Compound Summary


  Compound Information

药名:

catalpol

别名:

Catalpol; LMPR01020108; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-; 2415-24-9; Catalpinoside; NCGC00163523-01; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-; Catalposide, des-p-hydroxybenzoyl-; De(p-hydroxybenzoyl)catalposide; (1AS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside; C09773; EINECS 219-324-0

分子式:

C15H22O10

Smiles:

C1=COC(C2C1C(C3C2(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O

成分:

HBIN019909

OB_score:

5.06825

CAS_id:

2415-24-9

SymMap_id:

SMIT00168

TCMID_id:

3306

TCMSP_id:

MOL002819

PubChem_id:

138107792


   化合物对应的植物
植物ID 拉丁名 药用植物名 药名 来源 功能与主治 使用民族
TCMBANKHE000348 Scrophularia lepidota
TCMBANKHE000850 Radix Rehmanniae 生地黄 Treatment of exogenous heat invading at the nutritive and blood levels manifested as dry mouth and deep red tongue proper with scanty coating. Fresh rehmannia root (Shengdihuang) is used with Scrophularia (Xuanshen), Rhinoceros horn (Xijiao) and Ophiopogon root/1. Its decoction exerts a protective effect on experimental hepatitis of mice induced by carbon tetrachloride.2. Gastric feeding or injection of its decoction, water infusion or alcoholic extract can lower the blood sugar level in rabbits (this result is controversial in the recent years).3. Intravenous injection of its extract exerts a hypertensive and diuretic effect in rabbits and dogs.4. Its alcoholic extract shortens the blood coagulation time in rabbits.5. Its water infusion inhibits the growth of some pathogenic fungi.
TCMBANKHE004551 Gmelina philippensis 菲律宾石梓
TCMBANKHE001767 羊耳朵叶
TCMBANKHE002688 Semen armeniacae amarum 苦杏仁 To relieve cough and asthma, and to relax bowels./Treatment of cough and asthma accompanied by stuffiness in the chest and profuse expectoration, constipation due to deficiency of blood and fluid.
TCMBANKHE003718 Flos Chrysanthemi 菊花 To dispel wind-heat, to subdue hyperactivity of the liver, and improve eyesight./Angina pectoris, hypertension, externally contracted wind-heat, wind warmth, fever and headache, dizziness, common cold, red eyes, red eyes with gall, swelling toxin of clove sore.
TCMBANKHE003746 Radix Scutellariae 黄芩 To remove damp-heat, to quench fire and counteract toxicity, to arrest bleeding, and to prevent abortion./Chest oppression with retching, diarrhea, jaundice, lung heat cough, infection of upper respiratory tract, acute tonsillitis, acute pharyngolaryngitis, ardent fever with vexation and thirst, blood heat, blood ejection, spontaneous external bleeding, swelling toxin of welling abscess and sore, stirring fetus in pregnancy.
TCMBANKHE003827 Picrorhiza scrophulariiflora 西藏胡黄连 See Picrorhiza kurrooa ./See Picrorhiza kurrooa.
TCMBANKHE004259 Plantago major 大车前 See Plantago asiatica./See Plantago asiatica.
TCMBANKHE004616 地黄
TCMBANKHE009126 Asystasia intrusa 插入十万错
TCMBANKHE005363 Semen Plantaginis 车前子 To remove heat, to cause diuresis and eliminate damp, to relieve dysuria, to clear the eye, and to promote expectoration./1. Diuretic. 2. Expectorant and antitussive.
TCMBANKHE005793 Flos Chrysanthemi 菊花 To dispel wind-heat, to subdue hyperactivity of the liver, and improve eyesight./Angina pectoris, hypertension, externally contracted wind-heat, wind warmth, fever and headache, dizziness, common cold, red eyes, red eyes with gall, swelling toxin of clove sore.
TCMBANKHE008532 Radix Rehmanniae Preparata 熟地黄 To nourish n and replenish blood, reinforce the essence of life and marrow./Blood vacuity with yellow complexion, dizziness and palpitation, menstrual disorder [=menoxenia], incessant flooding and spotting, liver-kidney yin depletion, tidal fever with night sweat, impotence and emission, sterility and infertility, limp aching lumbus and knees, tinnitus and deafness, dizzy head and vision, premature graying in beard and hair, diabetes mellitus, constipation, kidney vacuity hasty asthma.
TCMBANKHE008552 Herba Capsellae 荠菜 1. Cool the blood and stop bleeding. 2. Clear away heat and promote diuresis. 3. Lower blood pressure./Blood ejection, spontaneous external bleeding, hemoptysis, hematuria, flooding and spotting, red eyes with gall, eyeground hemorrhage, hypertension, red and white dysentery, nephritis with edema, chyluria.
TCMBANKHE006991 胡黄连 Steaming bone tidal fever due to yin vacuity, night sweating, child gan accumulation, indigestion, abdominal distention and emaciation, dysentery, fever, gastrointestinal damp-heat diarrhea, hemorrhoids.
TCMBANKHE008565 Rehmannia glutinosa [Syn. Rehmannia glutinosa f. huechingensis] 干地黄 To enrich yin and clear heat, cool blood and supplement blood, lower blood sugar levels./Diabetes mellitus, dermatitis, rheumatism, diphtheria, acute tonsillitis, febrile diseases with vexation and thirst, steaming bone taxation fever, warm disease macular eruption, blood ejection due to blood heat, spontaneous external bleeding due to blood heat, flooding and spotting due to blood heat, hematuria due to blood heat, hematochezia due to blood heat, anemia with yellow complexion, palpitation and dizziness, blood depletion and amenorrhea.
TCMBANKHE008459 Rehmannia glutinosa [Syn. Rehmannia glutinosa f. huechingensis] 鲜地黄;鲜地黄(生地) To clear heat and cool blood, engender liquid and moisten dryness, lower blood sugar levels./Diabetes mellitus, dermatitis, rheumatism, diphtheria, acute tonsillitis, acute febrile diseases, ardent fever with clouded spirit, macula, fluid damage with vexation and thirst, blood ejection due to blood heat, spontaneous external bleeding due to blood heat, flooding and spotting due to blood heat, hematochezia due to blood heat, mouth and tongue sores, swelling pain in throat, taxation fever cough, painful wound from knocks and falls, swollen welling abscess.
TCMBANKHE007867/XU-103 Flos Buddlejae|Buddleja officinalis 密蒙花 云南省昆明市盘龙区 To remove heat, replenish the liver and clear the eye of corneal opacity./Red eyes with gall, delacrimation and photophobia, liver vacuity dim vision, dim vision, malaria.
TCMBANKHE008076 Verbascum lychnites 剪秋罗毛蕊花
TCMBANKHE008383/XU-340 Paulownia tomentosa 毛泡桐 云南省昭通市威信县 See Paulownia fortunei ./See Paulownia fortunei .
TCMBANKHE006292/YNS-298/YEM-187/XU-40/XU-99 Verbascum thapsus|Verbascum thapsus L|Verbascum thapsus L. 毛蕊花 一柱香 云南药材标准:第六册|云南民族药物志:第一卷|云南省昆明市盘龙区 清热解毒,活血止血。用于肺热咳嗽,湿热痹痛,肠痈,疮毒,湿疹,跌打扭伤,创伤出血。|To clear heat and resolve toxin, stanch bleeding and dissipate stasis./Pneumonia, chronic appendicitis, sore toxin, sprain from knocks and falls, bleeding due to external injury. 白族/傈僳族/纳西族/彝族/藏族
TCMBANKHE005361/YEM-268/XU-394 Catalpa ovata|Catalpa ovata Don. 梓木|梓 梓木 云南民族药物志:第二卷|云南省保山市腾冲市明光镇中塘村 To promote vomiting, relieve pain./Pain wind in limbs, cholera. 傈僳族/水族
TCMBANKHE004194/YEM-268/XU-394 Catalpa ovata|Catalpa ovata Don. 梓实|梓木|梓 梓木 云南民族药物志:第二卷|云南省保山市腾冲市明光镇中塘村 To disinhibit water and disperse edema./Inhibited urination, edema, ascites. 傈僳族/水族

