Compound Summary
Compound Information
药名: | Butein |
别名: | 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; 2′,4′,3,4-Tetrahydroxychalcone; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-; NCGC00163519-01; (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; NSC652892; AIDS057944; AC1NST6X; AIDS-057944; 3,4,2',4'-Tetrahydroxychalcone; ST5331397; 2',3,4,4'-Tetrahydrochalcone; 2',3,4,4'-Tetrahydroxychalcone; B178_SIGMA; butein ; MolMap_000005; Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI); EINECS 207-659-5; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-; C08578; butein; 2',4',3,4-Tetrahydroxychalcone; 2′,3,4,4′-Tetrahydroxychalcone; Acrylophenone, 2',4'-dihydroxy-3-(3,4-dihydroxyphenyl)-; NCI60_018489; HSCI1_000162; 21849-70-7; (Z)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; 487-52-5; 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one |
分子式: | C15H12O5 |
Smiles: | C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O |
成分: | HBIN019083 |
OB_score: | 1.374286 |
CAS_id: | 21849-70-7 |
SymMap_id: | SMIT05121;SMIT14524 |
TCMID_id: | 2779 |
TCMSP_id: | MOL002974 |
PubChem_id: | 5281222 |
化合物对应的植物
| 植物ID | 拉丁名 | 药用植物名 | 药名 | 来源 | 功能与主治 | 使用民族 |
|---|
| TCMBANKHE001846 | 狼把草 | |||||
| TCMBANKHE003463 | 荆芥穗 | |||||
| TCMBANKHE004208 | Thallus Lamiriae | 昆布 | To eliminate phlegm, soften hard masses and dissolve lumps, and to cause diuresis./Goiter and tuberculosis, scrofula, bleeding, painful swollen testes, phlegm-rheum and edema, prevention of cataracts. | |||
| TCMBANKHE004862 | Lignum Dalbergiae odoriferae Rosewood | 降香 | To relieve pain by promoting the circulation of qi and blood, and to arrest bleeding./Shortening the plasma recalcification time in rabbits. | |||
| TCMBANKHE007994 | Herba Humuli Scandentis;Rhaponticum carthamoides | 葎草 | 1. Diurectic. 2. Bacteriostatic. Flower and fruit inhibit the growth of Bacillus tuberculosis and its alcoholic infusion of stemsand leaves inhibits that of gram-positive bacteria in vitro. ;To boost qi and fortify spleen, quiet spirit./Tuberculosis, cystitis, mastitis, tonsillitis, lung heat cough, pulmonary welling abscess, vacuity heat with vexation and thirst, heat strangury, edema, inhibited urination, damp-heat diarrhea dysentery, heat toxin sores, itchy skin. | |||
| TCMBANKHE007521 | Sophora alopecuroides | 苦豆子 | To clear heat and dry damp, kill worms and relieve pain./Dysentery, stomachache, excessive leukorrhea, eczema, sore and boil, intractable lichen. | |||
| TCMBANKHE007222 | Spatholobus suberectus | 密花豆 | To supplement blood, quicken blood, free network vessels./Septicemia, menstrual disorder, blood vacuity, anemia due to malnutrition, anemia due to bleeding, anemia with yellow complexion, numbness and paralysis, wind-damp impediment pain. | |||
| TCMBANKHE008081 | herba ecliptae | 墨旱莲 | To replenish the liver and the kidney, and to arrest bleeding by removing heat from blood./Tooth mobilizing, premature graying in beard and hair, dizziness and tinnitus, limp aching lumbus and knees, yin vacuity blood heat, hemoptysis, blood ejection, duodenal bleeding, nosebleed(epistaxis), hematuria, blood dysentery, flooding and spotting, bleeding due to external injury, eczema of skin, bleeding of skin, snake bite. | |||
| TCMBANKHE008099 | Rhus verniciflua [Syn. Toxicadendron verniciflum ] | 杞子 | To quicken blood and stanch bleeding, warm channels and relieve pain./Hematochezia, hematuria, flooding and spotting, abdominal pain due to stagnation, amenorrhea. | |||
