Compound Summary

  Compound Information

TCMBANKIN061715

药名:	9,10-dihydroxy-7-methoxy-3-methylene-4H-benzo[g]isochromen-1-one
别名:	80503-54-4; 1H-Naphtho(2,3-c)pyran-1-one, 3,4-dihydro-9,10-dihydroxy-7-methoxy-3-methylene-; 9,10-dihydroxy-7-methoxy-3-methylidene-4H-benzo[g]isochromen-1-one; isotoralactone
分子式:	C15H12O5
Smiles:	COC1=CC(=C2C(=C1)C=C3CC(=C)OC(=O)C3=C2O)O
成分:	HBIN013947; HBIN031313
OB_score:	63.251379
CAS_id:	80503-54-4
SymMap_id:	SMIT08092
TCMID_id:	11741
TCMSP_id:	MOL006482
PubChem_id:	157661

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004160	Semen Cassiae;Semen Sene	决明子			To remove heat from the liver, to improve eyesight, and to relax bowels./See Cassia obtusifolia.
TCMBANKHE006959/YNS-135/YEM-14	Semen Cassiae;Semen Sene|Cassia tora Linn.|Cassia tora L.	决明子;草决明|决明	决明根|草决明	云南药材标准：第三册|云南民族药物志：第一卷	安神补脑，清肝明目，理气止痛。主治失眠多梦，入睡易惊，腹内痉挛剧痛，腹部包块，黄疸，疟疾。|To remove heat from the liver, to improve eyesight, and to relax bowels.Treatment of inflammation in the eye with pain, photophobia and lacrimination, headache, dizziness, blurred vision and constipation./See Cassia obtusifolia.1. Oral adminstration of the hearbal powder can inhibit the rising of serum cholesterol and formation of atherosclerosis in rabbits.2. Its tincture and infusion can inhibit the myocardium of toad in vitro, and contract th eblood vessels of lower limbs.3. Its infusion can lower the blood pressure in dogs, cats and rabbits.4. Chrysophanol, one of the active components, is a laxative.5. Bacteriostatic.	傣族/基诺族/拉祜族/傈僳族/苗族/佤族/彝族/藏族
TCMBANKHE004281/YNS-135/YEM-14	Cassia obtusifolia|Cassia tora Linn.|Cassia tora L.	钝叶决明|决明	决明根|草决明	云南药材标准：第三册|云南民族药物志：第一卷	安神补脑，清肝明目，理气止痛。主治失眠多梦，入睡易惊，腹内痉挛剧痛，腹部包块，黄疸，疟疾。|To clear liver and brighten eyes, disinhibit water and free stool./Red eyes with gall, delacrimation and photophobia, clear-eye blindness, night blindness, dizziness and headache, dim vision, cirrhosis with ascites, inhibited urination, habitual constipation, toxin swelling, skin lichen.	傣族/基诺族/拉祜族/傈僳族/苗族/佤族/彝族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000181	PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase
TCMBANKGE000201	ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1
TCMBANKGE000205	NOS2	HEP-NOS; INOS; NOS; NOS2A	nitric oxide synthase 2
TCMBANKGE000286	GSK3B	-	glycogen synthase kinase 3 beta
TCMBANKGE000360	CCNA2	CCN1; CCNA	cyclin A2
TCMBANKGE000478	CHEK1	CHK1	checkpoint kinase 1
TCMBANKGE000701	ESR2	ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8	estrogen receptor 2
TCMBANKGE000813	DPP4	ADABP; ADCP2; CD26; DPPIV; TP103	dipeptidyl peptidase 4
TCMBANKGE000903	PTGS1	COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS	prostaglandin-endoperoxide synthase 1
TCMBANKGE000938	CDK2	CDKN2; p33(CDK2)	cyclin dependent kinase 2
TCMBANKGE001073	PTGS2	COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2	prostaglandin-endoperoxide synthase 2
TCMBANKGE001185	PPARG	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma	peroxisome proliferator activated receptor gamma
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE004266	AR	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM	androgen receptor
TCMBANKGE006339	CA2	CA-II; CAC; CAII; Car2; HEL-76; HEL-S-282	carbonic anhydrase 2
TCMBANKGE009758	PDE3A	CGI-PDE; CGI-PDE A; CGI-PDE-A; HTNB	phosphodiesterase 3A