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疾病ID:TCMBANKDI009935
疾病名:Holoprosencephaly
MeSH_Name:Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
HPO_Name:Abnormality of the nervous system
UMLS_Name:Congenital Abnormality
DO_Name:genetic disease; disease of anatomical entity; syndrome; physical disorder
疾病类型:disease
DisGeNET_Link:C0079541
MeSH_Link:C16; C05; C10
HPO_Link:HP:0000707
UMLS_Link:T019
DO_Link:DOID:630; DOID:7; DOID:225; DOID:0080015
HERB_ID:HBDIS003197
疾病对应的植物
| ID | 拉丁名 | 药名 | 药用植物名 | 功能与主治 | 来源 | 药用部位 | 使用民族 |
|---|
疾病对应的化合物
| 化合物ID | 化合物名 | 别名 | 分子式 | 分子质量 | Smiles |
|---|
疾病对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE001033 | FGFR1 | BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD; bFGF-R-1 | fibroblast growth factor receptor 1 |
| TCMBANKGE002581 | PROP1 | CPHD2; PROP-1 | PROP paired-like homeobox 1 |
| TCMBANKGE002746 | PIGN | MCAHS; MCAHS1; MCD4; MDC4; PIG-N | phosphatidylinositol glycan anchor biosynthesis class N |
| TCMBANKGE000897 | GLI3 | ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV | GLI family zinc finger 3 |
| TCMBANKGE006856 | NOG | SYM1; SYNS1; SYNS1A | noggin |
| TCMBANKGE007080 | PSTPIP1 | CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP | proline-serine-threonine phosphatase interacting protein 1 |
| TCMBANKGE009435 | PPP1R12A | GUBS; M130; MBS; MYPT1 | protein phosphatase 1 regulatory subunit 12A |
| TCMBANKGE000298 | SOD1 | ALS; ALS1; HEL-S-44; IPOA; SOD; STAHP; hSod1; homodimer | superoxide dismutase 1 |
| TCMBANKGE007507 | PAX2 | FSGS7; PAPRS | paired box 2 |
| TCMBANKGE011851 | SEMA3E | M-SEMAH; M-SemaK; SEMAH; coll-5 | semaphorin 3E |
| TCMBANKGE008710 | TCTN1 | JBTS13; TECT1 | tectonic family member 1 |
| TCMBANKGE000844 | CYP2E1 | CPE1; CYP2E; P450-J; P450C2E | cytochrome P450 family 2 subfamily E member 1 |
| TCMBANKGE000493 | NR4A3 | CHN; CSMF; MINOR; NOR1; TEC | nuclear receptor subfamily 4 group A member 3 |
| TCMBANKGE014297 | KRIT1 | CAM; CCM1 | KRIT1 ankyrin repeat containing |
| TCMBANKGE001179 | SMAD2 | JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2 | SMAD family member 2 |
| TCMBANKGE012832 | LSS | APMR4; CTRCT44; HYPT14; OSC | lanosterol synthase |
| TCMBANKGE003138 | STAG2 | HPE13; MKMS; NEDXCF; SA-2; SA2; SCC3B; bA517O1.1 | stromal antigen 2 |
| TCMBANKGE004802 | POMGNT1 | GNTI.2; GnT I.2; LGMD2O; LGMDR15; MEB; MGAT1.2; RP76; gnT-I.2 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) |
| TCMBANKGE011125 | ZIC1 | BAIDCS; CRS6; ZIC; ZNF201 | Zic family member 1 |
| TCMBANKGE014952 | CEP57 | MVA2; PIG8; TSP57 | centrosomal protein 57 |
| TCMBANKGE001676 | GMPPB | LGMDR19; MDDGA14; MDDGB14; MDDGC14 | GDP-mannose pyrophosphorylase B |
| TCMBANKGE011962 | HOXA2 | HOX1K; MCOHI | homeobox A2 |
| TCMBANKGE003228 | LRP2 | DBS; GP330; LRP-2 | LDL receptor related protein 2 |
| TCMBANKGE004866 | BUB1B | BUB1beta; BUBR1; Bub1A; MAD3L; MVA1; SSK1; hBUBR1 | BUB1 mitotic checkpoint serine/threonine kinase B |
| TCMBANKGE004430 | BUB3 | BUB3L; hBUB3 | BUB3 mitotic checkpoint protein |
| TCMBANKGE000980 | SOX2 | ANOP3; MCOPS3 | SRY-box transcription factor 2 |
| TCMBANKGE000784 | CALM3 | CALM; CAM1; CAM2; CAMB; CPVT6; CaM; CaMIII; HEL-S-72; LQT16; PHKD; PHKD3 | calmodulin 3 |
| TCMBANKGE003618 | RALGAPA1 | GARNL1; GRIPE; NEDHRIT; RalGAPalpha1; TULIP1; p240 | Ral GTPase activating protein catalytic subunit alpha 1 |
| TCMBANKGE001176 | CAT | - | catalase |
| TCMBANKGE011593 | TDGF1 | CR; CR-1; CRGF; CRIPTO | teratocarcinoma-derived growth factor 1 |
| TCMBANKGE010873 | HUWE1 | ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MRXST; MULE; URE-B1; UREB1 | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 |
