Compound Summary


  Compound Information

药名:

(-)-discretamine

别名:

Prestwick3_000601; (13aS)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol; (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol; BPBio1_000554; CHEBI:17129; C02106; (13aS)-5,8,13,13a-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol; BSPBio_000502; CHEMBL1395394; AKOS032949038; CAS-6451-73-6; AC1LMC5I; Scoulerine; ZINC28465423; (+)-Scoulerine; 4CN-3063; (13aR)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol; BDBM50429050; NCGC00016674-01; scoulerine; (S)-Scoulerine

分子式:

C19H21NO4

Smiles:

COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O

成分:

HBIN024240;HBIN044674;HBIN043457

OB_score:

32.284941

CAS_id:

6451-72-5

SymMap_id:

SMIT02864;SMIT17633

TCMID_id:

35624;19551

TCMSP_id:

MOL000217

PubChem_id:

439654;1152279


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE006167 Herba Corydalis bungeae 苦地丁 Influenza, infection of upper respiratory tract, tonsillitis, infective hepatitis, enteritis, dysentery, nephritis, parotitis, conjunctivitis, acute appendicitis, clove sore and swollen welling abscess, scrofula.
TCMBANKHE003616 Rhus lanceolata
TCMBANKHE005598 Erycibe schmidtii 光叶丁公藤 See Erycibe obtusifolia./See Erycibe obtusifolia.
TCMBANKHE004376 Pericarpium Grati 石榴皮 To check diarrhea, arrest bleeding and repel worms./Chronic diarrhea, chronic dysentery, hematochezia, prolapse of rectum, flooding and spotting, leukorrhea, abdominal pain due to worm accumulation.
TCMBANKHE004522 Rhizoma Corydalis 延胡索 1. To invigorate blood and promote qi circulation; 2. To stop pain/Chest and rib-side pain, pain in stomach duct and abdomen, neuralgia, gastrointestinal spasm, amenorrhea and dysmenorrhea, postpartum stasis stagnation abdominal pain, painful swelling from knocks and falls.
TCMBANKHE004901 Dicentra spectabilis 荷包牡丹根 To dispel wind, quicken blood, settle pain./Incised wound, sore toxin, stomachache.
TCMBANKHE005371 Scopolia japonica 东莨菪碱 To resolve tetany and settle pain, constrain sweat and astringe intestines./Various pains, mental manic agitation, swelling toxin of sore and welling abscess, anthrax, bleeding due to external injury, body lichen.
TCMBANKHE007483 Annona squamosa 番荔枝 To supplement stomach and spleen, clear heat and resolve toxin, kill worms./Malign sore and swelling toxin, intestinal parasitic disease.
TCMBANKHE007813 Corydalis pallida 菊花黄连 To clear heat and resolve toxin, disperse swelling and relieve pain./Welling abscess and boil, innominate toxin swelling.
TCMBANKHE008052 Corydalis incisa 紫花鱼灯草 To resolve toxin and kill worms, relieve pain./Toxin swelling of sores, scab and lai, intractable lichen, eczema, poisonous snake bite.
TCMBANKHE006313 Radix et Rhizoma Rhei 大黄 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.
TCMBANKHE006371 白屈菜 Pain in sensory nerve endings, pain from ulcer in digestive tract, stomachache, abdominal pain, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scab and lichen with swelling of sores, snake or insect bites.
TCMBANKHE006944 Caulis Erycibes 丁公藤 To dispel wind and deprive dampness, reduce swelling, relieve pain./Wind-damp impediment pain, hemiplegia, painful swelling from knocks and falls.
TCMBANKHE008642 Murraya paniculata [Syn. Chalcas paniculata] 九里香 To move qi and quicken blood, dissipate stasis and relieve pain, resolve toxin and disperse swelling, anesthetize and settle pain./Pain in stomach duct, wind-damp impediment pain, painful swelling from knocks and falls, sore and welling abscess, snake or insect bites, local anesthesia.
TCMBANKHE007150/YEM-237/XU-798 Helianthus annuus|Helianthus annuus L. 向日葵籽|向日葵 向日葵 云南民族药物志:第二卷|云南省昆明市呈贡区 To outthrust papules, check dysentery, outthrust welling abscess and pus./Blood dysentery, welling abscess with pus swelling. 阿昌族/傣族/德昂族/景颇族/傈僳族/藏族
TCMBANKHE008331/YEM-237/XU-798 Helianthus annuus|Helianthus annuus L. 向日葵叶|向日葵 向日葵 云南民族药物志:第二卷|云南省昆明市呈贡区 To lower blood pressure, interrupt malaria, resolve toxin./Hypertension, malaria, clove sore. 阿昌族/傣族/德昂族/景颇族/傈僳族/藏族
TCMBANKHE005971/YEM-237/XU-798 Helianthus annuus|Helianthus annuus L. 向日葵茎髓|向日葵 向日葵 云南民族药物志:第二卷|云南省昆明市呈贡区 To clear heat, disinhibit urine, relieve cough./Blood strangury, urethral stone, chyluria, inhibited urination. 阿昌族/傣族/德昂族/景颇族/傈僳族/藏族
TCMBANKHE003737/YEM-277 Nicotiana tabacum|Nicotiana tabacum L. 烟草 烟草 云南民族药物志:第二卷 To move qi and relieve pain, resolve toxin and kill worms./Food stagnation, qi bind pain, welling abscess and flat abscess, clove sore, scab and lichen, snake bite, dog bite. 阿昌族/傣族/德昂族/哈尼族/基诺族/景颇族/傈僳族/佤族/彝族
