Compound Summary


  Compound Information

药名:

Magnograndiolide

别名:

magnograndiolide; (3aS,6R,6aR,9R,9aS,9bS)-6,9-dihydroxy-6,9-dimethyl-3-methylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one; SCHEMBL18334098; CHEMBL2206436; (3as,6r,6ar,9r,9as,9bs)-6,9-dihydroxy-6,9-dimethyl-3-methylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one; (3aS,6R,6aR,9R,9aS,9bS)-6,9-dihydroxy-6,9-dimethyl-3-methylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one; 92618-98-9; AC1NSXRC; (3aS,6R,6aR,9R,9aS,9bS)-6,9-dihydroxy-6,9-dimethyl-3-methylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

分子式:

C15H22O4

Smiles:

CC1(CCC2C(C3C1CCC3(C)O)OC(=O)C2=C)O

成分:

HBIN034220

OB_score:

63.708884

CAS_id:

92618-98-9

SymMap_id:

SMIT03177;SMIT16410

TCMID_id:

13368

TCMSP_id:

MOL000622

PubChem_id:

5319198


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE002369 Croton cumingii
TCMBANKHE002730 橘络
TCMBANKHE002762 Radix et Rhizoma Thalictri 马尾莲 Influenza, fever in children, common cold with fever, measles papules, malaria, damp-heat diarrhea dysentery, jaundice, red eyes with gall.
TCMBANKHE003748 Rhizoma Coptidis 黄连 To remove damp-heat, quench fire and counteract toxicity./Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds.
TCMBANKHE005768 Aristolochia moupinensis 淮通
TCMBANKHE004222 Hypericum curvisepalum 贯叶金丝桃
TCMBANKHE004312 Mahonia japonica 华南功劳木 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE004385 Fructus Aristolochiae 马兜铃 To remove heat from the lung and relieve cough and asthma, and to remove heat from the large intestine./Lung heat cough asthma, phlegm congestion and hasty qi , lung vacuity enduring cough, intestinal heat bleeding from hemorrhoids, swelling pain from hemorrhoids, edema.
TCMBANKHE004608 Magnolia grandiflora 荷花玉兰 To dispel wind and dissipate cold, move qi and relieve pain./Externally contracted wind-cold, headache and nasal congestion, distending pain in stomach duct, vomiting and diarrhea, hypertension, tuberculosis.
TCMBANKHE006458 Coptis teetoides [Syn. Coptis teeta] 云南黄连 See Coptis chinensis./See Coptis chinensis.
TCMBANKHE004679 Cocculus pendulus; Cocculus trilobus [Syn. Cocculus sarmentosus] 木防己 To dispel wind and eliminate damp, free channels and quicken network vessels, resolve toxin, disperse swelling and settle pain./Wind-damp impediment pain, pain from arthritis, edema, pulmonary edema, edema due to heart disease, neuralgia, dribbling pain of urination, amenorrhea, knocks and falls, swelling pain in throat, toxin swelling of sores, eczema, poisonous snake bite.
TCMBANKHE009006 Caltha palustris 马蹄叶 To expel wind, resolve summerheat, quicken blood and disperse swelling./Wind damage common cold, summerheat stroke with sand, knocks and falls, burns and scalds.
TCMBANKHE006788 Aristolochia fangchi 广防己 To dispel wind and relieve pain, clear heat and disinhibit water./Damp-heat generalized pain, wind-damp impediment pain, edema in lower limb, inhibited urination.
TCMBANKHE006868 Aristolochia contorta 北马兜铃根 See Aristolochia debilis./See Aristolochia debilis.
TCMBANKHE005156 Thalictrum baicalense 贝加尔唐松草 See Thalictrum foliolosum ./See Thalictrum foliolosum.
TCMBANKHE005158 淫羊藿 Angina pectoris, chronic bronchitis, neurasthenia, climacteric hypertension, poliomyelitis, impotence and emission, limp wilting sinew and bone, wind-damp impediment pain, hypertonicity and numbness.
TCMBANKHE005202 Berberis thunbergii 日本小檗 To clear heat and dry damp, drain fire and resolve toxin./Damp-heat diarrhea dysentery, stomach heat pain, red eyes with gall, mouth sore, swelling pain in throat, acute eczema, scalds.
TCMBANKHE005207 Thalictrum dasycarpum 粗果唐松草
TCMBANKHE007110 Semen Citri Reticulatae 橘核 To regulate the flow of qi, cause subsidence of modulation, and relieve pain./Mounting qi, painful swollen testes, mammary welling abscess, lumbago, bladder qi pain.
TCMBANKHE005259 Aristolochia heterophylla 汉防己 To dispel wind and relieve pain, clear heat and disinhibit water./Rheumatic pain in joints, damp-heat pain in limbs, edema, inhibited urination, beriberi with edema.
