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疾病ID:TCMBANKDI006127
疾病名:Alzheimer Disease, Early Onset
MeSH_Name:Nervous System Diseases; Mental Disorders
HPO_Name:-
UMLS_Name:Disease or Syndrome
DO_Name:-
疾病类型:disease
DisGeNET_Link:C0750901
MeSH_Link:C10; F03
HPO_Link:-
UMLS_Link:T047
DO_Link:-
HERB_ID:-
疾病对应的植物
| ID | 拉丁名 | 药名 | 药用植物名 | 功能与主治 | 来源 | 药用部位 | 使用民族 |
|---|
疾病对应的化合物
| 化合物ID | 化合物名 | 别名 | 分子式 | 分子质量 | Smiles |
|---|
疾病对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE013564 | PYY | PYY-I; PYY1 | peptide YY |
| TCMBANKGE012410 | ARC | Arg3.1; hArc | activity regulated cytoskeleton associated protein |
| TCMBANKGE000260 | APOB | FCHL2; FLDB; LDLCQ4; apoB-100; apoB-48 | apolipoprotein B |
| TCMBANKGE008479 | PICALM | CALM; CLTH; LAP | phosphatidylinositol binding clathrin assembly protein |
| TCMBANKGE014832 | DHCR24 | DCE; Nbla03646; SELADIN1; seladin-1 | 24-dehydrocholesterol reductase |
| TCMBANKGE014509 | CTSF | CATSF; CLN13 | cathepsin F |
| TCMBANKGE000137 | PLAU | ATF; BDPLT5; QPD; UPA; URK; u-PA | plasminogen activator, urokinase |
| TCMBANKGE005402 | CST3 | ARMD11; HEL-S-2 | cystatin C |
| TCMBANKGE001132 | BAX | BCL2L4 | BCL2 associated X, apoptosis regulator |
| TCMBANKGE014015 | BCHE | BCHED; CHE1; CHE2; E1 | butyrylcholinesterase |
| TCMBANKGE001197 | FOS | AP-1; C-FOS; p55 | Fos proto-oncogene, AP-1 transcription factor subunit |
| TCMBANKGE005007 | UPK3B | P35; UP3B; UPIIIB | uroplakin 3B |
| TCMBANKGE007917 | IDUA | IDA; MPS1; MPSI | alpha-L-iduronidase |
| TCMBANKGE013844 | UBQLN1 | DA41; DSK2; PLIC-1; UBQN; XDRP1 | ubiquilin 1 |
| TCMBANKGE010304 | ADAMTS1 | C3-C5; METH1 | ADAM metallopeptidase with thrombospondin type 1 motif 1 |
| TCMBANKGE008806 | RCBTB1 | CLLD7; CLLL7; GLP; RDEOA | RCC1 and BTB domain containing protein 1 |
| TCMBANKGE010781 | BRCA2 | BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11 | BRCA2 DNA repair associated |
| TCMBANKGE000096 | TBK1 | FTDALS4; IIAE8; NAK; T2K | TANK binding kinase 1 |
| TCMBANKGE012932 | GCHFR | GFRP; HsT16933; P35 | GTP cyclohydrolase I feedback regulator |
| TCMBANKGE000261 | INS | IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10; PNDM4 | insulin |
| TCMBANKGE003205 | WWOX | D16S432E; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1 | WW domain containing oxidoreductase |
| TCMBANKGE000313 | JUN | AP-1; AP1; c-Jun; cJUN; p39 | Jun proto-oncogene, AP-1 transcription factor subunit |
| TCMBANKGE001076 | SOD2 | GClnc1; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD | superoxide dismutase 2 |
| TCMBANKGE014599 | PLCG2 | APLAID; FCAS3; PLC-IV; PLC-gamma-2 | phospholipase C gamma 2 |
| TCMBANKGE000010 | CDK5R1 | CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a | cyclin dependent kinase 5 regulatory subunit 1 |
| TCMBANKGE004872 | GAPDHS | GAPD2; GAPDH-2; GAPDS; HEL-S-278; HSD-35 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
| TCMBANKGE009975 | LAMC2 | B2T; BM600; CSF; EBR2; EBR2A; LAMB2T; LAMNB2 | laminin subunit gamma 2 |
| TCMBANKGE000871 | IGFBP3 | BP-53; IBP3 | insulin like growth factor binding protein 3 |
| TCMBANKGE000836 | BACE1 | ASP2; BACE; HSPC104 | beta-secretase 1 |
| TCMBANKGE005376 | SLC30A4 | ZNT4; znT-4 | solute carrier family 30 member 4 |
