Compound Summary

  Compound Information

TCMBANKIN000085

药名:	CUCURBITACIN I
别名:	JSI-124; cucurbitacin i
分子式:	C14H9NO2
Smiles:	CC1(C2=CCC3C4(CC(C(C4(CC(=O)C3(C2C=C(C1=O)O)C)C)C(C)(C(=O)C=CC(C)(C)O)O)O)C)C
成分:	HBIN021855
OB_score:	8.917641
CAS_id:	117793
SymMap_id:	SMIT04988
TCMID_id:	4322
TCMSP_id:	MOL002806
PubChem_id:	5281321

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE004640	Iberis amara	屈曲花
TCMBANKHE004709	Begonia nantoensis	南投秋海棠
TCMBANKHE004718	Bryonia alba	白泻根
TCMBANKHE006621	Gratiola officinalis	药水八角
TCMBANKHE008403	Crinodendron hookerianum	红百合木
TCMBANKHE006991		胡黄连			Steaming bone tidal fever due to yin vacuity, night sweating, child gan accumulation, indigestion, abdominal distention and emaciation, dysentery, fever, gastrointestinal damp-heat diarrhea, hemorrhoids.
TCMBANKHE008763	Ecballium elaterium	喷瓜
TCMBANKHE006668/YEM-19	Aquilaria sinensis|Aquilaria sinensis (Lour.) Spreng.	白木香	沉香	云南民族药物志：第一卷	See Aquilaria agallocha./See Aquilaria agallocha .	阿昌族/傣族/德昂族/哈尼族/景颇族/傈僳族/彝族/藏族
TCMBANKHE004517/YEM-793	Hemsleya macrosperma|Hemsleya macrosperma C.Y.Wu ex C.Y.Wu et C.L.Chen.	大籽雪胆|罗锅底	苦金盆	云南民族药物志：第四卷	See Hemsleya amabilis./See Hemsleya amabilis.	傣族/苗族/佤族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI000001	Stomach Neoplasms	group	Digestive System Diseases; Neoplasms	26890145
TCMBANKDI000047	Neoplasm Metastasis	phenotype	Pathological Conditions, Signs and Symptoms; Neoplasms	21225866
TCMBANKDI000088	Lung Neoplasms	group	Neoplasms; Respiratory Tract Diseases	21225866

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000727	MAP1LC3A	ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3	microtubule associated protein 1 light chain 3 alpha
TCMBANKGE000920	GADD45A	DDIT1; GADD45	growth arrest and DNA damage inducible alpha
TCMBANKGE001085	MAPK8	JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c	mitogen-activated protein kinase 8
TCMBANKGE001126	NFE2L2	HEBP1; IMDDHH; NRF2; Nrf-2	nuclear factor, erythroid 2 like 2
TCMBANKGE001166	BCL2	Bcl-2; PPP1R50	BCL2 apoptosis regulator
TCMBANKGE001169	BCL2L1	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52	BCL2 like 1
TCMBANKGE001177	TP53	BCC7; BMFS5; LFS1; P53; TRP53	tumor protein p53
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001203	MAPK1	ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK	mitogen-activated protein kinase 1