   植物对应的疾病
疾病ID 病名 疾病类型 MeSH 参考文献
TCMBANKDI000031 Insulin Resistance phenotype Nutritional and Metabolic Diseases 29284152
TCMBANKDI000037 Colitis disease Digestive System Diseases 28655643
TCMBANKDI000081 Diabetes Mellitus, Experimental disease Nutritional and Metabolic Diseases; Endocrine System Diseases 29284152

   化合物对应的靶点
靶点ID 基因名 基因别名 描述
TCMBANKGE000047 AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA AKT serine/threonine kinase 1
TCMBANKGE000288 ATF6 ACHM7; ATF6A activating transcription factor 6
TCMBANKGE000305 PIK3CD APDS; IMD14; P110DELTA; PI3K; p110D phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
TCMBANKGE000306 PIK3CG PI3CG; PI3K; PI3Kgamma; PIK3; p110gamma; p120-PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
TCMBANKGE000307 PIK3CB P110BETA; PI3K; PI3KBETA; PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
TCMBANKGE000321 NOX4 KOX; KOX-1; RENOX NADPH oxidase 4
TCMBANKGE000471 POMC ACTH; CLIP; LPH; MSH; NPP; OBAIRH; POC proopiomelanocortin
TCMBANKGE000472 KLHL1 MRP2 kelch like family member 1
TCMBANKGE000473 TRPC6 FSGS2; TRP6 transient receptor potential cation channel subfamily C member 6
TCMBANKGE000758 HSF1 HSTF1 heat shock transcription factor 1
TCMBANKGE000924 MIR132 MIRN132; miRNA132; mir-132 microRNA 132
TCMBANKGE000955 ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP ATP binding cassette subfamily C member 2
TCMBANKGE001064 GLP1R GLP-1; GLP-1-R; GLP-1R glucagon like peptide 1 receptor
TCMBANKGE001077 HSPA5 BIP; GRP78; HEL-S-89n; MIF2 heat shock protein family A (Hsp70) member 5
TCMBANKGE001083 MAP3K5 ASK1; MAPKKK5; MEKK5 mitogen-activated protein kinase kinase kinase 5
TCMBANKGE001085 MAPK8 JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c mitogen-activated protein kinase 8
TCMBANKGE001112 PRKAB1 AMPK; HAMPKb protein kinase AMP-activated non-catalytic subunit beta 1
TCMBANKGE001127 PRKAA1 AMPK; AMPKa1 protein kinase AMP-activated catalytic subunit alpha 1
TCMBANKGE001128 PRKAA2 AMPK; AMPK2; AMPKa2; PRKAA protein kinase AMP-activated catalytic subunit alpha 2
TCMBANKGE001132 BAX BCL2L4 BCL2 associated X, apoptosis regulator
TCMBANKGE001166 BCL2 Bcl-2; PPP1R50 BCL2 apoptosis regulator
TCMBANKGE001182 SIRT1 SIR2; SIR2L1; SIR2alpha sirtuin 1
TCMBANKGE001202 MAPK14 CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA mitogen-activated protein kinase 14
TCMBANKGE001205 DDIT3 AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153 DNA damage inducible transcript 3