Compound Summary


  Compound Information

药名:

jatrorrizine

别名:

Jatrorrhizine, iodide; 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol iodide; iatrorrhizine; JATRORRHIZINE IODIDE; jatrorhizinc; CHEMBL1990190; NSC-93137; AC1NURFL; Q-100433; Ambap3621-38-3; 7,8,13,13alpha-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; jatrorrhizine; 1168-00-9; KB-78657; NSC93137; jatrorrhizine; jatrorrhizine

分子式:

C20H20NO4+

Smiles:

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC

成分:

HBIN031501; HBIN031499

OB_score:

19.651242; 30.436871

CAS_id:

3621-38-3

SymMap_id:

SMIT00358; SMIT00247

TCMID_id:

11848

TCMSP_id:

MOL000789; MOL006397

PubChem_id:

72323


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000156 河谷地不容
TCMBANKHE000785 Coptis gulinensis
TCMBANKHE001149 Caulis Mahoniae 功劳木 To remove dimp-heat, quench fire, and counteract toxicity./Berberine is the main active component with an action similar to Rhizoma Coptidis. Another active component, isotetrandrine, is an anticarcinogenic agent.
TCMBANKHE002046 金果揽 See Tinospora sagittata .
TCMBANKHE002730 橘络
TCMBANKHE002762 Radix et Rhizoma Thalictri 马尾莲 Influenza, fever in children, common cold with fever, measles papules, malaria, damp-heat diarrhea dysentery, jaundice, red eyes with gall.
TCMBANKHE003021 关黄柏
TCMBANKHE003124 黄菠萝果
TCMBANKHE003402 十大功劳根
TCMBANKHE003746 Radix Scutellariae 黄芩 To remove damp-heat, to quench fire and counteract toxicity, to arrest bleeding, and to prevent abortion./Chest oppression with retching, diarrhea, jaundice, lung heat cough, infection of upper respiratory tract, acute tonsillitis, acute pharyngolaryngitis, ardent fever with vexation and thirst, blood heat, blood ejection, spontaneous external bleeding, swelling toxin of welling abscess and sore, stirring fetus in pregnancy.
TCMBANKHE003748 Rhizoma Coptidis 黄连 To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds.
TCMBANKHE003878 Folium Mahoe 十大功劳叶 Tuberculosis and hemoptysis, steaming bone tidal fever, dizziness and tinnitus, limp aching lumbus and knees, damp-heat jaundice, vaginal discharge, dysentery, wind-heat common cold, red eyes with gall, swollen welling abscess and sores.
TCMBANKHE003925 Berberis diaphana 鲜黄小檗 To clear damp heat, resolve heat toxin./Damp-heat dysentery, jaundice, vaginal discharge, heat toxin swollen welling abscess.
TCMBANKHE005714 Mahonia shenii 城口十大功劳 To clear heat, dry damp, resolve toxin./Damp-heat dysentery, diarrhea, jaundice (icterus, ICT), red eyes with gall, burns and scalds.
TCMBANKHE005722 Tinospora hainanensis 海南青牛胆
TCMBANKHE005792 Thalictrum petaloideum 瓣蕊唐松草 To clear heat, dry damp, resolve toxin./Damp-heat diarrhea dysentery, jaundice, lung heat cough, red eyes with gall, swelling welling abscess and sore and boil, exudative dermatitis
TCMBANKHE004088 Rhizoma Corydalis Decumbentis 夏天无 To promote the flow of qi and blood, to remove obstruction from the collaterals and to relieve pain./Pain in deep tissues, neuralgia, swelling pain from fracture, hypertension, hemiplegia, sequel of poliomyelitis, sciatica, rheumatic arthritis, knocks and falls.
TCMBANKHE004093 Mahonia eurybracteata 宽苞十大功劳
TCMBANKHE005818 Thalictrum lucidum 透明唐松草
TCMBANKHE004198 Magnolia biondii [Syn. Magnolia fargesii] 望春玉兰 See Magnolia liliflora./See Magnolia liliflora.
TCMBANKHE004222 Hypericum curvisepalum 贯叶金丝桃
TCMBANKHE004312 Mahonia japonica 华南功劳木 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE004368 Mahonia gracilipes 细柄十大功劳 See Mahonia confusa./See Mahonia confusa.
TCMBANKHE006139 Berberis poiretii 细叶小檗 To clear heat and dry damp, drain fire and resolve toxin./Bacillary dysentery, damp-heat dysentery, diarrhea, jaundice, infection of upper respiratory tract, sore pharynx, urinary tract infection, cholecystitis, leukopenic complications of carcinoma, eczema, sores, mouth sore,red eyes.
TCMBANKHE004446 Mahonia bodinieri 小果十大功劳
TCMBANKHE004459 Fructus Lycii 枸杞子 To benefit the liver and the kidney, to replenish vital essence and to improve eyesight./Lassitude in lumbus and knees, emission, dizziness and dim vision, lung disease with cough, diabetes mellitus.
