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疾病ID:TCMBANKDI011000

疾病名:Hyperkeratosis

MeSH_Name:Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases

HPO_Name:Abnormality of the integument

UMLS_Name:Disease or Syndrome

DO_Name:disease of anatomical entity

疾病类型:disease

DisGeNET_Link:C0870082

MeSH_Link:C23; C17

HPO_Link:HP:0001574

UMLS_Link:T047

DO_Link:DOID:7

HERB_ID:HBDIS012258

   疾病对应的植物
ID 拉丁名 药名 药用植物名 功能与主治 来源 药用部位 使用民族
   疾病对应的化合物
化合物ID 化合物名 别名 分子式 分子质量 Smiles
   疾病对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE012734 POLA1 NSX; POLA; VEODS; p180 DNA polymerase alpha 1, catalytic subunit
TCMBANKGE012965 DSG1 CDHF4; DG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1 desmoglein 1
TCMBANKGE008802 TSLP - thymic stromal lymphopoietin
TCMBANKGE000070 CAV1 BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21 caveolin 1
TCMBANKGE013320 HDAC6 CPBHM; HD6; JM21; PPP1R90 histone deacetylase 6
TCMBANKGE014592 ALDH3A2 ALDH10; FALDH; SLS aldehyde dehydrogenase 3 family member A2
TCMBANKGE009204 MBTPS2 BRESEK; IFAP; KFSD; KFSDX; OI19; OLMSX; S2P membrane bound transcription factor peptidase, site 2
TCMBANKGE011670 ATP2C1 ATP2C1A; BCPM; HHD; PMR1; SPCA1; hSPCA1 ATPase secretory pathway Ca2+ transporting 1
TCMBANKGE003689 MFAP1 AMP microfibril associated protein 1
TCMBANKGE009926 AP1S1 AP19; CLAPS1; EKV3; MEDNIK; SIGMA1A adaptor related protein complex 1 subunit sigma 1
TCMBANKGE011654 NPS - neuropeptide S
TCMBANKGE000567 CDKN2A ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16 cyclin dependent kinase inhibitor 2A
TCMBANKGE005766 PMVK HUMPMKI; PMK; PMKA; PMKASE; POROK1 phosphomevalonate kinase
TCMBANKGE005807 NSDHL H105E3; SDR31E1; XAP104 NAD(P) dependent steroid dehydrogenase-like
TCMBANKGE014606 ERCC5 COFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC ERCC excision repair 5, endonuclease
TCMBANKGE000173 BRAF B-RAF1; B-raf; BRAF1; NS7; RAFB1 B-Raf proto-oncogene, serine/threonine kinase
TCMBANKGE000917 IL17RA CANDF5; CD217; CDw217; IL-17RA; IL17R; IMD51; hIL-17R interleukin 17 receptor A
TCMBANKGE008312 CKAP4 CLIMP-63; CLIMP63; ERGIC-63; p63 cytoskeleton associated protein 4
TCMBANKGE013293 ELOVL4 ADMD; CT118; ISQMR; SCA34; STGD2; STGD3 ELOVL fatty acid elongase 4
TCMBANKGE000009 GJA1 AVSD3; CMDR; CX43; EKVP; EKVP3; GJAL; HLHS1; HSS; ODDD; PPKCA gap junction protein alpha 1
TCMBANKGE000230 ADIPOQ ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28 adiponectin, C1Q and collagen domain containing
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000720 KRT1 CK1; EHK; EHK1; EPPK; K1; KRT1A; NEPPK keratin 1
TCMBANKGE015086 NAGA D22S674; GALB alpha-N-acetylgalactosaminidase
TCMBANKGE001110 OGG1 HMMH; HOGG1; MUTM; OGH1 8-oxoguanine DNA glycosylase
TCMBANKGE000441 ERCC3 BTF2; GTF2H; RAD25; TFIIH; TTD2; XPB ERCC excision repair 3, TFIIH core complex helicase subunit
TCMBANKGE009239 SRD5A3 CDG1P; CDG1Q; KRIZI; SRD5A2L; SRD5A2L1 steroid 5 alpha-reductase 3
TCMBANKGE000196 FAS ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6 Fas cell surface death receptor
TCMBANKGE008140 MVK LRBP; MK; MVLK; POROK3 mevalonate kinase