TCMBANKHE006476/YEM-509 Papaver somniferum|Papaver somniferum L. 鸦片|罂粟 罂粟 云南民族药物志:第三卷 To relieve pain, astringe intestines, suppress cough./Pain in heart and abdomen, chronic diarrhea, chronic dysentery, dry cough without phlegm. 傣族/基诺族/佤族/彝族
TCMBANKHE008476/YEM-68 Artemisia annua|Artemisia annua L. 黄花蒿 黄花蒿 云南民族药物志:第一卷 To clear heat, resolve summerheat, eliminate steam, interrupt malaria./Summerheat-heat, summerheat-damp, damp warmth, yin vacuity fever, malaria, jaundice. 阿昌族/白族/傣族/德昂族/独龙族/景颇族/傈僳族/纳西族/怒族/瑶族/彝族/藏族/壮族
TCMBANKHE007363/YEM-744/XU-850 Radix et Rhizoma Rhei|Rheum palmatum L.|Rheum palmatum 大黄; 生锦纹; 生军|掌叶大黄 掌叶大黄 云南民族药物志:第四卷|西藏昌都地区芒康县 To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge.; Treatment of fever with constipation, retention of the feces and abdominal pain, dysentery with inadequate discharge from the bowels, jaundice caused by damp-heat, haematemesis, epistaxis, inflammation of eye and swelling of the throat due to heat in the blood, appendicitis with abdominal pain, boils, sores and abscess, amenorrhea due to blood stasis, traumatic injuries, hemorrhage from the upper gastrointestinal tract. External use for scalds and burns.Radixet Rhizoma Rhei (stir-fried with wine) Inflammation of the eye, swelling of the throat and painful swelling of the gums. Radix et Rhizoma Rhei (prepared) Boils, sores and abscess. Radix et Rhizoma Rhei (carbonized) Hemorrhage with blood stasis due to heat in the blood./Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds.; 1. Sennoside A is the component for purgation.2. Promoting biliary secretion and enhancing the amount of bilirubin and bile acid.3. Rhein and Emodin exert bacteriostatic effect by inhibting the synthesis of DNA, RNA and protein in bacteria4. Emodin is a component for hypotensive5. Oral use of its extract reduces the raio of serum cholesterol and total phospholipid in rabbits with hypercholesterolemia.6. Chrysophanol, an other active component, exerts a hemostatic effect. 阿昌族/傣族/德昂族/回族/景颇族/傈僳族/彝族/藏族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000121 KCNH2 ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000425 DRD1 DADR; DRD1A dopamine receptor D1
TCMBANKGE000474 NCOA1 F-SRC-1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 nuclear receptor coactivator 1
TCMBANKGE000476 NCOA2 GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75 nuclear receptor coactivator 2
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000633 ADRB2 ADRB2R; ADRBR; B2AR; BAR; BETA2AR adrenoceptor beta 2
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000784 CALM3 CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3 calmodulin 3
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000869 DRD2 D2DR; D2R dopamine receptor D2
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE001194 ADRA2A ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32 adrenoceptor alpha 2A
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001506 ADRA1B ADRA1; ALPHA1BAR adrenoceptor alpha 1B
TCMBANKGE001943 ADRA1D ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 adrenoceptor alpha 1D
TCMBANKGE003157 CHRM2 HM2 cholinergic receptor muscarinic 2
TCMBANKGE003625 SLC6A4 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT solute carrier family 6 member 4
TCMBANKGE003643 F7 SPCA coagulation factor VII
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE005535 CHRM1 HM1; M1; M1R cholinergic receptor muscarinic 1
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE006943 CHRM3 EGBRS; HM3; PBS cholinergic receptor muscarinic 3
TCMBANKGE008056 ADRA2C ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR adrenoceptor alpha 2C
TCMBANKGE008124 ADRA2B ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; FAME2; alpha-2BAR adrenoceptor alpha 2B
TCMBANKGE008702 OPRM1 LMOR; M-OR-1; MOP; MOR; MOR1; OPRM opioid receptor mu 1
TCMBANKGE008921 RXRA NR2B1 retinoid X receptor alpha
TCMBANKGE009256 SLC6A2 NAT1; NET; NET1; SLC6A5 solute carrier family 6 member 2
TCMBANKGE009455 CHRM5 HM5 cholinergic receptor muscarinic 5
TCMBANKGE009758 PDE3A CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB phosphodiesterase 3A
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1
TCMBANKGE011923 CHRM4 HM4; M4R cholinergic receptor muscarinic 4
TCMBANKGE012155 SLC6A3 DAT; DAT1; PKDYS; PKDYS1 solute carrier family 6 member 3
TCMBANKGE012345 DRD3 D3DR; ETM1; FET1 dopamine receptor D3
TCMBANKGE013826 DRD5 DBDR; DRD1B; DRD1L2 dopamine receptor D5
TCMBANKGE014423 ADRA1A ADRA1C; ADRA1L1; ALPHA1AAR adrenoceptor alpha 1A
TCMBANKGE014625 OPRD1 DOP; DOR; DOR1; OPRD opioid receptor delta 1