| TCMBANKHE005104/XU-626/XU-651 | Robinia pseudoacacia | 刺槐花|刺槐 | 贵州省毕节市金沙县 | To stanch bleeding./Precipitate blood of large intestine, hemoptysis, flooding. |
植物对应的疾病
| 疾病ID | 病名 | 疾病类型 | MeSH | 参考文献 |
|---|
| TCMBANKDI000022 | Prostatic Neoplasms | group | Neoplasms; Male Urogenital Diseases | 22114764 |
| TCMBANKDI000026 | Obesity | disease | Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases | 30158592 |
| TCMBANKDI000031 | Insulin Resistance | phenotype | Nutritional and Metabolic Diseases | 30158592 |
| TCMBANKDI000047 | Neoplasm Metastasis | phenotype | Pathological Conditions, Signs and Symptoms; Neoplasms | 21131551 |
| TCMBANKDI015496 | Liver neoplasms | group | Digestive System Diseases; Neoplasms | 21131551 |
| TCMBANKDI020066 | Weight Gain | phenotype | Pathological Conditions, Signs and Symptoms | 30158592 |
化合物对应的靶点
| 靶点ID | 基因名 | 基因别名 | 描述 |
|---|
| TCMBANKGE000047 | AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | AKT serine/threonine kinase 1 |
| TCMBANKGE000051 | IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | interleukin 1 beta |
| TCMBANKGE000052 | TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | tumor necrosis factor |
| TCMBANKGE000053 | NFKB1 | CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB | nuclear factor kappa B subunit 1 |
| TCMBANKGE000089 | PIK3R2 | MPPH; MPPH1; P85B; p85; p85-BETA | phosphoinositide-3-kinase regulatory subunit 2 |
| TCMBANKGE000090 | SART3 | DSAP1; P100; RP11-13G14; TIP110; p110; p110(nrb) | spliceosome associated factor 3, U4/U6 recycling protein |
| TCMBANKGE000091 | PRDM4 | PFM1 | PR/SET domain 4 |
| TCMBANKGE000241 | CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | caspase 8 |
| TCMBANKGE000308 | PIK3CA | CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; PI3K; PI3K-alpha; p110-alpha | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| TCMBANKGE000330 | HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | heme oxygenase 1 |
| TCMBANKGE000338 | CHUK | IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16 | component of inhibitor of nuclear factor kappa B kinase complex |
| TCMBANKGE000734 | GCLC | GCL; GCS; GLCL; GLCLC | glutamate-cysteine ligase catalytic subunit |
| TCMBANKGE000938 | CDK2 | CDKN2; p33(CDK2) | cyclin dependent kinase 2 |
| TCMBANKGE001070 | UCP1 | SLC25A7; UCP | uncoupling protein 1 |
| TCMBANKGE001085 | MAPK8 | JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c | mitogen-activated protein kinase 8 |
| TCMBANKGE001098 | NFKBIA | EDAID2; IKBA; MAD-3; NFKBI | NFKB inhibitor alpha |
| TCMBANKGE001114 | IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | interleukin 6 |
| TCMBANKGE001126 | NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | nuclear factor, erythroid 2 like 2 |
| TCMBANKGE001131 | CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | caspase 9 |
| TCMBANKGE001156 | CASP3 | CPP32; CPP32B; SCA-1 | caspase 3 |
| TCMBANKGE001170 | CDK4 | CMM3; PSK-J3 | cyclin dependent kinase 4 |
| TCMBANKGE001178 | STAT3 | ADMIO; ADMIO1; APRF; HIES | signal transducer and activator of transcription 3 |
| TCMBANKGE001180 | SMAD3 | HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3 | SMAD family member 3 |
| TCMBANKGE001201 | MAPK3 | ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK | mitogen-activated protein kinase 3 |
| TCMBANKGE001202 | MAPK14 | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA | mitogen-activated protein kinase 14 |
| TCMBANKGE001203 | MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | mitogen-activated protein kinase 1 |
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