Compound Summary

  Compound Information

TCMBANKIN036846

药名:	Icariin
别名:	5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromen-4-one; MLS000759413; Spectrum4_001975; ZINC03960893; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chromen-4-one; Spectrum2_001695; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-3-[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl]oxy]-4-chromenone; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromone; Spectrum3_001130; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one; 489-32-7; 2-(4'-methoxyl phenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3'-methyl-2-butylenyl)-4-chromanone; SPBio_001650; SPECTRUM1505257; KBio3_002099; KBioGR_002475; SDCCGMLS-0066754.P001; SMR000466309; BB_NC-0999; 3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; Spectrum5_000933; icariin; BSPBio_002599; 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-; ICA
分子式:	C33H40O15
Smiles:	O1[C@@]([H])(Oc2c(C([H])([H])\C([H])=C(/C([H])([H])[H])\C([H])([H])[H])c(OC(c3c([H])c([H])c(OC([H])([H])[H])c([H])c3[H])=C(O[C@@]4([H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]([H])(C([H])([H ])[H])O4)C5=O)c5c(O[H])c2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])C([H])([H])O[H]
成分:	HBIN029922
OB_score:	41.5834
CAS_id:	489-32-7
SymMap_id:	SMIT06349;SMIT19571
TCMID_id:	23160
TCMSP_id:	MOL004425
PubChem_id:	5318997

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   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE002453	herba epimedii	仙灵脾			Treatment of impotence, seminal emission, weakness of the limbs, rheumatic or rheumatoid arthralgia with numbness and muscle contracture, climacteric hypertension./1. Dilating coronary artery and increasing coronary flow.2. Acting as androgenic hormone, such as increasing the weight of prostate, seminal vesicle and musculi levator ani in mice.3. Enhancing lymphocyte-blastogenesis rate.
TCMBANKHE003940	Herba Elsholtziae;Haichow Elsholtzia;Mosla chinensis	香薷			1. To promote diaphoresis and release the exterior; 2. To resolve dampness and harmonize the spleen and stomach; 3. To promote water metabolism and release edema/Fever, aversion of cold, headache, absence of sweating, abdominal pain, vomiting and diarrhea, edema and inhibited urination, beriberi.
TCMBANKHE004976	Epimedium brevicornum	淫羊藿根			To supplement kidney and invigorate yang , dispel wind and eliminate damp./Vacuity strangury, white turbidity, dizziness (for men), vaginal discharge, menstrual disorder, asthma (for women).
TCMBANKHE005158		淫羊藿			Angina pectoris, chronic bronchitis, neurasthenia, climacteric hypertension, poliomyelitis, impotence and emission, limp wilting sinew and bone, wind-damp impediment pain, hypertonicity and numbness.
TCMBANKHE008158	Rhizoma Bistortae	拳参			To remove toxic heat, to promote the subsidence of swelling, and to arrest bleeding./Red dysentery, heat diarrhea, lung heat cough, swollen welling abscess, scrofula, mouth sore, tongue sores, blood ejection, spontaneous external bleeding, bleeding from hemorrhoids, poisonous snake bite.
TCMBANKHE008279		山楂叶			Hypertension, lacquer sore, enduring sores.
TCMBANKHE007758/YEM-743	Rhizoma Polygoti Odorati|Polygonatum odoratum(Mill.)Druce	玉竹	玉竹	云南民族药物志：第四卷	To nourish yin, promote the production of body fluid, and relieve dryness syndromes./Lung stomach yin damage, dry cough, dry throat, diabetes mellitus due to internal heat.	哈尼族/傈僳族/瑶族/彝族/壮族
TCMBANKHE006111/YEM-858	Lamiophlomis rotata [Syn. Phlomis rotata ]|Lamiophlomis rotata(Benth.)Kudo	独一味	独一味	云南民族药物志：第五卷	To quicken blood and transform stasis, disperse swelling and relieve pain./Knocks and falls, pain in sinews and bones, swelling pain in joints, dysmenorrhea, flooding and spotting.	阿昌族/傣族/德昂族/景颇族/傈僳族/纳西族/普米族/藏族

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   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

TCMBANKDI006641	Myocardial Reperfusion Injury	phenotype	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases	30051466
TCMBANKDI009610	Parkinsonian Disorders	group	Nervous System Diseases	31010422
TCMBANKDI029081	Alveolar Bone Loss	disease	Musculoskeletal Diseases; Stomatognathic Diseases	31943455

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   化合物对应的靶点

靶点ID	基因名	基因别名	描述

TCMBANKGE000202	RUNX2	AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA	RUNX family transcription factor 2
TCMBANKGE000246	FOXO1	FKH1; FKHR; FOXO1A	forkhead box O1
TCMBANKGE000402	MID1	BBBG1; FXY; GBBB1; MIDIN; OGS1; OS; OSX; RNF59; TRIM18; XPRF; ZNFXY	midline 1
TCMBANKGE000403	ATF2	CRE-BP1; CREB-2; CREB2; HB16; TREB7	activating transcription factor 2
TCMBANKGE000627	BGLAP	BGP; OC; OCN	bone gamma-carboxyglutamate protein
TCMBANKGE001108	BMP2	BDA2; BMP2A; SSFSC	bone morphogenetic protein 2
TCMBANKGE001153	EPHB2	BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5	EPH receptor B2
TCMBANKGE001178	STAT3	ADMIO; ADMIO1; APRF; HIES	signal transducer and activator of transcription 3
TCMBANKGE001201	MAPK3	ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK	mitogen-activated protein kinase 3
TCMBANKGE001202	MAPK14	CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA	mitogen-activated protein kinase 14
TCMBANKGE001203	MAPK1	ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK	mitogen-activated protein kinase 1