Compound Summary

  Compound Information

TCMBANKIN048200

药名:	hypaconitine
别名:	Hypaconitine; aconitine alkaloids
分子式:	C33H45NO10
Smiles:	C1([H])([H])[C@]([H])(OC([H])([H])[H])[C@]2([C@@]([H])([C@@]([H])([C@]3(OC(C([H])([H])[H])=O)[C@@]([H])([C@@]([H])(OC(=O)c4c([H])c([H])c([H])c([H])c4[H])[C@]([C@]([H])(OC([H])([H])[H])[C@]3([H])O[H])( O[H])C5([H])[H])[C@]25[H])[C@]6([H])OC([H])([H])[H])N(C([H])([H])[H])C7([H])[H])[C@@]6([H])[C@@]7(C([H])([H])OC([H])([H])[H])C1([H])[H]
成分:	HBIN029816
OB_score:	31.388459
CAS_id:	6900-87-4
SymMap_id:	SMIT00058
TCMID_id:	10874
TCMSP_id:	MOL000538;MOL009659;MOL011520
PubChem_id:	138115321

---

   化合物对应的植物

植物ID	拉丁名	药用植物名	药名	来源	功能与主治	使用民族

TCMBANKHE001875	Herba Clinopodii	断血流			To arrest bleeding./Treatment of excessive menstrual discharge, hemorrhage from hysteromyoma, hematuria, epistaxis, gingival bleeding, traumatic bleeding.
TCMBANKHE002499	Rhizoma Ahemones Daddeae	两头尖			To relieve rheumatic conditions, and to cure carbuncle./Treatment of rheumatoid arthritis with muscular contracture and joint pain, carbuncle with ulceration.
TCMBANKHE002581	Bombyx Batryticatus Preparata	制僵蚕			1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chronic convulsions with prolo/1. Treatment of convulsions due to high fever and epileptic spasms. White-stiff silkworm (Baijiangcan) is used with Gastrodia tuber (Tianma), Arisaema tuber with bile (Dannanxing) and Ox gallstone (Niuhuang) in the formula Qianjin San. 2. Treatment of chr
TCMBANKHE002918	Folium Aconiti Kusnezoffii	草乌叶			To remove toxic heat, and to relieve pain./Treatment of fever in febrile disease, diarrhea and abdominal pain, headache, toothache.
TCMBANKHE003681	Radix Aconiti Kusnezoffii	草乌			To relieve rheumatic conditions, to warm the channels and to alleviate pain./Treatment of rheumatic and rheumatoid arthralgia, precordial and abdominal pain with cold sensation, abdominal colic caused by cold, anaethesia.
TCMBANKHE003690		草乌头
TCMBANKHE003754	Hyoscyamus niger	莨菪子			To resolve spasm and relieve pain, quiet heart and settle epilepsy./Pain in stomach duct and abdomen, wind-damp impediment pain, decayed toothache due to wind, painful wound from knocks and falls, incessant asthma and cough, prolapse of rectum due to diarrhea, mania and withdrawal, fright epilepsy, swelling toxin of welling abscess and sore.
TCMBANKHE003775	Radix Aconiti	川乌			To relieve rheumatic conditions and alleviate pain by warming the channels./Treatment of joint pain in rheumatic or rheumatoid arthritis, epigastric pain with cold sensation, or abdominal colic due to cold, also used as an analgesic in anaesthesis.
TCMBANKHE007666	Datura innoxia	毛曼陀罗花			See Datura metel./See Datura metel.
TCMBANKHE004022	Cordyceps	冬虫夏草			To tonify the lung and the kidney, arrest bleeding, and dispel phlegm./Impotence and emission, neurasthenia, backache, aching in lumbus and knees, enduring cough and vacuity asthma, taxation damage hemoptysis.
TCMBANKHE004029	Aconitum bullatifolium var. homotrichum [Syn. Aconitum nagarum ]	保山乌头			To dispel wind and overcome damp, free network vessels and relieve pain./Wind-cold-damp impediment, headache.
TCMBANKHE006056	Rhizoma Menispermi	北豆根			To remove toxic heat and relieve rheumatic pains./Treatment of sore throat, colitis, dysentery, rheumatic arthralgia.
TCMBANKHE004459	Fructus Lycii	枸杞子			To benefit the liver and the kidney, to replenish vital essence and to improve eyesight./Lassitude in lumbus and knees, emission, dizziness and dim vision, lung disease with cough, diabetes mellitus.
TCMBANKHE004470	Aconitum kusnezoffii	北乌头;草乌			To dispel wind and overcome damp, warm channels and dissipate cold, disperse swelling and relieve pain./Wind-cold-damp impediment, pain in joints, head wind headache, wind stroke with hemiplegia, cold pain in heart and abdomen, cold mounting with pain, knocks and falls, blood stasis swelling and pain, swelling toxin of flat abscess, anesthesia.
TCMBANKHE004539	Fructus Kochiae	地肤子			To remove damp-heat, to dispel zvind, and to relieve itching./Inhibiting the growth of various dermatomyces in vitro.
TCMBANKHE006650	Lycium barbarum	宁夏枸杞子			See Lycium chinense./See Lycium chinense.
TCMBANKHE004922	Datura innoxia	毛曼陀罗叶			See Datura metel./See Datura metel.