| TCMBANKGE010739 | TFF1 | BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2 | trefoil factor 1 |
| TCMBANKGE000247 | SLC2A4 | GLUT4 | solute carrier family 2 member 4 |
| TCMBANKGE001061 | CDK5 | LIS7; PSSALRE | cyclin dependent kinase 5 |
| TCMBANKGE012004 | NUDT11 | APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta | nudix hydrolase 11 |
| TCMBANKGE004355 | EHMT1 | EHMT1-IT1; EUHMTASE1; Eu-HMTase1; FP13812; GLP; GLP1; KLEFS1; KMT1D | euchromatic histone lysine methyltransferase 1 |
| TCMBANKGE013252 | PLD3 | AD19; HU-K4; HUK4; SCA46 | phospholipase D family member 3 |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE000872 | IGF1R | CD221; IGFIR; IGFR; JTK13 | insulin like growth factor 1 receptor |
| TCMBANKGE010712 | MME | CALLA; CD10; CMT2T; NEP; SCA43; SFE | membrane metalloendopeptidase |
| TCMBANKGE011516 | SLC30A6 | MST103; MSTP103; ZNT6 | solute carrier family 30 member 6 |
| TCMBANKGE000201 | ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 |
| TCMBANKGE005853 | TRIM59 | IFT80L; MRF1; RNF104; TRIM57; TSBF1 | tripartite motif containing 59 |
| TCMBANKGE000196 | FAS | ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6 | Fas cell surface death receptor |
| TCMBANKGE006947 | CDK5R2 | NCK5AI; P39; p39nck5ai | cyclin dependent kinase 5 regulatory subunit 2 |
| TCMBANKGE012777 | BIN1 | AMPH2; AMPHL; CNM2; SH3P9 | bridging integrator 1 |
| TCMBANKGE000225 | TFAM | MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3 | transcription factor A, mitochondrial |
| TCMBANKGE000588 | TYROBP | DAP12; KARAP; PLOSL; PLOSL1 | transmembrane immune signaling adaptor TYROBP |
| TCMBANKGE000611 | CSF2 | CSF; GMCSF | colony stimulating factor 2 |
| TCMBANKGE001107 | NOS3 | ECNOS; eNOS | nitric oxide synthase 3 |
| TCMBANKGE007141 | MTHFR | - | methylenetetrahydrofolate reductase |
| TCMBANKGE011915 | APBB1 | FE65; MGC:9072; RIR | amyloid beta precursor protein binding family B member 1 |
| TCMBANKGE002205 | ABCA7 | ABCA-SSN; ABCX; AD9 | ATP binding cassette subfamily A member 7 |
| TCMBANKGE001069 | MPO | - | myeloperoxidase |
| TCMBANKGE001037 | MMP2 | CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1 | matrix metallopeptidase 2 |
| TCMBANKGE001755 | MAOB | - | monoamine oxidase B |
| TCMBANKGE011697 | ABCA2 | ABC2; IDPOGSA | ATP binding cassette subfamily A member 2 |
| TCMBANKGE000271 | APOE | AD2; APO-E; ApoE4; LDLCQ5; LPG | apolipoprotein E |
| TCMBANKGE006565 | NPY | PYY4 | neuropeptide Y |
| TCMBANKGE012249 | DLST | DLTS; KGD2; PGL7 | dihydrolipoamide S-succinyltransferase |
| TCMBANKGE011947 | AQP1 | AQP-CHIP; CHIP28; CO | aquaporin 1 (Colton blood group) |
| TCMBANKGE000017 | MAPT | DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU | microtubule associated protein tau |
| TCMBANKGE004847 | EPHA1 | EPH; EPHT; EPHT1 | EPH receptor A1 |
| TCMBANKGE002137 | PSEN1 | ACNINV3; AD3; FAD; PS-1; PS1; S182 | presenilin 1 |
| TCMBANKGE002933 | CR1 | C3BR; C4BR; CD35; KN | complement C3b/C4b receptor 1 (Knops blood group) |
| TCMBANKGE014529 | ENO1 | ENO1L1; HEL-S-17; MPB1; NNE; PPH | enolase 1 |
| TCMBANKGE000563 | CLU | AAG4; APO-J; APOJ; CLI; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2 | clusterin |