TCMBANKHE004610 Ramulus Uncariae cum Uncis 钩藤 To remove heat, subdue hyperactivity of the liver, and arrest convulsions./Infant fright wind and night crying, exuberant heat stirring wind, epilepsy of pregnancy, liver yang dizziness, liver fire headache.
TCMBANKHE006458 Coptis teetoides [Syn. Coptis teeta] 云南黄连 See Coptis chinensis./See Coptis chinensis.
TCMBANKHE004719 Stephania viridiflavens 黄叶地不容 See Stephania dicentrinifera./See Stephania dicentrinifera .
TCMBANKHE007303 广藿香 Summerheat-damp lassitude, oppression in chest, vomiting diarrhea with abdominal pain, deep-source nasal congestion and headache.
TCMBANKHE005202 Berberis thunbergii 日本小檗 To clear heat and dry damp, drain fire and resolve toxin./Damp-heat diarrhea dysentery, stomach heat pain, red eyes with gall, mouth sore, swelling pain in throat, acute eczema, scalds.
TCMBANKHE007078 Berberis dubia 置疑小檗
TCMBANKHE007084 Tinospora sagittata 青牛胆 To clear heat and resolve toxin, disinhibit throat, relieve pain./Swelling pain in throat, welling abscess and flat abscess with clove sore, diarrhea, dysentery, heat pain in stomach duct and abdomen.
TCMBANKHE007642 Corydalis lutea 深黄紫堇
TCMBANKHE007866 Coptis deltoidea 三角叶黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE007977 Thalictrum thunbergii 烟锅草 To clear heat and resolve toxin, dry damp./Pertussis, toothache, swelling toxin of welling abscess and sore, acute dermitis, eczema.
TCMBANKHE005974 Berberis potaninii 少齿小檗
TCMBANKHE008275 Coptis chinensis var. brevisepala 短萼黄连 See Coptis chinensis ./See Coptis chinensis .
TCMBANKHE007383 Berberis julianae 土黄连 To clear heat and disinhibit damp, drain fire and resolve toxin./Damp-heat diarrhea dysentery, heat strangury, red eyes with gall, gum swelling, swelling pain in throat, epidemic parotitis, erysipelas, eczema, heat toxin sores.
TCMBANKHE006761 nodus nelumbinis rhizomatis 藕节 To arrest bleeding and remove blood stasis./Treament of hematemesis, hemoptysis, hematuria, abnormal uterine bleeding.
TCMBANKHE006768 Coptis linearisepala 线萼黄连
TCMBANKHE006154 Thalictrum faberi 大叶唐松草 To clear heat, drain fire, resolve toxin./Dysentery, diarrhea, red eyes with gall, damp-heat jaundice.
TCMBANKHE006160 Berberis amurensis 小檗;小蘗 To clear heat and dry damp, resolve toxin./Enteritis, dysentery, chronic cholecystitis, acute hepatitis, chronic hepatitis, bacillary dysentery, infection of upper respiratory tract, urinary tract infection, leukopenic complications of carcinoma, innominate toxin swelling, erysipelas, eczema, red eyes, mouth sore.
TCMBANKHE009177 青果 Swelling pain in throat, cough, vexation and thirst, poisoning of fish or crab.
TCMBANKHE007062 Mahonia veitchiorum 川滇十大功劳
TCMBANKHE006703 Berberis poiretii 细叶小檗 To clear heat and dry damp, drain fire and resolve toxin./Bacillary dysentery, damp-heat dysentery, diarrhea, jaundice, infection of upper respiratory tract, sore pharynx, urinary tract infection, cholecystitis, leukopenic complications of carcinoma, eczema, sores, mouth sore,red eyes.
TCMBANKHE007173 Thalictrum atriplex 狭序唐松草 To clear heat and resolve toxin, cool liver, check dysentery./Swelling and toxin of sore and welling abscess, damp-heat jaundice, dysentery, conjunctivitis.
TCMBANKHE006924 Coptis omeiensis 峨眉野黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE009013 Cortex Illicii 地枫皮 To relieve rheumatic conditions, and to promote the flow of qi and relieve pain./Pain in joints due to rheumatalgia, taxation damage in lumbar muscle, centipede bite.
TCMBANKHE007238 Radix Stephaniae Tetrandrae 防己 To cause diuresis and to relieve rheumatic conditions./Beriberi with edema, inhibited urination, eczema, sore toxin, wind-damp impediment pain, hypertension, adjuvant in anesthesia.
TCMBANKHE008122 Thalictrum microgynum 小果唐松草 To clear heat and resolve toxin, disinhibit damp./Yellow swelling in whole body, yellow eyes, knocks and falls.
TCMBANKHE008359 Semen Oroxyli 木蝴蝶 To remove heat from the lung and relieve sore throat, and to regulate the flow of qi of the liver and the stomach./Lung heat cough, throat impediment, aphonia, liver stomach qi pain.