| TCMBANKGE014551 | TRIP13 | 16E1BP; MVA3 | thyroid hormone receptor interactor 13 |
| TCMBANKGE006691 | FGFR3 | ACH; CD333; CEK2; HSFGFR3EX; JTK4 | fibroblast growth factor receptor 3 |
| TCMBANKGE006873 | CNOT1 | AD-005; CDC39; HPE12; NOT1; NOT1H | CCR4-NOT transcription complex subunit 1 |
| TCMBANKGE009809 | STIL | MCPH7; SIL | STIL centriolar assembly protein |
| TCMBANKGE000904 | PTCH1 | BCNS; NBCCS; PTC; PTC1; PTCH | patched 1 |
| TCMBANKGE009274 | TGIF1 | HPE4; TGIF | TGFB induced factor homeobox 1 |
| TCMBANKGE000471 | POMC | ACTH; CLIP; LPH; MSH; NPP; OBAIRH; POC | proopiomelanocortin |
| TCMBANKGE009443 | GPKOW | GPATC5; GPATCH5; Mos2; Spp2; T54 | G-patch domain and KOW motifs |
| TCMBANKGE014661 | ZIC2 | HPE5 | Zic family member 2 |
| TCMBANKGE005556 | CAMKMT | C2orf34; CLNMT; CaM KMT; Cam; KMT | calmodulin-lysine N-methyltransferase |
| TCMBANKGE008220 | RAC3 | - | Rac family small GTPase 3 |
| TCMBANKGE014508 | PRRX1 | AGOTC; PHOX1; PMX1; PRX-1; PRX1 | paired related homeobox 1 |
| TCMBANKGE002584 | CHD7 | CRG; HH5; IS3; KAL5 | chromodomain helicase DNA binding protein 7 |
| TCMBANKGE000912 | SHH | HHG1; HLP3; HPE3; MCOPCB5; SMMCI; ShhNC; TPT; TPTPS | sonic hedgehog signaling molecule |
| TCMBANKGE000030 | FKRP | FKTR; LGMD2I; LGMDR9; MDC1C; MDDGA5; MDDGB5; MDDGC5 | fukutin related protein |
| TCMBANKGE004968 | FGF8 | AIGF; FGF-8; HBGF-8; HH6; KAL6 | fibroblast growth factor 8 |
| TCMBANKGE002696 | ZIC5 | - | Zic family member 5 |
| TCMBANKGE002431 | ARID1A | B120; BAF250; BAF250a; BM029; C1orf4; CSS2; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1 | AT-rich interaction domain 1A |
| TCMBANKGE004706 | MOGS | CDG2B; CWH41; DER7; GCS1 | mannosyl-oligosaccharide glucosidase |
| TCMBANKGE009440 | PGAP1 | Bst1; ISPD3024; MRT42; SPG67 | post-GPI attachment to proteins inositol deacylase 1 |
| TCMBANKGE000286 | GSK3B | - | glycogen synthase kinase 3 beta |
| TCMBANKGE014368 | HESX1 | ANF; CPHD5; RPX | HESX homeobox 1 |
| TCMBANKGE009587 | GAS1 | - | growth arrest specific 1 |
| TCMBANKGE004381 | NODAL | HTX5 | nodal growth differentiation factor |
| TCMBANKGE013001 | SMC1A | CDLS2; DXS423E; EIEE85; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB | structural maintenance of chromosomes 1A |
| TCMBANKGE012286 | WIF1 | WIF-1 | WNT inhibitory factor 1 |
| TCMBANKGE000899 | GLI2 | CJS; HPE9; PHS2; THP1; THP2 | GLI family zinc finger 2 |
| TCMBANKGE003208 | DKK1 | DKK-1; SK | dickkopf WNT signaling pathway inhibitor 1 |
| TCMBANKGE000906 | FOXA2 | HNF-3-beta; HNF3B; TCF3B | forkhead box A2 |
| TCMBANKGE011723 | DHCR7 | SLOS | 7-dehydrocholesterol reductase |
| TCMBANKGE008528 | DLL1 | DELTA1; DL1; Delta; NEDBAS | delta like canonical Notch ligand 1 |
| TCMBANKGE013392 | BOC | CDON2 | BOC cell adhesion associated, oncogene regulated |
| TCMBANKGE002427 | BUB1 | BUB1A; BUB1L; hBUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
| TCMBANKGE000895 | SUFU | JBTS32; PRO1280; SUFUH; SUFUXL | SUFU negative regulator of hedgehog signaling |
| TCMBANKGE014740 | PLTP | BPIFE; HDLCQ9 | phospholipid transfer protein |
| TCMBANKGE011910 | MNX1 | HB9; HLXB9; HOXHB9; SCRA1 | motor neuron and pancreas homeobox 1 |
| TCMBANKGE000771 | TWIST1 | ACS3; BPES2; BPES3; CRS; CRS1; CSO; SCS; SWCOS; TWIST; bHLHa38 | twist family bHLH transcription factor 1 |
| TCMBANKGE000824 | RB1 | OSRC; PPP1R130; RB; p105-Rb; p110-RB1; pRb; pp110 | RB transcriptional corepressor 1 |
| TCMBANKGE012009 | TGIF2 | - | TGFB induced factor homeobox 2 |
| TCMBANKGE003672 | CALM1 | CALML2; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; CPVT4; DD132; LQT14; PHKD; caM | calmodulin 1 |
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Dai SX Lab