| TCMBANKGE005229 | DPP6 | DPL1; DPPX; MRD33; VF2 | dipeptidyl peptidase like 6 |
| TCMBANKGE012841 | HLA-A | HLAA | major histocompatibility complex, class I, A |
| TCMBANKGE005054 | HLA-DRB5 | - | major histocompatibility complex, class II, DR beta 5 |
| TCMBANKGE009185 | MEFV | FMF; MEF; TRIM20 | MEFV innate immuity regulator, pyrin |
| TCMBANKGE006817 | PCDH11X | PCDH-X; PCDH-Y; PCDH11; PCDH11Y; PCDH22; PCDHX; PPP1R119 | protocadherin 11 X-linked |
| TCMBANKGE000761 | FANCD2 | FA-D2; FA4; FACD; FAD; FAD2; FANCD | FA complementation group D2 |
| TCMBANKGE001158 | LEP | LEPD; OB; OBS | leptin |
| TCMBANKGE002052 | CIB1 | CIB; CIBP; KIP1; PRKDCIP; SIP2-28 | calcium and integrin binding 1 |
| TCMBANKGE007705 | CYP46A1 | CP46; CYP46 | cytochrome P450 family 46 subfamily A member 1 |
| TCMBANKGE010372 | BACE2 | AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP | beta-secretase 2 |
| TCMBANKGE011469 | DAPK1 | DAPK; ROCO3 | death associated protein kinase 1 |
| TCMBANKGE000277 | CD33 | SIGLEC-3; SIGLEC3; p67 | CD33 molecule |
| TCMBANKGE000542 | NLRP1 | AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NALP1; PP1044; SLEV1; VAMAS1 | NLR family pyrin domain containing 1 |
| TCMBANKGE014042 | INPP5D | SHIP; SHIP-1; SHIP1; SIP-145; hp51CN; p150Ship | inositol polyphosphate-5-phosphatase D |
| TCMBANKGE005990 | TTK | CT96; ESK; MPH1; MPS1; MPS1L1; PYT | TTK protein kinase |
| TCMBANKGE000766 | ACHE | ACEE; ARACHE; N-ACHE; YT | acetylcholinesterase (Cartwright blood group) |
| TCMBANKGE005810 | HTT | HD; IT15; LOMARS | huntingtin |
| TCMBANKGE000889 | HFE | HFE1; HH; HLA-H; MVCD7; TFQTL2 | homeostatic iron regulator |
| TCMBANKGE012260 | TF | HEL-S-71p; PRO1557; PRO2086; TFQTL1 | transferrin |
| TCMBANKGE011200 | ADAM10 | AD10; AD18; CD156c; CDw156; HsT18717; MADM; RAK; kuz | ADAM metallopeptidase domain 10 |
| TCMBANKGE011244 | ATP6V0D1 | ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD | ATPase H+ transporting V0 subunit d1 |
| TCMBANKGE000835 | APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | amyloid beta precursor protein |
| TCMBANKGE011193 | RPS27 | DBA17; MPS-1; MPS1; S27 | ribosomal protein S27 |
| TCMBANKGE008126 | TPI1 | HEL-S-49; TIM; TPI; TPID | triosephosphate isomerase 1 |
| TCMBANKGE010285 | A2M | A2MD; CPAMD5; FWP007; S863-7 | alpha-2-macroglobulin |
| TCMBANKGE002387 | RIN3 | - | Ras and Rab interactor 3 |
| TCMBANKGE000643 | TTR | ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA | transthyretin |
| TCMBANKGE011348 | IGF2R | CD222; CI-M6PR; CIMPR; M6P-R; M6P/IGF2R; MPR 300; MPR1; MPR300; MPRI | insulin like growth factor 2 receptor |
| TCMBANKGE014557 | ANXA1 | ANX1; LPC1 | annexin A1 |
| TCMBANKGE014466 | TPP1 | CLN2; GIG1; LPIC; SCAR7; TPP-1 | tripeptidyl peptidase 1 |
| TCMBANKGE003283 | AGPS | ADAP-S; ADAS; ADHAPS; ADPS; ALDHPSY; RCDP3 | alkylglycerone phosphate synthase |
| TCMBANKGE000689 | GRAP2 | GADS; GRAP-2; GRB2L; GRBLG; GRID; GRPL; GrbX; Grf40; Mona; P38 | GRB2 related adaptor protein 2 |
| TCMBANKGE006156 | RELN | ETL7; LIS2; PRO1598; RL | reelin |
| TCMBANKGE010277 | CYP2D6 | CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 | cytochrome P450 family 2 subfamily D member 6 |