TCMBANKHE008039 Mahonia confusa 湖北十大功劳 To clear heat and dry damp, drain fire and resolve toxin./Damp-heat dysentery, diarrhea, jaundice, red eyes with gall, swollen welling abscess and sores, wind-damp-heat impediment, taxation fever steaming bone, hemoptysis, dizzy head.
TCMBANKHE008723/XU-511 Thalictrum glandulosissimum 金丝马尾连 湖北省远安县荷花镇 See Thalictrum foliolosum./See Thalictrum foliolosum.
TCMBANKHE004238/YEM-1014 Phellodendron amurense;Cortex Phellodendri|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄柏|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 1. To clear heat and dry dampness; 2. To reduce fire and release toxins/Damp-heat dysentery, tuberculosis, epidemic meningitis, acute conjunctivitis, trachoma, fever, abdominal pain, diarrhea, suppurative hematochezia, tenesmus, jaundice, yellow thick foul leukorrhagia, swelling pain in knees and feet, urinary tract infection, boil, sore, ulcer, eczema, mouth sore, hemorrhoids, burns, scalds, exuberance of fire with tidal fever, tidal fever with night sweat, emission. 瑶族/壮族
TCMBANKHE000649/YEM-168 Cortex Berberidis|Berberis wilsonae Hemsl. 三颗针|金花小檗 小三颗针 云南民族药物志:第一卷 For clearing heat and removing toxic substances 傈僳族/彝族
TCMBANKHE005424/YEM-332/YEM-708 Mahonia bealei|Mahonia fortunei(Lindl.)Fedde 十大功劳木|十大功劳 十大功劳 云南民族药物志:第四卷 To clear heat, dry damp, resolve toxin./Lung heat cough, jaundice, diarrhea, dysentery, red eyes with gall, sores, eczema, scalds. 布依族/傣族/苗族/瑶族/彝族/壮族
TCMBANKHE008695/YEM-708 Mahonia fortunei|Mahonia fortunei(Lindl.)Fedde 细叶功劳木|十大功劳 十大功劳 云南民族药物志:第四卷 See Mahonia bealei./See Mahonia bealei. 布依族/傣族/苗族/瑶族/彝族/壮族
TCMBANKHE006083/YEM-791 Herba Aristolochiae;Fibraurea recisa Pierre|Fibraurea recisa Pierre 天仙藤 大黄藤 云南民族药物志:第四卷 To promote the flow of qi and blood, and to induce diuresis./Acute tonsillitis, pharyngolaryngitis, infection of upper respiratory tract, conjunctivitis, jaundice, gastroenteritis, dysentery, child indigestion, food poisoning, salpingitis, acute endometritis, chronic endometritis, acute pelvic inflammation, vaginitis, sore and boil, burns and scalds. 瑶族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000121 KCNH2 ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 potassium voltage-gated channel subfamily H member 2
TCMBANKGE000181 PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201 ESR1 ER; ESR; ESRA; ESTRR; Era; NR3A1 estrogen receptor 1
TCMBANKGE000205 NOS2 HEP-NOS; INOS; NOS; NOS2A nitric oxide synthase 2
TCMBANKGE000286 GSK3B - glycogen synthase kinase 3 beta
TCMBANKGE000309 SCN5A CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1 sodium voltage-gated channel alpha subunit 5
TCMBANKGE000360 CCNA2 CCN1; CCNA cyclin A2
TCMBANKGE000476 NCOA2 GRIP1; KAT13C; NCoA-2; SRC2; TIF2; bHLHe75 nuclear receptor coactivator 2
TCMBANKGE000478 CHEK1 CHK1 checkpoint kinase 1
TCMBANKGE000637 SDHB CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP succinate dehydrogenase complex iron sulfur subunit B
TCMBANKGE000701 ESR2 ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8 estrogen receptor 2
TCMBANKGE000766 ACHE ACEE; ARACHE; N-ACHE; YT acetylcholinesterase (Cartwright blood group)
TCMBANKGE000784 CALM3 CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3 calmodulin 3
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE000903 PTGS1 COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS prostaglandin-endoperoxide synthase 1
TCMBANKGE000938 CDK2 CDKN2; p33(CDK2) cyclin dependent kinase 2
TCMBANKGE001073 PTGS2 COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 prostaglandin-endoperoxide synthase 2
TCMBANKGE001185 PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma peroxisome proliferator activated receptor gamma
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001755 MAOB - monoamine oxidase B
TCMBANKGE004266 AR AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM androgen receptor
TCMBANKGE006339 CA2 CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282 carbonic anhydrase 2
TCMBANKGE008172 MAOA BRNRS; MAO-A monoamine oxidase A
TCMBANKGE008921 RXRA NR2B1 retinoid X receptor alpha
TCMBANKGE011079 PRSS1 TRP1; TRY1; TRY4; TRYP1 serine protease 1