TCMBANKGE013379 PIGL CHIME phosphatidylinositol glycan anchor biosynthesis class L
TCMBANKGE004445 OPN5 GPR136; GRP136; PGR12; TMEM13 opsin 5
TCMBANKGE000068 VEGFC Flt4-L; LMPH1D; LMPHM4; VRP vascular endothelial growth factor C
TCMBANKGE002022 XRCC1 RCC; SCAR26 X-ray repair cross complementing 1
TCMBANKGE008559 GJB2 BAPS; CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; PPK gap junction protein beta 2
TCMBANKGE011035 DIP2B - disco interacting protein 2 homolog B
TCMBANKGE001069 MPO - myeloperoxidase
TCMBANKGE000243 LMNA CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1 lamin A/C
TCMBANKGE000858 RBPJ AOS3; CBF-1; CBF1; IGKJRB; IGKJRB1; KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJK; RBPSUH; SUH; csl recombination signal binding protein for immunoglobulin kappa J region
TCMBANKGE013919 ECM1 URBWD extracellular matrix protein 1
TCMBANKGE001126 NFE2L2 HEBP1; IMDDHH; NRF2; Nrf-2 nuclear factor, erythroid 2 like 2
TCMBANKGE004826 FLT4 CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; PCL; VEGFR-3; VEGFR3 fms related receptor tyrosine kinase 4
TCMBANKGE007764 MAPKAP1 JC310; MIP1; SIN1; SIN1b; SIN1g MAPK associated protein 1
TCMBANKGE004597 ATL3 HSN1F atlastin GTPase 3
TCMBANKGE012464 GLS AAD20; CASGID; EIEE71; GAC; GAM; GDPAG; GLS1; KGA glutaminase
TCMBANKGE002113 CTSC CPPI; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS cathepsin C
TCMBANKGE011325 CYP4F22 ARCI5; INLNE; LI3 cytochrome P450 family 4 subfamily F member 22
TCMBANKGE009405 KRT6A CK-6C; CK-6E; CK6A; CK6C; CK6D; K6A; K6C; K6D; KRT6C; KRT6D; PC3 keratin 6A
TCMBANKGE008716 ZNF750 ZFP750 zinc finger protein 750
TCMBANKGE007385 NRAS ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6 NRAS proto-oncogene, GTPase
TCMBANKGE014531 ENPP1 ARHR2; COLED; M6S1; NPP1; NPPS; PC-1; PCA1; PDNP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
TCMBANKGE007797 KITLG DCUA; DFNA69; FPH2; FPHH; KL-1; Kitl; MGF; SCF; SF; SHEP7; SLF KIT ligand
TCMBANKGE004101 RPE65 BCO3; LCA2; RP20; mRPE65; p63; rd12; sRPE65 retinoid isomerohydrolase RPE65
TCMBANKGE000432 ADAM17 ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE ADAM metallopeptidase domain 17
TCMBANKGE011937 LIPN ARCI8; LI4; LIPL4; bA186O14.3 lipase family member N
TCMBANKGE011387 CYGB HGB; STAP cytoglobin
TCMBANKGE001030 NOTCH1 AOS5; AOVD1; TAN1; hN1 notch receptor 1
TCMBANKGE001557 XPA XP1; XPAC XPA, DNA damage recognition and repair factor
TCMBANKGE000163 TNFRSF1B CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR TNF receptor superfamily member 1B
TCMBANKGE010462 ALOX12B 12R-LOX; ARCI2 arachidonate 12-lipoxygenase, 12R type
TCMBANKGE003331 IL20 IL-20; IL10D; ZCYTO10 interleukin 20
TCMBANKGE004538 LORICRIN LOR loricrin cornified envelope precursor protein
TCMBANKGE003866 ABCA12 ARCI4A; ARCI4B; ICR2B; LI2 ATP binding cassette subfamily A member 12
TCMBANKGE000542 NLRP1 AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NALP1; PP1044; SLEV1; VAMAS1 NLR family pyrin domain containing 1
TCMBANKGE001176 CAT - catalase
TCMBANKGE003195 PDGFRB CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT platelet derived growth factor receptor beta