| TCMBANKGE012415 | PSEN2 | AD3L; AD4; CMD1V; PS2; STM2 | presenilin 2 |
| TCMBANKGE001185 | PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | peroxisome proliferator activated receptor gamma |
| TCMBANKGE000286 | GSK3B | - | glycogen synthase kinase 3 beta |
| TCMBANKGE001125 | IGF1 | IGF; IGF-I; IGFI; MGF | insulin like growth factor 1 |
| TCMBANKGE012423 | PRNP | ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30 | prion protein |
| TCMBANKGE002728 | CNTF | HCNTF | ciliary neurotrophic factor |
| TCMBANKGE012048 | HLA-B | AS; B-4901; HLAB | major histocompatibility complex, class I, B |
| TCMBANKGE000504 | IL12A | CLMF; IL-12A; NFSK; NKSF1; P35 | interleukin 12A |
| TCMBANKGE001189 | IL1A | IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1 | interleukin 1 alpha |
| TCMBANKGE001150 | EIF2S1 | EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A | eukaryotic translation initiation factor 2 subunit alpha |
| TCMBANKGE007310 | MNAT1 | CAP35; MAT1; RNF66; TFB3 | MNAT1 component of CDK activating kinase |
| TCMBANKGE004182 | CDCA5 | SORORIN | cell division cycle associated 5 |
| TCMBANKGE007543 | INSR | CD220; HHF5 | insulin receptor |
| TCMBANKGE008674 | MS4A4A | 4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4; MS4A7 | membrane spanning 4-domains A4A |
| TCMBANKGE008503 | ASL | ASAL | argininosuccinate lyase |
| TCMBANKGE000828 | TREM2 | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c | triggering receptor expressed on myeloid cells 2 |
| TCMBANKGE000186 | IGF2 | C11orf43; GRDF; IGF-II; PP9974 | insulin like growth factor 2 |
| TCMBANKGE014473 | CRH | CRF; CRH1 | corticotropin releasing hormone |
| TCMBANKGE002676 | SORL1 | C11orf32; LR11; LRP9; SORLA; SorLA-1; gp250 | sortilin related receptor 1 |
| TCMBANKGE000330 | HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | heme oxygenase 1 |
| TCMBANKGE013459 | IQCK | - | IQ motif containing K |
| TCMBANKGE008183 | ACE | ACE1; CD143; DCP; DCP1 | angiotensin I converting enzyme |
| TCMBANKGE006961 | F2 | PT; RPRGL2; THPH1 | coagulation factor II, thrombin |
| TCMBANKGE008232 | RUFY1 | RABIP4; ZFYVE12 | RUN and FYVE domain containing 1 |
| TCMBANKGE009818 | PGRMC1 | Dap1; HPR6.6; IZA; MPR | progesterone receptor membrane component 1 |
| TCMBANKGE000965 | CHRNA7 | CHRNA7-2; NACHRA7 | cholinergic receptor nicotinic alpha 7 subunit |
| TCMBANKGE009252 | PNMT | PENT; PNMTase | phenylethanolamine N-methyltransferase |
| TCMBANKGE007175 | FCN2 | EBP-37; FCNL; P35; ficolin-2 | ficolin 2 |
| TCMBANKGE000236 | BDNF | ANON2; BULN2 | brain derived neurotrophic factor |
| TCMBANKGE003829 | CHRNB2 | EFNL3; nAChRB2 | cholinergic receptor nicotinic beta 2 subunit |
| TCMBANKGE007873 | VSNL1 | HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1 | visinin like 1 |
| TCMBANKGE000110 | DPYSL2 | CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2 | dihydropyrimidinase like 2 |
| TCMBANKGE001808 | MPEG1 | MPG1; MPS1; Mpg-1; P-2 | macrophage expressed 1 |
| TCMBANKGE003672 | CALM1 | CALML2; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; CPVT4; DD132; LQT14; PHKD; caM | calmodulin 1 |
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Dai SX Lab