10B	CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9	TNF receptor superfamily member 10b
TCMBANKGE001037	MMP2	CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1	matrix metallopeptidase 2
TCMBANKGE001045	CCND1	BCL1; D11S287E; PRAD1; U21B31	cyclin D1
TCMBANKGE001074	ATM	AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1	ATM serine/threonine kinase
TCMBANKGE001089	PARP1	ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1	poly(ADP-ribose) polymerase 1
TCMBANKGE001107	NOS3	ECNOS; eNOS	nitric oxide synthase 3
TCMBANKGE001109	ALPP	ALP; ALPI; IAP; PALP; PLAP; PLAP-1	alkaline phosphatase, placental
TCMBANKGE001118	MMP9	CLG4B; GELB; MANDP2; MMP-9	matrix metallopeptidase 9
TCMBANKGE001126	NFE2L2	HEBP1; IMDDHH; NRF2; Nrf-2	nuclear factor, erythroid 2 like 2
TCMBANKGE001131	CASP9	APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56	caspase 9
TCMBANKGE001148	VEGFA	MVCD1; VEGF; VPF	vascular endothelial growth factor A
TCMBANKGE001156	CASP3	CPP32; CPP32B; SCA-1	caspase 3
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001176	CAT	-	catalase
TCMBANKGE001177	TP53	BCC7; BMFS5; LFS1; P53; TRP53	tumor protein p53
TCMBANKGE001432	ALPG	ALPPL; ALPPL2; GCAP	alkaline phosphatase, germ cell
TCMBANKGE005226	LDHA	GSD11; HEL-S-133P; LDHM; PIG19	lactate dehydrogenase A
TCMBANKGE005821	LDHC	CT32; LDH3; LDHX	lactate dehydrogenase C
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE006368	UGT1A1	BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A	UDP glucuronosyltransferase family 1 member A1
TCMBANKGE006373	TYW1	RSAFD1; TYW1A; YPL207W	tRNA-yW synthesizing protein 1 homolog
TCMBANKGE006950	CA14	CAXiV	carbonic anhydrase 14
TCMBANKGE008022	AKR1C3	DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; PGFS; hluPGFS	aldo-keto reductase family 1 member C3
TCMBANKGE009863	MTRR	MSR; cblE	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
TCMBANKGE011031	CYP2C9	CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9	cytochrome P450 family 2 subfamily C member 9
TCMBANKGE011356	NDOR1	CIAE1; NR1; bA350O14.9	NADPH dependent diflavin oxidoreductase 1
TCMBANKGE011364	GDF15	GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB	growth differentiation factor 15
TCMBANKGE012726	MTTP	ABL; MTP	microsomal triglyceride transfer protein
TCMBANKGE012736	CA9	CAIX; MN	carbonic anhydrase 9
TCMBANKGE012981	LDHB	HEL-S-281; LDH-B; LDH-H; LDHBD; TRG-5	lactate dehydrogenase B
TCMBANKGE013390	CASP2	CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57	caspase 2
TCMBANKGE013409	GSR	GR; GSRD; HEL-75; HEL-S-122m	glutathione-disulfide reductase