TCMBANKGE001051 MAP2K7 JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4 mitogen-activated protein kinase kinase 7
TCMBANKGE013761 DDB2 DDBB; UV-DDB2; XPE damage specific DNA binding protein 2
TCMBANKGE005862 COG6 CDG2L; COD2; SHNS component of oligomeric golgi complex 6
TCMBANKGE002136 GBA GBA1; GCB; GLUC glucosylceramidase beta
TCMBANKGE006691 FGFR3 ACH; CD333; CEK2; HSFGFR3EX; JTK4 fibroblast growth factor receptor 3
TCMBANKGE007509 KRT5 CK5; DDD; DDD1; EBS2; K5; KRT5A keratin 5
TCMBANKGE014174 WRN RECQ3; RECQL2; RECQL3 WRN RecQ like helicase
TCMBANKGE000823 GABPA E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07 GA binding protein transcription factor subunit alpha
TCMBANKGE006609 RIT1 NS8; RIBB; RIT; ROC1 Ras like without CAAX 1
TCMBANKGE000956 NR1H4 BAR; FXR; HRR-1; HRR1; PFIC5; RIP14 nuclear receptor subfamily 1 group H member 4
TCMBANKGE011521 CLEC7A BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2 C-type lectin domain containing 7A
TCMBANKGE007816 UVRAG DHTX; VPS38; p63 UV radiation resistance associated
TCMBANKGE011987 TP63 AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L tumor protein p63
TCMBANKGE011200 ADAM10 AD10; AD18; CD156c; CDw156; HsT18717; MADM; RAK; kuz ADAM metallopeptidase domain 10
TCMBANKGE002475 SDR9C7 ARCI13; RDHS; SDR-O; SDRO short chain dehydrogenase/reductase family 9C member 7
TCMBANKGE001879 STS ARSC; ARSC1; ASC; ES; SSDD; XLI steroid sulfatase
TCMBANKGE007624 CD28 Tp44 CD28 molecule
TCMBANKGE001170 CDK4 CMM3; PSK-J3 cyclin dependent kinase 4
TCMBANKGE002627 MCC MCC1 MCC regulator of WNT signaling pathway
TCMBANKGE003065 NXT1 MTR2; P15 nuclear transport factor 2 like export factor 1
TCMBANKGE005934 IKBKG AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
TCMBANKGE005449 XPC RAD4; XP3; XPCC; p125 XPC complex subunit, DNA damage recognition and repair factor
TCMBANKGE002000 CTLA4 ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12 cytotoxic T-lymphocyte associated protein 4
TCMBANKGE013930 TYR ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3 tyrosinase
TCMBANKGE000328 PTPN11 BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 protein tyrosine phosphatase non-receptor type 11
TCMBANKGE009874 CDKN2B CDK4I; INK4B; MTS2; P15; TP15; p15INK4b cyclin dependent kinase inhibitor 2B
TCMBANKGE014974 KLK7 PRSS6; SCCE; hK7 kallikrein related peptidase 7
TCMBANKGE014504 ST14 ARCI11; HAI; MT-SP1; MTSP1; PRSS14; SNC19; TADG15; TMPRSS14 ST14 transmembrane serine protease matriptase
TCMBANKGE004727 TRAF3IP2 ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13 TRAF3 interacting protein 2
TCMBANKGE007651 NOTCH2 AGS2; HJCYS; hN2 notch receptor 2
TCMBANKGE009234 COL7A1 EBD1; EBDCT; EBR1; NDNC8 collagen type VII alpha 1 chain
TCMBANKGE011634 CDH3 CDHP; HJMD; PCAD cadherin 3
TCMBANKGE000361 ERCC2 COFS2; EM9; TFIIH; TTD; TTD1; XPD ERCC excision repair 2, TFIIH core complex helicase subunit
TCMBANKGE010270 APEX1 APE; APE1; APEN; APEX; APX; HAP1; REF1 apurinic/apyrimidinic endodeoxyribonuclease 1
TCMBANKGE002298 KRT6C K6E; KRT6E; PPKNEFD keratin 6C
TCMBANKGE006003 APRT AMP; APRTD adenine phosphoribosyltransferase
TCMBANKGE005330 ERCC4 ERCC11; FANCQ; RAD1; XFEPS; XPF ERCC excision repair 4, endonuclease catalytic subunit