TCMBANKHE007201 Mahonia japonica 华南功劳叶 See Mahonia bealei./See Mahonia bealei.
TCMBANKHE005412 Magnolia denudata [Syn. Magnolia heptapata] 玉兰 See Magnolia liliflora./See Magnolia liliflora.
TCMBANKHE007866 Coptis deltoidea 三角叶黄连 See Coptis chinensis ./See Coptis chinensis.
TCMBANKHE006129 Thalictrum foetidum 香唐松草 To clear heat and dry damp, resolve toxin./Damp-heat dysentery, jaundice, red eyes with gall, swollen welling abscess, sore and boil, wind-damp-heat impediment.
TCMBANKHE006160 Berberis amurensis 小檗;小蘗 To clear heat and dry damp, resolve toxin./Enteritis, dysentery, chronic cholecystitis, acute hepatitis, chronic hepatitis, bacillary dysentery, infection of upper respiratory tract, urinary tract infection, leukopenic complications of carcinoma, innominate toxin swelling, erysipelas, eczema, red eyes, mouth sore.
TCMBANKHE008209 Aristolochia moupinensis 淮通 To clear heat and eliminate damp, dispel wind and relieve pain./Abdominal pain and diarrhea, damp-heat edema, inhibited voidings of reddish urine, hematuria, wind-damp-heat impediment, swollen welling abscess and malign sore, eczema, poisonous snake bite.
TCMBANKHE007303 广藿香 Summerheat-damp lassitude, oppression in chest, vomiting diarrhea with abdominal pain, deep-source nasal congestion and headache.
TCMBANKHE007977 Thalictrum thunbergii 烟锅草 To clear heat and resolve toxin, dry damp./Pertussis, toothache, swelling toxin of welling abscess and sore, acute dermitis, eczema.
TCMBANKHE007462 青风藤 Wind-damp impediment pain, pain from arthritis, swelling in joints, paralytic and pruritus.
TCMBANKHE007696 Aristolochia contorta 北马兜铃 See Aristolochia debilis./See Aristolochia debilis.
TCMBANKHE003785/YEM-1014 Phellodendron chinense|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄皮树|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 See Phellodendron amurense./See Phellodendron amurense. 瑶族/壮族
TCMBANKHE002460/YEM-1014 Phellodendron chinense var. glabriusculum|Phellodendron chinense Schneid var.glabriusculum Schneid. 土叶黄皮树|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 See Phellodendron amurense./See Phellodendron amurense. 瑶族/壮族
TCMBANKHE004238/YEM-1014 Phellodendron amurense;Cortex Phellodendri|Phellodendron chinense Schneid var.glabriusculum Schneid. 黄柏|秃叶黄蘗 广西黄柏 云南民族药物志:第五卷 1. To clear heat and dry dampness; 2. To reduce fire and release toxins/Damp-heat dysentery, tuberculosis, epidemic meningitis, acute conjunctivitis, trachoma, fever, abdominal pain, diarrhea, suppurative hematochezia, tenesmus, jaundice, yellow thick foul leukorrhagia, swelling pain in knees and feet, urinary tract infection, boil, sore, ulcer, eczema, mouth sore, hemorrhoids, burns, scalds, exuberance of fire with tidal fever, tidal fever with night sweat, emission. 瑶族/壮族
TCMBANKHE005228/YEM-235 Cortex Magnoliae officilis;Magnolia officinalis|Magnolia officinalis Rehd.et Wils. 厚朴 厚朴 云南民族药物志:第二卷 To eliminate damp and relieve distension;To dry damp and disperse phlegm, precipitate qi and eliminate fullness, lower blood pressure./1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate.5.Amebic dysentery, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distention and constipation, phlegm-rheum cough asthma. 彝族
TCMBANKHE004819/YEM-708 Mahonia fortunei|Mahonia fortunei(Lindl.)Fedde 细叶功劳叶|十大功劳 十大功劳 云南民族药物志:第四卷 See Mahonia bealei./See Mahonia bealei. 布依族/傣族/苗族/瑶族/彝族/壮族
TCMBANKHE008695/YEM-708 Mahonia fortunei|Mahonia fortunei(Lindl.)Fedde 细叶功劳木|十大功劳 十大功劳 云南民族药物志:第四卷 See Mahonia bealei./See Mahonia bealei. 布依族/傣族/苗族/瑶族/彝族/壮族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000221 GRIA2 GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B glutamate ionotropic receptor AMPA type subunit 2
TCMBANKGE000813 DPP4 ADABP; ADCP2; CD26; DPPIV; TP103 dipeptidyl peptidase 4
TCMBANKGE014050 GABRA1 ECA4; EIEE19; EJM; EJM5 gamma-aminobutyric acid type A receptor subunit alpha1