TCMBANKHE005079	Aconitum coreanum	黄花乌头			To dispel wind and transform phlegm, settle fright epilepsy, dissipate cold and relieve pain./Wind stroke with congesting phlegm, deviated eyes and mouth, epilepsy, migraine, headache, wind-phlegm dizziness,tetanus, infant fright wind, wind-damp impediment pain, sores scab and lichen, damp itchy skin.
TCMBANKHE005135	Aconitum napellus	欧乌头
TCMBANKHE005172	Datura innoxia	毛曼陀罗根			See Datura metel./See Datura metel.
TCMBANKHE007536		天雄
TCMBANKHE005731		石上柏			To clear heat and dampness, promote blood circulation and remove blood stasis: For jaundice of dampness-heat type and abdominal mass. Recently used for acute and chronic hepatitis, cirrhosis, cholecysitis, etc., also for diarrhea, desentery and leucorrhag
TCMBANKHE005742	Atropa belladonna	颠茄			To resolve spasm and relieve pain, inhibit secretion./Gastric ulcer, duodenal ulcer, colic of gastrointestinal tract, cholecystalgia, renal colic, vomiting nausea, night sweating, drooling.
TCMBANKHE006426	Flos Daturae	洋金花			To relieve asthma and cough, to alleviate pain, and to arrest spasm./Cough and asthma without phlegm, cold pain in heart and Datura stramonium .
TCMBANKHE005956	Przewalskia tangutica	马尿泡			To resolve spasm and relieve pain, disperse swelling./Stomachache, cholecystitis, acute gastroenteritis, chronic gastroenteritis, innominate toxin swelling.
TCMBANKHE006608	Datura innoxia	毛曼陀罗子			See Datura metel./See Datura metel.
TCMBANKHE008361		荜茇			Cold pain in stomach duct and abdomen, vomiting, diarrhea, headache, toothache, deep-source nasal congestion, coronary heart disease, angina pectoris.
TCMBANKHE008545/YNS-163/YEM-260	Datura stramonium|Datura stramonium L.	偶曼陀罗根;欧曼陀罗根|曼陀罗叶|曼陀罗	曼陀罗叶|曼陀罗	云南药材标准：第一册|云南民族药物志：第二卷	平喘止咳，散寒止痛。用于喘咳，脘腹疼痛，痛经，寒湿痹痛。|See Datura metel./See Datura metel.	阿昌族/白族/傣族/德昂族/景颇族/傈僳族/纳西族/佤族/藏族
TCMBANKHE004220/YEM-273	Datura metel|Datura metel L.	曼陀罗子|洋金花	洋金花	云南民族药物志：第二卷	To calm asthma, dispel wind, relieve pain./Cough and asthma, fright epilepsy, wind-cold-damp impediment, dysentery, prolapse of rectum, knocks and falls.	傣族/傈僳族/彝族/壮族
TCMBANKHE005737/YEM-273	Datura metel|Datura metel L.	曼陀罗叶|洋金花	洋金花	云南民族药物志：第二卷	To suppress cough and calm asthma, relieve pain and draw out pus./Cough and asthma, impediment pain, beriberi, prolapse of rectum.	傣族/傈僳族/彝族/壮族
TCMBANKHE005962/YEM-928	Radix Aconiti Lateralis Praeparata|Aconitum carmichaeli Debx.	制附子|乌头	乌头	云南民族药物志：第五卷	Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE003980/YEM-928	Aconitum carmichaeli|Aconitum carmichaeli Debx.	乌头	乌头	云南民族药物志：第五卷	To dispel wind and eliminate damp, warm channels, dissipate cold and relieve pain./Wind-cold-damp impediment, pain in joints, numbness in limbs, hemiplegia, head wind headache, cold pain in heart and abdomen, cold mounting with pain, stasis pain from knocks and falls, swelling toxin of flat abscess.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE005961/YEM-928	Radix Aconiti Lateralis Preparata|Aconitum carmichaeli Debx.	炮附子|乌头	乌头	云南民族药物志：第五卷	Treatment of collapse with cold limbs and faint pulse, impotence, frigidity, precordial and abdominal pain with cold sensation, vomiting and diarrhea or edema accompanied by aversion to cold and cold extremities, colds in patients with yang deficiency, chronic arthritis due to attack of cold and damp (marked by persistent severe joint pain, fixed in place and accompanied by heaviness sensation and numbness)./1. Aconitine is a physiologically active component, and becomes aconine after hydrolized. The toxicity of aconine is lower than aconitine.2. The prepared products may dilate the blood vessels of lower limbs and coronary artery, and increase coronary flow.3. Aconine and hypaconitine are analgesics and sedatives.4. Acclerating the metabolism of lipids and cholesterol.5. LD50 of aconitine is 0.295mg/kg in mice hypodermally and that of the decoction of prepared aconite is 17.42g/kg in mice orally.6. Its components, higenamine and coryneine chloride exert a significant cardiotonic effect.	阿昌族/布依族/傣族/德昂族/回族/景颇族/傈僳族/苗族/水族/彝族
TCMBANKHE001051/YEM-955	Aconitum brachypodum|Aconitum brachypodum Diels	雪上一枝蒿|短柄乌头	雪上一枝蒿	云南民族药物志：第五卷	To dispel wind and eliminate damp, quicken blood and relieve pain./Wind-damp bone pain, knocks and falls, pain in limbs, toothache,toxin swelling of sores, pain from carcinoma, pain in joints.	阿昌族/傣族/德昂族/景颇族/傈僳族

---

   植物对应的疾病

疾病ID	病名	疾病类型	MeSH	参考文献

---

   化合物对应的靶点

靶点ID	基因名	基因别名	描述