TCMBANKGE014865 ATP2A2 ATP2B; DAR; DD; SERCA2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
TCMBANKGE000586 IL17F CANDF6; IL-17F; ML-1; ML1 interleukin 17F
TCMBANKGE001189 IL1A IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1 interleukin 1 alpha
TCMBANKGE013441 SUB1 P15; PC4; p14 SUB1 regulator of transcription
TCMBANKGE008893 TAT - tyrosine aminotransferase
TCMBANKGE008754 H3P10 p16 H3 histone pseudogene 10
TCMBANKGE007543 INSR CD220; HHF5 insulin receptor
TCMBANKGE002727 ALOXE3 ARCI3; E-LOX; eLOX-3; eLOX3 arachidonate lipoxygenase 3
TCMBANKGE004675 CARD14 BIMP2; CARMA2; PRP; PSORS2; PSS1 caspase recruitment domain family member 14
TCMBANKGE013777 SLURP1 ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM secreted LY6/PLAUR domain containing 1
TCMBANKGE007958 SPTLC1 HSAN1; HSN1; LBC1; LCB1; SPT1; SPTI serine palmitoyltransferase long chain base subunit 1
TCMBANKGE009780 SULT2B1 ARCI14; HSST2 sulfotransferase family 2B member 1
TCMBANKGE012900 KLF5 BTEB2; CKLF; IKLF Kruppel like factor 5
TCMBANKGE014065 SERPINB8 C18orf53; CAP2; PI-8; PI8; PSS5 serpin family B member 8
TCMBANKGE000223 KEAP1 INrf2; KLHL19 kelch like ECH associated protein 1
TCMBANKGE000358 GLA GALA galactosidase alpha
TCMBANKGE000092 DDX58 RIG-I; RIG1; RIGI; RLR-1; SGMRT2 DExD/H-box helicase 58
TCMBANKGE001620 TMPRSS6 IRIDA; MT2 transmembrane serine protease 6
TCMBANKGE011390 IL17RC CANDF9; IL17-RL; IL17RL interleukin 17 receptor C
TCMBANKGE014164 KLK8 HNP; NP; NRPN; PRSS19; TADG14 kallikrein related peptidase 8
TCMBANKGE007337 NAT9 EBSP, hNATL N-acetyltransferase 9 (putative)
TCMBANKGE005254 RHBDF2 RHBDL5; RHBDL6; TEC; TOC; TOCG; iRhom2 rhomboid 5 homolog 2
TCMBANKGE011864 TGM1 ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK transglutaminase 1
TCMBANKGE007414 KLKB1 KLK3; PKK; PKKD; PPK kallikrein B1
TCMBANKGE002832 IL17B IL-17B; IL-20; NIRF; ZCYTO7 interleukin 17B
TCMBANKGE004656 ELMO2 CED-12; CED12; Ced-12A; ELMO-2; VMPI engulfment and cell motility 2
TCMBANKGE005460 XPR1 IBGC6; SLC53A1; SYG1; X3 xenotropic and polytropic retrovirus receptor 1
TCMBANKGE002174 TRPC1 HTRP-1; TRP1 transient receptor potential cation channel subfamily C member 1
TCMBANKGE000763 TRPV3 FNEPPK2; OLMS; VRL3 transient receptor potential cation channel subfamily V member 3
TCMBANKGE000703 AREG AR; AREGB; CRDGF; SDGF amphiregulin
TCMBANKGE014322 IL23A IL-23; IL-23A; IL23P19; P19; SGRF interleukin 23 subunit alpha
TCMBANKGE000722 KRT10 BCIE; BIE; CK10; EHK; K10; KPP keratin 10
TCMBANKGE000639 HRAS C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; RASH1; p21ras HRas proto-oncogene, GTPase
TCMBANKGE012516 DSP DCWHKTA; DP desmoplakin
TCMBANKGE004619 AP2A1 ADTAA; AP2-ALPHA; CLAPA1 adaptor related protein complex 2 subunit alpha 1
TCMBANKGE014777 NEU1 NANH; NEU; SIAL1 neuraminidase 1
TCMBANKGE013921 MPDU1 CDGIF; HBEBP2BPA; Lec35; My008; PP3958; PQLC5; SL15; SLC66A5 mannose-P-dolichol utilization defect 1
TCMBANKGE000075 IL1RN DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3; IL1F3; IL1RA; IRAP; MVCD4 interleukin 1 receptor antagonist

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